Professor Eva Qwarnstrom
Journal articles
Kennelly TM, Li Y, Cao Y, Qwarnstrom EE & Geoghegan M (2019) Distinct binding interactions of α5β1-integrin and proteoglycans with fibronectin . Biophysical Journal . View this article in WRRO
Smith SA, Samokhin AO, Alfadi M, Murphy EC, Rhodes D, Kiss-Toth E, Storey RF, Yee S-P, Francis SE & Qwarnstrom EE (2017) The IL-1RI Co-Receptor TILRR (FREM1 Isoform 2) Controls Aberrant Inflammatory Responses and Development of Vascular Disease . JACC - Journal of the American College of Cardiology bts , 2(4), 398-414. View this article in WRRO
Rhodes DM, Holcombe M & Qwarnstrom EE (2016) Reducing complexity in an Agent Based Reaction Model—Benefits and limitations of simplifications in relation to run time and system level output . Biosystems , 147, 21-27. View this article in WRRO
Williams RA, Timmis J & Qwarnstrom EE (2016) Statistical Techniques Complement UML When Developing Domain Models of Complex Dynamical Biosystems. . PLoS One , 11(8). View this article in WRRO
Williams RA, Timmis J & Qwarnstrom EE (2015) Towards a platform model of the IL-1 stimulated NF-kB signalling pathway using communicating stream X-machines. CosMoS 2015 , 2015, 107-110.
Rhodes DM, Smith SA, Holcombe M & Qwarnstrom EE (2015) Computational modelling of NF-κB activation by IL-1RI and its co-receptor TILRR, predicts a role for cytoskeletal sequestration of IκBαin inflammatory signalling . PLoS ONE , 10(6). View this article in WRRO
Williams RA, Timmis J & Qwarnstrom EE (2015) The rise in computational systems biology approaches for understanding NF-κB signaling dynamics . Science Signaling , 8(385), fs13-fs13.
Williams RA, Timmis J & Qwarnstrom EE (2014) Computational Models of the NF-KB Signalling Pathway . MDPI Computation , 2(4), 131-158.
Rhodes D, Smith S, Qwarnstrom E & Holcombe M (2014) 166 Increase in TILRR Expression in Areas of Vascular Inflammation Alters NF-KB Control Through Cytoskeletal Release of the Inhibitor IKBA - Interdisciplinary Analysis Using Predictive Agent Based Modelling. . Heart , 100 Suppl 3, A95.
Samokhin AO, Francis SE & Qwarnstrom EE (2014) Blocking the IL-1RI Co-receptor TILRR Reduces Vascular Inflammation – in vivo Analysis Using TILRR Knockout Mice . Heart , 100.
Samokhin A, Murphy E, Grant J, Boyle J, Haskard D, Francis S & Qwarnstrom E (2013) 210 A ROLE FOR THE IL-1RI CO-RECEPTOR TILRR IN ATHEROSCLEROSIS AND VASCULAR REPAIR . Heart , 99(suppl 2), A115.2-A115.
Hudson RC, Gray C, Kiss-Toth E, Chico TJA & Qwarnstrom EE (2012) Bioinformatics Analysis of the FREM1 Gene—Evolutionary Development of the IL-1R1 Co-Receptor, TILRR. Biology , 1(3), 484-494. View this article in WRRO
Zhang X, Montagut Pino G, Shephard F, Kiss-Toth E & Qwarnstrom EE (2012) Distinct control of MyD88 adapter-dependent and Akt kinase-regulated responses by the interleukin (IL)-1RI co-receptor, TILRR. . J Biol Chem , 287(15), 12348-12352.
Neilan M, Zhang X, Steiner T, Boyle J, Francis S, Haskard D & Qwarnstrom E (2012) 18 TILRR Functional Mutants Selectively Inhibit Inflammatory and Anti-Apoptotic Responses . Heart , 98, A6.
Holcombe M, Adra S, Bicak M, Chin S, Coakley S, Graham AI, Green J, Greenough C, Jackson D, Kiran M , MacNeil S et al (2012) Modelling complex biological systems using an agent-based approach. . Integr Biol (Camb) , 4(1), 53-64.
Pino GM, Zhang X & Qwarnstrom EE (2010) BAS/BSCR5 TILRR potentiates interleukin-1-induced anti-apoptosis . Heart , 96(17), e13-e14.
Neilan M, Zhang X, Francis S & Qwarnstrom EE (2010) BAS/BSCR51 Control of vascular cell inflammatory responses through TILRR, an interleukin 1 co-receptor . Heart , 96(17), e27-e27.
Zhang X, Shephard F, Kim HB, Palmer IR, McHarg S, Fowler GJS, O'Neill LAJ, Kiss-Toth E & Qwarnstrom EE (2010) TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappaB. . J Biol Chem , 285(10), 7222-7232.
Kim H-B, Evans I, Smallwood R, Holcombe M & Qwarnstrom EE (2010) NIK and IKKbeta interdependence in NF-kappaB signalling--flux analysis of regulation through metabolites. . Biosystems , 99(2), 140-149.
Dower SK, Qwarnstrom EE & Kiss-Toth E (2007) Fluorescent protein reporter systems for single-cell measurements. . Methods Mol Biol , 411, 111-119.
Guan H, Holland K, Qwarnstrom E, Dower SK & Kiss-Toth E (2006) Feedback loops in intracellular signal processing and their potential for identifying novel signalling proteins. . Cell Immunol , 244(2), 158-161.
Pogson M, Smallwood R, Qwarnstrom E & Holcombe M (2006) Formal agent-based modelling of intracellular chemical interactions. . Biosystems , 85(1), 37-45.
Kiss-Toth E, Wyllie DH, Holland K, Marsden L, Jozsa V, Oxley KM, Polgar T, Qwarnstrom EE & Dower SK (2006) Functional mapping and identification of novel regulators for the Toll/Interleukin-1 signalling network by transcription expression cloning. . Cell Signal , 18(2), 202-214.
Kiss-Toth E, Wyllie DH, Holland K, Marsden L, Jozsa V, Oxley KM, Polgar T, Qwarnstrom EE & Dower SK (2005) Functional mapping of Toll/interleukin-1 signalling networks by expression cloning. . Biochem Soc Trans , 33(Pt 6), 1405-1406.
Kiss-Toth E, Wyllie DH, Holland K, Marsden L, Jozsa V, Oxley KM, Polgar T, Qwarnstrom EE & Dower SK (2005) Functional mapping of Toll/interleukin-1 signalling networks by expression cloning . Biochemical Society Transactions , 33(6), 1405-1406.
Telekes A, Kiss-Tóth E, Nagy T, Qwarnstrom EE, Kúsz E, Polgár T, Resetár A, Dower SK & Duda E (2005) Synergistic effect of Avemar on proinflammatory cytokine production and Ras-mediated cell activation. . Ann N Y Acad Sci , 1051, 515-528.
Ganguli A, Persson L, Palmer IR, Evans I, Yang L, Smallwood R, Black R & Qwarnstrom EE (2005) Distinct NF-kappaB regulation by shear stress through Ras-dependent IkappaBalpha oscillations: real-time analysis of flow-mediated activation in live cells. . Circ Res , 96(6), 626-634.
Kiss-Toth E, Bagstaff SM, Sung HY, Jozsa V, Dempsey C, Caunt JC, Oxley KM, Wyllie DH, Polgar T, Harte M , O'neill LAJ et al (2004) Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. . J Biol Chem , 279(41), 42703-42708.
Kiss-Toth E, Qwarnstrom EE & Dower SK (2004) Hunting for genes by functional screens. . Cytokine Growth Factor Rev , 15(2-3), 97-102.
Dower SK & Qwarnstrom EE (2003) Signalling networks, inflammation and innate immunity. . Biochem Soc Trans , 31(Pt 6), 1462-1471.
Lawrie A, Brisken AF, Francis SE, Wyllie D, Kiss-Toth E, Qwarnstrom EE, Dower SK, Crossman DC & Newman CM (2003) Ultrasound-enhanced transgene expression in vascular cells is not dependent upon cavitation-induced free radicals.. Ultrasound Med Biol , 29(10), 1453-1461.
Yang L, Ross K & Qwarnstrom EE (2003) RelA control of IkappaBalpha phosphorylation: a positive feedback loop for high affinity NF-kappaB complexes. . J Biol Chem , 278(33), 30881-30888.
Schooley K, Zhu P, Dower SK & Qwarnström EE (2003) Regulation of nuclear translocation of nuclear factor-kappaB relA: evidence for complex dynamics at the single-cell level. . Biochem J , 369(Pt 2), 331-339.
Valles S, Caunt CJ, Walker MH & Qwarnstrom EE (2002) PDGF enhancement of IL-1 receptor levels in smooth muscle cells involves induction of an attachment-regulated, heparan sulfate binding site (IL-1RIII).. Lab Invest , 82(7), 855-862.
Evans IC, Ray K & Qwarnstrom E (2001) Regulation of IκBα by the upstream kinases . Biochemical Society Transactions , 29(5), A128.3-A128.
Caunt CJ, Kiss-Toth E, Walker M, Sims J & Qwarnstrom EE (2001) The putative GTPase activating protein IIP-1 functions antagonistically to Ras in the regulation of Interleukin-1 signalling . Biochemical Society Transactions , 29(5), A130.3-A130.
Yang L, Chen H & Qwarnstrom E (2001) Degradation of IkappaBalpha is limited by a postphosphorylation/ubiquitination event. . Biochem Biophys Res Commun , 285(3), 603-608.
Caunt CJ, Kiss-Toth E, Carlotti F, Chapman R & Qwarnstrom EE (2001) Ras controls tumor necrosis factor receptor-associated factor (TRAF)6-dependent induction of nuclear factor-kappa b. Selective regulation through receptor signaling components. . J Biol Chem , 276(9), 6280-6288.
Huang WY, Vallés S & Qwarnstrom EE (2001) Translocation of the IL-1 receptor to focal adhesions is regulated through the C-terminal end of the cytoplasmic domain. . Cell Biol Int , 25(4), 309-317.
Carlotti F, Dower SK & Qwarnstrom EE (2000) Dynamic shuttling of nuclear factor kappa B between the nucleus and cytoplasm as a consequence of inhibitor dissociation. . J Biol Chem , 275(52), 41028-41034.
Kiss-Toth E, Guesdon FM, Wyllie DH, Qwarnstrom EE & Dower SK (2000) A novel mammalian expression screen exploiting green fluorescent protein-based transcription detection in single cells. . J Immunol Methods , 239(1-2), 125-135.
Slack JL, Schooley K, Bonnert TP, Mitcham JL, Qwarnstrom EE, Sims JE & Dower SK (2000) Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways. . J Biol Chem , 275(7), 4670-4678.
Carlotti F, Chapman R, Dower SK & Qwarnstrom EE (1999) Activation of nuclear factor kappaB in single living cells. Dependence of nuclear translocation and anti-apoptotic function on EGFPRELA concentration. . J Biol Chem , 274(53), 37941-37949.
Vallés S, Tsoi C, Huang WY, Wyllie D, Carlotti F, Askari JA, Humphries MJ, Dower SK & Qwarnström EE (1999) Recruitment of a heparan sulfate subunit to the interleukin-1 receptor complex. Regulation by fibronectin attachment. . J Biol Chem , 274(29), 20103-20109.
Royds JA, Dower SK, Qwarnstrom EE & Lewis CE (1998) Response of tumour cells to hypoxia: role of p53 and NFkB. . Mol Pathol , 51(2), 55-61.
Zhu P, Xiong W, Rodgers G & Qwarnstrom EE (1998) Regulation of interleukin 1 signalling through integrin binding and actin reorganization: disparate effects on NF-kappaB and stress kinase pathways. . Biochem J , 330 ( Pt 2), 975-981.
Ostberg CO, Zhu P, Wight TN & Qwarnstrom EE (1995) Fibronectin attachment is permissive for IL-1 mediated gene regulation. . FEBS Lett , 367(1), 93-97.
Qwarnström EE, Ostberg CO, Turk GL, Richardson CA & Bomsztyk K (1994) Fibronectin attachment activates the NF-kappa B p50/p65 heterodimer in fibroblasts and smooth muscle cells.. J Biol Chem , 269(49), 30765-30768.
Qwarnström EE, Järveläinen HT, Kinsella MG, Ostberg CO, Sandell LJ, Page RC & Wight TN (1993) Interleukin-1 beta regulation of fibroblast proteoglycan synthesis involves a decrease in versican steady-state mRNA levels. . Biochem J , 294 ( Pt 2), 613-620.
Luddington S, Qwarnström EE, Page RC & Bordin S (1993) Expression and function of gingival fibroblast C1q receptors are upregulated by interleukin-1 beta and transforming growth factor-beta. . J Cell Physiol , 155(1), 157-163.
Wight TN, Kinsella MG & Qwarnström EE (1992) The role of proteoglycans in cell adhesion, migration and proliferation.. Curr Opin Cell Biol , 4(5), 793-801. View this article in WRRO
Qwarnström EE, Kinsella MG, MacFarlane SA, Page RC & Wight TN (1992) Modulation of proteoglycan metabolism by human fibroblasts maintained in an endogenous three-dimensional matrix.. Eur J Cell Biol , 57(1), 101-108.
DOWER SK, QWARNSTROM EE, PAGE RC, BLANTON RA, KUPPER TS, RAINES E, ROSS R & SIMS JE (1990) BIOLOGY OF THE INTERLEUKIN-1 RECEPTOR. JOURNAL OF INVESTIGATIVE DERMATOLOGY , 94(6), S68-S73.
Dower SK, Qwarnstrom EE, Page RC, Blanton RA, Kupper TS, Raines E, Ross R & Sims JE (1990) Biology of the interleukin-1 receptor. . J Invest Dermatol , 94(6 Suppl), 68S-73S.
Curtis BM, Widmer MB, deRoos P & Qwarnstrom EE (1990) IL-1 and its receptor are translocated to the nucleus.. J Immunol , 144(4), 1295-1303.
Dardick I, Jeans MT, Sinnott NM, Wittkuhn JF, Kahn HJ & Baumal R (1985) Salivary gland components involved in the formation of squamous metaplasia.. Am J Pathol , 119(1), 33-43.
Qwarnstrom E, Bodner L, Baum B, Hand A & Omnell K-A (1984) Basic Biological Sciences Saliva Secretion from the Rat Submandibular Gland after Retrograde Infusion of Radiographic Contrast Media . Journal of Dental Research , 63(5), 614-617.
Bodner L, Qwarnstrom E, Omnell K-A, Hand AR & Baum BJ (1983) Rat submandibular gland secretion: A bilateral and longitudinal comparative study . Comparative Biochemistry and Physiology Part A: Physiology , 74(4), 829-831.
Omnell K-Å & Qwarnström EE (1983) A Technique for Intraoral Cannulation and Infusion of the Rat Submandibular Gland . Dentomaxillofacial Radiology , 12(1), 13-15.
Bodner L, Qwarnstrom E & Baum B (1982) Stimulated rat submandibular gland secretion: Normal features and response to retrograde infusion. Journal of Dental Research , 61(Abs.).
Chapters
Conference proceedings papers
Williams RA, Timmis J & Qwarnstrom EE (2017) Investigating IKK dynamics in the NF-κB signalling pathway using X-Machines . 2017 IEEE Congress on Evolutionary Computation (CEC) , 5 June 2017 - 8 June 2017. View this article in WRRO
Qwarnstrom EE (2016) Regulation of Inflammatory and anti-apoptotic responses through the IL-1RI/TILRR complex.. Biol. Syst. Open access , Vol. 2(5) (pp 31-31) View this article in WRRO
Smith S, Samokhin A, Murphy E, Francis S & Qwarnstrom E (2015) 217 Altered Regulation of the Inhibitor IκBα Contributes to Changes in NF-κB Regulated Genes in the TILRR ko Mouse . Heart , Vol. 101(Suppl 4) (pp A118.2-A119)
Murphy E, Samokhin A, Francis S, Bowskill S & Qwarnstrom E (2014) 187 The inflammatory phenotype of the tilrr knockout mouse - mechanisms undelying reduced responses to vascular injury. . Heart , Vol. 100 Suppl 3 (pp A104-A105). England
Williams RA, Timmis J & Qwarnstrom EE (2012) Domain Modelling - When UML is not Enough: A Case Study using the IL-1 Stimulated NF-kB Intracellular Signalling Pathway. Artificial Immune Systems 11th International Conference, ICARIS 2012, Taormina, Italy, August 28-31, 2012, Proceedings , 28 August 2012 - 31 August 2012.
Montagut G, Palmer IR & Qwarnstrom EE (2011) TILRR AMPLIFIES ACTIVATION OF NF-kappa B AND INFLAMMATORY GENES THROUGH MECHANOTRANSDUCTION . HEART , Vol. 97(20) (pp 6-6)
