Presentations

Titles of the presentations by the invited speakers are below.

A full booklet of all the abstracts is available from the abstract pages - using the link to the right.

Session 1: Granulation - The Big Picture

Author(s) Affiliation(s) Presentation
D York Procter and Gamble, UK AGGLOMERATION AT THE SHARP END – INDUSTRIAL PRACTICE AND NEEDS
H Leuenberger Institute for Innovation in Industrial Pharmacy, Switzerland MANUFACTURING PHARMACEUTICAL GRANULES: IS THE GRANULATION END-POINT A MYTH?
P Kleinebudde and C Reitz Heinrich-Heine-University Duesseldorf, Germany SOLID LIPID EXTRUSION FOR THE PRODUCTION OF SUSTAINED RELEASE PELLETS
LX Liu, R Smith and JD Litster University of Queensland, Australia WET GRANULE BREAKAGE IN A BREAKAGE ONLY GRANULATOR: EFFECT OF FORMULATION PROPERTIES ON BREAKAGE BEHAVIOUR
G Frenning, J Hellström and G Alderborn Uppsala University, Sweden COMPRESSION AND COMPACTION OF BINARY MIXTURES OF GRANULES
J.M. Link (1), W. Godlieb (1), P. Tripp (2), N.G. Deen (1), S. Heinrich (3), J.A.M. Kuipers (1), M. Schönherr (4) and M. Peglow (3) 1) University of Twente, The Netherlands
2) Vibra Maschinenfabrik Schultheis GmbH, Germany
3) Otto-von-Guericke-University Magdeburg,Germany
4) BASF AG Ludwigshafen, Germany
COMPARISON OF FIBRE OPTICAL MEASUREMENTS AND DISCRETE ELEMENT SIMULATIONS FOR THE STUDY OF GRANULATION IN A SPOUT FLUIDIZED BED

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Session 2a: Compaction and Extrusion

Author(s) Affiliation(s) Presentation
J.P.K.Seville (1), R.F. Mansa (1) and B. Gururajan (2) 1) Centre for Formulation Engineering, Department of Chemical Engineering, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, U.K.
2) Pharmaceutical and Analytical R&D, AstraZeneca, Bakewell Road, Loughborough LE11 5RH, U.K.
ROLL PRESSING: THEORY AND APPLICATION
B. Gururajan (1,2*), P. Cote (1), N. Turnbull (1), E. Razzano (1) and A.C. Bentham (1) 1) Pfizer Global Research and Development, UK
2) Medway Sciences, University of Greenwich, UK (Now at AstraZeneca, R&D, UK)
MICRO SCALE PREDICTION OF THE ROLLER COMPACTION PROCESS
B Van Melkebeke, C Vervaet and JP Remon Laboratory of Pharmaceutical Technology, Ghent University, Belgium VALIDATION OF A CONTINUOUS WET GRANULATION PROCESS USING A TWIN-SCREW EXTRUDER

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Session 2b: Fluidised Bed Processes

Author(s) Affiliation(s) Presentation
N. Kivikero (1), M. Murtomaa (2), J. Aaltonen (1), K. Kogermann (1,3), E. Räsänen (4), J-P. Mannermaa (5) and A. Juppo (1) 1) University of Helsinki, Finland
2) University of Turku, Finland
3) University of Tartu, Estonia
4) South Carelian Hospital Pharmacy, Finland
5) Oy Verman Ab, Finland
FORMULATION AND POLYMORPHIC SCREENING USING MINIATURISED FLUID BED
M Jacob Glatt Ingenieurtechnik GmbH, Germany PROCELL-TECHNOLOGY: MODELLING AND APPLICATION
M Peglow (1), S Heinrich (2) and E Tsotsas (1) Otto-von-Guericke University Magdeburg, Germany TOWARDS A COMPLETE POPULATION BALANCE MODEL FOR FLUIDIZED BED SPRAY GRANULATION: SIMULTANEOUS DRYING AND PARTICLE FORMATION

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Session 3a: High Shear Processes 1

Author(s) Affiliation(s) Presentation
Y. Ouabbas, J. Dodds, A. Chamayou, L. Galet and M. Baron Ecole Nationale Supérieure des Techniques Industrielles et des Mines d’Albi-Carmaux, France PARTICLE-PARTICLE COATING IN A CYCLOMIX IMPACT MIXER
M Oullion (1), GK Reynolds (2), S Dilworth (2) and MJ Hounslow (1) 1) University of Sheffield, UK
2) AstraZeneca, UK
DETECTING AND MEASURING NUCLEATION IN HIGH SHEAR GRANULATION
K. Saleh, L. Forny, I. Pezron L. Komunjer and P.Guigon Université de Technologie de Compiègne, France ENCAPSULATION PROCESS: A WAY TO PRODUCE DRY WATER!
Wei-Da Tu, A. Ingram, J. Seville University of Birmingham, UK RELATIONS BETWEEN SIZE DISTRIBUTION AND GROWTH BEHAVIOUR IN HIGH-SHEAR MIXER

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Session 3b: Pharmaceutical Granulation 1

Author(s) Affiliation(s) Presentation
K.P. Hapgood and B. Khanmohammadi Monash University, Australia NUCLEATION AND GRANULATION OF HYDROPHOBIC POWDERS
G. Walker, S. Bell, M. Vann and G. Andrews Queens University Belfast, UK FLUIDISED BED GRANULATION OF PHARMACEUTICAL MATERIALS: CHARACTERISATION USING RAMAN SPECTROSCOPY
IC Sinka (1), F Motazedian (1), ACF Cocks (2) and KG Pitt (3) 1) University of Leicester, UK
2) University of Oxford, UK
3) GlaxoSmithKline, Ware, UK
THE EFFECT OF POWDER FLOW AND DIE FILL ON TABLET PROPERTIES
I.N. Björn AstraZeneca, Sweden MECHANISTIC BASED PREDICTION OF GRANULATION OUTPUT THROUGH MULTIDIMENSIONAL POPULATION BALANCES AND PAT SENSORS

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Session 4: High Shear Processes 2

Author(s) Affiliation(s) Presentation
PR Mort Procter & Gamble, USA SCALE-UP AND CONTROL OF BINDER AGGLOMERATION PROCESSES – BATCH AND CONTINUOUS
M. Ghadiri University of Leeds, UK EFFECT OF GRANULATION SCALE-UP ON THE STRUCTURE AND STRENGTH OF GRANULES
R. Boerefijn Purac, The Netherlands A NARROW SIZE DISTRIBUTION ON A HIGH SHEAR MIXER BY APPLYING A FLUX NUMBER APPROACH
K van den Dries Organon, The Netherlands FREEZING THE HIGH SHEAR GRANULATION PROCESS

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Session 5a: Industrial Granulation

Author(s) Affiliation(s) Presentation
K. Ax, M. Schoenherr and H. Feise BASF, Germany ASPECTS OF INDUSTRIAL GRANULATION
S Palzer Nestlé Product Technology Centre, Germany INFLUENCE OF MATERIAL PROPERTIES ON THE AGGLOMERATION OF FOOD PARTICLES
T.A. Nagy (1) and Z.G. Meszena (2) 1) Gedeon Richter Ltd., Hungary
2) Budapest University of Technology, Hungary
PROCESS PARAMETER ANALYSIS AND PROCESS UNDERSTANDING – SOME INDUSTRIAL EXAMPLES
GMH Meesters DSM Food Specialties, Delft, The Netherlands DETERMINATION OF THE DRYING CONDITIONS OF STICKY FOOD POWDERS IN A SPRAY DRYER

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Session 5b: Pharmaceutical Granulation 2

Author(s) Affiliation(s) Presentation
C. Wu and J.P.K. Seville University of Birmingham, UK A COMPARATIVE STUDY OF COMPACTION PROPERTIES OF BINARY AND BILAYER TABLETS
G.K. Reynolds (1), V.A. Chouk (2), M.J. Hounslow (2) and A.D. Salman (2) 1) AstraZeneca, UK
2) University of Sheffield, UK
SINGLE DROP BEHAVIOUR IN A HIGH SHEAR GRANULATOR
M. Adams, Siaw Fung Yap*, J. Seville and Z. Zhang University of Birmingham, UK COMPACTION OF BINARY MIXTURES OF PHARMACEUTICAL POWDERS
M.J. Adams (1), Y.S. Cheong (2), M.J. Hounslow (3) and A.D. Salman (3) 1) University of Birmingham, UK
2) University of Cambridge, UK
3) University of Sheffield, UK
MICROSCOPIC INTERPRETATION OF GRANULE STRENGTH IN LIQUID MEDIA

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Session 6: The Micro Scale - Granules and Smaller

Author(s) Affiliation(s) Presentation
S. Simons (1), S. Germana' (1) and J. Bonsall (2) 1) University College London, UK
2) Unilever, UK
REACTIVE BINDERS: WETTABILITY AND ADHESION BEHAVIOUR IN DETERGENT GRANULATION
S. Dorvlo (1), M. Hartmann (2), S. Palzer (2) and A.D. Salman (1) 1) University of Sheffield, UK
2) Nestlé, Germany
SURFACE AND WETTING ANALYSIS: AN INSIGHT INTO THE PRODUCTS OF GRANULATION
F. Stepanek (1), M. Ansari (1) and P. Rajniak (2) 1) Imperial College London, UK
2) Merck & Co, Inc., USA
MECHANISTIC MODELING OF THE FORMATION AND DISSOLUTION OF MULTI-COMPONENT GRANULES