Professor John W Haycock
BSc (Hons) PhD
Department of Materials Science and Engineering
Head of Department
Professor of Bioengineering
+44 114 222 5972
Full contact details
Department of Materials Science and Engineering
Sir Robert Hadfield Building
John Haycock obtained his first degree and PhD in Biochemistry at Newcastle University and was a Research Fellow at Albany Medical College in New York, USA. He joined the department in 2001 as a Lecturer from the Medical School at Sheffield University. He was Engineering Faculty Director of Research and Innovation from 2016-19 and became Head of Materials Science and Engineering in 2019. His research and teaching covers fundamental and applied biomedical materials science through to engineering applications
BSc (Hons) Biochemistry, Newcastle University
PhD Neurology, Newcastle University
- Research interests
John's research spans five interdisciplinary themes:
1. Nerve tissue engineering. The design of nerve guidance channels for repairing traumatic peripheral nerve injury – combining biomaterials, 3D fabrication, neuronal, glial and stem cell research.
2. 3D in vitro models of nerve. The use of 3D scaffolds and neuronal/glial co-cultures for 3D in vitro models of nerve as an alternative to animal models for disease, disorder and testing research.
3. 3D in vitro models of skin. The use of 3D scaffolds and keratinocyte/fibroblast co-cultures for 3D in vitro models of skin as an alternative to animal models for inflammatory testing.
4. 3D Imaging and technology development for bioscience applications Established confocal microscopy, 2-photon microscopy, time-resolved microscopy, light sheet microscopy and in vivo confocal microscopy facilities for a wide range of biomaterials and regenerative medicine research at Sheffield University
5. Bioactive surfaces. Creation of biologically active surfaces for medical device applications
- EPSRC Centre for Doctoral Training in Advanced Biomedical Materials with Manchester University (Professor Sarah Cartmell (PI) and Professor Julie Gough)
- 3D BioNet: An integrated technological platform for 3D micro-tissues. Technology Touching Life - BBSRC, MRC, EPSRC with Dr Raphael Lévy (PI), Professor Helen Byrne, Professor Paola Borri, Professor Stefan Przyborski, Dr Marianne Ellis, Dr Chris Goldring and Professor Ruth Cameron
- Sir Henry Royce Institute - Sheffield Equipment - EPSRC, with Professor Mark Rainforth (PI), Professor Dan Allwood, Professor Ian Reaney, Professor Iain Todd, Professor Neil Hyatt and Professor Derek Sinclair
- Sir Henry Royce Institute - Sheffield Build - EPSRC, with Professor Mark Rainforth (PI), Professor Dan Allwood, Professor Ian Reaney, Professor Iain Todd, Professor Neil Hyatt and Professor Derek Sinclair
- Development and validation of a human brain micro physiological system derived from induced pluripotent stem cells in amyotrophic lateral sclerosis (ALS) 3D BioNet, with Dr Ke Ning (PI)
- The Design, Manufacture and Testing of Advanced Nerve Guidance Conduits. Dr Jeff Wadsworth - Battelle Memorial Institute. With SUNY, New York – Melendez A, as PI with Dr Fred Claeyssens and Professor Fiona Boissonade
Previous major projects
- Cellular Force Microscope - BBSRC with Professor Jamie Hobbs and Dr N Brown.
- Affordable Healthcare in Pakistan - Developing Biomedical Materials for Clinical Impact. EPSRC (GCRF)
- NEURIMP (FP7) - Novel combination of biopolymers and manufacturing technologies for production of a peripheral nerve implant containing an internal aligned channels array. An EC funded project with 8 EU partners.
- IPROMEDAI - Improved Protection of Medical Devices Against Infection. An EU COST (European Cooperation in Science & Technology) network across 24 countries. UK Management Committee member.
- Dinuclear ruthenium light-switches as multi-output sub-cellular imaging probes within live cells and tissues. EPSRC (with Dr James Thomas, Dr Julia Weinstein and Prof Sheila MacNeil).
- EPSRC Centre for Doctoral Training in Polymers, Soft Matter and Colloids (with Professor Steve Armes, Professor David Lidzey, Professor Neil Hopkinson, Professor Graham Leggett.
- Novel 3D coating of bioactive glass and metallic composites. EPSRC/Innovate UK (with Prof Mark Rainforth and Prof Iain Todd).
- Development of a 3D engineered skin model for inflammatory detection (EPSRC).
- The development of xenogenic decellularised nerve graft for traumatic repair (EPSRC).
- Toward the next generation of joint repair strategies. Using plasma polymerization to produce bioinspired, biofunctional, biomaterial implants (Dunhill Medical Trust) – with Dr Aileen Crawford and Dr Dave Buttle.
- Development of early melanoma detection using O2 probes and time-resolved emission imaging microscopy (BBSRC) – with Dr Julia Weinstein.
- Sensor Integrated Bioreactors (TSB) – with Dr Jon Aylott, Kirkstall Ltd and Locate Therapeutics (formerly Regentec Ltd).
- Cross-cutting Directors of Research and Innovation - Interdisciplinary PhD Scholarships. The Construction of Human Perfection (with Prof Tammy Hervey, Prof Paul Hatton, Prof Adam Piette, Dr Fabienne Collignon, Dr Sarah Baker, Dr Keith Smith, Dr Amanda Warren-Jones).
John’s research and opinion on nerve injury repair has been featured in a number of recent media publications:
- BBC World News “Science in Action” - Spinal Cord Repair - Nose cells are used to repair a spinal cord injury
- BBC World News “Horizons” – Technobody (with colleague Dr Fred Claeyssens)
- YouTube – Research@Sheffield - Tissue Engineering – Nerve Guides
- The Daily Telegraph - Paralysed man walks again
- The Daily Mail - Spinal Surgery Breakthrough Hailed
- Cellular In Vitro Testing: Methods and Protocols. Singapore: Pan Stanford Publishing.
- 3D Cell Culture : Methods and Protocols. Humana Press.
- Cost effective optimised synthetic surface modification strategies for enhanced control of neuronal cell differentiation and supporting neuronal and Schwann cell viability.. J Biomed Mater Res B Appl Biomater.
- Patterning the neuronal cells via inkjet printing of self-assembled peptides on silk scaffolds. Progress in Natural Science: Materials International.
- Biomimetic surface delivery of NGF and BDNF to enhance neurite outgrowth. Biotechnology and Bioengineering. View this article in WRRO
- UV-Casting on methacrylated PCL for the production of a peripheral nerve implant containing an array of porous aligned microchannels. Polymers, 12(4). View this article in WRRO
- A dinuclear ruthenium(II) complex excited by near-infrared light through two-photon absorption induces phototoxicity deep within hypoxic regions of melanoma cancer spheroids. Journal of the American Chemical Society. View this article in WRRO
- Unidirectional neuronal cell growth and differentiation on aligned polyhydroxyalkanoate blend microfibres with varying diameters. Journal of Tissue Engineering and Regenerative Medicine, 13(9), 1581-1594. View this article in WRRO
- Development of a 3D in vitro Model of the Kidney Cortical Collecting Duct. The FASEB Journal, 33(S1), 575.7-575.7.
- A dinuclear ruthenium(II) phototherapeutic that targets duplex and quadruplex DNA. Chemical Science, 10(12), 3502-3513. View this article in WRRO
- Additive manufactured biodegradable poly(glycerol sebacate methacrylate) nerve guidance conduits. Acta Biomaterialia, 78, 48-63. View this article in WRRO
- An Improved In Vivo Methodology to Visualise Tumour Induced Changes in Vasculature Using the Chick Chorionic Allantoic Membrane Assay. In Vivo, 32(3). View this article in WRRO
- Recent concepts in biodegradable polymers for tissue engineering paradigms: a critical review. International Materials Reviews. View this article in WRRO
- Oxygen Mapping of Melanoma Spheroids using Small Molecule Platinum Probe and Phosphorescence Lifetime Imaging Microscopy.. Scientific Reports, 7. View this article in WRRO
- Decellularisation and histological characterisation of porcine peripheral nerves. Biotechnology and Bioengineering, 113(9), 2041-2053. View this article in WRRO
- Combining 3D human in vitro methods for a 3Rs evaluation of novel titanium surfaces in orthopaedic applications. Biotechnology and Bioengineering, 113(7), 1586-1599. View this article in WRRO
- Inkjet printing Schwann cells and neuronal analogue NG108-15 cells. Biofabrication, 8(1), 015017-015017. View this article in WRRO
- Photochemically modified diamond-like carbon surfaces for neural interfaces. Materials Science and Engineering: C, 58, 1199-1206. View this article in WRRO
- Investigating NF-κB signaling in lung fibroblasts in 2D and 3D culture systems. Respiratory Research, 16(1). View this article in WRRO
- An anatomical study of porcine peripheral nerve and its potential use in nerve tissue engineering. Journal of Anatomy, 227(3), 302-314. View this article in WRRO
- Three-dimensional imaging and uptake of the anticancer drug combretastatin in cell spheroids and photoisomerization in gels with multiphoton excitation. Journal of Biomedical Optics, 20(7), 078003-078003. View this article in WRRO
- Nerve guides manufactured from photocurable polymers to aid peripheral nerve repair. Biomaterials, 49, 77-89. View this article in WRRO
- Nerve tissue engineering using blends of poly(3-hydroxyalkanoates) for peripheral nerve regeneration. Engineering in Life Sciences, 15(6), 612-621. View this article in WRRO
- Two-photon phosphorescence lifetime imaging of cells and tissues using a long-lived cyclometallated N pyridyl ^C phenyl ^N pyridyl Pt( ii ) complex. RSC Advances, 4(66), 35003-35008. View this article in WRRO
- Amine functionalized nanodiamond promotes cellular adhesion, proliferation and neurite outgrowth.. Biomed Mater, 9(4), 045009.
- Immunocompetent 3D Model of Human Upper Airway for Disease Modeling and In Vitro Drug Evaluation. Molecular Pharmaceutics, 11(7), 2082-2091.
- Development of 3D skin models for in vitro testing. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 8, 377-377.
- Development of an acellular xenogeneic nerve graft. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 8, 405-405.
- Titelbild: Dinuclear Ruthenium(II) Complexes as Two‐Photon, Time‐Resolved Emission Microscopy Probes for Cellular DNA (Angew. Chem. 13/2014). Angewandte Chemie, 126(13), 3349-3349.
- Dinuclear ruthenium(II) complexes as two-photon, time-resolved emission microscopy probes for cellular DNA.. Angew Chem Int Ed Engl, 53(13), 3367-3371. View this article in WRRO
- Amine functional hydrogels as selective substrates for corneal epithelialization. Acta Biomaterialia, 10(7), 3029-3037.
- Long-lived metal complexes open up microsecond lifetime imaging microscopy under multiphoton excitation: From FLIM to PLIM and beyond. Chemical Science, 5(3), 879-886. View this article in WRRO
- The development of a 3D immunocompetent model of human skin. BIOFABRICATION, 5(3).
- Combined Effects of Capsaicin and HA14-1 in Inducing Apoptosis in Melanoma Cells. Journal of Cosmetics, Dermatological Sciences and Applications, 03(03), 175-189.
- Skin stem cell hypotheses and long term clone survival--explored using agent-based modelling.. Sci Rep, 3, 1904. View this article in WRRO
- Effects of laser-exposed gold nanorods on biochemical pathways of neuronal cells. Proceedings of SPIE - The International Society for Optical Engineering, 8923.
- Laser exposure of gold nanorods can induce intracellular calcium transients. Journal of Biophotonics.
- Laser exposure of gold nanorods can increase neuronal cell outgrowth. Biotechnology and Bioengineering.
- Plasmonic properties of gold nanoparticles can promote neuronal activity. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8579.
- Integrated culture and purification of rat Schwann cells from freshly isolated adult tissue.. Nat Protoc, 7(11), 1996-2004.
- RGD functionalised highly branched poly(N-isopropylacrylamide) (HB-p(NIPAM)) semi interpenetrating polymer networks (semi-IPNs) for peripheral nerve repair. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 78-79.
- Development of a 3D neuronal glial co-culture model for peripheral nerve studies and repair strategies. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 352-352.
- Functionalised degrable photocurable polymers for peripheral nerve repair. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 78-78.
- Investigating maleic anhydride and acrylic acid plasma polymers as coatings for peripheral nerve guide conduits. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, 76-76.
- Two-photon polymerization-generated and micromolding-replicated 3D scaffolds for peripheral neural tissue engineering applications.. Biofabrication, 4(2), 025005.
- An aligned 3D neuronal-glial co-culture model for peripheral nerve studies. Biomaterials, 33(25), 5901-5913.
- An aligned 3D neuronal-glial co-culture model for peripheral nerve studies. Biomaterials.
- Human hair follicle dermal cells and skin fibroblasts show differential activation of NF-κB in response to pro-inflammatory challenge.. Exp Dermatol, 21(2), 158-160.
- Next generation nerve guides: materials, fabrication, growth factors, and cell delivery.. Tissue Eng Part B Rev, 18(2), 116-128.
- Direct laser writing of 3D scaffolds for neural tissue engineering applications.. Biofabrication, 3(4), 045005.
- Anatomical site influences the differentiation of adipose-derived stem cells for Schwann-cell phenotype and function.. Glia, 59(5), 734-749.
- Modifying biomaterial surfaces to control stem cell growth and differentiation, 344-364.
- Adipose-derived stem cells (ASCs) for peripheral nerve repair. 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials.
- Directing neuronal cell outgrowth and schwann cell organisation with aligned polycaprolactone microfibre scaffolds. 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials.
- Improving nerve guidance conduits with biodegradable aligned microfibres. European Cells and Materials, 22(SUPPL.2), 1.
- Directing neuronal cell outgrowth and schwann cell organisation with aligned polycaprolactone microfibre scaffolds. European Cells and Materials, 22(SUPPL.3), 17.
- The use of plasma polymerised acrylic acid and maleic anhydride for neuronal cell engineering. European Cells and Materials, 22(SUPPL.3), 23.
- Adipose-derived stem cells (ASCs) for peripheral nerve repair. European Cells and Materials, 22(SUPPL.2), 9.
- Development of a tissue-engineered skin model for detecting irritants. European Cells and Materials, 22(SUPPL.2), 23.
- Adipose-derived stem cells for peripheral nerve repair. European Cells and Materials, 22(SUPPL.3), 16.
- Microstructuring of photocurable biomaterials with applications in neuronal repair. European Cells and Materials, 22(SUPPL.3), 15.
- Direct laser writing of 3D scaffolds for neural tissue engineering applications. Biofabrication, 3(4).
- 3D cell culture: a review of current approaches and techniques.. Methods Mol Biol, 695, 1-15.
- Three-dimensional alignment of schwann cells using hydrolysable microfiber scaffolds: strategies for peripheral nerve repair.. Methods Mol Biol, 695, 155-166.
- A Novel 3D Immuno-Competent Co-Cultured Skin Model to Investigate the Allergenic Potential of Chemicals. J PHARM PHARMACOL, 62(10), 1241-1242.
- Development of a 3D human in vitro skin co-culture model for detecting irritants in real-time.. Biotechnol Bioeng, 106(5), 794-803.
- The effect of trapping superparamagnetic beads on domain wall motion (vol 96, 192503, 2010). APPL PHYS LETT, 96(23).
- The effect of trapping superparamagnetic beads on domain wall motion. APPL PHYS LETT, 96(19). View this article in WRRO
- Mechanisms of fluid-flow-induced matrix production in bone tissue engineering. P I MECH ENG H, 224(H12), 1509-1521.
- Switchable cell trapping using superparamagnetic beads. IEEE Magnetics Letters, 1.
- Melanocortin Signalling Mechanisms. ADV EXP MED BIOL, 681, 19-28.
- Generation of Bioactive Materials with Rapid Self-Assembling Resorcinarene-Peptides. ADV MATER, 21(28), 2909-2915.
- The use of aligned polymer microfibres in peripheral nerve engineering. European Cells and Materials, 18(SUPPL. 2), 82.
- Adipose-derived stem cells (ASCs) for peripheral nerve repair. European Cells and Materials, 18(SUPPL. 2), 23.
- Sub-micron poly(N-isopropylacrylamide) particles as temperature responsive vehicles for the detachment and delivery of human cells. SOFT MATTER, 5(24), 4928-4937.
- Regionally-selective cell colonization of micropatterned surfaces prepared by plasma polymerization of acrylic acid and 1,7-octadiene.. Physiol Res, 58(5), 669-684.
- Time-resolved and two-photon emission imaging microscopy of live cells with inert platinum complexes.. Proc Natl Acad Sci U S A, 105(42), 16071-16076.
- Development of biodegradable electrospun scaffolds for dermal replacement.. Biomaterials, 29(21), 3091-3104.
- Anti-microbial action of melanocortin peptides and identification of a novel X-Pro-D/L-Val sequence in Gram-positive and Gram-negative bacteria.. Peptides, 29(6), 1004-1009.
- Development of a bioreactor for evaluating novel nerve conduits.. Biotechnol Bioeng, 99(5), 1250-1260.
- In vivo analysis on the early response of electrospun poly-DL-lactide (PDLA) and polyglycolic acid (PGA) 3D scaffolds for tissue engineering. 8th World Biomaterials Congress 2008, 1, 253.
- Use of aligned polymer microfibres for peripheral nerve repair. 8th World Biomaterials Congress 2008, 1, 260.
- Mesenchymal stems cells and endothelial cells on micropatterned surfaces prepared by plasma polymerisation. 8th World Biomaterials Congress 2008, 3, 1480.
- Long term degradation study of electrospun scaffolds for soft tissue reconstruction. 8th World Biomaterials Congress 2008, 1, 2.
- Development of a synthetic matrix to replace human dermis. European Cells and Materials, 16(SUPPL. 3), 4.
- Peripheral nerve engineering using aligned polymer microfibres. European Cells and Materials, 16(SUPPL. 3), 15.
- Differential effects of glutathione S-transferase pi (GSTP1) haplotypes on cell proliferation and apoptosis.. Carcinogenesis, 28(11), 2268-2273.
- Development of a 3D cell culture system for investigating cell interactions with electrospun fibers.. Biotechnol Bioeng, 97(5), 1318-1328.
- Real-time detection of stress in 3D tissue-engineered constructs using NF-kappaB activation in transiently transfected human dermal fibroblast cells.. Tissue Eng, 13(5), 1013-1024.
- Monofunctionalised resorcinarenes. TETRAHEDRON LETT, 48(8), 1317-1319.
- Investigation of fibroblast and keratinocyte cell-scaffold interactions using a novel 3D cell culture system.. J Mater Sci Mater Med, 18(2), 321-328.
- Evaluation of anti-inflammatory and antimicrobial resorcinarene-peptides for biomaterial modification. European Cells and Materials, 14(SUPPL.3), 126.
- Evaluation of anti-inflammatory and antimicrobial resorcinarene-peptides for biomaterial modification. European Cells and Materials, 14(SUPPL.3), 23.
- Highly branched poly-(N-isopropylacrylamide)s with arginine-glycine-aspartic acid (RGD)- or COOH-chain ends that form sub-micron stimulus-responsive particles above the critical solution temperature. SOFT MATTER, 3(8), 971-973.
- A selective small molecule agonist of the melanocortin-1 receptor inhibits lipopolysaccharide-induced cytokine accumulation and leukocyte infiltration in mice. J LEUKOCYTE BIOL, 80(4), 897-904.
- Anti-inflammatory peptide approaches for preventing vascular inflammation. Vascular Pharmacology, 45(3), e85-e85.
- Function-blocking autoantibodies to the melanin-concentrating hormone receptor in vitiligo patients.. Lab Invest, 86(8), 781-789.
- In situ image analysis of interactions between normal human keratinocytes and fibroblasts cultured in three-dimensional fibrin gels.. Biomaterials, 27(18), 3459-3465.
- Culture of skin cells in 3D rather than 2D improves their ability to survive exposure to cytotoxic agents.. J Biotechnol, 122(3), 372-381.
- Sodium salicylate inhibits TNF-alpha-induced NF-kappaB activation, cell migration, invasion and ICAM-1 expression in human melanoma cells.. Melanoma Res, 16(1), 11-22.
- Immobilized alpha-melanocyte stimulating hormone 10-13 (GKPV) inhibits tumor necrosis factor-alpha stimulated NF-kappaB activity.. Peptides, 27(2), 431-437.
- Melanocyte stimulating hormone peptides inhibit TNF-alpha signaling in human dermal fibroblast cells.. Peptides, 27(2), 421-430.
- alpha-Melanocyte stimulating hormone, inflammation and human melanoma.. Peptides, 27(2), 444-452.
- Anti-inflammatory peptide approaches for preventing vascular inflammation. European Cells and Materials, 11(SUPPL.2), 45.
- Evaluation of anti-inflammatory calixarene-peptides for biomaterial modification. European Cells and Materials, 11(SUPPL.2), 26.
- Development of a closed bioreactor system for culture of tissue-engineered skin at an air-liquid interface.. Tissue Eng, 11(11-12), 1824-1831.
- Alpha-melanocyte stimulating hormone cytoprotective biology in human dermal fibroblast cells.. Peptides, 26(7), 1150-1158.
- Self-organization of skin cells in three-dimensional electrospun polystyrene scaffolds.. Tissue Eng, 11(7-8), 1023-1033.
- Anti-inflammatory peptide Approaches for Preventing vascular inflammation. European Cells and Materials, 10(SUPPL.2), 17.
- Developments in xenobiotic-free culture of human keratinocytes for clinical use.. Wound Repair Regen, 12(6), 626-634.
- Measurement of NF-kappaB in normal and reconstructed human skin in vitro.. J Mater Sci Mater Med, 15(7), 743-749.
- Melanoma cell migration is upregulated by tumour necrosis factor-alpha and suppressed by alpha-melanocyte-stimulating hormone.. Br J Cancer, 90(7), 1457-1463. View this article in WRRO
- alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in human keratinocyte cells.. J Invest Dermatol, 122(4), 1010-1019.
- Alpha-MSH inhibits inflammatory signalling in Schwann cells.. Neuroreport, 15(3), 493-498.
- Smart scaffolds or smart cells? Steps towards the development of a synthetic scaffold for skin reconstruction. Transactions - 7th World Biomaterials Congress, 567.
- α-melanocyte stimulating hormone anti-inflammatory action in human dermal fibroblast cells: Application in skin tissue engineering. Transactions - 7th World Biomaterials Congress, 1069.
- Anti-inflammatory and cytoprotective action of novel synthetic MSH peptides in human skin keratinocytes. Transactions - 7th World Biomaterials Congress, 1067.
- Alpha-MSH inhibits inflammatory signalling in olfactory ensheathing cells.. Neuroreport, 14(17), 2171-2175.
- Anti-inflammatory and anti-invasive effects of alpha-melanocyte-stimulating hormone in human melanoma cells.. Br J Cancer, 89(10), 2004-2015. View this article in WRRO
- Tumor necrosis factor alpha increases and alpha-melanocyte-stimulating hormone reduces uveal melanoma invasion through fibronectin.. J Invest Dermatol, 121(3), 557-563.
- -msh inhibits inflammatory signalling in olfactory ensheathing cells. NeuroReport, 14(17), 749-755.
- Measurement of NF-κB as an indicator of stress in skin cells in 2D culture and a 3D reconstructed skin model. European Cells and Materials, 6(SUPPL. 2), 51.
- α-melanocyte stimulating hormone anti-inflammatory action in human dermal fibroblast cells. European Cells and Materials, 6(SUPPL. 2), 42.
- Alpha-MSH inhibits inflammatory signalling in glial cells. European Cells and Materials, 6(SUPPL. 2), 52.
- Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function. EUR J BIOCHEM, 269(24), 6133-6141.
- Inhibition of tumor necrosis factor-alpha stimulated NFkappaB/p65 in human keratinocytes by alpha-melanocyte stimulating hormone and adrenocorticotropic hormone peptides.. J Invest Dermatol, 119(6), 1244-1253.
- Melanoma cell attachment, invasion, and integrin expression is upregulated by tumor necrosis factor alpha and suppressed by alpha melanocyte stimulating hormone.. J Invest Dermatol, 119(5), 1165-1171.
- Melanoma cell attachment, invasion and integrin expression is upregulated by the proinflammatory cytokine TNF-alpha and suppressed by the anti-inflammatory peptide alpha-MSH. BRIT J CANCER, 86, S94-S94.
- Alpha-melanocyte stimulating hormone inhibits porcine vascular smooth muscle and endothelial cell responses to tumor necrosis factor-alpha. J AM COLL CARDIOL, 39(5), 54A-54A.
- α-melanocyte-stimulating hormone anti-inflammatory action in human dermal fibroblast cells. European Cells and Materials, 4(SUPPL. 2), 50.
- Proopiomelanocortin anti-inflammatory peptide signalling in human skin keratinocyte cells. European Cells and Materials, 4(SUPPL. 2), 46.
- alpha-MSH peptides inhibit cytokine-stimulated NF-kappa B/p65 activation in HaCaT keratinocytes. J INVEST DERMATOL, 117(2), 425-425.
- Cellular and hormonal regulation of pigmentation in human ocular melanocytes.. Pigment Cell Res, 14(4), 298-309.
- Cellular and hormonal regulation of pigmentation in human choroidal and iridial melanocytes.. INVEST OPHTH VIS SCI, 42(4), S214-S214.
- Alpha-melanocyte-stimulating hormone reduces impact of proinflammatory cytokine and peroxide-generated oxidative stress on keratinocyte and melanoma cell lines.. J Biol Chem, 275(21), 15629-15636.
- Investigation of uveal melanocyte pigmentation. INVEST OPHTH VIS SCI, 41(4), S771-S771.
- alpha-MSH immunomodulation acts via rel/NF-kappa B in cutaneous and ocular melanocytes and in melanoma cells.. Ann N Y Acad Sci, 885, 396-399.
- Alpha-melanocyte-stimulating hormone inhibits NF-kappaB activation in human melanocytes and melanoma cells.. J Invest Dermatol, 113(4), 560-566.
- Involvement of calcium in retinal pigment epithelial cell proliferation and pigmentation.. Curr Eye Res, 17(8), 813-822.
- Differential protein oxidation in Duchenne and Becker muscular dystrophy.. Neuroreport, 9(10), 2201-2207.
- Evidence for an immunomodulatory role for alpha-MSH in cutaneous and ocular melanoma. BRIT J CANCER, 78(2), 156-157.
- The participation of proliferative keratinocytes in the preimmune response to sensitizing agents.. Br J Dermatol, 138(1), 45-56.
- Oxidative damage to protein and alterations to antioxidant levels in human cutaneous thermal injury.. Burns, 23(7-8), 533-540.
- Role of intracellular calcium in co-regulation of RPE cell contraction and proliferation by platelet mitogens.. INVEST OPHTH VIS SCI, 38(4), 3490-3490.
- Oxidative damage to muscle protein in Duchenne muscular dystrophy.. Neuroreport, 8(1), 357-361.
- Differential susceptibility of human skeletal muscle proteins to free radical induced oxidative damage: a histochemical, immunocytochemical and electron microscopical study in vitro.. Acta Neuropathol, 92(4), 331-340.
- Effect of prednisone on protease activities and structural protein levels in rat muscles in vivo.. Clin Chim Acta, 249(1-2), 47-58.
- Allergen-induced upregulation of intracellular adhesion molecule-1 in keratinocytes. J INVEST DERMATOL, 106(4), 702-702.
- Bioresorbable and Mechanically Optimized Nerve Guidance Conduit Based on a Naturally Derived Medium Chain Length Polyhydroxyalkanoate and Poly(ε-Caprolactone) Blend. ACS Biomaterials Science & Engineering.
- Correction: A dinuclear ruthenium(ii) phototherapeutic that targets duplex and quadruplex DNA. Chemical Science, 11(9), 2566-2566.
- Pre-clinical evaluation of advanced nerve guide conduits using a novel 3D in vitro testing model. International Journal of Bioprinting, 4(1). View this article in WRRO
- Utilising Inkjet Printed Paraffin Wax for Cell Patterning Applications. International Journal of Bioprinting, 2(0).
- Arginine–glycine–aspartic acid functional branched semi-interpenetrating hydrogels. Soft Matter, 11(38), 7567-7578. View this article in WRRO
- Modulation of neuronal cell affinity of composites scaffolds based on polyhydroxyalkanoates and bioactive glasses. Biomedical Materials. View this article in WRRO
- A Tuneable, Photocurable, Poly(Caprolactone)-Based Resin for Tissue Engineering—Synthesis, Characterisation and Use in Stereolithography. Molecules, 26(5), 1199-1199.
- Polyhydroxyalkanoates, Their Processing and Biomedical Applications, The Handbook of Polyhydroxyalkanoates (pp. 255-284). CRC Press
- The Role of Schwann Cells in Peripheral Nerve Function, Injury, and Repair, Cell Engineering and Regeneration (pp. 215-236). Springer International Publishing
- Biomaterials and Scaffolds for Repair of the Peripheral Nervous System, Peripheral Nerve Tissue Engineering and Regeneration (pp. 1-35). Springer International Publishing
- Development of a paracrine-signaling model for detecting irritancy using human keratinocytes and fibroblasts In Haycock J, Ahluwalia A & Wilkinson J (Ed.), Cellular in Vitro Testing: Methods and Protocols (pp. 109-121). Singapore: Pan Stanford.
- The Premise of Tissue Engineering: Molecular Recognition, Scaffolds for Tissue Engineering (pp. 57-78). Pan Stanford Publishing
- The premise of tissue engineering: Molecular recognition, Scaffolds for Tissue Engineering: Biological Design, Materials, and Fabrication (pp. 57-78).
- Fluorescence Microscopy In Morgan S, Rose FR & Matcher SJ (Ed.), Optical Techniques in Regenerative Medicine (pp. 29-59). Boca Raton: Taylor & Francis.
- Modifying biomaterial surfaces to control stem cell growth and differentiation, Surface Modification of Biomaterials (pp. 344-364). Elsevier
- Contributor contact details, Surface Modification of Biomaterials (pp. xi-xiv). Elsevier
- Differential susceptibility of skeletal muscle proteins to free radical-induced oxidative damage in vitro, Oxidative Stress in Skeletal Muscle (pp. 157-176). Birkhäuser Basel
Conference proceedings papers
- In situ repair of full-thickness cartilage defects using biomimetic biofunctionalised implants. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 99(6) (pp A17-A17)
- 95 Investigating fibroblast involvement in vascular inflammation using co-culture models. Basic Science
- View this article in WRRO Biomimetic, biofunctionalised polymer implants to promote in situ repair of traumatic and early osteoarthritic cartilage defects. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 98(3) (pp A15-A15)
- Optical measurement of oxygen concentration in melanoma spheroid and skin engineered models. European Cells and Materials (ECM), Vol. Collection 5 (pp 8-8)
- 3D Printing and Plasma Coating of Nerve Guide Conduits (NGC). TISSUE ENGINEERING PART A, Vol. 21 (pp S359-S360)
- Nerve Tissue Engineering using Blends of Polyhydroxyalkanoates for Peripheral Nerve Regeneration. TISSUE ENGINEERING PART A, Vol. 21 (pp S325-S325)
- PERIPHERAL NERVE REGENERATION USING BLENDS OF POLYHYDROXYALKANOATES. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, Vol. 20(2) (pp 185-185)
- Development of 3D In Vitro Models of Nerve and Skin for Disease, Disorder and Testing Studies. The FASEB Journal, Vol. 29
- Nerve guides from photocurable polymers for peripheral nerve repair. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 8 (pp 172-172)
- Oxygen difference in live melanoma muticellular tumour spheroids using novel platinum compound and time-resolved imaging microscopy. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 8 (pp 314-314)
- State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. ALTEX (pp 441-477)
- Time-resolved two-photon emission imaging microscopy with transition metal complexes (TPE-TREM). ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 245
- Tissue Engineering and Regenerative Medicine. Journal of Tissue Engineering and Regenerative Medicine, Vol. 6 (pp 1-429)
- Human hair follicle dermal cells and skin fibroblasts show differential activation of NF-kappa B in response to pro-inflammatory challenge. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 131 (pp S81-S81)
- Hyaluronan as a potential mechanotransduction mediator. European Cells and Materials, Vol. 22(SUPPL.2) (pp 6)
- The Response of Matrix Synthesizing MLO-A5 Cells to Fluid Shear. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S147-S147)
- Mechanobiology in bone tissue engineering: responses to fluid flow. TISSUE ENGINEERING PART A, Vol. 14(5) (pp 878-878)
- Human hair follicle dermal cells activate NF-kappa B in response to TNF-alpha and IL-1 beta but are lipopolysaccharide tolerant. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 128 (pp S149-S149)
- The role of mechanotransduction in bone tissue engineering. European Cells and Materials, Vol. 16(SUPPL. 3) (pp 84)
- Development of biocompatible, biodegradable electrospun scaffolds for tissue engineering of human skin. TISSUE ENGINEERING, Vol. 13(7) (pp 1670-1671)
- Use of aligned polymer microfibres for peripheral nerve repair. TISSUE ENGINEERING, Vol. 13(7) (pp 1774-1774)
- Highly branched polymers via RAFT: Chain-end functionalization with peptides. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 230 (pp U3645-U3646)
- Antioxidant and anti-inflammatory activities of melanocortin peptides. EXPERIMENTAL DERMATOLOGY, Vol. 13(9) (pp 576-576)
- Sodium salicylate inhibits inflammation induced invasion and migration of human melanoma cells. BRITISH JOURNAL OF CANCER, Vol. 91 (pp S71-S71)
- Research group
- Dr Caroline Taylor
- Ana Sandoval Castellanos (with Dr Ke Ning)
- Ana Jiminez Franco (Co-supervisor - Jon Xiao)
- Sara Memarpour Hobbi (Co-supervisors - Fiona Boissonade and Fred Claeyssens)
- Rebecca Lomax (Co-supervisors - Fiona Boissonade and Fred Claeyssens)
- Emmanuel Asare (Co-supervisor – Ipsita Roy)
- Annabelle Fricker (Co-supervisor – Ipsita Roy)
- Dila Hatun Sal (Co-supervisor – Ipsita Roy)
- Teaching activities
- MAT209 – 10 credits – Cell & Molecular Biology
- MAT300/407 – 20 credits – Tissue Engineering (10%)
- MAT372/6305 – 20 credits – Group projects in Bioengineering
- Professional activities
- Head of Materials Science & Engineering, University of Sheffield (2019 - present)
- Engineering Faculty Director of Research & Innovation (2016 - 2019)
- EPSRC CDT Advanced Biomedical Materials Co-director (Manchester-Sheffield) (2019-28)
- UKRI Future Leaders Fellowships Panel (2018 – present)
- Government of Ireland Panel Member (2018 – present)
- EPSRC UKCCSRC Board Member (2017 – 2020)
- Chair and Scientific Adviser - Versus Arthritis UK Centre for Tissue Engineering & Regenerative Medicine (Cambridge University) 2017 - present
- BBSRC Core Panel C and TRDF panel (2014 - 20)
- UK Tissue and Cell Engineering Society Board (2009 - present)
- Chair – Technicians Commitment for the University of Sheffield
- External RAE Panel assessor – National University of Ireland (2018 – present)
- Executive Board of TERMIS-EU (2013-16)
- Member of EPSRC Peer Review College (2010-17)
- Academy of Finland Panel member (2015-18)
- Canada Foundation for Innovation panel member (2015)
- Editor of ‘Methods in Molecular Biology’ book on 3D Cell Culture (Springer, USA, 2011)
- Editor of ‘Cellular In Vitro Testing” book (PanStanford, Singapore, 2014)
- Basnett P, Bazán Goñi X, Claeyssens F, Díez Ahedo R, Glen A, González Pérez Francisco J, Haycock JW, Lukasiewicz B, Mendibil Blasco X, Merino Álvarez S, Márquez Posadas María Del C, Nigmatullin R, Quintana Fernández I, Rodríguez Muñoz Francisco J, Roy I, Sherborne C, Taylor C. Implantable Nerve Guidance Conduit for Nerve Repair (2019). Priorities: EP2018054984W·2018-02-28. Application: EP2018054984W·2018-02-28. Publication: WO2019166087A1·2019-09-06.
- Crawford A, Buttle D, Haycock JW (2017) Medical Implant. Priorities: GB201513097A·2015-07-24. Application: GB2016052270W·2016-07-25. Publication: WO2017017425A1·2017-02-02.
- Botchway SW, Haycock J, Weinstein JA, Williams JAG. (2008) Imaging Techniques Using A Tridentate Ligand. Priorities: GB0818151A·2008-10-03; GB2009002369W·2009-10-05. Application: US200913122361A·2009-10-05. Publication: US2011262897A1·2011-10-27
- Haycock J, Hunter C, MacNeil S, Ryan T, Short R, Williams N (2002). Biomaterials Comprising a Melanocyte Stimulating Hormone (α-MSH), and method of forming. Priorities: EP2018054984W·2018-02-28. Application: EP2018054984W·2018-02-28. Publication: WO2019166087A1·2019-09-06.