Dementia

Dementia remains a key priority for NIHR. ACFs and CLs can be held in a number of GMC specialities e.g. general practice, old age psychiatry or neurology.

On

Infrastructure and Environment to support this NIHR Theme

The University of Sheffield is home to an NIHR BRC and the Sheffield Institute of

Translational Neurology (SITraN). Our dementia research unites researchers in two of the University’s flagship institutes- Neuroscience and the Healthy Lifespan Institute (HELSI). Translational neuroscience is one of the Academic Unit of Primary Medical Care research themes, in close collaboration with SITraN. Key players in dementia research demonstrate the multidisciplinary nature of this area at Sheffield.

At the University of Sheffield our experts carry out research into many aspects of dementia, from developing new models of disease using cells taken from patients with Alzheimer's to new diagnostic testing and helping people live full lives with dementia.

Pre-clinical research

Our pre-clinical research is working to understand the underlying mechanisms of dementia so that we can identify new targets for therapies.

Clinical research

Our interdisciplinary research focuses on the accurate and early detection of all types of dementia, and improving treatments for patients.

Ageing and multimorbidity

Multimorbidity refers to the presence of two or more chronic conditions. Our research is looking at the effects of ageing on dementia and how other diseases present alongside it.

Social research

Our applied health and psychology research is examining the social factors of living with dementia.

Primary care and the community

Our research explores the importance of primary care and the community for people with dementia and their friends, families and carers.

Engineering and robotics

We are advancing technology to develop devices that can benefit people with dementia - particularly in their own homes.

Computer science

We are using methods including mathematical modelling, machine learning, artificial intelligence to advance dementia research.

Grant Income 

  • COMPutational Assessment of Stroke Survivors (COMPASS) (co-funded with Knowledge Exchange,(UoS), Clinical Research Network Yorkshire & Humber, Rosetrees Charity Interdisciplinary Prize 2019, £250,000
  • Remote monitoring people with Mild Cognitive Impairment using combined technology of the Digital Doctor and ViVA Health & Care Partnership, Sheffield. £24,774
  • How are Care Decisions Negotiated: An Ethnographic Transnational Comparison of Dementia Care Transitions. Alzheimer’s Society £79,569
  • AcTo Dementia for OTs - NIHR RCF £5,521
  • Measuring and evaluating social participation with people living with dementia Alzheimer’s Society £224,942
  • SRSF1-targeted gene therapy for C9ORF72-linked Amyotrophic Lateral Sclerosis and Frontotemporal Dementia LIFEARC £513,141
  • Cellular and Molecular pathology of anterior cognitive circuits as a basis of post stroke dementia MRC £414,772
  • Characterisation of the gene expression profile of astrocytes in the ageing brain to determine their contribution to white matter pathology and dementia MRC £70,326
  • Neutrophil derived microvesicles: linking systemic inflammation and dementia Alzheimer’s Research UK, £49,781
  • Chronic traumatic encephalopathy and dementia in the ageing population. Alzheimer's Research UK: £186,870
  • Disease Specific Diffusion MRI Model for Early Differential Diagnosis of Vascular Cognitive Impairment, Alzheimer’s Society £80,108
  • On TReND: Mild Traumatic Brain Injury and the Contentious Reimagining of Alzheimer Disease-Related Dementias as Environmental Diseases Wellcome £333,089
  • Visual dysfunction as a biomarker of Frontotemporal Dementia and Motor Neurone Disease, White Rose Consortium £11,505
  • VR technologies with people with dementia: Time Train TSB Innovate £34,986
  • Dementia and Intimate Relationships (DaIR): An exploratory study and intervention development to support people with dementia living independently in the community NIHR RfPB £131,135
  • Atherosclerosis, the Brain and Vascular Dementia : the role of inflammation in neurovascular function, BHF, £262,307
  • Occludin as a Mediator of Neuroglial RNA Dysmetabolism in Dementia, Alzheimer’s Research UK, £47,703
  • ApoE4 induced blood-brain barrier dysfunction in Alzheimer’s disease, Pathological Soc of GB&I, £105,600
  • Loneliness and SI among people with dementia, Alzheimer’s Society £133,2336
  • Neutrophil derived microvesicles: linking systemic inflammation and dementia, Alzheimer’s Research UK, £49,781

Publications

Publications

Mitochondrial dysfunction in Alzheimer’s disease : a biomarker of the future? Biomedicines, (2021) 9(1). 

Fully automated cognitive screening tool based on assessment of speech and language. Journal of Neurology, Neurosurgery & Psychiatry (2021), 92(1), 12-15. 

The association between polygenic hazard scores and clinical markers of Alzheimer’s disease following stratification for APOE genotype. Alzheimer's & Dementia (2020), 16(S4). 

Do deficits in mitochondrial spare respiratory capacity contribute to neuropsychological changes seen in Alzheimer’s disease?.(2020) Alzheimer's & Dementia, 16(S6). 

A fully automated cognitive screening tool based on assessment of speech and language. Alzheimer's & Dementia,(2020) 16(S6). 

The Association between Polygenic Hazard and Markers of Alzheimer’s Disease Following Stratification for APOE Genotype. Current Alzheimer Research, (2020) 17. 

C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts. Neurology,(2020)  95(24), e3288-e3302. 

The Edinburgh Cognitive and Behavioral ALS Screen (ECAS) in frontotemporal dementia. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. (2020) Volume 21,  Issue 7-8

Functional cognitive disorder : dementia’s blind spot. (2020) Brain

26 Can an automated assessment of language help distinguish between Functional Cognitive Disorder and early neurodegeneration?. Journal of Neurology, Neurosurgery & Psychiatry, (2020) 91(8), e18.2-e19. 

Characterising spoken responses to an intelligent virtual agent by persons with mild cognitive impairment. Clinical Linguistics & Phonetics.(2020) 

Understanding the links between hearing impairment and dementia : development and validation of the social and emotional impact of hearing impairment (SEI-HI) questionnaire. Neurological Sciences (2020). 

Cognitive behavioural therapy for adults with dissociative seizures (CODES): a pragmatic, multicentre, randomised controlled trial. The Lancet Psychiatry (2020), 7(6), 491-505. 

Deficits in mitochondrial spare respiratory capacity contribute to the neuropsychological changes of alzheimer’s disease. Journal of Personalized Medicine(2020), 10(2). 

045 Food for thought: an unusual case of frontotemporal dementia. Journal of Neurology Neurosurgery & Psychiatry (2019), 90(12), a21. 

11.39 Association of british neurologists sustainability special interest group (ABN sustainability SIG): formation, objectives and invitation. Journal of Neurology Neurosurgery & Psychiatry, (2019) 90(12), a2. 

055 The digital doctor : a fully automated stratification and monitoring system for patients with memory complaints. Journal of Neurology Neurosurgery & Psychiatry, (2019) 90(12). 

056 Exploring the feasibility of automating verbal fluency tasks for cognitive assessment: data collection and analysis. Journal of Neurology Neurosurgery & Psychiatry, (2019) 90(12). 

Imaging of nonlinear and dynamic functional brain connectivity based on EEG recordings with the application on the diagnosis of Alzheimer’s disease. IEEE Transactions on Medical Imaging (2019). 

Altered frontal and insular functional connectivity as pivotal mechanisms for apathy in Alzheimer’s disease. Cortex, (2019)119, 100-110. View this article in WRRO 

Cognitive deficits in vasculitis of the nervous system: a cross-sectional study. Postgraduate Medicine,  (2019) 131(7), 546-549. 

A new diagnostic approach for the identification of patients with neurodegenerative cognitive complaints. PLoS ONE, (2019) 14(5). 

A Dementia Classification Framework using Frequency and Time-frequency Features based on EEG signals. IEEE Transactions on Neural Systems and Rehabilitation Engineering.(2019)

Dementia detection using automatic analysis of conversations. Computer Speech and Language,  (2019) 53, 65-79. 

Ursodeoxycholic Acid Improves Mitochondrial Function and Redistributes Drp1 in Fibroblasts from Patients with either Sporadic or Familial Alzheimer's Disease. Journal of Molecular Biology, (2018)  430(21), 3942-3953. 

Developing an intelligent virtual agent to stratify people with cognitive complaints: A comparison of human-patient and intelligent virtual agent-patient interaction. (2018) Dementia

Patients accounts of memory lapses in interactions between neurologists and patients with functional memory disorders. (2018) Sociology of Health and Illness

A Pilot Study Investigating a Novel Non-Linear Measure of Eyes Open versus Eyes Closed EEG Synchronization in People with Alzheimer’s Disease and Healthy Controls. Brain Sciences,(2018)  8(7), 134-134. 

Motion artifacts in standard clinical setting obscure disease-specific differences in quantitative susceptibility mapping. Physics in Medicine and Biology, (2018) 63(14), 14nt01-14nt01. 

An Interactional Profile to Assist the Differential Diagnosis of Neurodegenerative and Functional Memory Disorders. Alzheimer Disease and Associated Disorders, (2018)  32(3), 197-206. 

Identifying patterns of communication in patients attending memory clinics: A systematic review of observations and signs with potential diagnostic utility. British Journal of General Practice, (2018) 68(667), e123-e138. 

PO029 An avatar aid in memory clinic. Journal of Neurology, Neurosurgery & Psychiatry, (2017) 88(Suppl 1), A19.4-A20. 

PO017 Seeing the wood for the trees: a challenging case of altered consciousness. Journal of Neurology, Neurosurgery & Psychiatry,(2017)  88(Suppl 1), A17.1-A17. 

Distinctive neuropsychological profiles differentiate patients with functional memory disorder from patients with amnestic-mild cognitive impairment. (2017) Acta Neuropsychiatrica. 

[P4-034]: Mitochondrial Abnormalities Are Found In Fibroblasts From Sporadic Alzheimer's Disease Patients: Recovery With Ursodoxycholic Acid Treatment. Alzheimer's & Dementia, (2017) 13(7S_Part_26), P1269-P1269. 

[P3-260]: Central Auditory Dysfunction As A Marker Of Neurodegeneration. Alzheimer's & Dementia, (2017) 13(7S_Part_21), P1042-P1043. 

Toward the Automation of Diagnostic Conversation Analysis in Patients with Memory Complaints. Journal of Alzheimer's Disease,(2017)  58(2), 373-387. 

How the UK describes functional memory symptoms. (2017)  Psychogeriatrics

Intensive versus Guideline Blood Pressure and Lipid Lowering in Patients with Previous Stroke: Main Results from the Pilot ‘Prevention of Decline in Cognition after Stroke Trial’ (PODCAST) Randomised Controlled Trial. PLOS ONE, (2017) 12(1). 

P2-307: Is Social Handicap the Link Between Hearing Loss and Cognitive Decline? Development and Validation of a New Tool: The Social and Emotional Associations of Hearing Loss (SEAH). Alzheimer's & Dementia, (2016) 12, P753-P754. 

P2-188: Conversation Analysis In The Memory Clinic To Distinguish Dementia From Functional Memory Disorder. Alzheimer's & Dementia, (2016), 12, P691-P691. 

Conversational assessment in memory clinic encounters: Interactional profiling for differentiating dementia from functional memory disorders. Aging and Mental Health  (2016), 20(5), 500-509. 

Journeying through Dementia, a community-based self-management intervention for people aged 65 years and over: a feasibility study to inform a future trial. Pilot and Feasibility Studies, (2015) 1. 

Functional (Psychogenic) Cognitive Disorders. A Perspective from the neurology clinic. Journal of Alzheimer’s Disease. 2015, 48 sup1, s5-s17

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