Rebecca CorriganDr Rebecca Corrigan

Research Fellow


Tel: 0114 222 4238
Email: r.corrigan@sheffield.ac.uk

Research

Research Precis

fig1My research involves an in-depth characterisation of nucleotide signalling systems in the Gram-positive pathogen Staphylococcus aureus. S. aureus is a human pathogen responsible for a vast array of disease and morbidity worldwide, a problem that is exacerbated by the spread of antibiotic-resistant strains such as methicillin resistant S. aureus (MRSA). When this bacterium invades a human host it encounters a number of different stresses, such as nutrient limitation. The bacteria respond to these stresses by switching on a nucleotide signalling system called the stringent response. This response results in the synthesis of two small nucleotides, collectively referred to as (p)ppGpp, which can be made in the cell by three different enzymes – RSH, RelP and RelQ. These nucleotides are the effectors of the stringent response and function by binding to target proteins leading to the bacterial cells shutting down active growth and entering a persistent state that promotes survival.

My previous research has led to the development of a genome-wide approach to analyse nucleotide-protein interactions. The current focus of the lab is on utilising this methodology, in conjunction with biochemical assays, to identify binding targets for (p)ppGpp in S. aureus in order to precisely map how these nucleotides function in a bacterial cell.

By mapping of the (p)ppGpp signalling network this research will provide key insights into the functioning of (p)ppGpp and so generate important mechanistic data on the pathogenesis of S. aureus.

Research Keywords

Microbiology, S. aureus, nucleotide signalling, (p)ppGpp signalling

fig2

if you are interested in joining my group you can contact me directly by email at r.corrigan@sheffield.ac.uk

PhD studentships:

Funded PhD studentships will be advertised here as they become available but well qualified graduates, including those intending to self fund, should contact me directly to discuss possible projects.

Examples of potential projects could include the molecular characterisation of a nucleotide-protein interaction in vitro and the elucidation of the importance of this interaction for bacterial virulence in vivo.

You can apply for a PhD position in MBB here.

Postdoctoral fellowships:

Postdocs who wish to apply for a fellowship to join the group are more than welcome. Please contact me directly to discuss potential projects.

Project Students and Internships:

Students wishing to apply for summer internships are welcome and should send a CV describing their motivations and interests.

Teaching

Level 3 Modules

Career History

Career History

  • 2018 - present:  Lister Institute Fellowship, University of Sheffield
  • 2015 – present: Royal Society/ Wellcome Trust Sir Henry Dale Research Fellow, University of Sheffield, UK
  • 2008 – 2014: Postdoctoral Research Associate, Imperial College London, UK
  • 2004 – 2008: PhD, Trinity College Dublin, Ireland








































Publications

Journal articles