Prof. Iain D Wilkinson BSc, MSc, PhD, CSci, ARCP, FIPEM
Professor of Magnetic Resonance Physics
IICD Reward & Recognition Lead
NIHR-Sheffield Biomedical Research Centre: Advanced Medical Imaging Lead
Consultant Clinical Scientist (MR Physics), Sheffield Teaching Hospitals NHS Foundation Trust
Department of Infection, Immunity & Cardiovascular Disease
Royal Hallamshire Hospital
I am Professor of Magnetic Resonance (MR) Physics and lead the adult neuroimaging research programme within the Academic Unit of Radiology, part of the University's Medical School based at the Royal Hallamshire Hospital. I particularly enjoy the clinical applications of MR and am a UK state-registered Clinical Scientist. I am an honorary Consultant with our local acute healthcare partner, Sheffield Teaching Hospitals, one of the largest NHS Foundation Trusts in the country (>2,000 beds and 16,000 staff).
Prior to joining the University of Sheffield in 1997, I was an NHS physicist at The Middlesex Hospital (UCLH), part of a team using MR imaging and spectroscopy to investigate the neurological sequelae to HIV infection. Before that I was at Addenbrooke´s Hospital in Cambridge, funded by the UK Department of Health to study MR on a whole-body system built to image at different static magnetic field strengths. I obtained my Bachelors in Physics from the University of Lancaster (the Physics ultra-low temperature lab was at that time the coolest place in the world), Masters in Radiation Physics from St Bartholomew´s Hospital Medical College and Doctorate in MR from the Royal Postgraduate Medical School (Hammersmith Hospital, Imperial College).
I aim to further our understanding of neurological disease and aid its diagnosis and treatment via human in-vivo MR imaging & spectroscopy. Emphasis is on the translation of MR techniques and the findings of MR studies into clinical use. Clinical areas thus far concentrated on have included:
- central nervous system involvement in Diabetes Mellitus (particularly diabetic ‘peripheral’ neuropathy/ pain sensation)
- neurodegeneration: MND / the dementias
- cerebrovascular pathologies (particularly associated with Type-2 Diabetes)
- psychiatric illness
- retroviral infection/encephalopathies
I´m also interested in the non-medical applications of MR particularly with respect to our understanding of the human mind.
I am Principle Investigator of a Wellcome Trust - funded 3T human clinical research MR scanner within our Unit’s base at the Royal Hallamshire Hospital where we partner with many groups that form Sheffield Neuroscience.
I am indebted to the Garfield Weston Foundation, Wellcome Trust, Neurocare, Action for M.E, EAFD/Novo Nordisk, JDRF, Diabetes UK, EU, MRC, DH / NIHR, EPSRC, University of Sheffield Alumni, Ataxia UK, Sheffield Health & Social Research Consortium, Sheffield Hospital’s Charitable Trust, Pfizer IIR and Philips Healthcare for their financial help in support of collaborative imaging research endeavours.
- Supervision of research projects for students undertaking BMedSci, MSc, MD and PhD projects.
- Undergraduate tutor for students studying on Sheffield’s Medical Course.
In addition to being a Fellow of the Institute of Medical Physics & Engineering in Medicine (IPEM), I am currently a corresponding member of the IPEM´s MR Special Interest Group that organises scientific and educational meetings and deals with professional matters relating to the Institute´s involvement in MR Physics. I am an active member of the International Society of Magnetic Resonance in Medicine (ISMRM) and the British Chapter of the ISMRM that hold `cutting edge´ scientific meetings and symposia. I´m also a member of the British Institute of Radiology which is a forum for the multidisciplinary teams who are professionally involved or interested in medical imaging. When applying physics to medicine and clinical research, it is important to grasp an understanding of what drives clinical problem solving and to link with the medical professionals involved. To this end, I am an Affiliate (non-clinical Fellow) of the Royal College of Physicians and an Associate of the British Society of NeuroRadiologists (BSNR). Since one of my main current interests is in `Diabetes and the Brain´, I am a Professional Member of Diabetes UK and a member of the American Diabetes Association, NeuroDiab and the European Association for the Study of Diabetes. Work in this area has recently led to a Visiting Professorship at Shanghai Jiao Tong University Medical School, China.
- Sheffield is home to a NIHR-funded Biomedical Research Centre (BRC) which focuses on experimental medicine and translational neuroscience. I lead the cross-cutting ‘Advanced Medical Imaging’ theme where we apply MR techniques to areas that include neurodegeneration (MND, the dementias, Parkinson’s disease), neuro-inflammation (MS, the ataxias) and cerebrovascular disease (carotid stenosis and stroke). Our BRC forms a very important infrastructure that links we-lab and genomics work (such as that undertaken in SITraN) with the real patients’ needs (Sheffield Teaching Hospitals).
- Cerebrovascular autoregulatory dysfunction in Diabetes (analysis techniques linked to this study form part of Sheffield’s NeuroImaging in Cardiac Disease (NICAD) Network).
- Type-2 Diabetes, cognitive status and concurrent quantitative Cardiac and Brain imaging.
- Status of the CNS on MR Imaging & Spectroscopy in Diabetic Neuropathy.
- MR (1H-imaging and 31P-spectroscopy) of brain & muscle status Amyotrophic Lateral Sclerosis (MND).
- Cerebellar status in the ataxias & neuronal degenerative disorders.
Publications (out of 189 papers):
- McGrath DM, Ravikumar N, Beltrachini L, Wilkinson ID, Frangi AF & Taylor ZA (2016) Evaluation of Wave Delivery Methodology for Brain MRE: Insights from Computational Simulations. Magnetic Resonance in Medicine. View this article in WRRO
- Benn Y, Bergman O, Glazer L, Arent P, Wilkinson ID, Varley R & Whittaker S (2015) Navigating through digital folders uses the same brain structures as real world navigation. Scientific Reports, 5. View this article in WRRO
- Selvarajah D, Wilkinson ID, Maxwell M, Davies J, Sankar A, Boland E, Gandhi R, Tracey I & Tesfaye S (2014) Magnetic resonance neuroimaging study of brain structural differences in diabetic peripheral neuropathy.. Diabetes Care, 37(6), 1681-1688.
- Boland EG, Selvarajah D, Hunter M, Ezaydi Y, Tesfaye S, Ahmedzai SH, Snowden JA & Wilkinson ID (2014) Central pain processing in chronic chemotherapy-induced peripheral neuropathy: a functional magnetic resonance imaging study.. PLoS One, 9(5), e96474. View this article in WRRO
- Wilkinson ID, Selvarajah D, Greig M, Shillo P, Boland E, Gandhi R & Tesfaye S (2013) Magnetic resonance imaging of the central nervous system in diabetic neuropathy.. Curr Diab Rep, 13(4), 509-516.
- Hadjivassiliou M, Wallis LI, Hoggard N, Grünewald RA, Griffiths PD & Wilkinson ID (2012) MR spectroscopy and atrophy in Gluten, Friedreich's and SCA6 ataxias.. Acta Neurol Scand, 126(2), 138-143.
- Romanowski CAJ & Wilkinson ID (2011) Atrophy: When too much atrophy is too little brain.. Neuroradiology, 53 Suppl 1, S133-S139.
- Selvarajah D, Wilkinson ID, Gandhi R, Griffiths PD & Tesfaye S (2011) Microvascular perfusion abnormalities of the Thalamus in painful but not painless diabetic polyneuropathy: a clue to the pathogenesis of pain in type 1 diabetes.. Diabetes Care, 34(3), 718-720. View this article in WRRO
- Gwilliam MN, Hoggard N, Capener D, Singh P, Marzo A, Verma PK & Wilkinson ID (2009) MR derived volumetric flow rate waveforms at locations within the common carotid, internal carotid, and basilar arteries.. J Cereb Blood Flow Metab, 29(12), 1975-1982.
- Giesel FL, Mehndiratta A, Risse F, Rius M, Zechmann CM, von Tengg-Kobligk H, Gerigk L, Kauczor HU, Politi M, Essig M, Griffiths PD & Wilkinson ID (2009) Intraindividual Comparison between Gadopentetate Dimeglumine and Gadobutrol for Magnetic Resonance Perfusion in Normal Brain and Intracranial Tumors at 3 Tesla. ACTA RADIOL, 50(5), 521-530.
- Laycock SK, Wilkinson ID, Wallis LI, Darwent G, Wonders SH, Fawcett AJ, Griffiths PD & Nicolson RI (2008) Cerebellar volume and cerebellar metabolic characteristics in adults with dyslexia.. Ann N Y Acad Sci, 1145, 222-236.
- Selvarajah D, Wilkinson ID, Emery CJ, Shaw PJ, Griffiths PD, Gandhi R & Tesfaye S (2008) Thalamic neuronal dysfunction and chronic sensorimotor distal symmetrical polyneuropathy in patients with type 1 diabetes mellitus.. Diabetologia, 51(11), 2088-2092.
- Spence SA, Kaylor-Hughes C, Farrow TFD & Wilkinson ID (2008) Speaking of secrets and lies: the contribution of ventrolateral prefrontal cortex to vocal deception.. Neuroimage, 40(3), 1411-1418.
- Wallis LI, Griffiths PD, Ritchie SJ, Romanowski CAJ, Darwent G & Wilkinson ID (2007) Proton spectroscopy and imaging at 3T in ataxia-telangiectasia.. AJNR Am J Neuroradiol, 28(1), 79-83.
- Wilkinson ID, Jellineck DA, Levy D, Giesel FL, Romanowski CAJ, Miller B-A & Griffiths PD (2006) Dexamethasone and enhancing solitary cerebral mass lesions: alterations in perfusion and blood-tumor barrier kinetics shown by magnetic resonance imaging.. Neurosurgery, 58(4), 640-646.
- Wilkinson ID, Griffiths PD, Hoggard N, Cleveland TJ, Gaines PA, Macdonald S, McKevitt F & Venables GS (2003) Short-term changes in cerebral microhemodynamics after carotid stenting.. AJNR Am J Neuroradiol, 24(8), 1501-1507.
- Wilkinson ID, Romanowski CAJ, Jellinek DA, Morris J & Griffiths PD (2003) Motor functional MRI for pre-operative and intraoperative neurosurgical guidance.. Br J Radiol, 76(902), 98-103.
Conference proceedings papers
- Tesfaye S, Selvarajah D, Gandhi R, Greig M, Shillo P, Fang F & Wilkinson ID (2016) Diabetic peripheral neuropathy may not be as its name suggests. Pain, Vol. 157 (pp S72-S80)