Professor Eva E Qwarnstrom
Professor of Cell Biology
Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Beech Hill Road
Tel: +44 (0)114 215 9547
Fax: +44 (0)114 271 1863
Secretary: Mrs Susan Clary
Tel: +44 (0) 114 215 9503
I graduated from the University of Lund Sweden in 1984 after spending three years as a Fogarty Fellow in Biological Structure, at the National Institute of Health, Bethesda, USA. This was followed by a postdoctoral fellowship in the Department of Pathology at the University of Washington in Seattle, where I was appointed Associate Professor in 1993. In 1996 I was granted an Affiliated Associate Professorship in Pathology at the University of Washington, as I joined the University of Sheffield, where I took up a chair in Cell Biology in 2001.
My research focuses on regulation of inflammatory responses, specifically on events related to receptor function and cell signalling. The programme includes analysis of activities induced by soluble mediators such as growth-factors and cytokines, and by biomechanical events, regulated through matrix structure and the cytoskeleton. Current studies focus on TIR mediated responses, primarily the analysis of Toll-like and IL-1 receptor function and signal transduction. Recent findings include identification of a novel TIR regulating receptor (TILRR), which controls immune and inflammatory signal transduction through the IL-1 type I signalling receptor. Work on signal transduction is centred on analysis of molecular mechanism controlling the NF-κβ pathway, with particular emphasis on signalling crosstalk, and the use of real time analysis of regulatory events. Collaborative projects include the use of single cell analysis and GFP-based methods as the basis for computational modelling of complex regulatory networks.
I teach on the MSc course in Molecular Medicine, the Cardiovascular Pathway, on interdisciplinary approaches, and using computational modelling to investigate inflammatory receptor function and signal transduction.
SM Journal of Cardiology and Cardiovascular Diseases.
Journal of Clinical and Interventional Cardiology (JCIC).
Journal of Cardiology and Cardiovascular Medicine.
- Vascular disease progression (collaboration with Sheila Francis and Rob Storey, Univ. Sheffield, and Siu-Pok Yee, Univ. Connecticut).
- The impact of receptor polymorphisms on regulatory networks.
- Extracellular protein interactions (collaboration with Mark Geoghegan, Univ. Sheffield).
- Signalling crosstalk (collaboration with Chris Zhang, GIBH, Guangzhou).
For key publications see below. For a full list of publications click here.
- Smith SA, Samokhin AO, Alfadi M, Murphy EC, Rhodes D, Kiss-Toth E, Storey RF, Yee S-P, Francis SE & Qwarnstrom EE (2017) The IL-1RI Co-Receptor TILRR (FREM1 Isoform 2) Controls Aberrant Inflammatory Responses and Development of Vascular Disease. JACC - Journal of the American College of Cardiology bts, 2(4), 398-414. View this article in WRRO
- Rhodes DM, Holcombe M & Qwarnstrom EE (2016) Reducing complexity in an Agent Based Reaction Model—Benefits and limitations of simplifications in relation to run time and system level output. Biosystems, 147, 21-27. View this article in WRRO
- Williams RA, Timmis J & Qwarnstrom EE (2016) Statistical Techniques Complement UML When Developing Domain Models of Complex Dynamical Biosystems.. PLoS One, 11(8). View this article in WRRO
- Rhodes DM, Smith SA, Holcombe M & Qwarnstrom EE (2015) Computational modelling of NF-κB activation by IL-1RI and its co-receptor TILRR, predicts a role for cytoskeletal sequestration of IκBαin inflammatory signalling. PLoS ONE, 10(6). View this article in WRRO
- Williams RA, Timmis J & Qwarnstrom EE (2015) The rise in computational systems biology approaches for understanding NF- B signaling dynamics. Science Signaling, 8(385), fs13-fs13.
- Williams RA, Timmis J & Qwarnstrom EE (2014) Computational Models of the NF-KB Signalling Pathway. MDPI Computation, 2(4), 131-158.
- Hudson RC, Gray C, Kiss-Toth E, Chico TJA & Qwarnstrom EE (2012) Bioinformatics Analysis of the FREM1 Gene—Evolutionary Development of the IL-1R1 Co-Receptor, TILRR. Biology, 1(3), 484-494. View this article in WRRO
- Zhang X, Montagut Pino G, Shephard F, Kiss-Toth E & Qwarnstrom EE (2012) Distinct control of MyD88 adapter-dependent and Akt kinase-regulated responses by the interleukin (IL)-1RI co-receptor, TILRR.. J Biol Chem, 287(15), 12348-12352.
- Holcombe M, Adra S, Bicak M, Chin S, Coakley S, Graham AI, Green J, Greenough C, Jackson D, Kiran M, MacNeil S, Maleki-Dizaji A, McMinn P, Pogson M, Poole R, Qwarnstrom E, Ratnieks F, Rolfe MD, Smallwood R, Sun T & Worth D (2012) Modelling complex biological systems using an agent-based approach.. Integr Biol (Camb), 4(1), 53-64.
- Zhang X, Shephard F, Kim HB, Palmer IR, McHarg S, Fowler GJS, O'Neill LAJ, Kiss-Toth E & Qwarnstrom EE (2010) TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappaB.. J Biol Chem, 285(10), 7222-7232.
- Kim H-B, Evans I, Smallwood R, Holcombe M & Qwarnstrom EE (2010) NIK and IKKbeta interdependence in NF-kappaB signalling--flux analysis of regulation through metabolites.. Biosystems, 99(2), 140-149.
- Pogson M, Smallwood R, Qwarnstrom E & Holcombe M (2006) Formal agent-based modelling of intracellular chemical interactions.. Biosystems, 85(1), 37-45.
- Ganguli A, Persson L, Palmer IR, Evans I, Yang L, Smallwood R, Black R & Qwarnstrom EE (2005) Distinct NF-kappaB regulation by shear stress through Ras-dependent IkappaBalpha oscillations: real-time analysis of flow-mediated activation in live cells.. Circ Res, 96(6), 626-634.
Conference proceedings papers
- Williams RA, Timmis J & Qwarnstrom EE (2017) Investigating IKK dynamics in the NF-κB signalling pathway using X-Machines. IEEE Proceedings on Computational Biology (pp 249-256) View this article in WRRO