Professor Iain D Wilkinson BSc, MSc, PhD, CSci, ARCP, FIPEM
Professor of Magnetic Resonance Physics
Departmental Reward & Recognition Lead
Department of Infection, Immunity & Cardiovascular Disease
Royal Hallamshire Hospital
I am Professor of Magnetic Resonance (MR) Physics and lead the adult neuroimaging research programme within the Academic Unit of Radiology, part of the University´s Medical School based at the Royal Hallamshire Hospital. I particularly enjoy the clinical applications of MR and as a UK state-registered Clinical Scientist, am an honorary Consultant with local NHS Trusts.
Prior to joining the University of Sheffield in 1997, I was an NHS physicist at The Middlesex Hospital (UCLH) and Addenbrooke´s Hospital in Cambridge. I obtained my Bachelors in Physics from the University of Lancaster, Masters in Radiation Physics from St Bartholomew´s Hospital Medical College and Doctorate in MR from the Royal Postgraduate Medical School (at Hammersmith Hospital, now part of Imperial College).
I aim to further our understanding of neurological disease and thereby aid its diagnosis and treatment via in-vivo MR Imaging & Spectroscopy. The emphasis of this has always been on the translation of MR techniques and the findings of MR studies into clinical use. Clinical areas thus far concentrated on have included:
- central nervous system involvement in Diabetes Mellitus
- neurodegereration / the dementias
- psychiatric diseases
- retroviral infection/encephalopathies
- abnormalities of the spino-cerebellar thalamic tracts
I'm also interested in the non-medical applications of MR particularly with respect to our understanding of the human mind.
I am indebted to the Wellcome Trust, Neurocare, Action for M.E, EAFD/Novo Nordisk, JDRF, Diabetes UK, EU, MRC, DH / NIHR, EPSRC, University of Sheffield Alumni, Ataxia UK, Sheffield Health & Social Research Consortium, Sheffield Hospital’s Charitable Trust, Leverhulme Trust, Pfizer IIR and Philips Healthcare for their financial help in support of collaborative imaging research.
I supervise research projects for students undertaking BMedSci, MD and PhD projects. I am also an undergraduate tutor for students studying on Sheffield’s Medical Course.
In addition to being a Fellow of the Institute of Medical Physics & Engineering in Medicine (IPEM), I am currently a member of the IPEM´s MR Special Interest Group that organises scientific and educational meetings and deals with professional matters relating to the Institute´s involvement in MR Physics. I am an active member of the International Society of Magnetic Resonance in Medicine (ISMRM) and the British Chapter of the ISMRM that hold `cutting edge´ scientific meetings and symposia. I´m also a member of the British Institute of Radiology which is a forum for the multidisciplinary teams who are professionally involved or interested in medical imaging. When applying physics to medicine and clinical research, it is important to grasp an understanding what drives clinical problem solving and to link with the medical professionals involved. To this end, I am an Affiliate (non-clinical Fellow) of the Royal College of Physicians and an Associate of the British Society of NeuroRadiologists (BSNR). Since one of my main current interests is in `Diabetes and the Brain´, I am a Professional Member of Diabetes UK and a member of NeuroDiab and the European Association for the Study of Diabetes (EASD).
- Principle Investigator of a Wellcome Trust - funded replacement 3T human clinical research MR scanner within our Unit’s base at the Royal Hallamshire Hospital.
- Cerebrovascular & cardiovascular autoregulatory dysfunction in Diabetes.
- Arterial brain perfusion & the brain’s functional pain matrix in Diabetic Neuropathy.
- Virtual Physiological Human modelling of the Dementias (VPH-DARE@IT).
- Functional correlates of pain in Chemotherapy Induced Peripheral Neuropathy.
- MR of muscle status in Amyotrophic Lateral Sclerosis (MND).
- Post-exertion resting-state brain status in Myalgic Encephalopathy.
- Brain function in schizophrenia (auditory hallucinations, emotion regulation and ‘tranquility’).
- Cerebellar status in the ataxias & neuronal degenerative disorders.
Publications (out of 165 papers):
For key publications see below. For a full list of publications click here.
- Wilkinson ID, Selvarajah D, Greig M, Shillo P, Boland E, Gandhi R & Tesfaye S (2013) Magnetic resonance imaging of the central nervous system in diabetic neuropathy.. Curr Diab Rep, 13(4), 509-516.
- Hadjivassiliou M, Wallis LI, Hoggard N, Grünewald RA, Griffiths PD & Wilkinson ID (2012) MR spectroscopy and atrophy in Gluten, Friedreich's and SCA6 ataxias.. Acta Neurol Scand, 126(2), 138-143.
- Romanowski CAJ & Wilkinson ID (2011) Atrophy: When too much atrophy is too little brain.. Neuroradiology, 53 Suppl 1, S133-S139.
- Selvarajah D, Wilkinson ID, Davies J, Gandhi R & Tesfaye S (2011) Central nervous system involvement in diabetic neuropathy.. Curr Diab Rep, 11(4), 310-322.
- Selvarajah D, Wilkinson ID, Gandhi R, Griffiths PD & Tesfaye S (2011) Microvascular perfusion abnormalities of the Thalamus in painful but not painless diabetic polyneuropathy: a clue to the pathogenesis of pain in type 1 diabetes.. Diabetes Care, 34(3), 718-720. View this article in WRRO
- Gwilliam MN, Hoggard N, Capener D, Singh P, Marzo A, Verma PK & Wilkinson ID (2009) MR derived volumetric flow rate waveforms at locations within the common carotid, internal carotid, and basilar arteries.. J Cereb Blood Flow Metab, 29(12), 1975-1982.
- Giesel FL, Mehndiratta A, Risse F, Rius M, Zechmann CM, von Tengg-Kobligk H, Gerigk L, Kauczor HU, Politi M, Essig M, Griffiths PD & Wilkinson ID (2009) Intraindividual Comparison between Gadopentetate Dimeglumine and Gadobutrol for Magnetic Resonance Perfusion in Normal Brain and Intracranial Tumors at 3 Tesla. ACTA RADIOL, 50(5), 521-530.
- Laycock SK, Wilkinson ID, Wallis LI, Darwent G, Wonders SH, Fawcett AJ, Griffiths PD & Nicolson RI (2008) Cerebellar volume and cerebellar metabolic characteristics in adults with dyslexia.. Ann N Y Acad Sci, 1145, 222-236.
- Selvarajah D, Wilkinson ID, Emery CJ, Shaw PJ, Griffiths PD, Gandhi R & Tesfaye S (2008) Thalamic neuronal dysfunction and chronic sensorimotor distal symmetrical polyneuropathy in patients with type 1 diabetes mellitus.. Diabetologia, 51(11), 2088-2092.
- Spence SA, Kaylor-Hughes C, Farrow TFD & Wilkinson ID (2008) Speaking of secrets and lies: the contribution of ventrolateral prefrontal cortex to vocal deception.. Neuroimage, 40(3), 1411-1418.
- Wallis LI, Griffiths PD, Ritchie SJ, Romanowski CAJ, Darwent G & Wilkinson ID (2007) Proton spectroscopy and imaging at 3T in ataxia-telangiectasia.. AJNR Am J Neuroradiol, 28(1), 79-83.
- Wilkinson ID, Jellineck DA, Levy D, Giesel FL, Romanowski CAJ, Miller B-A & Griffiths PD (2006) Dexamethasone and enhancing solitary cerebral mass lesions: alterations in perfusion and blood-tumor barrier kinetics shown by magnetic resonance imaging.. Neurosurgery, 58(4), 640-646.
- Hunter MD, Eickhoff SB, Miller TWR, Farrow TFD, Wilkinson ID & Woodruff PWR (2006) Neural activity in speech-sensitive auditory cortex during silence.. Proc Natl Acad Sci U S A, 103(1), 189-194.
- Wilkinson ID, Romanowski CAJ, Jellinek DA, Morris J & Griffiths PD (2003) Motor functional MRI for pre-operative and intraoperative neurosurgical guidance.. Br J Radiol, 76(902), 98-103.