Professor Eva E Qwarnstrom

Professor of Cell Biology

Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Medical School
Beech Hill Road
Sheffield
S10 2RX
Tel: +44 (0)114 215 9547
Fax: +44 (0)114 271 1863
Email: e.qwarnstrom@sheffield.ac.uk

Secretary: Mrs Susan Clary
Tel: +44 (0) 114 215 9503
Email: s.clary@sheffield.ac.uk

Biography:

I graduated from the University of Lund Sweden in 1984 after spending three years as a Fogarty Fellow in Biological Structure, at the National Institute of Health, Bethesda, USA. This was followed by a postdoctoral fellowship in the Department of Pathology at the University of Washington in Seattle, where I was appointed Associate Professor in 1993. In 1996 I was granted an Affiliated Associate Professorship in Pathology at the University of Washington, as I joined the University of Sheffield, where I took up a chair in Cell Biology in 2001.

Research Interests:

My research focuses on regulation of inflammatory responses, specifically on events related to receptor function and cell signalling. The programme includes analysis of activities induced by soluble mediators such as growth-factors and cytokines, and by biomechanical events, regulated through matrix structure and the cytoskeleton. Current studies focus on TIR mediated responses, primarily the analysis of Toll-like and IL-1 receptor function and signal transduction. Recent findings include identification of a novel TIR regulating receptor (TILRR), which controls immune and inflammatory signal transduction through the IL-1 type I signalling receptor. Work on signal transduction is centred on analysis of molecular mechanism controlling the NF-κβ pathway, with particular emphasis on signalling crosstalk, and the use of real time analysis of regulatory events. Collaborative projects include the use of single cell analysis and GFP-based methods as the basis for computational modelling of complex regulatory networks.

Teaching interests:

I teach on the MSc course in Molecular Medicine, the Cardiovascular Pathway, on interdisciplinary approaches, and using computational modelling to investigate inflammatory receptor function and signal transduction.

Professional Activities:

Editorial Member,
SM Journal of Cardiology and Cardiovascular Diseases.
Journal of Clinical and Interventional Cardiology (JCIC).
Journal of Cardiology and Cardiovascular Medicine.

Current Projects:

  • Vascular disease progression (collaboration with Sheila Francis and Rob Storey, Univ. Sheffield, and Siu-Pok Yee, Univ. Connecticut).
  • The impact of receptor polymorphisms on regulatory networks.
  • Extracellular protein interactions (collaboration with Mark Geoghegan, Univ. Sheffield).
  • Signalling crosstalk (collaboration with Chris Zhang, GIBH, Guangzhou).

Publications:

For key publications see below. For a full list of publications click here.

Journal articles