Dr. Robert Wilkinson BSc MSc DPhil
Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Beech Hill Road
Tel: +44 (0) 114 226 1201
Fax: +44 (0) 114 271 1863
I graduated from the University of Leeds with a BSc in Biology in 2001 and an MSc in Human Genetics in 2002. After a research position at the University of Manchester, I joined Prof. Roger Patient’s lab on an MRC studentship at the MRC Molecular Haematology Unit, Weatherall Institute for Molecular Medicine, University of Oxford. During my DPhil I studied the embryonic signals that regulate arterial differentiation and blood stem cell formation in the zebrafish. I joined the University of Sheffield in 2008 as a Wellcome Trust Postdoctoral Fellow with Dr. Freek van Eeden, in the MRC Centre for Biomedical and Developmental Genetics, studying the formation of arteries and veins. I moved to the Department of Cardiovascular Science in 2013 to establish an independent research group.
My research focuses on two important areas of vascular biology; firstly, unravelling the molecular and genetic mechanisms governing blood vessel formation and maturation as a strategy to combat cardiovascular disease. Secondly, we are characterising the genetic mechanisms which underlie blood stem cell formation from the embryonic artery. Exploiting the processes of angiogenesis and stem cell formation are key strategies in regenerative cardiovascular medicine. We currently employ the zebrafish as a model system to study these processes.
- Characterisation of the mechanisms which regulate blood vessel formation, stability and maturation.
- Transcriptional programming of zebrafish HSC formation.
- Early Career Group representative, Department of Cardiovascular Science.
- Member of the British Society for Developmental Biology.
- Member of The Genetics Society.
For key publications see below. For a full list of publications click here.
- Thambyrajah R, Ucanok D, Jalali M, Hough Y, Wilkinson RN, McMahon K, Moore C & Gering M (2016) A gene trap transposon eliminates haematopoietic expression of zebrafish Gfi1aa, but does not interfere with haematopoiesis. Developmental Biology, 417(1), 25-39. View this article in WRRO
- Wilkinson RN & van Eeden FJM (2014) The zebrafish as a model of vascular development and disease.. Prog Mol Biol Transl Sci, 124, 93-122.
- Wilkinson RN, Jopling C & van Eeden FJM (2014) Zebrafish as a model of cardiac disease.. Prog Mol Biol Transl Sci, 124, 65-91.
- Wilkinson RN, Elworthy S, Ingham PW & van Eeden FJM (2013) A method for high-throughput PCR-based genotyping of larval zebrafish tail biopsies.. Biotechniques, 55(6), 314-316.
- Wilkinson RN, Koudijs MJ, Patient RK, Ingham PW, Schulte-Merker S & van Eeden FJ (2012) Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish.. Blood, 120(2), 477-488. View this article in WRRO
- Wilkinson RN, Pouget C, Gering M, Russell AJ, Davies SG, Kimelman D & Patient R (2009) Hedgehog and Bmp polarize hematopoietic stem cell emergence in the zebrafish dorsal aorta.. Dev Cell, 16(6), 909-916.
- Monteiro R, van Dinther M, Bakkers J, Wilkinson R, Patient R, ten Dijke P & Mummery C (2008) Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish.. Dev Biol, 315(1), 55-71.