Dr David Buttle BSc PhD

Reader in Matrix Biology

Department of Infection, Immunity & Cardiovascular DiseaseDave Buttle
K Floor
The University of Sheffield
Medical School
Beech Hill Road
S10 2RX
United Kingdom

Tel: +44 (0)114 215 9516
Email: d.j.buttle@sheffield.ac.uk
Fax: +44 (0)114 271 3892

Secretary: Mrs Susan Clary
Tel: +44 (0) 114 215 9503
Email: s.clary@sheffield.ac.uk


I began my career as a technician before obtaining, in 1978, a Research Fellowship at Shriners Burns Institute & Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, U.S.A. From 1982 I held research posts in the Department of Biochemistry, Strangeways Research Laboratory, Cambridge, after which I became a post-doctoral Research Fellow with the Arthritis & Rheumatism Council. In 1993 I was appointed to a Senior Lecturer post at The University of Sheffield Medical School then as Reader in Matrix Biology in 2000.

Research Interests:

My major interest is in proteolytic enzymes and extracellular matrix turnover, with principal funding from Arthritis Research UK, The Wellcome Trust, MRC and the Dunhill Medical Trust.

Teaching Interests:

I teach in the musculoskeletal module of the MBChB degree course, as well as on the Molecular Medicine and Translational Oncology MSc courses.

Professional Activities:

I am a member of the following Learned Societies:

  • The Biochemical Society.
  • British Society for Matrix Biology (formerly British Connective Tissue Society).

Current Projects:

  • Glycosaminoglycans as modifiers of protein localisation and function.
  • Developing new aids for cartilage regeneration.
  • Proteoglycans – functions and turnover.
  • Developing plant cysteine proteinases as anthelmintics.
  • The importance of the stromal compartment in cancer progression.
  • Proteinases in kidney fibrosis.


For Key Publications see below.  For full list of publications click here.

Journal articles