|Developing a Microfluidic Chip for Mechanobioengineering|
|Supervisor: Dr C Perrault|
Microfluidic systems offer unprecedented opportunities for the development of novel cellular platforms. Microsystems are perfectly suited for analysis of individual cells as well as more complex cell culture and tissue systems, since the integrated tools match the length scales of cells. Moreover, small liquid volumes can be precisely controlled, enabling very accurate definition and control of parameters in the cellular environment.
Control over the external cellular environment has always been of interest for tissue engineering, as external stimuli, such as diffusible chemical messengers, are known to influence crucial events such as stem cell differentiation. Yet, in the recent years, physical stimuli have also been proven similarly effective in controlling cellular behaviour and function. The field of mechanobiology has now become a major research focus and is considered of great clinical importance, particularly in areas of tissue engineering and regenerative medicine.
This project intends to develop microfluidic systems for mechanobiological research, thus merging technological advances with scientific innovation.
More details about our research: cmm.group.shef.ac.uk