Dr Maria Fragiadaki
Kidney Research UK Non-Clinical Fellow
Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Beech Hill Road
Tel: +44(0) 114 215 59527
Fax: +44(0) 114 271 1863
I was awarded my PhD in Molecular Medicine from Imperial College London (Hammersmith) in 2009. During my PhD I studied key molecular mechanisms that underpin type I collagen transcription in kidney fibrosis. Following up my interest in renal disease I performed a postdoctoral study under the mentorship of Prof Roger M Mason (Imperial, 2008-2011). I subsequently joined Dr Martin Zeidler’s team to study JAK/STAT signalling using human cells and Drosophila as model systems (MRC Centre for Developmental and Biomedical Genetics, 2011-2013). I was awarded a Thomas-Berry and Simpson Fellowship in 2013 to establish an independent research programme focusing on the cytokine sensing signalling pathway JAK/STAT and renal disease.
My research focuses on molecular mechanisms of renal injury in the context of chronic and acute kidney disease. In specific, I am interested in better understanding signaling pathways, such as the JAK/STAT pathway, and their involvement in kidney damage. I study how resident and infiltrating inflammatory cells contribute to pathogenesis through investigation of migration, proliferation, cell death and inflammation using both in vivo and in vitro models of kidney fibrosis (e.g. Aristolochic acid nephropathy), acute renal injury (e.g. ischemia-reperfusion injury) and genetic renal disorders (e.g. autosomal dominant polycystic kidney disease).
- Member of the Biochemical Society
- Member of the Renal Association
- Member of the British Society for Cell Biology
- 2011 Young Life Scientist Prize, Biochemical Society
- 2010 Lockwood Award, Renal Association
- 2008 Young Renal Scientist of the year, Renal Association
- 2008 Walls Travel Bursary, Renal Association
- 2007 Best PhD Poster Prize, Imperial College London
- 2005 Kidney Research UK PhD Studentship, Imperial College
For key publications see below. For a full list of publications click here.
- Feng S, Bowden N, Fragiadaki M, Souilhol C, Hsiao S, Mahmoud M, Allen S, Pirri D, Ayllon BT, Akhtar S, Thompson AAR, Jo H, Weber C, Ridger V, Schober A & Evans PC (2017) Mechanical Activation of Hypoxia-Inducible Factor 1α Drives Endothelial Dysfunction at Atheroprone Sites.. Arterioscler Thromb Vasc Biol. View this article in WRRO
- Fragiadaki M, Lannoy M, Themanns M, Maurer B, Leonhard WN, Peters DJM, Moriggl R & Ong ACM (2017) STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease. Kidney International, 91(3), 575-586. View this article in WRRO
- Luong LA, Fragiadaki M, Smith J, Boyle J, Lutz J, Dean JLE, Harten S, Ashcroft M, Walmsley SR, Haskard DO, Maxwell PH, Walczak H, Pusey C & Evans PC (2013) Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.. Circ Res, 112(12), 1583-1591.
- Fragiadaki M, Hill N, Hewitt R, Bou-Gharios G, Cook T, Tam FW, Domin J & Mason RM (2012) Hyperglycemia causes renal cell damage via CCN2-induced activation of the TrkA receptor: implications for diabetic nephropathy.. Diabetes, 61(9), 2280-2288.
- Fragiadaki M, Witherden AS, Kaneko T, Sonnylal S, Pusey CD, Bou-Gharios G & Mason RM (2011) Interstitial fibrosis is associated with increased COL1A2 transcription in AA-injured renal tubular epithelial cells in vivo. Matrix Biology, 30(7-8), 396-403.
- Fragiadaki M & Mason RM (2011) Epithelial-mesenchymal transition in renal fibrosis - evidence for and against. International Journal of Experimental Pathology, 92(3), 143-150.
- Fragiadaki M, Ikeda T, Witherden A, Mason RM, Abraham D & Bou-Gharios G (2011) High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1. Molecular Biology of the Cell, 22(11), 1836-1844.