Science facilities and services: A-Z
Below you can find details of science and related research facilities at the University of Sheffield.
AWEC has a state of the art 'Grodome' in which 16 discrete units simulate plant growth conditions for different regions around the globe. It contains dedicated laboratory, office and meeting room space to enable researchers to investigate the wide variety of environmental challenges facing the planet.
Zebrafish are the pre-eminent non-mammalian vertebrate species for modelling human disease processes. The zebrafish aquarium is one the largest in Europe, with capacity for 108,000 fish and a dedicated team who run the facility and breeding programmes to the highest standards.
This suite comprises of the following equipment for analysis of biomolecular interactions: 2 x Nano ITC TA Instruments Isothermal Titration Calorimeters and 1 x Nanotemper Monolith NT.115 Microscale Thermophoresis Machine. The machines allow the quantitative measurement of molecular interactions and the facility is open for academic and industrial use.
This facility consists of three NMR spectrometers, 500, 600 and 800MHz, for the analysis of biological samples. All standard solution-state NMR techniques are available for the study of proteins, DNA, small molecules (ligands and metabolites) and peptides. We offer extensive experience in a wide range of studies from biomolecular interactions to protein dynamics and enzyme catalysis.
The Department of Chemistry has a wide range of analytical equipment for external companies to access, including chromatography, mass spectrometry, glass blowing, inductively coupled plasma spectroscopy, microanalytical, NMR, X-ray, Differential scanning calorimetry, polarimetry and sample packaging.
From small organisms to macromolecules, and from cell biology to bio-nanotechnology, we image various experiments by transmission electron microscopy and scanning electron microscopy including, micro-structures, cell interactions, cellular processes, macromolecular complexes, membrane proteins, nano-particles.
The Faculty of Science Mass Spectrometry Centre together with the biOMICS Facility uses state-of-the art instrumentation for the mass analysis of a wide range of complex mixtures and pure molecules for proteome profiling, phosphoproteomics, affinity-purification mass spectrometry and metabolomics.
FaraPack Polymers Ltd offers business-to-business, rapid turn-round research services in polymer science for the industrial sector; which is achieved by drawing on the world-leading academic expertise at the UoS. FPP’s services include short to medium term research (trouble-shooting, proof-of-concept/feasibility studies), contract synthesis, and characterisation and analysis.
Imagine's goal is not to do more of the same, but to do something very different. It combines three fundamentally different – but very complementary – advanced imaging techniques to answer fundamental questions in biology and medicine. Imagine will be unique in the world for providing this level of technology and application.
The Light Microscopy Facility offers a range of microscopes, including confocal (scanning and spinning disc), widefield and deconvolution microscopes. There are also two super-resolution light microscopes, one based on Structured Illumination, another on Localisation microscopy and a light sheet microscope.
Laboratories supporting the following techniques; microsatellite isolation, microsatellite genotyping, SNP-typing, sex-typing, DNA sequencing, amplified fragment length polymorphism analysis, reference strand-mediated conformation analysis and multilocus and single-locus minisatellite DNA fingerprinting.
The Nuclear Magnetic Resonance (NMR) Facility within Chemistry at the Faculty of Science is a core analytical facility, with wide applicability and a comprehensive service offering to researchers at the University of Sheffield and to external customers. It comprises five NMR instruments. Nuclear Magnetic Resonance (NMR) spectroscopy is an analytical chemistry technique used in quality control and research for determining the content and purity of a sample as well as its molecular structure. Please note that the link above is currently only accessible to University of Sheffield staff, for external enquiries please contact Sandra van Meurs directly.
The University of Sheffield has invested £1.5 million in a state of the art pre-clinical 7 Tesla Magnetic Resonance Imaging (MRI) facility. MRI uses the magnetic resonance properties of nuclei within a subject to allow direct visualization of internal structures with high spatial resolution. Applications cover a broad range of topics; from functional MRI, to cardiac imaging and molecular spectroscopy.
The Sheffield RNAi Screening Facility is a contract research facility, offering high throughput genome-wide siRNA and small molecule screens. Staff can facilitate assay development, small scale pilots or genome-wide screens using either a plate reader or high content microscopy.
The facility identifies proteins using classical Edman protein sequencing techniques and by peptide mass fingerprinting using mass spectrometry. The facility also provides a service for peptide synthesis and DNA sequencing, using capillary electrophoresis. synthesis of standard primers and of primers containing modified bases is also provided by the facility.
Sheffield Solar's microgen database collects data from over 6,000 UK installations. Monthly data is available online for domestic users, industry and policy makers. The centre has a test facility that demonstrates different PV technology online, and new and emerging technology can be tested alongside established products.
The Sheffield Surface Analysis Centre provides access to state of the art instrumentation for the characterisation of surfaces. Techniques available facilitate the identification of contaminants, mapping of contaminants and coatings, fracture analysis and determination of the kinetics of surface reactions or modifications.
The Sheffield Single-Cell Omics Facility (sCOF) is a core facility of the Faculty of Science at the University of Sheffield. The single-cell approach to a scientific question allows the exploration of cellular hetereogeneity and the identification of novel cellular sub-populations in complex tissue samples.
This world-leading climate controlled plant growth facility is made up of 32 individual units that are independently able to simulate the majority of terrestrial environments from tropical to Polar regions as well as past and future global atmospheric environments including elevated and sub-ambient CO2.
The SSU provides statistical consultancy to a range of clients, supported by technical and practical experience and a commitment to quality. The Unit's expertise includes planning statistical investigations, analysis and reporting of data, web-based survey design and analysis, expert statistical review and training workshops.
Key areas of expertise include all aspects of protein preparation for structural analysis, including purification of tagged and un-tagged proteins, crystallisation and structural determination of protein and protein-inhibitor complexes. The facility has a number of long-running collaborations with industrial partners and particular experience in rational inhibitor development.