Professor John W Haycock

BSc (Hons) PhD

Department of Materials Science and Engineering

Head of Department

Professor of Bioengineering

Professor John Haycock
j.w.haycock@sheffield.ac.uk
+44 114 222 5972

Full contact details

Professor John W Haycock
Department of Materials Science and Engineering
Sir Robert Hadfield Building
Mappin Street
Sheffield
S1 3JD
Profile

John Haycock obtained his first degree and PhD in Biochemistry at Newcastle University and was a Research Fellow at Albany Medical College in New York, USA.  He joined the department in 2001 as a Lecturer from the Medical School at Sheffield University. He was Engineering Faculty Director of Research and Innovation from 2016-19 and became Head of Materials Science and Engineering in 2019. His research and teaching covers fundamental and applied biomedical materials science through to engineering applications

Qualifications

BSc (Hons) Biochemistry, Newcastle University

PhD Neurology, Newcastle University

Research interests

John's research spans five interdisciplinary themes:

1. Nerve tissue engineering. The design of nerve guidance channels for repairing traumatic peripheral nerve injury – combining biomaterials, 3D fabrication, neuronal, glial and stem cell research.

2. 3D in vitro models of nerve. The use of 3D scaffolds and neuronal/glial co-cultures for 3D in vitro models of nerve as an alternative to animal models for disease, disorder and testing research.

3. 3D in vitro models of skin. The use of 3D scaffolds and keratinocyte/fibroblast co-cultures for 3D in vitro models of skin as an alternative to animal models for inflammatory testing.

4. 3D Imaging and technology development for bioscience applications Established confocal microscopy, 2-photon microscopy, time-resolved microscopy, light sheet microscopy and in vivo confocal microscopy facilities for a wide range of biomaterials and regenerative medicine research at Sheffield University

5. Bioactive surfaces. Creation of biologically active surfaces for medical device applications


Key projects

  • EPSRC Centre for Doctoral Training in Advanced Biomedical Materials with Manchester University (Professor Sarah Cartmell (PI) and Professor Julie Gough)
  • 3D BioNet: An integrated technological platform for 3D micro-tissues. Technology Touching Life - BBSRC, MRC, EPSRC with Dr Raphael Lévy (PI), Professor Helen Byrne, Professor Paola Borri, Professor Stefan Przyborski, Dr Marianne Ellis, Dr Chris Goldring and Professor Ruth Cameron
  • Sir Henry Royce Institute - Sheffield Equipment - EPSRC, with Professor Mark Rainforth (PI), Professor Dan Allwood, Professor Ian Reaney, Professor Iain Todd, Professor Neil Hyatt and Professor Derek Sinclair
  • Sir Henry Royce Institute - Sheffield Build - EPSRC, with Professor Mark Rainforth (PI), Professor Dan Allwood, Professor Ian Reaney, Professor Iain Todd, Professor Neil Hyatt and Professor Derek Sinclair
  • Development and validation of a human brain micro physiological system derived from induced pluripotent stem cells in amyotrophic lateral sclerosis (ALS) 3D BioNet, with Dr Ke Ning (PI)  
  • The Design, Manufacture and Testing of Advanced Nerve Guidance Conduits. Dr Jeff Wadsworth - Battelle Memorial Institute.  With SUNY, New York – Melendez A, as PI with Dr Fred Claeyssens and Professor Fiona Boissonade

Previous major projects

  • Cellular Force Microscope - BBSRC with Professor Jamie Hobbs and Dr N Brown.
  • Affordable Healthcare in Pakistan - Developing Biomedical Materials for Clinical Impact.  EPSRC (GCRF)
  • NEURIMP (FP7) - Novel combination of biopolymers and manufacturing technologies for production of a peripheral nerve implant containing an internal aligned channels array. An EC funded project with 8 EU partners.
  • IPROMEDAI - Improved Protection of Medical Devices Against Infection. An EU COST (European Cooperation in Science & Technology) network across 24 countries. UK Management Committee member.
  • Dinuclear ruthenium light-switches as multi-output sub-cellular imaging probes within live cells and tissues. EPSRC (with Dr James Thomas, Dr Julia Weinstein and Prof Sheila MacNeil).
  • EPSRC Centre for Doctoral Training in Polymers, Soft Matter and Colloids (with Professor Steve Armes, Professor David Lidzey, Professor Neil Hopkinson, Professor Graham Leggett.
  • Novel 3D coating of bioactive glass and metallic composites. EPSRC/Innovate UK (with Prof Mark Rainforth and Prof Iain Todd).
  • Development of a 3D engineered skin model for inflammatory detection (EPSRC).
  • The development of xenogenic decellularised nerve graft for traumatic repair (EPSRC).
  • Toward the next generation of joint repair strategies. Using plasma polymerization to produce bioinspired, biofunctional, biomaterial implants (Dunhill Medical Trust) – with Dr Aileen Crawford and Dr Dave Buttle.
  • Development of early melanoma detection using O2 probes and time-resolved emission imaging microscopy (BBSRC) – with Dr Julia Weinstein.
  • Sensor Integrated Bioreactors (TSB) – with Dr Jon Aylott, Kirkstall Ltd and Locate Therapeutics (formerly Regentec Ltd).
  • Cross-cutting Directors of Research and Innovation - Interdisciplinary PhD Scholarships. The Construction of Human Perfection (with Prof Tammy Hervey, Prof Paul Hatton, Prof Adam Piette, Dr Fabienne Collignon, Dr Sarah Baker, Dr Keith Smith, Dr Amanda Warren-Jones).

Research themes/centres


John’s research and opinion on nerve injury repair has been featured in a number of recent media publications:

Publications

Edited books

Journal articles

Chapters

Conference proceedings papers

  • Buttle D, Haycock J, Pead M, Meeson R, Blunn G & Crawford A (2018) In situ repair of full-thickness cartilage defects using biomimetic biofunctionalised implants. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 99(6) (pp A17-A17) RIS download Bibtex download
  • Wright K, Haycock J & Francis S (2018) 95 Investigating fibroblast involvement in vascular inflammation using co-culture models. Basic Science RIS download Bibtex download
  • Buttle DJ, Haycock JH, Pead M, Meeson R, Blunn G & Crawford A (2017) Biomimetic, biofunctionalised polymer implants to promote in situ repair of traumatic and early osteoarthritic cartilage defects. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 98(3) (pp A15-A15) View this article in WRRO RIS download Bibtex download
  • Raza A, Colley H, Baggaley E, Green N, Botchway S, Weinstein J, MacNeil S & Haycock J (2016) Optical measurement of oxygen concentration in melanoma spheroid and skin engineered models. European Cells and Materials (ECM), Vol. Collection 5 (pp 8-8) RIS download Bibtex download
  • Clarke J, Harding AJ, Boissonade FM, Haycock JW & Claeyssens F (2015) 3D Printing and Plasma Coating of Nerve Guide Conduits (NGC). TISSUE ENGINEERING PART A, Vol. 21 (pp S359-S360) RIS download Bibtex download
  • Valderrama LRL, Nigmatullin R, Taylor C, Haycock JW, Claeyssens F & Roy I (2015) Nerve Tissue Engineering using Blends of Polyhydroxyalkanoates for Peripheral Nerve Regeneration. TISSUE ENGINEERING PART A, Vol. 21 (pp S325-S325) RIS download Bibtex download
  • Lizarraga-Valderrama LR, Nigmatullin R, Taylor C, Haycock JW, Claeyssens F & Roy I (2015) PERIPHERAL NERVE REGENERATION USING BLENDS OF POLYHYDROXYALKANOATES. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, Vol. 20(2) (pp 185-185) RIS download Bibtex download
  • Haycock J (2015) Development of 3D In Vitro Models of Nerve and Skin for Disease, Disorder and Testing Studies. The FASEB Journal, Vol. 29 RIS download Bibtex download
  • Pateman CJ, Harding A, Plenderleith R, Boissonade F, Rimmer S, Haycock JW & Claeyssens F (2014) Nerve guides from photocurable polymers for peripheral nerve repair. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 8 (pp 172-172) RIS download Bibtex download
  • Raza A, Colley H, Baggaley E, Botchway S, Macneil S, Weinstein J & Haycock J (2014) Oxygen difference in live melanoma muticellular tumour spheroids using novel platinum compound and time-resolved imaging microscopy. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol. 8 (pp 314-314) RIS download Bibtex download
  • Alépée N (2014) State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. ALTEX (pp 441-477) RIS download Bibtex download
  • Baggaley E, Sazanovich IV, Williams JAG, Haycock JW, Botchway SW & Weinstein JA (2013) Time-resolved two-photon emission imaging microscopy with transition metal complexes (TPE-TREM). ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 245 RIS download Bibtex download
  • (2012) Tissue Engineering and Regenerative Medicine. Journal of Tissue Engineering and Regenerative Medicine, Vol. 6 (pp 1-429) RIS download Bibtex download
  • Hill R, Haycock J & Jahoda C (2011) Human hair follicle dermal cells and skin fibroblasts show differential activation of NF-kappa B in response to pro-inflammatory challenge. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 131 (pp S81-S81) RIS download Bibtex download
  • Morris HL, Haycock JW & Reilly GC (2011) Hyaluronan as a potential mechanotransduction mediator. European Cells and Materials, Vol. 22(SUPPL.2) (pp 6) RIS download Bibtex download
  • Morris HL, Sittichokechaiwut A, Jacobs CR, Haycock JW & Reilly GC (2008) The Response of Matrix Synthesizing MLO-A5 Cells to Fluid Shear. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S147-S147) RIS download Bibtex download
  • Morris HL, Haycock JW & Reilly GC (2008) Mechanobiology in bone tissue engineering: responses to fluid flow. TISSUE ENGINEERING PART A, Vol. 14(5) (pp 878-878) RIS download Bibtex download
  • Hill RP, Haycock JW, Lawrence CM & Jahoda CA (2008) Human hair follicle dermal cells activate NF-kappa B in response to TNF-alpha and IL-1 beta but are lipopolysaccharide tolerant. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 128 (pp S149-S149) RIS download Bibtex download
  • Morris HL, Haycock JW & Reilly GC (2008) The role of mechanotransduction in bone tissue engineering. European Cells and Materials, Vol. 16(SUPPL. 3) (pp 84) RIS download Bibtex download
  • Blackwood K, Freeman CO, McKean R, Farthing P, Haycock JW, Ryan AJ, Brook I & MacNeil S (2007) Development of biocompatible, biodegradable electrospun scaffolds for tissue engineering of human skin. TISSUE ENGINEERING, Vol. 13(7) (pp 1670-1671) RIS download Bibtex download
  • Murray-Dunning C, Sane N, McKean R, MacNeil S, Ryan A & Haycock JW (2007) Use of aligned polymer microfibres for peripheral nerve repair. TISSUE ENGINEERING, Vol. 13(7) (pp 1774-1774) RIS download Bibtex download
  • Carter SR, Rimmer S, Rutkaite R, Swanson L & Haycock J (2005) Highly branched polymers via RAFT: Chain-end functionalization with peptides. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 230 (pp U3645-U3646) RIS download Bibtex download
  • Haycock JW, Hill RP, Elliott RJ, Wagner MJ & MacNeil S (2004) Antioxidant and anti-inflammatory activities of melanocortin peptides. EXPERIMENTAL DERMATOLOGY, Vol. 13(9) (pp 576-576) RIS download Bibtex download
  • Katerinaki E, Lalla R, Haycock JW, Lorigan PC & MacNeil S (2004) Sodium salicylate inhibits inflammation induced invasion and migration of human melanoma cells. BRITISH JOURNAL OF CANCER, Vol. 91 (pp S71-S71) RIS download Bibtex download
Research group

Postdoctoral Fellows

  • Dr Caroline Taylor                    
  • Ana Sandoval Castellanos (with Dr Ke Ning)

PhD Students

Teaching activities
  • MAT209 – 10 credits – Cell & Molecular Biology
  • MAT300/407 – 20 credits – Tissue Engineering (10%)
  • MAT372/6305 – 20 credits – Group projects in Bioengineering
Professional activities
  • Head of Materials Science & Engineering, University of Sheffield (2019 - present)
  • Engineering Faculty Director of Research & Innovation (2016 - 2019)
  • EPSRC CDT Advanced Biomedical Materials Co-director (Manchester-Sheffield) (2019-28)
  • UKRI Future Leaders Fellowships Panel (2018 – present)
  • Government of Ireland Panel Member (2018 – present)
  • EPSRC UKCCSRC Board Member (2017 – 2020)
  • Chair and Scientific Adviser - Versus Arthritis UK Centre for Tissue Engineering & Regenerative Medicine (Cambridge University) 2017 - present
  • BBSRC Core Panel C and TRDF panel (2014 - 20)
  • UK Tissue and Cell Engineering Society Board (2009 - present)
  • Chair – Technicians Commitment for the University of Sheffield
  • External RAE Panel assessor – National University of Ireland (2018 – present)
  • Executive Board of TERMIS-EU (2013-16)
  • Member of EPSRC Peer Review College (2010-17)
  • Academy of Finland Panel member (2015-18)
  • Canada Foundation for Innovation panel member (2015)
  • Editor of ‘Methods in Molecular Biology’ book on 3D Cell Culture (Springer, USA, 2011)
  • Editor of ‘Cellular In Vitro Testing” book (PanStanford, Singapore, 2014)
Patents
  1. Basnett P, Bazán Goñi X, Claeyssens F, Díez Ahedo R, Glen A, González Pérez Francisco J, Haycock JW, Lukasiewicz B, Mendibil Blasco X, Merino Álvarez S, Márquez Posadas María Del C, Nigmatullin R, Quintana Fernández I, Rodríguez Muñoz Francisco J, Roy I, Sherborne C, Taylor C.  Implantable Nerve Guidance Conduit for Nerve Repair (2019). Priorities: EP2018054984W·2018-02-28. Application: EP2018054984W·2018-02-28. Publication: WO2019166087A1·2019-09-06.
  1. Crawford A, Buttle D, Haycock JW (2017) Medical Implant. Priorities: GB201513097A·2015-07-24. Application: GB2016052270W·2016-07-25.  Publication: WO2017017425A1·2017-02-02.
  1. Botchway SW, Haycock J, Weinstein JA, Williams JAG. (2008) Imaging Techniques Using A Tridentate Ligand. Priorities: GB0818151A·2008-10-03; GB2009002369W·2009-10-05. Application: US200913122361A·2009-10-05. Publication: US2011262897A1·2011-10-27
  1. Haycock J, Hunter C, MacNeil S, Ryan T, Short R, Williams N (2002). Biomaterials Comprising a Melanocyte Stimulating Hormone (α-MSH), and method of forming. Priorities: EP2018054984W·2018-02-28. Application: EP2018054984W·2018-02-28. Publication: WO2019166087A1·2019-09-06.