Professor Mark E McAlindon BM BS MRCP DM

Consultant Gastroenterologist and Honorary Professor of GastroenterologyMark McAlindon

Department of Gastroenterology
Sheffield Teaching Hospitals NHS Trust
Department of Gastroenterology
Royal Hallamshire Hospital
Glossop Road
S10 2JF


NHS secretary:
Tel: +44 (0) 114 271 1900 extension 61180
Fax: +44 (0) 114 271 2692


I qualified from the University of Nottingham in 1987 and trained in gastroenterology in Nottingham, Stoke-on-Trent, Melbourne (Australia). In Melbourne I studied gastric adaptation to the effects of non-steroidal anti-inflammatory drugs (NSAIDs) in human subjects, using some of the techniques learnt to continue the same on my return to Nottingham where I subsequently became a British Digestive Foundation research training (1994-6) investigating the processing of interleukin-1 in inflammatory bowel disease. I was appointed Consultant Gastroenterologist in Sheffield in 1998.

The Sheffield Small Bowel Service which I run with colleagues based on the Clinical Investigation Unit is the largest centre in the UK and one of the largest in Europe. It has received awards for innovation, service delivery and patient care from the British Medical Journal, the British Society of Gastroenterology, the Health Service Journal, Medipex and Movetis. I was the recipient of the Hopkins Endoscopy Medal in 2017 for contributions to the field of endoscopy.

Research Interests:

My research interests are the roles of non-invasive technology, specifically capsule endoscopy, in the investigation of the gastrointestinal tract. Capsule endoscopy is a first line modality for small bowel investigation and current projects address issues bowel preparation, the use of capsule endoscopes with two cameras at either end to improve lesion detection and the use of virtual reality to improve visualisation. We are studying patient acceptability of different colonic imaging modalities to establish the role of colon capsule endoscopy as well as the use of panenteric capsule endoscopy. Research into the use of capsule endoscopes in the upper gastrointestinal tract focusses on the use of magnetic control and automated lesion recognition in indications including dyspepsia, anaemia and acute upper gastrointestinal bleeding.

Teaching Interests:

I have been a co-director of the European Lumley Castle Capsule Endoscopy Course since 2005, training over 700 delegates in capsule endoscopy and have taught at conferences and courses around Europe.

I organise the undergraduate gastroenterology module teaching for the University of Sheffield Dental School.

Professional Activities:

  • Ex-officio member of the British Society of Gastroenterology Endoscopy committee.
  • UK Clinical Lead for Quality Improvement in Small Bowel Endoscopy.
  • Member of the European Society of Gastroenterological Endoscopy Research Working Party.
  • Member of the European Society of Gastroenterological Endoscopy Quality Improvement Group (small bowel endoscopy section).
  • Trustee for the Bardhan Research and Educational Trust.

Current Projects:

  1. Patient acceptability of robot magnet-controlled upper gastrointestinal endoscopy.
  2. Handheld magnet controlled capsule endoscopy investigating anaemia and upper gastrointestinal bleeding.
  3. Upper gastrointestinal capsule endoscopy controlled with patient positional change.
  4. Virtual reality in capsule endoscopy.
  5. Gastric mapping of capsule endoscopy images.
  6. Patient acceptability of different colonic imaging modalities.

Key Publications:

  1. Tontini GE, Wiedbrauck F, Cavallaro F, Koulaouzidis A, Marino R, Pastorelli L, Spina L, McAlindon ME, Leoni P, Vitagliano P, Cadoni S, Rondonotti E, Vecchi M. Small-bowel capsule endoscopy with panoramic view: results of the first multicenter, observational study (with videos). Gastrointest Endosc. 2016 [Epub ahead of print]

  2. Hale MF, Drew K, McAlindon ME, Sidhu R. The diagnostic accuracy of faecal calprotectin and small bowel capsule endoscopy and their correlation in suspected isolated small bowel Crohn's disease. Eur J Gastroenterol Hepatol. 2016;28:1145-50.

  3. Hale MF, Drew K, Sidhu R, McAlindon ME. Does magnetically assisted capsule endoscopy improve capsule endoscopy completion rate? A randomised controlled trial. Endosc Int Open 2016;4:E215-21.

  4. Hale MF, Rahman I, Drew K, Sidhu R, Riley SA, Patel P, McAlindon ME. Magnetically steerable gastric capsule endoscopy is equivalent to flexible endoscopy in the detection of markers in an excised porcine stomach model: results of a randomised trial. Endoscopy 2015;47:650-3.

  5. Assadsangabi A, Blakeborough A, Drew K, Lobo AJ, Sidhu R. McAlindon ME. Small bowel patency assessment using the patency device and a novel targeted (limited radiation) computed tomography based protocol. J Gastroenterol Hepatol 2015;30:984-9.

  6. Pennazio M, Spada C, Eliakim R, Keuchel M, May A, Mulder CJ, Rondonotti E, Adler SN, Albert J, Baltes P, Barbaro F, Cellier C, Charton JP, Delvaux M, Despott EJ, Domagk D, Klein A, McAlindon M, Rosa B, Rowse G, Sanders DS, Saurin JC, Sidhu R, Dumonceau JM, Hassan C, Gralnek IM. Small bowel endoscopy and device assisted enteroscopy for diagnosis and treatment of small bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) clinical guideline. Endoscopy 2015;47:352-76.

  7. Liao Z, Li Z, McAlindon ME (eds): Handbook of Capsule Endoscopy. Springer, 2014.

  8. Hale M, McAlindon ME. Capsule endoscopy as a panenteric diagnostic tool. Br J Surg 2014;101:148-9.

  9. McAlindon ME, Parker CE, Hendy P, Mosea H, Panter S, Davison C, Fraser C, Despott EJ, Sidhu R, Sanders DS, Makins R. Provision of service and training for small bowel endoscopy in the UK. Frontline Gastroenterol 2012;3:2 98-103.

  10. Sidhu R, Brunt LK, Morley SR, Sanders DS, McAlindon ME. Undisclosed use of non-steroidal anti-inflammatory drugs may underlie small bowel injury observed by capsule endoscopy. Clin Gastroenterol Hepatol. 2010;8:992-5.

  11. Sidhu R, Sanders DS, Morris AJ, McAlindon ME. Guidelines on small bowel enteroscopy and capsule endoscopy in adults. Gut 2008;57:125-36.

  12. Hopper AD, Cross SS, Hurlstone DP, McAlindon ME, Lobo AJ, Hadjivassiliou M, Sloan ME, Dixon S, Sanders DS. Pre-endoscopy serological testing for coeliac disease: evaluation of a clinical decision tool. BMJ. 2007;334:729.

  13. Sidhu R, Sanders DS, Kapur K, Hurlstone DP, McAlindon ME. Capsule endoscopy changes patient management in routine clinical practice. Dig Dis Sci. 2007;52:1382-6.

  14. Sidhu R, Sanders DS, McAlindon ME. Gastrointestinal capsule endoscopy: from tertiary centres to primary care. BMJ 2006;332:528-531.

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