Dr. Noémie Hamilton [PhD] (née Haud)
ELA International Research Fellow
Department of Infection, Immunity and Cardiovascular Disease
University of Sheffield
The Bateson Centre
Tel: +44 (0) 114 222 2769
I joined the University of Sheffield in 2015 to work with zebrafish models of auto-inflammatory neurological disorders. My interest in disease modelling using zebrafish started early when I went to the University of Manchester with my ERASMUS bursary for a 6-month placement in Dr Hurlstone’s lab. I continued my training using zebrafish as an animal model during my PhD and my post doctoral positions in Germany and in the UK, using zebrafish in cancer and neurological disease modelling. I also worked for a short period of time with Astyanax Mexicanus, another fish model to study eye degeneration and heart regeneration.
2016-2010: PhD in genetics- University of Manchester (Supervisor: Dr Adam Hurlstone)
2010-2012: Post Doctoral Associate in Universitat Georg August Goettingen, Germany (Geartner/Henneke group)
2012-2015: Post Doctoral Associate at UCL (Prof Whitmore Group/ Dr Yamamoto/ Dr Mommersteeg)
2015-2016: Post Doctoral Associate at University of Sheffield (Prof Renshaw/Prof Sabroe)
2017-Present: ELA Research Fellow at University of Sheffield
My research interests are to dissect the mechanism of auto-inflammatory neurological disorders using zebrafish as an animal model.
My current fellowship is entitled: A zebrafish model to identify new therapeutic strategies for RNAseT2-deficient cystic leukoencephalopathy without megalencephaly.
My teaching activities will start in 2018 in the Translational Neuroscience MSc course, teaching about Endogenous Retrovirus and neurodegenerative diseases.
Fellowship from European Leukodystrophy Association (ELA).
- Elucidate the role of endogenous retrovirus in neurological disorders.
- Identifying therapeutic drugs to reverse brain inflammation in rnaset2 zebrafish mutants.
For Key Publications see below. For a full list of publications click here.
- Laranjeiro R, Tamai TK, Letton W, Hamilton N & Whitmore D (2018) Circadian Clock Synchronization of the Cell Cycle in Zebrafish Occurs through a Gating Mechanism Rather Than a Period-phase Locking Process. Journal of Biological Rhythms, 33(2), 137-150.
- Hamilton N, Sabroe I & Renshaw SA (2018) A method for transplantation of human HSCs into zebrafish, to replace humanised murine transplantation models. F1000Research, 7, 594-594. View this article in WRRO
- Hamilton N, Diaz-de-Cerio N & Whitmore D (2015) Impaired light detection of the circadian clock in a zebrafish melanoma model. Cell Cycle, 14(8), 1232-1241.
- Haud N, Kara F, Diekmann S, Henneke M, Willer JR, Hillwig MS, Gregg RG, MacIntosh GC, Gartner J, Alia A & Hurlstone AFL (2011) rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA. Proceedings of the National Academy of Sciences, 108(3), 1099-1103.