Dr Stefaan Verbruggen
Department of Mechanical Engineering
Lecturer in Biomechanics
INSIGNEO Institute for in silico Medicine
Dr Stefaan Verbruggen is a Lecturer in Biomechanics in the Department of Mechanical Engineering, and a Principal Investigator at the INSIGNEO Institute for in silico Medicine, at the University of Sheffield. Dr Verbruggen’s research focuses on the mechanobiology of musculoskeletal cells and metastatic cancer.
Prior to his appointment, Dr Verbruggen obtained a first class degree in biomedical engineering, and in 2014 completed his PhD research in bone cell mechanobiology in the Biomechanics Research Centre at the National University of Ireland, Galway. This was followed by postdoctoral research in how fetal movements affect joint development in the Developmental Biomechanics Lab at Imperial College London. Most recently, Stefaan completed a Marie Skłodowska-Curie Global Fellowship at Queen Mary University of London and at Columbia University, New York, identifying new target mechanisms involved in metastatic bone disease.
- Research interests
- Cell mechanics
- Computational biology
- Developmental biomechanics
- Cancer metastasis
- Skeletal tumour lesions
- Metastatic bone disease
- Mechanobiology in Health and Disease. Elsevier.
- Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-β signaling. Proceedings of the National Academy of Sciences, 118(25). View this article in WRRO
- Mechanical stimulation modulates osteocyte regulation of cancer cell phenotype. Cancers, 13(12). View this article in WRRO
- European Society of Biomechanics S.M. Perren Award 2018: Altered biomechanical stimulation of the developing hip joint in presence of hip dysplasia risk factors. Journal of Biomechanics, 78, 1-9. View this article in WRRO
- Stresses and strains on the human fetal skeleton during development. Journal of The Royal Society Interface, 15(138). View this article in WRRO
- Function and failure of the fetal membrane : modelling the mechanics of the chorion and amnion. PLoS ONE, 12(3). View this article in WRRO
- Ontogeny of the human pelvis. The Anatomical Record, 300(4), 643-652. View this article in WRRO
- In silico bone mechanobiology: modeling a multifaceted biological system.. Wiley Interdiscip Rev Syst Biol Med. View this article in WRRO
- Mechanisms of osteocyte stimulation in osteoporosis. Journal of the Mechanical Behavior of Biomedical Materials, 62, 158-168. View this article in WRRO
- Modeling the biomechanics of fetal movements. Biomechanics and Modeling in Mechanobiology, 15(4), 995-1004. View this article in WRRO
- Bone cell mechanosensation of fluid flow stimulation: a fluid–structure interaction model characterising the role integrin attachments and primary cilia. Biomechanics and Modeling in Mechanobiology, 14(4), 703-718.
- Altered Mechanical Environment of Bone Cells in an Animal Model of Short- and Long-Term Osteoporosis. Biophysical Journal, 108(7), 1587-1598. View this article in WRRO
- Fluid flow in the osteocyte mechanical environment: a fluid–structure interaction approach. Biomechanics and Modeling in Mechanobiology, 13(1), 85-97. View this article in WRRO
- Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes. International Journal for Numerical Methods in Biomedical Engineering, 29(12), 1361-1372.
- Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes. Journal of The Royal Society Interface, 9(75), 2735-2744.
- Bone mechanobiology in health and disease, Mechanobiology in Health and Disease (pp. 157-214). Elsevier
- Techniques for studying mechanobiology, Mechanobiology in Health and Disease (pp. 1-53). Elsevier
Conference proceedings papers
- Loading-Induced Interstitial Fluid Flow in Bone Mechanobiology: An FSI Approach to the Osteocyte Environment. ASME 2012 Summer Bioengineering Conference, Parts A and B, 20 June 2012 - 23 June 2012.
- Teaching activities
- MEC322 - Anatomy and Physiology for Engineers
- MEC307 - Engineering Group Design Project
- Professional activities
- Co-Chair of the Musculoskeletal Bioengineering Gordon Research Seminar 2020/22
- Editor of Mechanobiology in Health and Disease, in the Elsevier Biomedical Engineering Book Series
- Selected to sit on the UKRI Early Career Forum
- Topic Editor on the Editorial Board of the journal Materials
- S.M. Perren Research Award, World Congress of Biomechanics
- Selected for the 2018 Lindau Nobel Laureate Meeting on Physiology & Medicine