Clinical Trials


Title: An Investigation of the Genetics and Skin Barrier Function in Atopic Eczema and Related Diseases
Site Investigators: Michael J Cork
Status: Recruitment open
Reference: 04/MRE04/70 and STH13839
Contact Details: Les Hunter on +44 (0) 114 215 9576 or dermatologyresearch@sheffield.ac.uk


Star LogoTitle: A longitudinal investigation of skin barrier development from birth and the validation of early predictors of atopic eczema risk: The Skin Testing for Atopic eczema Risk (STAR) study
Site Investigators: Simon G Danby, John Chittock, Alison Cook, Tina Lavender, Michael J Cork
Status: Recruitment open
Reference: 16/NW/0848 and STH19479
Contact Details: The STAR study team on 07834392439 or starstudy@sheffield.ac.uk


BOND LogoTitle: A Randomized Controlled Trial of Gentle Touch/Early Massage with a New Wash and Lotion Regimen for Improved Skin Barrier Strength, Parental Bonding, and Physical Development in Newborn Babies: The Barrier Optimizing Skincare and Newborn Development (BOND) Trial
Site Investigators: Michael J Cork, Simon G Danby, Shatha Shibib, Tina Lavender
Status: In set-up
Reference: STH19623
Contact Details: The BOND study team on 07834392439 or BOND@sheffield.ac.uk


Title: A Comparison between Optical Coherence Tomography (OCT) determined basal cell carcinoma (BCC) margins against surgeon excision margins and histology – an observational pilot study
Site Investigators: Anna-Victoria Giblin, Poonam Valand, Michael J Cork, Simon Danby, Stephen Matcher
Status: Recruitment open
Reference: STH19474
Contact Details: Poonam Valand, valandpoonam@gmail.com


Title: Open-label Study of Dupilumab (REGN668/SAR231893) in Patients With Atopic Dermatitis
Site Investigators: Michael J Cork
Status: Recruitment open
Reference: NCT01949311


Treat LogoTitle: A Randomised Controlled Trial Assessing the Effectiveness, Safety and Cost-effectiveness of Methotrexate versus Ciclosporin in the Treatment of Severe Atopic Dermatitis in Children: The TREatment of Severe Atopic Dermatitis Trial (TREAT)
Site Investigators: Michael J Cork, Ruth Murphy
Status: In set-up
Reference: ISRCTN15837754
Contact details: Heather Chisem/Stuart Gormley on +(0) 114 305 3136 or website http://www.treat-trial.org.uk/


BEEP LogoTitle: Barrier Enhancement for Eczema Prevention – BEEP
Site Investigators: Michael J Cork
Status: Closed to recruitment - in follow-up
Reference: ISRCTN21528841
Contact details: Heather Chisem/Stuart Gormley on +44 (0) 114 305 3136 or website http://www.nottingham.ac.uk/research/groups/cebd/projects/1eczema/beep-maintrial.aspx


Title: A Study to Determine the Safety and Tolerability of Dupilumab (REGN668/SAR231893) in Patients Aged ≥6 to <18 Years With Atopic Dermatitis (Eczema)
Site Investigators: Michael J Cork and Ruth Murphy
Status: Closed - follow up complete
Reference: NCT02407756
Contact details: Heather Chisem/Stuart Gormley on +44 (0) 114 305 3136


Title: A Study to Assess the Long-term Safety of Dupilumab (REGN668/SAR231893) Administered in Patients 6 to <18 Year of Age With Atopic Dermatitis (AD)
Site Investigators: Michael J Cork and Ruth Murphy
Status: Closed to recruitment - In follow up
Reference: NCT02612454
Contact details: Heather Chisem/Stuart Gormley on +44 (0) 114 305 3136


Title: Identification of Susceptibility Genes for Eczema & Food Allergy
Site Investigators: Michael J Cork
Status: Closed - follow up complete
Reference: NIHR Portfolio Study ID: 10226
Contact details: Heather Chisem/Stuart Gormley on +44 (0) 114 305 3136


Title: A Study to Assess the Efficacy and Safety of Dupilumab in Patients With Severe Atopic Dermatitis (AD) That Are Not Controlled With Oral Cyclosporine A (CSA) or for Those Who Cannot Take Oral CSA Because it is Not Medically Advisable (CAFÉ)
Site Investigators: Michael J Cork
Status: Recruitment closed
Reference: NCT02755649


Title: A Study to Confirm the Efficacy and Safety of Different Dupilumab Dose Regimens in Adults With Atopic Dermatitis (AD) (SOLO-Continue)
Site Investigators: Michael J Cork
Status: Recruitment closed
Reference: NCT02395133


Title: Study of Dupilumab (REGN668/SAR231893) Monotherapy Administered to Adult Patients With Moderate-to-Severe Atopic Dermatitis (SOLO 2)
Site Investigators: Michael J Cork
Status: Recruitment closed
Reference: NCT02277769