Lynda Partridge

Dr Lynda Partridge

Senior Lecturer
Principal Admissions Tutor


Tel: 0114 222 4185
Email: l.partridge@sheffield.ac.uk

Research

Research Precis

Tetraspanins in health and disease

fig1Tetraspanins constitute a highly conserved superfamily of transmembrane proteins, with the first member having appeared some 570 million years ago. They are widely expressed in multicellular organisms and are involved in basic cell functions such as motility, fusion and membrane trafficking. Tetraspanins are distinguished from other four-pass membrane proteins by the presence of conserved charged residues in the transmembrane domains and a defining “signature” motif in the larger of the two extracellular domains. Characteristically, they form promiscuous associations with one another and with other membrane proteins and lipids to generate a specialised type of microdomain: the tetraspanin enriched microdomain (TEM). As components of TEMs, tetraspanins maintain a network of interactions with other membrane proteins (e.g. integrins, signalling molecules), regulating the assembly of multi-molecular signalling platforms.

There are 33 tetraspanins in mammals and they have been implicated in fertilisation, the immune response, cancer progression and pathogen susceptibility. Our group is using specific antibodies, recombinant proteins and site-directed mutagenesis to investigate the role of tetraspanins in health and disease. We have recently demonstrated that tetraspanins are involved in controlling the formation of multinucleated giant cells (MNGCs), which are associated with chronic inflammation and certain types of infection. We are also studying tetraspanin function using a zebrafish embryo model, using morpholinos and the CRISPR/Cas9 system to knock down or knock out specific zebrafish tetraspanin genes, which show remarkable conservation with humans. After finding that they are involved in bacterial infections, we are also currently developing tetraspanin-based reagents as alternatives to antibiotics for treating infections caused by microbes such as Staphylococcus aureus (including MRSA).

Antibodies in research

I have also had a long-standing interest in the production and use of antibodies as tools in research and medicine. In the early 1990s, I helped establish a dedicated facility at the University for custom production of antibodies for researchers. A related spin-out company, Bioserv UK Ltd, was established in 2009, which specialises in the production of antibodies and other proteins from mammalian cell culture.

Research Keywords

Eukaryotic cell biology, immunology, tetraspanins, antibodies


I welcome applications from self-funded prospective home and international PhD students; see examples of possible projects below.

You can apply for a PhD position in MBB here.

Contact me at l.partridge@sheffield.ac.uk for further information.



Tetraspanin structure and function

The tetraspanins are a diverse, conserved family of eukaryotic membrane proteins. Their principal feature is the ability to form dynamic multi-molecular assemblies in cell membranes known as tetraspanin enriched microdomains (TEM). Tetraspanins play roles in many basic cell functions and are involved in cancer metastasis, fertilisation, the immune response and pathogen susceptibility. The project will involve investigating the biology of individual tetraspanins using novel monoclonal antibodies, model cell lines, site-directed mutagenesis, recombinant protein expression and gene knockdown techniques.

Tetraspanins and bacterial infection

The tetraspanins are a diverse, conserved family of eukaryotic membrane proteins. Their principal feature is the ability to form dynamic multi-molecular assemblies in cell membranes known as tetraspanin enriched microdomains (TEM). We have recently found that a number of bacterial species appear to “hijack” TEM as a means of adhering to and infecting mammalian cells. The project will investigate the molecular basis of this adhesion and the development of tetraspanin-based reagents for preventing bacterial infections.

Development of a novel immunotoxin

Immunotoxins represent a form of immunotherapy whereby antibodies are used to target a toxin, usually to cancer or infected host cells. However, to date, their clinical use has been limited in part due to dose-limited toxicity. We have recently indentified a novel toxin, which exhibits selectivity for rapidly dividing cells and is not taken up by most normal cells. We have shown that we can target the toxin to cancer cell lines using specific antibodies and that it inhibits their growth. The project will involve the further development and improvement of the immunotoxin.

Teaching

Level 4 Modules

MBB405 Advanced Research Topics

Level 3 Modules

MBB303 Cells as Factories
MBB311 Molecular Immunology (Module Coordinator)

Level 2 Modules

MBB263 Microbiology 2

Level 1 Modules

MBB163 Microbiology

Career History

Career History

  • 1998 - present: Senior Lecturer, Dept. Molecular Biology & Biotechnology, University of Sheffield
  • 2009 - present: Scientific Director, Bioserv UK Ltd.
  • 1988 - 1998: Lecturer, Dept. Molecular Biology & Biotechnology, University of Sheffield
  • 1982 - 1988: Post-doctoral research assistant, Dept. Biochemistry, University of Sheffield
  • 1979 - 1982: PhD student, Dept Immunology, University of Birmingham

Honours and Distinctions

  • Fellow of the Royal Society of Biology (FRSB)
  • Chair, Royal Society of Biology, Yorkshire Branch. 








































Publications

Journal articles

  • Champion TC, Partridge LJ, Ong S-M, Malleret B, Wong S-C & Monk PN (2018) Monocyte Subsets Have Distinct Patterns of Tetraspanin Expression and Different Capacities to Form Multinucleate Giant Cells. Frontiers in Immunology, 9. View this article in WRRO RIS download Bibtex download
  • Rust A, Partridge LJ, Davletov B & Hautbergue GM (2017) The Use of Plant-Derived Ribosome Inactivating Proteins in Immunotoxin Development: Past, Present and Future Generations. Toxins, 9(11), 344. View this article in WRRO RIS download Bibtex download
  • Hassuna NA, Monk PN, Ali F, Read RC & Partridge LJ (2017) A role for the tetraspanin proteins in Salmonella infection of human macrophages. Journal of Infection, 75(2), 115-124. View this article in WRRO RIS download Bibtex download
  • Yaseen IH, Monk PN & Partridge LJ (2017) Tspan2: a tetraspanin protein involved in oligodendrogenesis and cancer metastasis.. Biochem Soc Trans, 45(2), 465-475. View this article in WRRO RIS download Bibtex download
  • Ventress JK, Partridge LJ, Cozens D, Read RC, MacNeil S & Monk PN (2016) Peptides from Tetraspanin CD9 Are Potent Inhibitors of Staphylococcus Aureus Adherence to Keratinocytes. PLoS One, 11(7). View this article in WRRO RIS download Bibtex download
  • Rust A, Hassan HHA, Sedelnikova S, Niranjan D, Hautbergue G, Abbas SA, Partridge L, Rice D, Binz T & Davletov B (2015) Two complementary approaches for intracellular delivery of exogenous enzymes. Scientific Reports, 5, 12444-12444. View this article in WRRO RIS download Bibtex download
  • Hulme RS, Higginbottom A, Palmer J, Partridge LJ & Monk PN (2014) Distinct Regions of the Large Extracellular Domain of Tetraspanin CD9 Are Involved in the Control of Human Multinucleated Giant Cell Formation. PLoS ONE, 9(12). View this article in WRRO RIS download Bibtex download
  • Monk PN & Partridge LJ (2012) Tetraspanins: gateways for infection.. Infect Disord Drug Targets, 12(1), 4-17. RIS download Bibtex download
  • Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang C-T, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM , Marshall LE et al (2011) A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.. Science, 334(6057), 821-824. RIS download Bibtex download
  • Green LR, Monk PN, Partridge LJ, Morris P, Gorringe AR & Read RC (2011) Cooperative role for tetraspanins in adhesin-mediated attachment of bacterial species to human epithelial cells.. Infect Immun, 79(6), 2241-2249. View this article in WRRO RIS download Bibtex download
  • Fanaei M, Monk PN & Partridge LJ (2011) The role of tetraspanins in fusion.. Biochem Soc Trans, 39(2), 524-528. RIS download Bibtex download
  • Trikić MZ, Monk P, Roehl H & Partridge LJ (2011) Regulation of zebrafish hatching by tetraspanin cd63.. PLoS One, 6(5), e19683. View this article in WRRO RIS download Bibtex download
  • Parthasarathy V, Martin F, Higginbottom A, Murray H, Moseley GW, Read RC, Mal G, Hulme R, Monk PN & Partridge LJ (2009) Distinct roles for tetraspanins CD9, CD63 and CD81 in the formation of multinucleated giant cells.. Immunology, 127(2), 237-248. RIS download Bibtex download
  • Hassuna N, Monk PN, Moseley GW & Partridge LJ (2009) Strategies for targeting tetraspanin proteins: potential therapeutic applications in microbial infections.. BioDrugs, 23(6), 341-359. RIS download Bibtex download
  • Wright AJ, Higginbottom A, Philippe D, Upadhyay A, Bagby S, Read RC, Monk PN & Partridge LJ (2007) Characterisation of receptor binding by the chemotaxis inhibitory protein of Staphylococcus aureus and the effects of the host immune response.. Mol Immunol, 44(10), 2507-2517. RIS download Bibtex download
  • Scola A-M, Higginbottom A, Partridge LJ, Reid RC, Woodruff T, Taylor SM, Fairlie DP & Monk PN (2007) The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding.. J Biol Chem, 282(6), 3664-3671. RIS download Bibtex download
  • Ho SH, Martin F, Higginbottom A, Partridge LJ, Parthasarathy V, Moseley GW, Lopez P, Cheng-Mayer C & Monk PN (2006) Recombinant extracellular domains of tetraspanin proteins are potent inhibitors of the infection of macrophages by human immunodeficiency virus type 1. J VIROL, 80(13), 6487-6496. RIS download Bibtex download
  • Hamidpour M, Behrendt M, Griffiths B, Partridge L & Lindsey N (2006) The isolation and characterisation of antiplatelet antibodies. EUR J HAEMATOL, 76(4), 331-338. RIS download Bibtex download
  • Martin F, Roth DM, Jans DA, Pouton CW, Partridge LJ, Monk PN & Moseley GW (2005) Tetraspanins in viral infections: a fundamental role in viral biology?. J Virol, 79(17), 10839-10851. RIS download Bibtex download
  • Muranova TA, Ruzheinikov SN, Higginbottom A, Clipson JA, Blackburn GM, Wentworth P, Datta A, Rice DW & Partridge LJ (2004) Crystallization of a carbamatase catalytic antibody Fab fragment and its complex with a transition-state analogue.. Acta Crystallogr D Biol Crystallogr, 60(Pt 1), 172-174. RIS download Bibtex download
  • Higginbottom A, Takahashi Y, Bolling L, Coonrod SA, White JM, Partridge LJ & Monk PN (2003) Structural requirements for the inhibitory action of the CD9 large extracellular domain in sperm/oocyte binding and fusion.. Biochem Biophys Res Commun, 311(1), 208-214. RIS download Bibtex download
  • Ruzheinikov SN, Muranova TA, Sedelnikova SE, Partridge LJ, Blackburn GM, Murray IA, Kakinuma H, Takahashi-Ando N, Shimazaki K, Sun J , Nishi Y et al (2003) High-resolution crystal structure of the Fab-fragments of a family of mouse catalytic antibodies with esterase activity.. J Mol Biol, 332(2), 423-435. RIS download Bibtex download
  • Moseley GW, Elliott J, Wright MD, Partridge LJ & Monk PN (2003) Interspecies contamination of the KM3 cell line: Implications for CD63 function in melanoma metastasis. INT J CANCER, 105(5), 613-616. RIS download Bibtex download
  • Cesaro-Tadic S, Lagos D, Honegger A, Rickard JH, Partridge LJ, Blackburn GM & Pluckthun A (2003) Turnover-based in vitro selection and evolution of biocatalysts from a fully synthetic antibody library. NAT BIOTECHNOL, 21(6), 679-685. RIS download Bibtex download
  • Behrendt M, Partridge LJ, Griffiths B, Goodfield M, Snaith M & Lindsey NJ (2003) The role of somatic mutation in determining the affinity of anti-DNA antibodies.. Clin Exp Immunol, 131(1), 182-189. RIS download Bibtex download
  • Buckle C, Wells M & Partridge LJ (2002) Production of human monoclonal antibodies to an ovarian carcinoma-associated antigen (HPLAP) using phage display. J PATHOL, 198, 19A-19A. RIS download Bibtex download
  • Betley JR, Cesaro‐Tadic S, Mekhalfia A, Rickard JH, Denham H, Partridge LJ, Plückthun A & Blackburn GM (2002) Direct Screening for Phosphatase Activity by Turnover‐Based Capture of Protein Catalysts. Angewandte Chemie International Edition, 41(9), 1460-1460. RIS download Bibtex download
  • Betley JR, Cesaro‐Tadic S, Mekhalfia A, Rickard JH, Denham H, Partridge LJ, Plückthun A & Blackburn GM (2002) Direkte Identifizierung von Proteinkatalysatoren mit Phosphatase‐Aktivität durch kovalente Bindung an ein Suizid‐Substrat. Angewandte Chemie, 114(9), 1528-1528. RIS download Bibtex download
  • Betley JR, Cesaro‐Tadic S, Mekhalfia A, Rickard JH, Denham H, Partridge LJ, Plückthun A & Blackburn GM (2002) Direkte Identifizierung von Proteinkatalysatoren mit Phosphatase‐Aktivität durch kovalente Bindung an ein Suizid‐Substrat. Angewandte Chemie, 114(5), 801-803. RIS download Bibtex download
  • Betley JR, Cesaro-Tadic S, Mekhalfia A, Rickard JH, Denham H, Partridge LJ, Plückthun A & Blackburn GM (2002) Direct screening for phosphatase activity by turnover-based capture of protein catalysts.. Angew Chem Int Ed Engl, 41(5), 775-777. RIS download Bibtex download
  • Betley JR, Cesaro-Tadic S, Mekhalfia A, Rickard JH, Denham H, Partridge LJ, Plückthun A & Blackburn GM (2002) Erratum: (Angewandte Chemie - International Edition (2002) 5 (775-777)). Angewandte Chemie - International Edition, 41(9), 1460. RIS download Bibtex download
  • Muranova TA, Ruzheinikov SN, Sedelnikova SE, Moir A, Partridge LJ, Kakinuma H, Takahashi N, Shimazaki K, Sun J, Nishi Y & Rice DW (2001) The preparation and crystallization of Fab fragments of a family of mouse esterolytic catalytic antibodies and their complexes with a transition-state analogue.. Acta Crystallogr D Biol Crystallogr, 57(Pt 8), 1192-1195. RIS download Bibtex download
  • Yazici ZA, Behrendt M, Cooper D, Goodfield M, Partridge LJ & Lindsey NJ (2000) The identification of endothelial cell autoantigens. J AUTOIMMUN, 15(1), 41-49. RIS download Bibtex download
  • Higginbottom A, Wilkinson I, McCullough B, Lanza F, Azorsa DO, Partridge LJ & Monk PN (2000) Antibody cross-linking of human CD9 and the high-affinity immunoglobulin E receptor stimulates secretion from transfected rat basophilic leukaemia cells.. Immunology, 99(4), 546-552. RIS download Bibtex download
  • Clayton R, Cooke ID, Partridge LJ & Moore HD (1998) A combinatorial phage display library for the generation of specific Fab fragments recognizing human spermatozoa and inhibiting fertilizing capacity in vitro.. Biol Reprod, 59(5), 1180-1186. RIS download Bibtex download
  • Yazici ZA, Beherendt M, Goodfield M, Partridge LJ & Lindsey NJ (1997) A human monoclonal antiendothelial cell autoantibody uses a VH gene associated with an anti-DNA autoantibody.. Biochem Soc Trans, 25(2), 321S. RIS download Bibtex download
  • Yazici ZA, Beherendt M, Goodfield M, Partridge LJ & Lindsey NJ (1997) A human monoclonal antiendothelial cell autoantibody uses a V-H gene associated with an anti-DNA autoantibody.. BIOCHEM SOC T, 25(2), S321-S321. RIS download Bibtex download
  • Wentworth P, Datta A, Smith S, Marshall A, Partridge LJ & Blackburn GM (1997) Antibody catalysis of B(Ac)2 aryl carbamate ester hydrolysis: A highly disfavored chemical process. J AM CHEM SOC, 119(9), 2315-2316. RIS download Bibtex download
  • Blackburn GM, Datta A & Partridge LJ (1996) The medical potential of catalytic antibodies. PURE APPL CHEM, 68(11), 2009-2016. RIS download Bibtex download
  • Yazici ZA, Beherendt M, Goodfield M, Partridge LJ & Lindsey NJ (1996) A human monoclonal antiendothelial cell autoantibody uses a V-H gene associated an anti-DNA autoantibody. IMMUNOLOGY, 89, BB321-BB321. RIS download Bibtex download
  • McCullough B, Monk P, Morton I & Partridge L (1996) hCD63 binding by MAb's from the platelet workshop blind panel. TISSUE ANTIGENS, 48(4-II), PL105-PL105. RIS download Bibtex download
  • McCullough B, Monk P, Morton I & Partridge L (1996) Analysis of the reactivity of antibodies from the blind panel of the myeloid workshop with hCD63. TISSUE ANTIGENS, 48(4-II), MC505-MC505. RIS download Bibtex download
  • Wentworth P, DAtta A, Blakey D, Boyle T, Partridge LJ & Blackburn GM (1996) Toward antibody-directed ''abzyme'' prodrug therapy, ADAPT: Carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell killing. P NATL ACAD SCI USA, 93(2), 799-803. RIS download Bibtex download
  • Smith DA, Monk PN & Partridge LJ (1995) Antibodies against human CD63 activate transfected rat basophilic leukemia (RBL-2H3) cells.. Mol Immunol, 32(17-18), 1339-1344. RIS download Bibtex download
  • Monk PN, Barker MD, Partridge LJ & Pease JE (1995) Mutation of glutamate 199 of the human C5a receptor defines a binding site for ligand distinct from the receptor N terminus.. J Biol Chem, 270(28), 16625-16629. RIS download Bibtex download
  • RYAN GJ, MULCAHY KA, MORTON K & PARTRIDGE LJ (1995) CHARACTERIZATION OF NUCLEAR TRANSPORT-SYSTEM AND MOLECULES INVOLVED IN NUCLEAR-PROTEIN LOCALIZATION IN HUMAN MONONUCLEAR PHAGOCYTE CELL-LINES. J CELL BIOCHEM, 145-145. RIS download Bibtex download
  • Monk PN, Barker MD & Partridge LJ (1994) Multiple signalling pathways in the C5a-induced expression of adhesion receptor Mac-1.. Biochim Biophys Acta, 1221(3), 323-329. RIS download Bibtex download
  • MOIR AJG, MCKENZIE A, BUDDRUS S, REED M & PARTRIDGE LJ (1994) DIGESTION OF ACTIN WITH GLY-C AND THE LOCALIZATION OF THE EPITOPE FOR THE MONOCLONAL-ANTIBODY NH3. J MUSCLE RES CELL M, 15(2), 196-196. RIS download Bibtex download
  • HEXHAM JM, PARTRIDGE LJ, FURMANIAK J, PETERSEN VB, COLLS JC, PEGG CAS, SMITH BR & BURTON DR (1994) HUMAN THYROID AUTOANTIBODIES FROM PCOMB3 PHAGE DISPLAY COMBINATORIAL LIBRARIES. J CELL BIOCHEM, 200-200. RIS download Bibtex download
  • PARTRIDGE LJ, SHEN JQ, DENG SX, HEATON A, BORRIELLO A, BURTON DR & BLACKBURN GM (1994) STRATEGIES FOR THE PRODUCTION OF CATALYTIC ANTIBODIES USING COMBINATORIAL LIBRARIES. J CELL BIOCHEM, 195-195. RIS download Bibtex download
  • Partridge LJ (1994) The production of monoclonal antibodies to membrane proteins.. Methods Mol Biol, 27, 65-86. RIS download Bibtex download
  • Hexham JM, Partridge LJ, Furmaniak J, Petersen VB, Colls JC, Pegg C, Rees Smith B & Burton DR (1994) Cloning and characterisation of TPO autoantibodies using combinatorial phage display libraries.. Autoimmunity, 17(3), 167-179. RIS download Bibtex download
  • Monk PN & Partridge LJ (1993) Characterization of a complement-fragment-C5a-stimulated calcium-influx mechanism in U937 monocytic cells.. Biochem J, 295 ( Pt 3), 679-684. RIS download Bibtex download
  • Shen J, Deng SX, Partridge LJ & Blackburn GM (1993) New strategies for the generation of catalytic antibodies.. Biochem Soc Trans, 21(4), 415S. RIS download Bibtex download
  • Partridge LJ (1993) Production of catalytic antibodies using combinatorial libraries.. Biochem Soc Trans, 21(4), 1096-1098. RIS download Bibtex download
  • WILLIAMSON RA, BURIONI R, SANNA PP, PARTRIDGE LJ, BARBAS CF & BURTON DR (1993) HUMAN MONOCLONAL-ANTIBODIES AGAINST A PLETHORA OF VIRAL PATHOGENS FROM SINGLE COMBINATORIAL LIBRARIES. P NATL ACAD SCI USA, 90(9), 4141-4145. RIS download Bibtex download
  • Partridge LJ, Dransfield I & Burton D (1990) Characterization of a monoclonal antibody recognizing a novel leucocyte adhesion molecule.. Biochem Soc Trans, 18(2), 274-275. RIS download Bibtex download
  • Divecha N, Mansouri H, Peat D, Cope G, Partridge L & McDonald CJ (1989) Isoprenaline-induced and constitutive members of a proline-rich protein sub-group from mouse parotid glands studied with monoclonal antibody NAL1.. J Mol Endocrinol, 3(1), 7-14. RIS download Bibtex download
  • Burton DR, Jefferis R, Partridge LJ & Woof JM (1988) Molecular recognition of antibody (IgG) by cellular Fc receptor (FcRI).. Mol Immunol, 25(11), 1175-1181. RIS download Bibtex download
  • DUNCAN AR, WOOF JM, PARTRIDGE LJ, BURTON DR & WINTER G (1988) LOCALIZATION OF THE BINDING-SITE FOR THE HUMAN HIGH-AFFINITY FC RECEPTOR ON IGG. NATURE, 332(6164), 563-564. RIS download Bibtex download
  • DRANSFIELD I, MOIR AJG, SHETH B, BURTON DR & PARTRIDGE LJ (1988) INITIAL CHARACTERIZATION OF AN ANTI-ACTIN MONOCLONAL-ANTIBODY (NH3). BIOCHEM SOC T, 16(2), 163-164. RIS download Bibtex download
  • Dransfield I, Corcoran D, Partridge LJ, Hogg N & Burton DR (1988) Comparison of human monocytes isolated by elutriation and adherence suggests that heterogeneity may reflect a continuum of maturation/activation states.. Immunology, 63(3), 491-498. RIS download Bibtex download
  • Sheth B, Dransfield I, Partridge LJ, Barker MD & Burton DR (1988) Dibutyryl cyclic AMP stimulation of a monocyte-like cell line, U937: a model for monocyte chemotaxis and Fc receptor-related functions.. Immunology, 63(3), 483-490. RIS download Bibtex download
  • ALFADHL DH, SHARRARD RM, PARTRIDGE LJ, BURTON DR, GALLAGHER JA, SHEARD CE, BOBROW L, PRINGLE JAS & RUSSELL RGG (1987) CHARACTERIZATION OF A MONOCLONAL-ANTIBODY (DA1) WHICH REACTS WITH BONE-MATRIX AND BONE CELL CYTOPLASM. BONE, 8(1), 46-46. RIS download Bibtex download
  • PARTRIDGE LJ, WOOF JM, JEFFERIS R & BURTON DR (1986) THE USE OF ANTI-IGG MONOCLONAL-ANTIBODIES IN MAPPING THE MONOCYTE RECEPTOR-SITE ON IGG. MOL IMMUNOL, 23(12), 1365-1372. RIS download Bibtex download
  • WOOF JM, PARTRIDGE LJ, JEFFERIS R & BURTON DR (1986) LOCALIZATION OF THE MONOCYTE-BINDING REGION ON HUMAN IMMUNOGLOBULIN-G. MOL IMMUNOL, 23(3), 319-330. RIS download Bibtex download
  • PARTRIDGE L, JEFFERIS R, HARDIE D, LING NR & RICHARDSON P (1984) SUBCLASSES OF IGG ON THE SURFACE OF HUMAN-LYMPHOCYTES - A STUDY WITH MONOCLONAL-ANTIBODIES. CLIN EXP IMMUNOL, 56(1), 167-174. RIS download Bibtex download
  • PARTRIDGE LJ, LOWE J, HARDIE DL, LING NR & JEFFERIS R (1982) IMMUNOGENIC AND ANTIGENIC EPITOPES OF IMMUNOGLOBULINS .2. ANTIGENIC DIFFERENCES BETWEEN SECRETED AND MEMBRANE IGG DEMONSTRATED USING MONOCLONAL-ANTIBODIES. J IMMUNOL, 128(1), 1-6. RIS download Bibtex download

Conference proceedings papers

  • Marsay K, Roehl H, Monk P, Partridge L & Carney T (2017) Tetraspanins in zebrafish development. Mechanisms of Development, Vol. 145 (pp s64-s65) View this article in WRRO RIS download Bibtex download
  • Hassuna N, Monk P, Read R & Partridge L (2010) The role of tetraspanin proteins in macrophage uptake of Salmonella bacteria. IMMUNOLOGY, Vol. 131 (pp 80-80) RIS download Bibtex download
  • Partridge LJ, Varadharajan P, Hulme R & Monk P (2008) Roles for tetraspanin proteins in the fusion of human monocytes to form multinucleated giant cells. IMMUNOLOGY, Vol. 125 (pp 6-7) RIS download Bibtex download
  • Scola AM, Higginbottom A, Partridge LJ & Monk PN (2007) Different ligand-binding mechanisms used by the two C5a receptors, C5L2 and C5aR. MOLECULAR IMMUNOLOGY, Vol. 44(1-3) (pp 237-237) RIS download Bibtex download
  • Blackburn GM, Rickard JH, Cesaro-Tadic S, Lagos D, Mekhalfia A, Partridge L & Pluckthun A (2004) Passive and catalytic antibodies and drug delivery. PURE AND APPLIED CHEMISTRY, Vol. 76(5) (pp 983-989) RIS download Bibtex download
  • Wong CH, Higginbottom A, Monk P, Partridge LJ & Moore HD (2001) Inhibition of sperm-oolemma interactions by the extracellular domains of CD9 and CD81. ANDROLOGY IN THE 21ST CENTURY, SHORT COMMUNICATIONS (pp 565-572) RIS download Bibtex download
  • Yazici ZA, Behrendt M, Goodfield M, Partridge LJ & Lindsey NJ (1998) Does the CDR3 of the heavy chain determine the specificity of autoantibodies in systemic lupus erythematosus?. JOURNAL OF AUTOIMMUNITY, Vol. 11(5) (pp 477-483) RIS download Bibtex download
  • Higginbottom A, Partridge LJ & Monk PN (1996) Identification of potential ligands for CD63 from random peptide libraries. IMMUNOLOGY, Vol. 89 (pp OM117-OM117) RIS download Bibtex download
  • McCullough B, Peppa D, Monk PN, Skubitz KM & Partridge LJ (1996) A role for CD63 in signal transduction. IMMUNOLOGY, Vol. 89 (pp OM114-OM114) RIS download Bibtex download