Dr Oliver John Watson BSc, MBChB, MRCP, PhD
NIHR Clinical Lecturer in Cardiology
Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Beech Hill Road
Telephone: +44 (0) 114 215 9550
I completed a BSc in Biomedical sciences at the University of Sheffield in 1998, returning to study Medicine in 1999. On completion of my medical studies I completed my clinical training in the Sheffield Teaching Hospitals NHS Foundation Trust and surrounding District General Hospitals.
I commenced my Cardiology specialist training in 2008 and was awarded an MRC clinical training Fellowship through the University of Sheffield. My research utilised the zebrafish model of angiogenesis, with Dr Tim Chico and identified genetic factors influencing flow signal transduction in the developing endothelium. I am now a Clinical Lecturer and Honorary Specialist Trainee in Cardiology.
I am interested in genetic cardiology and the genetic basis of aortic valve disease and aortopathy. I want to use the unique advantages of the zebrafish as a tool to look at the genetic regulation of these genetic diseases.
I am also interested in the molecular signals which regulate angiogenesis in response to blood flow in the in vivo zebrafish embryo.
- Module lead: MED6052, Vascular disease therapy and clinical practice a component of the Molecular medicine MSc programme University of Sheffield 2014.
- Lecturer for clinical cardiology and cardiac physiology at the University of Sheffield Medical School.
For key publications see below. For a full list of publications click here.
- Rothman AMK, Arnold ND, Chang W, Watson O, Swift AJ, Condliffe R, Elliot CA, Kiely DG, Suvarna SK, Gunn J & Lawrie A (2015) Pulmonary Artery Denervation Reduces Pulmonary Artery Pressure and Induces Histological Changes in an Acute Porcine Model of Pulmonary Hypertension. Circulation: Cardiovascular Interventions, 8(11), e002569-e002569. View this article in WRRO
- Watson O, Novodvorsky P, Gray C, Rothman AMK, Lawrie A, Crossman DC, Haase A, McMahon K, Gering M, Van Eeden FJM & Chico TJA (2013) Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling.. Cardiovasc Res, 100(2), 252-261. View this article in WRRO
- Gray C, Bratt D, Lees J, daCosta M, Plant K, Watson OJ, Solaymani-Kohal S, Tazzyman S, Serbanovic-Canic J, Crossman DC, Keavney BD, Haase A, McMahon K, Gering M, Roehl H, Evans PC & Chico TJA (2013) Loss of Function of Parathyroid Hormone Receptor 1 Induces Notch-Dependent Aortic Defects During Zebrafish Vascular Development. Arteriosclerosis, Thrombosis, and Vascular Biology, 33(6), 1257-1263.
- Quaife NM, Watson O & Chico TJA (2012) Zebrafish: an emerging model of vascular development and remodelling.. Curr Opin Pharmacol, 12(5), 608-614.