Professor Martina Daly BSc PhDMartina Daly

Professor of Molecular Medicine and Faculty Lead for Postgraduate Research Programmes

Address:
Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Medical School
Beech Hill Road
Sheffield
South Yorkshire
S10 2RX

Tel: +44 (0) 114 215 9521
Fax: +44 (0) 114 271 1863
Email: m.daly@sheffield.ac.uk

Secretary: Mrs Vicky Cottam
Tel: +44 (0) 114 215 9504
Email: vicky.cottam@sheffield.ac.uk

Biography:

I joined the University of Sheffield in 1991 when I took up a postdoctoral research post with the Section of Molecular Genetics working with Professor Ian Peake on the investigation of genotype-phenotype relationships in von Willebrand disease. Before this, I completed a PhD in the Children´s Research Centre, Dublin where I developed an interest in haemostasis, in particular antithrombin deficiency, and undertook postdoctoral research posts first in the Children´s Research Centre, Dublin and then in the Department of Haematology, Cambridge UK, where I worked with Professor Robin Carrell´s group on the investigation of the molecular basis of antithrombin deficiency. I was appointed Lecturer in 1992, Senior Lecturer in 2001 and Professor in 2017.

Research Interests:

My research is aimed at improving understanding of the pathogenesis of inherited haemostatic disorders. Current areas of interest include the identification and characterisation of novel genetic defects underlying inherited platelet bleeding disorders and inherited thrombocytopenia. I am also interested in the contribution of platelet gene variation to the bleeding tendency in patients with type 1 von Willebrand factor.

Teaching Interests:

I have a longstanding interest in postgraduate research programmes, and in devising ways to improve the postgraduate research experience. From 2008 to 2014, I was the Postgraduate Research Lead for the University of Sheffield Medical School. In 2014, I was appointed Lead for Postgraduate Research Programmes for the Faculty of Medicine, Dentistry and Health and Chair of the Faculty Graduate Research Committee which is responsible for postgraduate research degree programmes provision within the Faculty and training of Postgraduate research students, and oversees postgraduate research student progress, supervision and support.

Current Projects:

  • Mapping and functional investigation of genetic mutations in patients with mild platelet bleeding disorders. Originally, funded through a British Heart Foundation Programme, this project seeks to identify and characterise the genetic defects underlying mild platelet bleeding abnormalities. Known as the Genotyping and Phenotyping of Platelets or GAPP project, the project is being carried out in collaboration with colleagues at the Universities of Birmingham (Steve Watson, Neil Morgan) and Bristol (Andrew Mumford, Stuart Mundell).
  • Identification and characterisation of FLI1 and RUNX1 regulated determinants of platelet granule biogenesis and secretion, funded by the British Heart Foundation and in collaboration with Dr Vincenzo Leo, Sheffield and Dr Neil Morgan, University of Birmingham.
  • The pathogenesis of inherited thrombocytopenia, in collaboration with Professor Mike Makris, Sheffield.
  • Investigation of the molecular basis of Glanzmann’s thrombasthenia.

Publications:

For key publications see below.  For a full list of publications click here.

Journal articles