Mechanics of Cellular Co-culture
Supervisor: Dr C Perrault

For biotechnological research in general and tissue engineering specifically, it is essential to mimic the natural conditions of the cellular environment as much as possible. Co-culture has proved to be a powerful in vitro tool in unravelling the importance of cellular interactions during normal physiology, homeostasis, repair and regeneration. Cellular interaction in co-culture systems occur through direct contact or through soluble factors via paracrine signalling, but recent data on the importance of extracellular mechanical forces and cellular traction forces raises the possibility that co-culture interaction could also be happening on a mechanical level.

This project will create a co-culture microfluidic system that would allow mechanical interaction between two cell types, but limit physical contact or paracrine signalling. The resulting knowledge from such a project could have large repercussions in tissue engineering and organogenesis.

More details about our research: cmm.group.shef.ac.uk

me-pgadmit@sheffield.ac.uk
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