Dr Sam Pashneh-Tala
BSc, BEng, PhD
Department of Materials Science and Engineering
Kroto Research Institute, North Campus, Broad Lane, Sheffield S3 7HQ
Telephone: +44 (0) 114 222 5931
Having previously completed undergraduate degrees in both Biology and Mechanical Engineering at The University of Sheffield, Sam Pashneh-Tala joined the department in 2012 as a PhD student within the White Rose DTC for Tissue Engineering and Regenerative Medicine. Having completed his thesis on the development of a tissue-engineered vascular graft using a novel polymer scaffold, Sam was awarded an EPSRC research fellowship in 2017.
Sam’s research is focused on developing novel tissue-engineered blood vessels for use in vascular surgery. There exists a great clinical need for blood vessels suitable for vascular bypass and repair. Current strategies rely on autograft vessels; which are of limited availability, variable quality and require invasive harvest; or synthetic conduits, which are prone to infection and thrombosis.
Using tissue engineering, Sam is exploring methods of growing blood vessels in the laboratory, suitable for implantation into patients. These utilise degradable porous scaffolds, produced from a novel photocurable polymer, seeded with cells and cultured under biomimetic conditions. Sam has designed bespoke bioreactors to support the growth of tissue-engineered blood vessels by mechanically stimulating them using a pulsatile flow to mimic the native blood vessel environment.
Sam is also developing 3D printing and additive manufacturing methods to allow blood vessels of various geometries to be produced.
Regener8 Early Career Researchers Network steering group
(2016) Pashneh-Tala S., MacNeil S. and Claeyssens F. The Tissue-Engineered Vascular Graft – Past Present, and Future. Tissue Engineering Part B: Reviews. 22 (1) 68-100
(2011) Pashneh-Tala S., Malins A., Lewis R. Heppell G and Rodriguez-Falcon E. The Little Book of Design. 1st edition, University of Sheffield, Sheffield, UK