Professor Eva E Qwarnstrom
Professor of Cell Biology
Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Beech Hill Road
Tel: +44 (0)114 215 9547
Tel Secretary: Margaret Beckett +44 (0)114 215 9502
Fax: +44 (0)114 271 1863
Secretary Email: firstname.lastname@example.org
I graduated from the University of Lund Sweden in 1984 after spending three years as a Fogarty Fellow in Biological Structure, at the National Institute of Health, Bethesda, USA. This was followed by a postdoctoral fellowship in the Department of Pathology at the University of Washington in Seattle, where I was appointed Associate Professor in 1993. In 1996 I was granted an Affiliated Associate Professorship in Pathology at the University of Washington, as I joined the University of Sheffield, where I took up a chair in Cell Biology in 2001.
My research focuses on regulation of inflammatory responses, specifically on events related to receptor function and cell signalling. The programme includes analysis of activities induced by soluble mediators such as growth-factors and cytokines, and by biomechanical events, regulated through matrix structure and the cytoskeleton. Current studies focus on TIR mediated responses, primarily the analysis of Toll-like and IL-1 receptor function and signal transduction. Recent findings include identification of a novel TIR regulating receptor (TILRR), which controls immune and inflammatory signal transduction through the IL-1 type I signalling receptor. Work on signal transduction is centred on analysis of molecular mechanism controlling the NF-κβ pathway, with particular emphasis on signalling crosstalk, and the use of real time analysis of regulatory events. Collaborative projects include the use of single cell analysis and GFP-based methods as the basis for computational modelling of complex regulatory networks.
I teach on the MSc course in Molecular Medicine, the Cardiovascular Pathway, on interdisciplinary approaches, and using computational modelling to investigate inflammatory receptor function and signal transduction.
- Arthritis Research UK - Fellowships Implementation Committee.
- Defining TILRR regulation of distinct IL-1RI responses using systems biology.
(BBSRC £686,795, 2012-2015).
- Establishing the role of TILRR, a novel IL-1RI co-receptor, in development of atherosclerosis –using a knockout model.
(BHF £157,746, 2012-2014).
- Modelling of Inflammatory responses.
(White Rose Collaboratory Network £200,00, 2010-2013).
For key publications see below. For a full list of publications click here.
- Williams RA, Timmis J & Qwarnstrom EE (2015) The rise in computational systems biology approaches for understanding NF- B signaling dynamics. Science Signaling, 8(385), fs13-fs13.
- Rhodes DM, Smith SA, Holcombe M & Qwarnstrom EE (2015) Computational modelling of NF-κB activation by IL-1RI and its co-receptor TILRR, predicts a role for cytoskeletal sequestration of IκBαin inflammatory signalling. PLoS ONE, 10(6). View this article in WRRO
- Williams RA, Timmis J & Qwarnstrom EE (2014) Computational Models of the NF-KB Signalling Pathway. MDPI Computation, 2(4), 131-158.
- Hudson RC, Gray C, Kiss-Toth E, Chico TJA & Qwarnstrom EE (2012) Bioinformatics Analysis of the FREM1 Gene—Evolutionary Development of the IL-1R1 Co-Receptor, TILRR. Biology, 1(3), 484-494. View this article in WRRO
- Zhang X, Pino GM, Shephard F, Kiss-Toth E & Qwarnstrom EE (2012) Distinct control of MyD88 adapter-dependent and Akt kinase-regulated responses by the interleukin (IL)-1RI co-receptor, TILRR.. J Biol Chem, 287(15), 12348-12352.
- Holcombe M, Adra S, Bicak M, Chin S, Coakley S, Graham AI, Green J, Greenough C, Jackson D, Kiran M, MacNeil S, Maleki-Dizaji A, McMinn P, Pogson M, Poole R, Qwarnstrom E, Ratnieks F, Rolfe MD, Smallwood R, Sun T & Worth D (2012) Modelling complex biological systems using an agent-based approach.. Integr Biol (Camb), 4(1), 53-64.
- Zhang X, Shephard F, Kim HB, Palmer IR, McHarg S, Fowler GJ, O'Neill LA, Kiss-Toth E & Qwarnstrom EE (2010) TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappaB.. J Biol Chem, 285(10), 7222-7232.
- Kim HB, Evans I, Smallwood R, Holcombe M & Qwarnstrom EE (2010) NIK and IKKbeta interdependence in NF-kappaB signalling--flux analysis of regulation through metabolites.. Biosystems, 99(2), 140-149.
- Pogson M, Holcombe M, Smallwood R & Qwarnstrom E (2008) Introducing spatial information into predictive NF-kappaB modelling--an agent-based approach.. PLoS One, 3(6), e2367. View this article in WRRO
- Pogson M, Smallwood R, Qwarnstrom E & Holcombe M (2006) Formal agent-based modelling of intracellular chemical interactions.. Biosystems, 85(1), 37-45.
- Ganguli A, Persson L, Palmer IR, Evans I, Yang L, Smallwood R, Black R & Qwarnstrom EE (2005) Distinct NF-kappaB regulation by shear stress through Ras-dependent IkappaBalpha oscillations: real-time analysis of flow-mediated activation in live cells.. Circ Res, 96(6), 626-634.
- Yang L, Ross K & Qwarnstrom EE (2003) RelA control of IkappaBalpha phosphorylation: a positive feedback loop for high affinity NF-kappaB complexes.. J Biol Chem, 278(33), 30881-30888.
- Valles S, Caunt CJ, Walker MH & Qwarnstrom EE (2002) PDGF enhancement of IL-1 receptor levels in smooth muscle cells involves induction of an attachment-regulated, heparan sulfate binding site (IL-1RIII).. Lab Invest, 82(7), 855-862.
- Yang L, Chen H & Qwarnstrom E (2001) Degradation of IkappaBalpha is limited by a postphosphorylation/ubiquitination event.. Biochem Biophys Res Commun, 285(3), 603-608.