Future Seminar Dates

Wednesday 26th June 2019

Title:  "Regulation of lung pathophysiology via circadian control of Integrinβ1 and RhoA”

Speaker:  Dr. John Blaikley, University of Manchester.

Venue:  Lecture Threatre 3, F Floor Medical School.

Time: 12:30pm - 1:30pm

Abstract:  In 2017 the Nobel Prize was awarded to researchers who discovered the circadian clock. It is now recognised that this clock alters 40% of known biological pathways; however the relevance of this clock and circadian biology to human pathophysiology is poorly understood. John Blaikley is a MRC clinician scientist investigating how the “clock” regulates pathophysiology in the lung. He has recently published papers showing that acute lung injury, asthma and wound healing are all under circadian control. Currently he is investigating the role of circadian biology in pulmonary fibrosis and pneumonia. During this talk he will discuss the translational relevance of pulmonary circadian biology and how its investigation can lead to novel therapeutic interventions.

Dr John Blaikley

Thursday 18th July 2019

Title:  "Recent Advances in Network Medicine"

Speaker:  Dr Helder Nakaya, University of Sao Paulo, Brazil.

Venue: Lecture Threatre 3, F Floor Medical School.

Time:  12:30pm - 1:30pm

Abstract:  Diseases are mostly a consequence of an abnormality in multiple genes. Network Medicine investigates how genes interact to each other in complex intracellular and intercellular networks. The talk will show the recent advances on this emerging field of research and its impact on precision medicine and drug repositioning.

Dr Helder Nakaya

Wednesday 31st July 2019

Title:  "Therapeutic vasculoprotection, autoimmune disease and premature atherosclerosis"

Speaker:  Professor Justin Mason, Imperial COllege London.

Venue: Lecture Threatre 3, F Floor Medical School.

Time: 12:30pm - 1:30pm

Abstract:  The vascular endothelium is a critical interface, separating the organs from the blood and its contents. Endothelial cells exhibit a wide variety of functions and maintenance of endothelial homeostasis is a multi-dimensional active process critical for health. Disruption of homeostasis is a common feature of autoimmune diseases. The presentation will outline the relationship between systemic inflammatory diseases and premature atherosclerosis and cardiovascular events. Development of therapeutic strategies, which combine immunosuppression with vascular conditioning and reversal of endothelial dysfunction, remains an important goal for clinicians. The innate constitutive and response mode signalling pathways that drive vasculoprotection will be described and recent experimental work aimed at the therapeutic manipulation of these pathways to restore homeostasis will be shown.

Professor Justin Mason

If you would like to meet with one of the speakers during their visit, please contact Victoria Palmer who will be able to assist.