Professor Eva E Qwarnstrom

Professor of Cell Biology

Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Medical School
Beech Hill Road
S10 2RX
Tel: +44 (0)114 215 9547
Tel Secretary: Margaret Beckett +44 (0)114 215 9502
Fax: +44 (0)114 271 1863
Secretary Email:


I graduated from the University of Lund Sweden in 1984 after spending three years as a Fogarty Fellow in Biological Structure, at the National Institute of Health, Bethesda, USA. This was followed by a postdoctoral fellowship in the Department of Pathology at the University of Washington in Seattle, where I was appointed Associate Professor in 1993. In 1996 I was granted an Affiliated Associate Professorship in Pathology at the University of Washington, as I joined the University of Sheffield, where I took up a chair in Cell Biology in 2001.

Research Interests:

My research focuses on regulation of inflammatory responses, specifically on events related to receptor function and cell signalling. The programme includes analysis of activities induced by soluble mediators such as growth-factors and cytokines, and by biomechanical events, regulated through matrix structure and the cytoskeleton. Current studies focus on TIR mediated responses, primarily the analysis of Toll-like and IL-1 receptor function and signal transduction. Recent findings include identification of a novel TIR regulating receptor (TILRR), which controls immune and inflammatory signal transduction through the IL-1 type I signalling receptor. Work on signal transduction is centred on analysis of molecular mechanism controlling the NF-κβ pathway, with particular emphasis on signalling crosstalk, and the use of real time analysis of regulatory events. Collaborative projects include the use of single cell analysis and GFP-based methods as the basis for computational modelling of complex regulatory networks.

Teaching interests:

I teach on the MSc course in Molecular Medicine, the Cardiovascular Pathway, on interdisciplinary approaches, and using computational modelling to investigate inflammatory receptor function and signal transduction.

Professional Activities:

  • Arthritis Research UK - Fellowships Implementation Committee.

Current Projects:

  • Defining TILRR regulation of distinct IL-1RI responses using systems biology.
    (BBSRC £686,795, 2012-2015).
  • Establishing the role of TILRR, a novel IL-1RI co-receptor, in development of atherosclerosis –using a knockout model.
    (BHF £157,746, 2012-2014).
  • Modelling of Inflammatory responses.
    (White Rose Collaboratory Network £200,00, 2010-2013).


For key publications see below. For a full list of publications click here.

Journal articles