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Genomics and Nucleic Acids

At the genomic level, state-of-the-art computational methods are being used for a broad range of applications to enhance our understanding of molecular evolution. At a cellular level, we are unravelling the molecular basis of nucleic acid stability, DNA damage repair and various RNA processes. Particular emphasis is put on genetic processes that lead to disorders such as neurological ataxia, amyloidoses and cancers.

Genomic and nucleic acid research in our department at a glance:

  • Genomics - molecular evolution, mutagenesis screens, whole genome sequencing, expression studies
  • DNA - genome stability, damage repair, meiosis, disorders, cancer
  • RNA - expression, assembly, export, trafficking, interference

Also see the closely related research theme Eukaryotic Cell Biology.

People

For further information and research opportunities, please see the staff page of individual researchers below:

dansmallDr Dan Bose

Research Fellow

Room: E21a
Tel: 0114 222 2838
Email: d.bose@sheffield.ac.uk

Studying the regulation of epigenetic-enzyme machinery and chromatin by non-protein coding RNAs, and how this regulation is disrupted in cancer and disease. We use a multidisciplinary approach, encompassing functional genomics, classical biochemistry and cryo-EM.

FundedPhD

chaudhurirDr Roy Chaudhuri

Lecturer

Room: B112
Tel: 0114 222 2837
Email: r.chaudhuri@sheffield.ac.uk

Functional and comparative genomics of bacteria, particularly E. coli and Salmonella. Development of methods for analysing data derived from transposon mutagenesis screens such as TraDIS. Development of user-friendly web interfaces for bacterial genomics.

el-khamisysProfessor Sherif El-Khamisy

Professor of Molecular Medicine
Director of Research and Innovation

Room: C7b
Tel: 0114 222 2791
Email: S.El-Khamisy@sheffield.ac.uk

Mammalian genome stability in health and disease. Head of the human DNA repair group aiming to understand how defects in repairing DNA damage cause degenerative disorders, cancer and ageing.

SelfPhD

goldmanaProf Alastair Goldman

Room: D6b
Tel: 0114 222 2779
Email: a.goldman@sheffield.ac.uk

Genetic and molecular analysis of DNA double-strand bread (DSB) repair in meiosis, using yeast aqs a model organisation. Analysis of testis cancer antigens expression in cancer cells, and determination of its significance.

SelfPhD

hornbydProfessor David Hornby

Professor of Biochemistry

Room: F22a
Tel: 0114 222 4232
Email: d.hornby@sheffield.ac.uk

Methodology in protein and nucleic acid biochemistry; developing analytical methods for genomics and proteomics, expanding the functional repertoire of natural macromolecular assemblies, remodelling enzymes and toxins.

mitchellpDr Phil Mitchell

Lecturer

Room: E22a
Tel: 0114 222 2821
Email: p.j.mitchell@sheffield.ac.uk

Building on the discovery and characterisation of the exosome ribonuclease complex (Mitchell et al., 1997; Allmang et al., 1999), my lab’s research addresses the molecular mechanisms of RNA quality control in eukaryotic cells.

SelfPhD

sorefankDr Karim Sorefan

Lecturer

Room: E1a
Tel: 0114 222 2720
Email: k.sorefan@sheffield.ac.uk

Molecular mechanisms regulating plant development with a particular focus on linking miRNA and hormonal pathways in plant stem cells. Understanding how meristematic cells are programmed will contribute to improving crop productivity.

sudberyiDr Ian Sudbery

Lecturer

Room: B108
Tel: 0114 222 2738
Email: i.sudbery@sheffield.ac.uk

Understanding how eukaryotes integrate information and regulate gene expression using computational and functional genomics tools, for example miRNAs in transcript destabilisation and translational inhibition.

wilsonsProfessor Stuart Wilson

Professor of Genetics

Room: E24a
Tel: 0114 222 2849
Email: stuart.wilson@sheffield.ac.uk

The regulation of gene expression in mammals, focusing on mRNA; mRNA export from the nucleus to the cytoplasm; mechanisms of RNA interference. Large scale sequencing and gene function analysis in vertebrates.