Professor Paul Evans
Professor of Cardiovascular Science
I joined Dr Graeme Alexander's laboratory (Cambridge, UK) in 1993 to study the immunological processes that govern chronic rejection of liver grafts and graduated with a PhD in 1996. Following Post-doctoral positions in Prof. Lee Nelson's group at the Fred Hutchinson Cancer Research Center (Seattle, USA) and Dr. Peter Kilshaw's laboratory at the Babraham Institute (Cambridge, UK), I was awarded Training and Senior Fellowships by Kidney Research UK to study the intracellular signalling pathways that control inflammatory activation and injury of vascular endothelial cells. My studies in this field were recognized by the British Transplantation Society who awarded me the Medawar Prize in 2000. I joined Imperial College London in 2004 as a Senior Lecturer in Endothelial Cell Physiology and was promoted to Reader in 2010. During this time, I headed the Intracellular Signalling Laboratory within the British Heart Foundation Cardiovascular Sciences Unit, which is headed by Prof. Dorian Haskard. I was appointed to the Chair in Cardiovascular Science at the University of Sheffield in October 2011.
My research is focussed on the effects of shear stress (a mechanical force generated by flowing blood) on the physiology of vascular endothelial cells. These studies are relevant to vascular injury and atherosclerosis which develop predominantly at branches and bends in the arterial tree that are exposed to disturbed patterns of blood flow. The cross-disciplinary nature of my work has led to interactions with molecular and cellular biologists, vascular physiologists and bioengineers. My research program will improve our understanding of the molecular mechanisms that give rise to the spatial distribution of atherosclerotic plaques, and will inform novel therapeutic approaches to prevent or treat atherosclerosis by inducing protective molecules at atherosusceptible regions. My studies in this field have been recognized by the British Atherosclerosis Society (John French Lecture 2011) and the British Cardiovascular Society (Michael Davies Award 2011), and members of my group have also won prestigious prizes (listed below).
Awards for the Evans Lab:
April 2015 - 10th International Symposium on Biomechanics and Vascular Biology – best oral presentation (Miss Marwa Mahmoud).
Sept 2014 - BAS Young Investigator Prize awarded to Marwa Mahmoud.
Sept 2014 - BAS Young Investigator Prize awarded to Neil Bowden.
July 2014 - ESC Frontiers in Cardiovascular Biology, Barcelona - Young Investigator Award (first prize) awarded to Dr Sarah Hsiao.
July 2014 - ESC Frontiers in Cardiovascular Biology, Barcelona – poster prize (Mr Ismael Gauci).
April 2014 - 9th International Symposium on Biomechanics and Vascular Biology – best oral presentation (Dr Sarah Hsiao).
April 2012 - Society for Cardiovascular Surgery in Great Britain and Ireland – Ronald Edwards Medal (Mr Bao Nguyen).
June 2010 - British Atherosclerosis Society/ British Society for Cardiovascular Research Young Investigator Award (Simon Cuhlmann).
April 2010 - 5th International Symposium on Biomechanics and Vascular Biology – best oral presentation (Dr Kim Van der Heiden).
March 2010 - Society for Cardiovascular Surgery in Great Britain and Ireland - Ronald Edwards Medal (Mr Mustafa Zakkar).
May 2009 - Promega UK Young Life Scientist Award - 1st Prize (Dr Kim Van der Heiden).
- Vice-Chair of the European Society for Cardiology Working Group on Atherosclerosis and Vascular Biology.
- British Heart Foundation Project Grant Committee Member.
- European Vascular Biology Organisation Council Member.
- NC3Rs Fellowship Committee Member.
- British Society for Cardiovascular Research Committee Member.
- Committee Member for the International Symposium on Biomechanics in Vascular Biology.
- Rapporteur for the European Commission - Marie Curie Framework 7 (2010) and Marie Curie Framework 6 (2005).
- Senior Editor for the Journal of Inflammation (2009-) and Editorial Board member for numerous international journals.
- Identification of novel mechanoresponsive signalling networks that control endothelial cell injury and activation. Professor Evans principal applicant with Professor Henning Walczak, Dr Chuh K Chong and Dr Tim Chico. British Heart Foundation Funding.
- Does shear stress sculpt focal atherosclerosis by inducing the NF-κB regulator Cezanne? Professor Evans principal applicant with Dr Sheila Francis. British Heart Foundation Funding.
- Using magnetic tweezers to decipher the mechanical code in endothelial cells. Professor Evans principal applicant with Dr Paul Watton.
- Interdisciplinary PhD Studentship network on ‘Mechanoreceptors in health and disease’. Professor Evans principal applicant with Professor Damien Lacroix, Dr Jarema Malicki, Dr Gwen Reilly, Dr Sarah Staniland and Professor Jon Waltho.
For key publications see below. For a full list of publications click here.
- Evans PC & Kwak BR (2013) Biomechanical factors in cardiovascular disease.. Cardiovasc Res, 99(2), 229-231.
- Van der Heiden K, Gijsen FJH, Narracott A, Hsiao S, Halliday I, Gunn J, Wentzel JJ & Evans PC (2013) The effects of stenting on shear stress: relevance to endothelial injury and repair.. Cardiovasc Res, 99(2), 269-275.
- Luong LA, Fragiadaki M, Smith J, Boyle J, Lutz J, Dean JLE, Harten S, Ashcroft M, Walmsley SR, Haskard DO, Maxwell PH, Walczak H, Pusey C & Evans PC (2013) Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.. Circ Res, 112(12), 1583-1591.
- Cuhlmann S, Van der Heiden K, Saliba D, Tremoleda JL, Khalil M, Zakkar M, Chaudhury H, Luong LA, Mason JC, Udalova I, Gsell W, Jones H, Haskard DO, Krams R & Evans PC (2011) Disturbed blood flow induces RelA expression via c-Jun N-terminal kinase 1: a novel mode of NF-κB regulation that promotes arterial inflammation.. Circ Res, 108(8), 950-959.
- Zakkar M, Luong LA, Chaudhury H, Ruud O, Punjabi PP, Anderson JR, Mullholand JW, Clements AT, Krams R, Foin N, Athanasiou T, Leen ELS, Mason JC, Haskard DO & Evans PC (2011) Dexamethasone arterializes venous endothelial cells by inducing mitogen-activated protein kinase phosphatase-1: a novel antiinflammatory treatment for vein grafts?. Circulation, 123(5), 524-532.
- Chaudhury H, Zakkar M, Boyle J, Cuhlmann S, van der Heiden K, Luong LA, Davis J, Platt A, Mason JC, Krams R, Haskard DO, Clark AR & Evans PC (2010) c-Jun N-terminal kinase primes endothelial cells at atheroprone sites for apoptosis.. Arterioscler Thromb Vasc Biol, 30(3), 546-553.
- Zakkar M, Van der Heiden K, Luong LA, Chaudhury H, Cuhlmann S, Hamdulay SS, Krams R, Edirisinghe I, Rahman I, Carlsen H, Haskard DO, Mason JC & Evans PC (2009) Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state.. Arterioscler Thromb Vasc Biol, 29(11), 1851-1857.
- Zakkar M, Chaudhury H, Sandvik G, Enesa K, Luong LA, Cuhlmann S, Mason JC, Krams R, Clark AR, Haskard DO & Evans PC (2008) Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis.. Circ Res, 103(7), 726-732.
- Enesa K, Ito K, Luong LA, Thorbjornsen I, Phua C, To Y, Dean J, Haskard DO, Boyle J, Adcock I & Evans PC (2008) Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms.. J Biol Chem, 283(27), 18582-18590.
- Enesa K, Zakkar M, Chaudhury H, Luong LA, Rawlinson L, Mason JC, Haskard DO, Dean JLE & Evans PC (2008) NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling.. J Biol Chem, 283(11), 7036-7045.
- Lutz J, Luong LA, Strobl M, Deng M, Huang H, Anton M, Zakkar M, Enesa K, Chaudhury H, Haskard DO, Baumann M, Boyle J, Harten S, Maxwell PH, Pusey C, Heemann U & Evans PC (2008) The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation. Journal of Molecular Medicine, 86(12), 1329-1339.
- Partridge J, Carlsen H, Enesa K, Chaudhury H, Zakkar M, Luong L, Kinderlerer A, Johns M, Blomhoff R, Mason JC, Haskard DO & Evans PC (2007) Laminar shear stress acts as a switch to regulate divergent functions of NF-kappaB in endothelial cells.. FASEB J, 21(13), 3553-3561.