Professor Eva Qwarnstrom

Journal articles

Kennelly TM, Li Y, Cao Y, Qwarnstrom EE & Geoghegan M (2019) Characterization of distinct binding interactions of fibronectin with α5β1-integrin and proteoglycans. Biophysical Journal.
Smith SA, Samokhin AO, Alfadi M, Murphy EC, Rhodes D, Kiss-Toth E, Storey RF, Yee S-P, Francis SE & Qwarnstrom EE (2017) The IL-1RI Co-Receptor TILRR (FREM1 Isoform 2) Controls Aberrant Inflammatory Responses and Development of Vascular Disease. JACC - Journal of the American College of Cardiology bts, 2(4), 398-414. View this article in WRRO
Rhodes DM, Holcombe M & Qwarnstrom EE (2016) Reducing complexity in an Agent Based Reaction Model—Benefits and limitations of simplifications in relation to run time and system level output. Biosystems, 147, 21-27. View this article in WRRO
Williams RA, Timmis J & Qwarnstrom EE (2016) Statistical Techniques Complement UML When Developing Domain Models of Complex Dynamical Biosystems.. PLoS One, 11(8). View this article in WRRO
Williams RA, Timmis J & Qwarnstrom EE (2015) Towards a platform model of the IL-1 stimulated NF-kB signalling pathway using communicating stream X-machines. CosMoS 2015, 2015, 107-110.
Rhodes DM, Smith SA, Holcombe M & Qwarnstrom EE (2015) Computational Modelling of NF-κB Activation by IL-1RI and Its Co-Receptor TILRR, Predicts a Role for Cytoskeletal Sequestration of IκBα in Inflammatory Signalling. PLoS ONE, 10(6), e0129888. View this article in WRRO
Williams RA, Timmis J & Qwarnstrom EE (2015) The rise in computational systems biology approaches for understanding NF-κB signaling dynamics. Science Signaling, 8(385), fs13-fs13.
Williams RA, Timmis J & Qwarnstrom EE (2014) Computational Models of the NF-KB Signalling Pathway. MDPI Computation, 2(4), 131-158.
Rhodes D, Smith S, Qwarnstrom E & Holcombe M (2014) 166 Increase in TILRR Expression in Areas of Vascular Inflammation Alters NF-KB Control Through Cytoskeletal Release of the Inhibitor IKBA - Interdisciplinary Analysis Using Predictive Agent Based Modelling.. Heart, 100 Suppl 3, A95.
Samokhin AO, Francis SE & Qwarnstrom EE (2014) Blocking the IL-1RI Co-receptor TILRR Reduces Vascular Inflammation – in vivo Analysis Using TILRR Knockout Mice. Heart, 100.
Samokhin A, Murphy E, Grant J, Boyle J, Haskard D, Francis S & Qwarnstrom E (2013) 210 A ROLE FOR THE IL-1RI CO-RECEPTOR TILRR IN ATHEROSCLEROSIS AND VASCULAR REPAIR. Heart, 99(suppl 2), a115-a115.
Hudson RC, Gray C, Kiss-Toth E, Chico TJA & Qwarnstrom EE (2012) Bioinformatics Analysis of the FREM1 Gene—Evolutionary Development of the IL-1R1 Co-Receptor, TILRR. Biology, 1(3), 484-494. View this article in WRRO
Zhang X, Montagut Pino G, Shephard F, Kiss-Toth E & Qwarnstrom EE (2012) Distinct control of MyD88 adapter-dependent and Akt kinase-regulated responses by the interleukin (IL)-1RI co-receptor, TILRR.. J Biol Chem, 287(15), 12348-12352.
Neilan M, Zhang X, Steiner T, Boyle J, Francis S, Haskard D & Qwarnstrom E (2012) 18 TILRR Functional Mutants Selectively Inhibit Inflammatory and Anti-Apoptotic Responses. Heart, 98, A6.
Holcombe M, Adra S, Bicak M, Chin S, Coakley S, Graham AI, Green J, Greenough C, Jackson D, Kiran M , MacNeil S et al (2012) Modelling complex biological systems using an agent-based approach.. Integr Biol (Camb), 4(1), 53-64.
Pino GM, Zhang X & Qwarnstrom EE (2010) BAS/BSCR5 TILRR potentiates interleukin-1-induced anti-apoptosis. Heart, 96(17), e13-e14.
Neilan M, Zhang X, Francis S & Qwarnstrom EE (2010) BAS/BSCR51 Control of vascular cell inflammatory responses through TILRR, an interleukin 1 co-receptor. Heart, 96(17), e27-e27.
Zhang X, Shephard F, Kim HB, Palmer IR, McHarg S, Fowler GJS, O'Neill LAJ, Kiss-Toth E & Qwarnstrom EE (2010) TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappaB.. J Biol Chem, 285(10), 7222-7232.
Kim H-B, Evans I, Smallwood R, Holcombe M & Qwarnstrom EE (2010) NIK and IKKbeta interdependence in NF-kappaB signalling--flux analysis of regulation through metabolites.. Biosystems, 99(2), 140-149.
Dower SK, Qwarnstrom EE & Kiss-Toth E (2007) Fluorescent protein reporter systems for single-cell measurements.. Methods Mol Biol, 411, 111-119.
Guan H, Holland K, Qwarnstrom E, Dower SK & Kiss-Toth E (2006) Feedback loops in intracellular signal processing and their potential for identifying novel signalling proteins.. Cell Immunol, 244(2), 158-161.
Pogson M, Smallwood R, Qwarnstrom E & Holcombe M (2006) Formal agent-based modelling of intracellular chemical interactions.. Biosystems, 85(1), 37-45.
Kiss-Toth E, Wyllie DH, Holland K, Marsden L, Jozsa V, Oxley KM, Polgar T, Qwarnstrom EE & Dower SK (2006) Functional mapping and identification of novel regulators for the Toll/Interleukin-1 signalling network by transcription expression cloning.. Cell Signal, 18(2), 202-214.
Kiss-Toth E, Wyllie DH, Holland K, Marsden L, Jozsa V, Oxley KM, Polgar T, Qwarnstrom EE & Dower SK (2005) Functional mapping of Toll/interleukin-1 signalling networks by expression cloning.. Biochem Soc Trans, 33(Pt 6), 1405-1406.
Kiss-Toth E, Wyllie DH, Holland K, Marsden L, Jozsa V, Oxley KM, Polgar T, Qwarnstrom EE & Dower SK (2005) Functional mapping of Toll/interleukin-1 signalling networks by expression cloning. Biochemical Society Transactions, 33(6), 1405-1406.
Telekes A, Kiss-Tóth E, Nagy T, Qwarnstrom EE, Kúsz E, Polgár T, Resetár A, Dower SK & Duda E (2005) Synergistic effect of Avemar on proinflammatory cytokine production and Ras-mediated cell activation.. Ann N Y Acad Sci, 1051, 515-528.
Ganguli A, Persson L, Palmer IR, Evans I, Yang L, Smallwood R, Black R & Qwarnstrom EE (2005) Distinct NF-kappaB regulation by shear stress through Ras-dependent IkappaBalpha oscillations: real-time analysis of flow-mediated activation in live cells.. Circ Res, 96(6), 626-634.
Kiss-Toth E, Bagstaff SM, Sung HY, Jozsa V, Dempsey C, Caunt JC, Oxley KM, Wyllie DH, Polgar T, Harte M , O'neill LAJ et al (2004) Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.. J Biol Chem, 279(41), 42703-42708.
Kiss-Toth E, Qwarnstrom EE & Dower SK (2004) Hunting for genes by functional screens.. Cytokine Growth Factor Rev, 15(2-3), 97-102.
Dower SK & Qwarnstrom EE (2003) Signalling networks, inflammation and innate immunity.. Biochem Soc Trans, 31(Pt 6), 1462-1471.
Lawrie A, Brisken AF, Francis SE, Wyllie D, Kiss-Toth E, Qwarnstrom EE, Dower SK, Crossman DC & Newman CM (2003) Ultrasound-enhanced transgene expression in vascular cells is not dependent upon cavitation-induced free radicals.. Ultrasound Med Biol, 29(10), 1453-1461.
Yang L, Ross K & Qwarnstrom EE (2003) RelA control of IkappaBalpha phosphorylation: a positive feedback loop for high affinity NF-kappaB complexes.. J Biol Chem, 278(33), 30881-30888.
Schooley K, Zhu P, Dower SK & Qwarnström EE (2003) Regulation of nuclear translocation of nuclear factor-kappaB relA: evidence for complex dynamics at the single-cell level.. Biochem J, 369(Pt 2), 331-339.
Valles S, Caunt CJ, Walker MH & Qwarnstrom EE (2002) PDGF enhancement of IL-1 receptor levels in smooth muscle cells involves induction of an attachment-regulated, heparan sulfate binding site (IL-1RIII).. Lab Invest, 82(7), 855-862.
Evans IC, Ray K & Qwarnstrom E (2001) Regulation of IκBα by the upstream kinases. Biochemical Society Transactions, 29(5), a128-a128.
Caunt CJ, Kiss-Toth E, Walker M, Sims J & Qwarnstrom EE (2001) The putative GTPase activating protein IIP-1 functions antagonistically to Ras in the regulation of Interleukin-1 signalling. Biochemical Society Transactions, 29(5), a130-a130.
Yang L, Chen H & Qwarnstrom E (2001) Degradation of IkappaBalpha is limited by a postphosphorylation/ubiquitination event.. Biochem Biophys Res Commun, 285(3), 603-608.
Caunt CJ, Kiss-Toth E, Carlotti F, Chapman R & Qwarnstrom EE (2001) Ras controls tumor necrosis factor receptor-associated factor (TRAF)6-dependent induction of nuclear factor-kappa b. Selective regulation through receptor signaling components.. J Biol Chem, 276(9), 6280-6288.
Huang WY, Vallés S & Qwarnstrom EE (2001) Translocation of the IL-1 receptor to focal adhesions is regulated through the C-terminal end of the cytoplasmic domain.. Cell Biol Int, 25(4), 309-317.
Carlotti F, Dower SK & Qwarnstrom EE (2000) Dynamic shuttling of nuclear factor kappa B between the nucleus and cytoplasm as a consequence of inhibitor dissociation.. J Biol Chem, 275(52), 41028-41034.
Kiss-Toth E, Guesdon FM, Wyllie DH, Qwarnstrom EE & Dower SK (2000) A novel mammalian expression screen exploiting green fluorescent protein-based transcription detection in single cells.. J Immunol Methods, 239(1-2), 125-135.
Slack JL, Schooley K, Bonnert TP, Mitcham JL, Qwarnstrom EE, Sims JE & Dower SK (2000) Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways.. J Biol Chem, 275(7), 4670-4678.
Carlotti F, Chapman R, Dower SK & Qwarnstrom EE (1999) Activation of nuclear factor kappaB in single living cells. Dependence of nuclear translocation and anti-apoptotic function on EGFPRELA concentration.. J Biol Chem, 274(53), 37941-37949.
Vallés S, Tsoi C, Huang WY, Wyllie D, Carlotti F, Askari JA, Humphries MJ, Dower SK & Qwarnström EE (1999) Recruitment of a heparan sulfate subunit to the interleukin-1 receptor complex. Regulation by fibronectin attachment.. J Biol Chem, 274(29), 20103-20109.
Royds JA, Dower SK, Qwarnstrom EE & Lewis CE (1998) Response of tumour cells to hypoxia: role of p53 and NFkB.. Mol Pathol, 51(2), 55-61.
Zhu P, Xiong W, Rodgers G & Qwarnstrom EE (1998) Regulation of interleukin 1 signalling through integrin binding and actin reorganization: disparate effects on NF-kappaB and stress kinase pathways.. Biochem J, 330 ( Pt 2), 975-981.
Ostberg CO, Zhu P, Wight TN & Qwarnstrom EE (1995) Fibronectin attachment is permissive for IL-1 mediated gene regulation.. FEBS Lett, 367(1), 93-97.
Qwarnström EE, Ostberg CO, Turk GL, Richardson CA & Bomsztyk K (1994) Fibronectin attachment activates the NF-kappa B p50/p65 heterodimer in fibroblasts and smooth muscle cells.. J Biol Chem, 269(49), 30765-30768.
Qwarnström EE, Järveläinen HT, Kinsella MG, Ostberg CO, Sandell LJ, Page RC & Wight TN (1993) Interleukin-1 beta regulation of fibroblast proteoglycan synthesis involves a decrease in versican steady-state mRNA levels.. Biochem J, 294 ( Pt 2), 613-620.
Luddington S, Qwarnström EE, Page RC & Bordin S (1993) Expression and function of gingival fibroblast C1q receptors are upregulated by interleukin-1 beta and transforming growth factor-beta.. J Cell Physiol, 155(1), 157-163.
Wight TN, Kinsella MG & Qwarnström EE (1992) The role of proteoglycans in cell adhesion, migration and proliferation.. Curr Opin Cell Biol, 4(5), 793-801. View this article in WRRO
Qwarnström EE, Kinsella MG, MacFarlane SA, Page RC & Wight TN (1992) Modulation of proteoglycan metabolism by human fibroblasts maintained in an endogenous three-dimensional matrix.. Eur J Cell Biol, 57(1), 101-108.
DOWER SK, QWARNSTROM EE, PAGE RC, BLANTON RA, KUPPER TS, RAINES E, ROSS R & SIMS JE (1990) BIOLOGY OF THE INTERLEUKIN-1 RECEPTOR. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 94(6), S68-S73.
Dower SK, Qwarnstrom EE, Page RC, Blanton RA, Kupper TS, Raines E, Ross R & Sims JE (1990) Biology of the interleukin-1 receptor.. J Invest Dermatol, 94(6 Suppl), 68S-73S.
Curtis BM, Widmer MB, deRoos P & Qwarnstrom EE (1990) IL-1 and its receptor are translocated to the nucleus.. J Immunol, 144(4), 1295-1303.
Dardick I, Jeans MT, Sinnott NM, Wittkuhn JF, Kahn HJ & Baumal R (1985) Salivary gland components involved in the formation of squamous metaplasia.. American Journal Of Pathology, 119(1), 33-43.
Qwarnstrom E, Bodner L, Baum B, Hand A & Omnell K-A (1984) Basic Biological Sciences Saliva Secretion from the Rat Submandibular Gland after Retrograde Infusion of Radiographic Contrast Media. Journal of Dental Research, 63(5), 614-617.
Bodner L, Qwarnstrom E, Omnell K-A, Hand AR & Baum BJ (1983) Rat submandibular gland secretion: A bilateral and longitudinal comparative study. Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology, 74(4), 829-831.
Omnell KA & Quarnstrom EE (1983) A Technique for Intraoral Cannulation and Infusion of the Rat Submandibular Gland. Dentomaxillofacial Radiology, 12(1), 13-15.
Bodner L, Qwarnstrom E & Baum B (1982) Stimulated rat submandibular gland secretion: Normal features and response to retrograde infusion. Journal of Dental Research, 61(Abs.).

Chapters

Dower SK, Qwarnstrom EE & Kiss-Toth E (2007) Fluorescent Protein Reporter Systems for Single-Cell Measurements, Reporter Genes: A Practical Guide (pp. 111-120).

Conference proceedings papers

Williams RA, Timmis J & Qwarnstrom EE (2017) Investigating IKK dynamics in the NF-κB signalling pathway using X-Machines (pp 249-256) View this article in WRRO
Qwarnstrom EE (2016) Regulation of Inflammatory and anti-apoptotic responses through the IL-1RI/TILRR complex.. Biol. Syst. Open access, Vol. 2(5) (pp 31-31) View this article in WRRO
Smith S, Samokhin A, Murphy E, Francis S & Qwarnstrom E (2015) 217 Altered Regulation of the Inhibitor IÎºBÎ± Contributes to Changes in NF-ÎºB Regulated Genes in the TILRR ko Mouse. Heart, Vol. 101(Suppl 4) (pp a118-a119)
Murphy E, Samokhin A, Francis S, Bowskill S & Qwarnstrom E (2014) 187 The inflammatory phenotype of the tilrr knockout mouse - mechanisms undelying reduced responses to vascular injury.. Heart, Vol. 100 Suppl 3 (pp A104-A105). England
Williams RA, Timmis J & Qwarnstrom EE (2012) Domain Modelling - When UML is not Enough: A Case Study using the IL-1 Stimulated NF-kB Intracellular Signalling Pathway. Artificial Immune Systems 11th International Conference, ICARIS 2012, Taormina, Italy, August 28-31, 2012, Proceedings, 28 August 2012 - 31 August 2012.
Montagut G, Palmer IR & Qwarnstrom EE (2011) TILRR AMPLIFIES ACTIVATION OF NF-kappa B AND INFLAMMATORY GENES THROUGH MECHANOTRANSDUCTION. HEART, Vol. 97(20) (pp 6-6)