CMIAD member Jason King awarded a prestigious Royal Society Fellowship
Over the course of this fellowship, I will be investigating the maturation of macropinosomes. Macropinocytosis is a bulk endocytic pathway that allows cells to capture large volumes of their aqueous environment and plays a number of physiologically important roles.
However surprisingly little is known about what happens to macropinosomes after they enter the cell. I want to understand the mechanisms underlying macropinosome maturation - in particular, the critical early events when macropinosomes are remodelled and concentrated in order to integrate with other trafficking pathways, whilst recycling plasma membrane components before degradation.