Dr Roslyn Simms
NIHR Clinical Lecturer in Nephrology
Department of Infection, Immunity & Cardiovascular Disease
University of Sheffield
Beech Hill Road
I moved to the University of Sheffield in August 2014 following appointment as a Clinical Lecturer in Nephrology to research polycystic kidney disease working with Professor Albert Ong. I am an honorary SpR in Nephrology at the Northern General Hospital, Sheffield.
I originally graduated with an intercalated B.Sc in Clinical Medicine in 2000 and Medicine in 2002 at the University of Glasgow. In 2007 I commenced Specialty Nephrology training in Newcastle, where I developed an interest in renal genetics. In 2008 I was awarded 9 months pump priming funding (Mason Medical Research Foundation) to commence full time research with Dr John Sayer, Institute of Genetic Medicine, Newcastle University. In 2009 I was delighted to accept a joint Kidney Research UK/MRC Clinical Fellowship to continue studying genetic (zebrafish) models of inherited cystic kidney disease leading to the award of my PhD in 2012. I became a National Institute for Health Research Clinical Lecturer in Nephrology in Newcastle University in 2013 and in order to develop a more clinically active research experience in polycystic kidney disease I moved to work with Professor Albert Ong here in the University of Sheffield.
I am interested in inherited cystic kidney diseases, particularly autosomal dominant polycystic kidney disease (ADPKD), which is the commonest inherited kidney disease and leads to end-stage renal failure in 50% by the sixth decade. In the UK, ADPKD accounts for 10% of all adults requiring renal replacement therapy and currently there is no cure. The clinical course of ADPKD is highly heterogeneous even within families.
During my PhD I used zebrafish models of inherited cystic kidney disease to understand how additional genetic mutations modified the expression of critical signalling organelles (cilia) and the disease phenotype. My current research focus is to understand the mechanisms of disease heterogeneity in patients with ADPKD in order to identify risks for disease progression and to modify patient management.
I give lectures to medical students attending the University of Sheffield and I am involved with teaching medical students during rotation in Sheffield Kidney Institute. I am a Personal Academic Tutor for groups of medical students (Phase 2b-4).
- Member of the ADPKD working group (Renal Association).
- Member of the UK Kidney Research Consortium (UKKRC) Clinical Study Group on Cystic Kidney Diseases.
- Member of the ARPKD rare disease working group (Renal Association).
- Member of the Renal Association, European Renal Association-European Dialysis and Transplant Association, American Society of Nephrology.
- Associate Faculty Member of Faculty of 1000 Medicine, Nephrology.
For key publications see below. For a full list of publications click here.
- Simms RJ, Thong KM, Dworschak GC & Ong ACM (2016) Increased psychosocial risk, depression and reduced quality of life living with autosomal dominant polycystic kidney disease. Nephrology Dialysis Transplantation, 31(7), 1130-1140.
- Simms RJ, Travis DL, Durkie M, Wilson G, Dalton A & Ong ACM (2015) Genetic Testing in the Assessment of Living Related Kidney Donors at Risk of Autosomal Dominant Polycystic Kidney Disease. Transplantation, 99(5), 1023-1029.
- Shaw C, Simms RJ, Pitcher D & Sandford R (2014) Epidemiology of patients in England and Wales with autosomal dominant polycystic kidney disease and end-stage renal failure. Nephrology Dialysis Transplantation, 29(10), 1910-1918.
- Simms RJ & Ong ACM (2014) How simple are 'simple renal cysts'?. Nephrology Dialysis Transplantation, 29(suppl 4), iv106-iv112.
- Adams M, Simms RJ, Abdelhamed Z, Dawe HR, Szymanska K, Logan CV, Wheway G, Pitt E, Gull K, Knowles MA, Blair E, Cross SH, Sayer JA & Johnson CA (2012) A meckelin–filamin A interaction mediates ciliogenesis. Human Molecular Genetics, 21(6), 1272-1286.
- Simms RJ, Hynes AM, Eley L, Inglis D, Chaudhry B, Dawe HR & Sayer JA (2012) Modelling a ciliopathy: Ahi1 knockdown in model systems reveals an essential role in brain, retinal, and renal development. Cellular and Molecular Life Sciences, 69(6), 993-1009.
- Simms RJ, Hynes AM, Eley L & Sayer JA (2011) Nephronophthisis: A Genetically Diverse Ciliopathy. International Journal of Nephrology, 2011, 1-10. View this article in WRRO
- Simms RJ, Eley L & Sayer JA (2009) Nephronophthisis. European Journal of Human Genetics, 17(4), 406-416.