Professor Alison CondliffeProfessor Alison Condliffe

Professor of Respiratory Medicine
Departmental Staff Development & Performance Lead 

Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Medical School
Beech Hill Road
Sheffield
S10 2RX
United Kingdom

Tel: +44 (0)114 215 9519
Fax: +44 (0)114 271 1863
Email: a.m.condliffe@sheffield.ac.uk

Secretary: Ms Jean Lazenby
Tel: +44 (0) 114 215 9509
Email: j.lazenby@sheffield.ac.uk

Biography:

I am a clinician scientist with an interest in respiratory infection, immune deficiency and inflammation. I studied medicine in Cambridge and London, and undertook clinical training in London and Edinburgh. My PhD was supervised by Professor Chris Haslett and Professor Edwin Chilvers in Edinburgh, and identified a key role for the phosphoinositde 3-kinase (PI3K) signalling pathway in neutrophil priming and activation. I was awarded a Wellcome Trust Intermediate Fellowship to pursue this finding at the Inositide Laboratory at the Babraham Institute in Cambridge, with Dr Phill Hawkins and Dr Len Stephens. My subsequent appointment as a University Lecturer in Cambridge in 2007 enabled a more translational research focus, in particular studying the impact of hypoxia on neutrophil function and establishing novel imaging techniques using radiolabelled neutrophils and eosinophils in man; during this time I forged clinical and research links with the Department of Immunology in Cambridge. This collaboration facilitated the identification the ‘Activated PI3-kinase Delta Syndrome’ or APDS, a novel immune deficiency syndrome characterised by severe recurrent respiratory infection, viral infections, autoimmunity and lymphoproliferation, and caused by excessive PI3K delta signalling in immune cells. I was appointed as Professor of Respiratory Medicine at the University of Sheffield in 2015.

Research Interests:

Defects in innate and adaptive immunity lead to infection with a predilection for the respiratory tract, yet immune cell infiltration underpins a range of inflammatory and allergic respiratory diseases such as chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS) and asthma. To clarify the role of dysregulated immunity in these diseases, I wish to address the following questions:

  1. How does immune cell function become deranged to promote disease pathogenesis rather than host defence?
  2. Can we identify cellular defects that predispose to recurrent respiratory infections?
  3. How can we use this knowledge to further diagnostic, prognostic and therapeutic interventions in diseases driven by aberrant immunity?

My current research funding encompasses the role of inappropriate neutrophil activation in COPD and ARDS, the impact of hypoxia on neutrophil function, and the role of PI3K delta in immune cell and airway biology.

Teaching Interests:

I am committed to medical education and prior to my recent move to Sheffield was the Departmental lead for Educational Supervision. My teaching focuses on respiratory infection and host-pathogen interactions.

Professional Activities:

  • External Examiner for Year 3 Medical Examinations, University of Edinburgh (2015-present).
  • British Thoracic Society Scientific Committee member (2015–2018).
  • British Thoracic Society Lung Infection Specialist Advisory Group member (2015-2018).
  • British Lung Foundation Scientific Committee Member (2011-present).
  • Antibiotic Stewardship Group, Addenbrooke’s Hospital (2010-2015).
  • Lead for Educational Supervision, Respiratory Medicine, Addenbrookes Hospital (2010-2015).
  • Lead for Infection and Infection Control, Respiratory Medicine, Addenbrookes Hospital (2008-2015).
  • Program Committee Member, American Thoracic Society, Respiratory Cell and Molecular Biology Assembly (2007-2011).
  • Planning Committee Member, American Thoracic Society, Respiratory Cell and Molecular Biology Assembly (2009-2012).

Current Projects:

  • How does hypoxia impact on host-pathogen interactions?
  • Contribution of hypoxic upregulation of neutrophil degranulation to airway disease and endothelial dysfunction in COPD
  • Role of PI3K signalling in neutrophil chemotaxis in COPD (with Dr Elizabeth Sapey, University of Birmingham)
  • Characterisation of a mouse model of the APDS (MRC program grant; with Dr Klaus Okkenhaug, Babraham Institute, Cambridge).
  • Use of novel PI3Kδ inhibitors in APDS (MRC-Industrial Collaboration Award, GSK).).
  • Identification of mutations in patients with bronchiectasis and/or recurrent infection (CTTV award with Dr David Michalovitch (GSK), Dr Paul Kelham (Wellcome Trust Sanger Centre) and Professor Andres Floto (Papworth Hospital NHS Foundation Trust)).
  • Role of PI3K signalling in airway epithelial-mediated host defence

Publications:

For key publications see below.  For a full list of publications click here.

Journal articles