Sarina Chand

Department of Materials Science and Engineering

Research Associate

Profile

In 2015, Sarina completed her Master’s degree in Chemistry at the University of Birmingham. Her dissertation focused on ferrocenyl beta blockers, investigating the organic synthesis of combining ferrocene and other organometallic compounds into Propranolol, used to prevent angina and heart attacks and treat high blood pressure.

After graduating with a MChem, Sarina went on to pursue a multidisciplinary PhD at the University of Sheffield with Dr Frederik Claeyssens and Dr Barbara Ciani in 2015.

Research interests

Sarina’s work investigates membrane fluidity in two-dimensions using FRAP and LSPR methods on solid-supported lipid bilayers. The in vitro cell membrane models were optimised to investigation membrane kinetics upon different cellular membrane components. Sarina’s research project utilizes expertise within different fields from surface chemistry, biochemistry and biophysics. Sarina’s research interests include analytical chemistry, in vitro models, biological kinetics, data science and programming languages used for large-scale data analysis. 

Sarina initiated a collaboration with Insplorion, a Swedish company, which develops instruments based on NanoPlasmonic Sensing (NPS), a technology that allows the study of nano processes on surfaces. Sarina completed a placement with Insplorion in Sweden, where she initiated her experimental work upon sensing with solid-supported lipid bilayers. Further information regarding her time spent at Insplorion can be found here: https://www.insplorion.com/en/a-visiting-phds-outlook-what-an-invaluable-experience/

Sarina has been awarded various fundings to continue her collaboration with Insplorion and is currently working on a scholarship. Her work combines robust surface functionalisation techniques onto Insplorion’s sensors to be used as a protein-based biosensor, to synthesise a new biosensing platform to investigate biomolecular interactions. 


Publications:

Chand, S., Beales, P. A., Claeyssens, F., & Ciani, B. (2019). Topography design in model membranes: Where biology meets physics. Experimental Biology and Medicine, 244, 294–303. https://doi.org/10.1177/1535370218809369