Detection of early subclinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarised gas MRI

Ventilation MRI detects early lung disease in children with Cystic Fibrosis (CF). This type of MRI uses inhaled gases to directly image the airspaces of the lungs. We studied a group of children with CF with very mild lung disease, and found that ventilation MRI was able to detect lung abnormalities which were not detected by other clinical tests (CT, lung clearance index and spirometry). Alongside this group of children with CF we studied healthy children without lung problems, who all had normal ventilation MRI.

Lung Images

This work was recently published in 'Thorax'.

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