Dr Dennis Wang
Senior Lecturer in Bioinformatics and Genomic Medicine
Room number: 150 Regent Court
Dennis graduated from the University of British Columbia (Vancouver, Canada) with a BSc in Computer Science, Microbiology and Immunology. He then moved to the University of Cambridge for an MPhil in Computational Biology working on bio-networks modeling with Prof Jasmin Fisher (Microsoft Research), and a PhD in Biostatistics working on statistical analysis of epigenetics with Prof Lorenz Wernisch (MRC Biostatistics Unit).
Following the completion of his PhD in 2012, he became a postdoc and a scientific associate at the Princess Margaret Cancer Centre in Toronto working with Prof Ming-Sound Tsao and Prof Frances Shepherd on clinical genomics sequencing and medical informatics techniques. With a greater interest in drug development, he went back to Cambridge in 2014 and joined the early drug discovery division of AstraZeneca Plc. where he developed machine learning methods to identify genetic signatures that predict drug response. He joined the Sheffield Institute for Translational Neuroscience, University of Sheffield in 2016 as a Lecturer (now Senior Lecturer) of Genomic Medicine and was jointly appointed to the Dept. of Computer Science in 2018. Dennis is also the Scientific Director of the Sheffield Bioinformatics Core and Genomics Theme Lead within the NIHR Sheffield Biomedical Research Centre.
The focus of Dr Wang's research group is on improving machine recognition of patterns in genomic data to enable the development of personalised medicines that can benefit patients suffering from complex diseases.
His computational work involves work involves applying machine learning methods to medical research in order to 1) predict patient outcome and 2) identify molecular causes of disease. Both of these aims enable working towards developing data driven approaches for personalising medicine.
Examples of current projects: