Dr Maria Fragiadaki

Kidney Research UK Non-Clinical Fellow

Dr Maria FragiadakiDepartment of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Medical School
Beech Hill Road
Sheffield
S10 2RX
United Kingdom

Tel: +44(0) 114 215 59527
Fax: +44(0) 114 271 3892
Email: m.fragiadaki@sheffield.ac.uk

Biography:

I was awarded my PhD in Molecular Medicine from Imperial College London (Hammersmith) in 2009.  During my PhD I studied key molecular mechanisms that underpin type I collagen transcription in kidney fibrosis.  Following up my interest in renal disease I performed a postdoctoral study under the mentorship of Prof Roger M Mason (Imperial, 2008-2011).  I subsequently joined Dr Martin Zeidler’s team to study JAK/STAT signalling using human cells and Drosophila as model systems (MRC Centre for Developmental and Biomedical Genetics, 2011-2013).  I was awarded a Thomas-Berry and Simpson Fellowship in 2013 to establish an independent research programme focusing on the cytokine sensing signalling pathway JAK/STAT and renal disease.

Research Interests:

My research focuses on molecular mechanisms of renal injury in the context of chronic and acute kidney disease. In specific, I am interested in better understanding signaling pathways, such as the JAK/STAT pathway, and their involvement in kidney damage.  I study how resident and infiltrating inflammatory cells contribute to pathogenesis through investigation of migration, proliferation, cell death and inflammation using both in vivo and in vitro models of kidney fibrosis (e.g. Aristolochic acid nephropathy), acute renal injury (e.g. ischemia-reperfusion injury) and genetic renal disorders (e.g. autosomal dominant polycystic kidney disease).

Professional Activities:

  • Member of the Biochemical Society
  • Member of the Renal Association
  • Member of the British Society for Cell Biology

Awards:

  • 2011 Young Life Scientist Prize, Biochemical Society
  • 2010 Lockwood Award, Renal Association
  • 2008 Young Renal Scientist of the year, Renal Association
  • 2008 Walls Travel Bursary, Renal Association
  • 2007 Best PhD Poster Prize, Imperial College London
  • 2005 Kidney Research UK PhD Studentship, Imperial College

Publications:

For key publications see below. For a full list of publications click here.

Journal articles