Professor John W Haycock

BSc (Hons) PhD

Department of Materials Science and Engineering

Head of Department

Professor of Bioengineering

Professor John Haycock
j.w.haycock@sheffield.ac.uk
+44 114 222 5972

Full contact details

Professor John W Haycock
Department of Materials Science and Engineering
Sir Robert Hadfield Building
Mappin Street
Sheffield
S1 3JD
Profile

John Haycock joined the department in 2001 from the Medical School at Sheffield University where he was a Research Fellow. He obtained his first degree and PhD in Biochemistry at Newcastle University and was a PDRA at Albany Medical College in New York. His research group is based in the Kroto Research Institute.

Research interests

John's research spans five interdisciplinary themes:

1. Nerve tissue engineering. The design of nerve guidance channels for repairing traumatic peripheral nerve injury – combining biomaterials, 3D fabrication, neuronal, glial and stem cell research.

2. 3D In vitro models of nerve. The use of 3D scaffolds and neuronal/glial co-cultures for 3D in vitro models of nerve as an alternative to animal models for disease, disorder and testing research.

3. 3D In vitro models of skin. The use of 3D scaffolds and keratinocyte/fibroblast co-cultures for 3D in vitro models of skin as an alternative to animal models for inflammatory testing.

4. 3D Imaging. Confocal and 2-photon microscopy + Time-resolved microscopy imaging

5. Bioactive surfaces. Anti-inflammatory and anti-microbial surfaces for medical applications

John also has an interest in single and 2-photon laser scanning microscopy for supporting a number of interdisciplinary research programmes, including tissue engineering. He was responsible for establishing the confocal and multiphoton imaging facility in the Kroto Research Institute funded by the BBSRC with support from Carl Zeiss.


Key projects


Research themes/centres


John’s research and opinion on nerve injury repair has been featured in a number of recent media publications:

Publications

Edited books

Journal articles

Chapters

Conference proceedings papers

  • Buttle D, Haycock J, Pead M, Meeson R, Blunn G & Crawford A (2018) In situ repair of full-thickness cartilage defects using biomimetic biofunctionalised implants. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 99(6) (pp A17-A17) RIS download Bibtex download
  • Wright K, Haycock J & Francis S (2018) 95 Investigating fibroblast involvement in vascular inflammation using co-culture models. Basic Science RIS download Bibtex download
  • Buttle DJ, Haycock JH, Pead M, Meeson R, Blunn G & Crawford A (2017) Biomimetic, biofunctionalised polymer implants to promote in situ repair of traumatic and early osteoarthritic cartilage defects. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 98(3) (pp A15-A15) View this article in WRRO RIS download Bibtex download
  • Raza A, Colley H, Baggaley E, Green N, Botchway S, Weinstein J, MacNeil S & Haycock J (2016) Optical measurement of oxygen concentration in melanoma spheroid and skin engineered models. European Cells and Materials (ECM), Vol. Collection 5 (pp 8-8) RIS download Bibtex download
  • Clarke J, Harding AJ, Boissonade FM, Haycock JW & Claeyssens F (2015) 3D Printing and Plasma Coating of Nerve Guide Conduits (NGC). TISSUE ENGINEERING PART A, Vol. 21 (pp S359-S360) RIS download Bibtex download
  • Valderrama LRL, Nigmatullin R, Taylor C, Haycock JW, Claeyssens F & Roy I (2015) Nerve Tissue Engineering using Blends of Polyhydroxyalkanoates for Peripheral Nerve Regeneration. TISSUE ENGINEERING PART A, Vol. 21 (pp S325-S325) RIS download Bibtex download
  • Lizarraga-Valderrama LR, Nigmatullin R, Taylor C, Haycock JW, Claeyssens F & Roy I (2015) PERIPHERAL NERVE REGENERATION USING BLENDS OF POLYHYDROXYALKANOATES. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, Vol. 20(2) (pp 185-185) RIS download Bibtex download
  • Haycock J (2015) Development of 3D In Vitro Models of Nerve and Skin for Disease, Disorder and Testing Studies. The FASEB Journal, Vol. 29 RIS download Bibtex download
  • Pateman CJ, Harding A, Plenderleith R, Boissonade F, Rimmer S, Haycock JW & Claeyssens F (2014) Nerve guides from photocurable polymers for peripheral nerve repair. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 8 (pp 172-172) RIS download Bibtex download
  • Raza A, Colley H, Baggaley E, Botchway S, Macneil S, Weinstein J & Haycock J (2014) Oxygen difference in live melanoma muticellular tumour spheroids using novel platinum compound and time-resolved imaging microscopy. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 8 (pp 314-314) RIS download Bibtex download
  • Alépée N (2014) State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. ALTEX (pp 441-477) RIS download Bibtex download
  • Baggaley E, Sazanovich IV, Williams JAG, Haycock JW, Botchway SW & Weinstein JA (2013) Time-resolved two-photon emission imaging microscopy with transition metal complexes (TPE-TREM). ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 245 RIS download Bibtex download
  • (2012) Tissue Engineering and Regenerative Medicine. Journal of Tissue Engineering and Regenerative Medicine, Vol. 6 (pp 1-429) RIS download Bibtex download
  • Hill R, Haycock J & Jahoda C (2011) Human hair follicle dermal cells and skin fibroblasts show differential activation of NF-kappa B in response to pro-inflammatory challenge. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 131 (pp S81-S81) RIS download Bibtex download
  • Morris HL, Haycock JW & Reilly GC (2011) Hyaluronan as a potential mechanotransduction mediator. European Cells and Materials, Vol. 22(SUPPL.2) (pp 6) RIS download Bibtex download
  • Morris HL, Sittichokechaiwut A, Jacobs CR, Haycock JW & Reilly GC (2008) The Response of Matrix Synthesizing MLO-A5 Cells to Fluid Shear. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S147-S147) RIS download Bibtex download
  • Morris HL, Haycock JW & Reilly GC (2008) Mechanobiology in bone tissue engineering: responses to fluid flow. TISSUE ENGINEERING PART A, Vol. 14(5) (pp 878-878) RIS download Bibtex download
  • Hill RP, Haycock JW, Lawrence CM & Jahoda CA (2008) Human hair follicle dermal cells activate NF-kappa B in response to TNF-alpha and IL-1 beta but are lipopolysaccharide tolerant. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 128 (pp S149-S149) RIS download Bibtex download
  • Morris HL, Haycock JW & Reilly GC (2008) The role of mechanotransduction in bone tissue engineering. European Cells and Materials, Vol. 16(SUPPL. 3) (pp 84) RIS download Bibtex download
  • Blackwood K, Freeman CO, McKean R, Farthing P, Haycock JW, Ryan AJ, Brook I & MacNeil S (2007) Development of biocompatible, biodegradable electrospun scaffolds for tissue engineering of human skin. TISSUE ENGINEERING, Vol. 13(7) (pp 1670-1671) RIS download Bibtex download
  • Murray-Dunning C, Sane N, McKean R, MacNeil S, Ryan A & Haycock JW (2007) Use of aligned polymer microfibres for peripheral nerve repair. TISSUE ENGINEERING, Vol. 13(7) (pp 1774-1774) RIS download Bibtex download
  • Carter SR, Rimmer S, Rutkaite R, Swanson L & Haycock J (2005) Highly branched polymers via RAFT: Chain-end functionalization with peptides. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 230 (pp U3645-U3646) RIS download Bibtex download
  • Haycock JW, Hill RP, Elliott RJ, Wagner MJ & MacNeil S (2004) Antioxidant and anti-inflammatory activities of melanocortin peptides. EXPERIMENTAL DERMATOLOGY, Vol. 13(9) (pp 576-576) RIS download Bibtex download
  • Katerinaki E, Lalla R, Haycock JW, Lorigan PC & MacNeil S (2004) Sodium salicylate inhibits inflammation induced invasion and migration of human melanoma cells. BRITISH JOURNAL OF CANCER, Vol. 91 (pp S71-S71) RIS download Bibtex download
Research group

Postdoctoral Researchers/RAs

PhD Students

Supervision of approx. 6 - 8 project students per year on: 

Teaching interests
  • FCE101 – 20 credits - Introduction to Bioengineering (10%)
  • FCE201 – 20 credits – Advanced Bioengineering Topics (10%)
  • MAT1410 – 10 credits – Biomaterials (10% - practical classes)
  • MAT1520 – 10 credits - Biology and Chemistry of Living Systems (50%)
  • MAT2530 – 10 credits – Biology & Chemistry of Living Systems (10% - practical classes)
  • MAT209 – 10 credits – Cell & Molecular Biology (100%)
  • MAT300 – 20 credits – Tissue Engineering (10%)
  • MAT6305 – Group projects in Bioengineering (50%)

Administration

Course Director for B.Eng/M.Eng (Hons) degree in Bioengineering 
Executive Board - Department of Materials Science and Engineering

Professional activities