Dr Francois Guesdon

Honorary Lecturer

Department of Infection, Immunity & Cardiovascular DiseaseFrancois Guesdon
University of Sheffield
Medical School
Beech Hill Road
S10 2RX
United Kingdom

Tel: +44(0) 114 215 9500
Fax: +44(0) 114 271 1863
Email: f.a.guesdon@sheffield.ac.uk


After obtaining my PhD in 1989 I joined the group of Jeremy Saklatvala in Cambridge. I was appointed in Sheffield in 1996 and am currently Course Tutor of the Msc in Molecular Medicine.

Research Interests:

My research interests are the signal transduction mechanisms of innate immunity cytokines such as IL-1, IL-17 or IL-25 and their roles in allergic (asthma) or chronic inflammatory diseases (arthritis).

Current Projects:

  • Induction of IL-25 expression by airborne allergens
  • Regulation of the protein kinase TAK1

Teaching Development and Innovation:

MSc module Leader: I have designed, set up and led six MSc modules since 2000, of which three are currently taught in the MSc of Molecular Medicine and / or the MSc in Reproductive and Developmental Medicine.

Deputy Course Leader and Course Tutor of the MSc of Molecular Medicine: Responsible for progress monitoring, student support, disciplinary matters and chairing examination board meetings.

Programme development and support:

  • 2000-present: I have designed, set up and led six MSc modules since 2000. I have also carried out yearly reviews of the contents, delivery formats and assessment of these modules and updated them when necessary.
  • 2005: Key contributor to the process of reviewing two overlapping MSc courses and fusing them into a single modular course (MSc in Molecular Medicine), launched in 2006-2007.
  • 2007-present: Designed and managed the personal tutoring scheme of the MSc in Molecular Medicine course and contributed to ensuring course compliance with QAA requirements
  • 2010-2011: Led a task group that reviewed and improved the teaching and assessment of practical research professional skills in the MSc in Molecular Medicine.
  • 2011-2012: Development and management of a new Faculty-wide training programme in Ethics and Integrity for post-graduate research students (in collaboration with Dr. P. Vivekananda-Schmidt).

Professional Recognition and Awards:

2010 - University Senate Award for Excellence in Learning and Teaching (Collaboration category)


  1. Guesdon F, Kaabi Y, Riley AH, Wilkinson IR, Gray C, James DC, Artymiuk PJ, Sayers JR & Ross RJ (2012) Expression of a glycosylphosphatidylinositol-anchored ligand, growth hormone, blocks receptor signalling. Biosci Rep, 32(6), 653-660.

  2. Greetham D, Ellis CD, Mewar D, Fearon U, Ultaigh SNA, Veale DJ, Guesdon F & Wilson AG (2007) Functional characterization of NF-kappa B inhibitor-like protein 1 (NF kappa BIL1), a candidate susceptibility gene for rheumatoid arthritis. HUM MOL GENET, 16(24), 3027-3036.

  3. Ross K, Yang L, Dower S, Volpe F & Guesdon F (2002) Identification of threonine 66 as a functionally critical residue of the interleukin-1 receptor-associated kinase. J Biol Chem, 277(40), 37414-37421.

  4. Dempsey CE, Sakurai H, Sugita T & Guesdon F (2000) Alternative splicing and gene structure of the transforming growth factor beta-activated kinase 1. Biochim Biophys Acta, 1517(1), 46-52.

  5. Guesdon F, Knight CG, Rawlinson LM & Saklatvala J (1997) Dual specificity of the interleukin 1- and tumor necrosis factor-activated beta casein kinase. J Biol Chem, 272(48), 30017-30024.

  6. Freshney NW, Rawlinson L, Guesdon F, Jones E, Cowley S, Hsuan J & Saklatvala J (1994) Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell, 78(6), 1039-1049.