Julien BergeronDr Julien Bergeron

Lecturer


Tel: 0114 222 2854
Email: j.bergeron@sheffield.ac.uk

Research

Research Precis

PrgHWe use cryo-Electron Microscopy, combined with X-ray crystallography, NMR and other biophysical methods, to study the structure and mechanism of bacterial nano-machines such as motor complexes, protein delivery systems, etc...

Protein nano-machines are large protein complexes that can perform a mechanical movement upon receiving specific stimuli. In bacteria in particular, these play essential roles in cell organization, motility and interaction with their surroundings. Our goal is to understand the molecular mechanism of action of these nano-machines, and their interaction with other cellular components. Ultimately, we hope to exploit this knowledge for the development of new antibiotics, and of drug delivery systems.

Research Keywords

Structural biology, cryo-EM, X-ray crystallography, NMR, nano-machines, bacteriology

Research In Depth

bergeron3Nano-machines are large protein complexes that can perform a mechanical movement upon receiving specific stimuli. In bacteria in particular, these play essential roles in cell organization, motility and interaction with their surroundings. We are interested in the characterization of these complexes at the atomic level, using a range of stuctural and biophysical methods (cryo-EM, X-ray crystallography, NMR, modelling etc...).

Our goal is to understand the molecular mechanism of action of these nano-machines, and their interaction with other cellular components. Ultimately, we hope to exploit this knowledge for the development of new antibiotics, and of drug delivery systems.

Some of the complexes we are interested in include the bacterial flagellum, the TAD pilus, and the R-body complex.

I welcome applications from prospective home / EU / overseas PhD students and post-doctoral fellows.
Contact me at j.bergeron@sheffield.ac.uk for further information.

Teaching
Career History

Career History

2017 - Present: Lecturer, Dept. of Molecular Biology and Biotechnology, University of Sheffield
2015 - 2017: Senior Fellow, Dept. of Biochemistry, University of Washington, Seattle, USA
2010 - 2015: Post-doctoral Fellow, Dept. of Biochemistry, University of British Columbia, Vancouver, Canada
2006 - 2010: PhD, Randall Division of Cell and Molecular Biophysics, King’s College London
2004 - 2005: MRes, Centre for Structural Biology, Imperial College London

Journal articles