2017 Hatfield Memorial Lecture
Tuesday 5 December, 7pm. The Octagon Centre, The University of Sheffield
Biomaterial Scaffolds for Tissue Repair – The “Hole” Story
For many years, there has been interest in the use of biomaterials to replace human tissues damaged by injury or disease. Over time, the materials of choice have gradually changed from those that simply offer mechanical support to those that interact directly with the biological environment.
Focus is now on the recruitment and delivery of biological cells to assist in the repair process. With this move from tissue replacement to cell-mediated tissue reconstruction and regeneration, there is increasing need for the design of appropriate biomaterial “scaffolds”. For cells to be able to migrate through a scaffold, it needs to contain holes of the appropriate dimensions.
This talk will consider two scaffold materials, a bone graft substitute (hydroxyapatite) and collagen, a highly versatile and bioactive natural macromolecule. To optimise the repair process using these scaffolds, it is important to understand the influences on cell behaviour of the structure and orientation of the holes in the scaffold, and the interconnections between them. Choice of scaffold surface biochemistry also allows us to balance scaffold “activity” and mechanical performance.
This talk will cover the recent work undertaken to study the structure and properties of scaffolds for a range of clinical applications in soft and hard tissue repair.
Serena Best is a Professor of Materials Science and Fellow of St. John’s College, Cambridge. She co-directs the Cambridge Centre for Medical Materials (along with Professor Ruth Cameron). She has published around 300 journal papers, books and book chapters, she holds 9 patents in the fields of biomaterials and skeletal repair and has played a part in the spin out two companies associated with this work. She is a Fellow of the Royal Academy of Engineering and also the Institute of Materials, Minerals and Mining and is Senior Vice President of the Institute. She was awarded a CBE in the Queen’s Birthday Honours List in 2017 for services to Biomaterials Engineering.