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Eukaryotic Cell Biology

Culturable mammalian cells are an invaluable model to study human genetics in combination with more traditional eukaryotic organisms, such as the model yeast Saccharomyces cerevisiae. Our department has a strong focus on the regulation of DNA damage repair systems and the disorders resulting from defects in DNA repair, including neurological ataxia and cancer.

Eukaryotic cell research in our department at a glance:

  • Genetics - regulation of meiosis, gene regulation, macromolecular complexes
  • Disorders - genome stability, DNA damage repair, degenerative disorders, cancer biology
  • Immunology - leucocytes, antibody response, tetraspanins

Also see the closely related research theme Genomics and Nucleic Acids.

People

For further information and research opportunities, please see the staff page of individual researchers below:

el-khamisysProfessor Sherif El-Khamisy

Professor of Molecular Medicine
Director of Research and Innovation

Room: C7b
Tel: 0114 222 2791
Email: S.El-Khamisy@sheffield.ac.uk

Mammalian genome stability in health and disease. Head of the human DNA repair group aiming to understand how defects in repairing DNA damage cause degenerative disorders, cancer and ageing.

SelfPhD

hettemaeDr Ewald Hettema

Reader in Molecular Cell Biology

Room: E28
Tel: 0114 222 2732
Email: e.hettema@sheffield.ac.uk

Use of the model yeast Saccharomyces cerevisiae and the fruitfly Drosophila melanogaster to study eukaryotic peroxisomes. Particular focus on the role of peroxisome membrane proteins in the biogenesis, maturation, segregation and breakdown of peroxisomes.

hornbydProfessor David Hornby

Professor of Biochemistry

Room: F22a
Tel: 0114 222 4232
Email: d.hornby@sheffield.ac.uk

Methodology in protein and nucleic acid biochemistry; developing analytical methods for genomics and proteomics, expanding the functional repertoire of natural macromolecular assemblies, remodelling enzymes and toxins.

hubDr Bin Hu

Research Fellow

Room: E18a
Tel: 0114 222 2715
Email: b.hu@sheffield.ac.uk

Eukaryotic cell cycle regulation, with particular focus on protein-DNA interactions in chromosomes and how cells incorporate environmental signals into cell proliferation and how cells make a decision on growth or death upon environmental stress.

mitchellpDr Phil Mitchell

Lecturer

Room: E22a
Tel: 0114 222 2821
Email: p.j.mitchell@sheffield.ac.uk

Building on the discovery and characterisation of the exosome ribonuclease complex (Mitchell et al., 1997; Allmang et al., 1999), my lab’s research addresses the molecular mechanisms of RNA quality control in eukaryotic cells.

SelfPhD

partridgelDr Lynda Partridge

Senior Lecturer

Room: E7a
Tel: 0114 222 4185
Email: l.partridge@sheffield.ac.uk

Human leucocyte antigens, specifically the structure and function of tetraspanins, a conserved family of mammalian transmembrane proteins. Role of tetraspanins in bacterial infection. Monoclonal antibody technology for research and medicine.

SelfPhD

sudberypProfessor Peter Sudbery

Roper Chair in Genetics

Room: D05c
0114 222 6186
p.sudbery@sheffield.ac.uk

The molecular and cellular biology of hyphal and pseudohyphal morphogenesis in the human fungal pathogen Candida albicans, the cause of thrush and candidiasis: a lethal infection common in immuno-compromised patients.

wilsonsProfessor Stuart Wilson

Professor of Genetics

Room: E24a
Tel: 0114 222 2849
Email: stuart.wilson@sheffield.ac.uk

The regulation of gene expression in mammals, focusing on mRNA; mRNA export from the nucleus to the cytoplasm; mechanisms of RNA interference. Large scale sequencing and gene function analysis in vertebrates.