MSc Translational Neuropathology course structure information
The taught component of this course is delivered through lectures, tutorials, laboratory practicals and student-led group work during the first two terms. In the self-directed literature review module, you will participate in a journal club and undertake a literature-based essay. In term 3, you'll undertake a research project under supervision from laboratory staff, which allows you to get practical experience of performing hypothesis-led scientific research.
You'll take four core modules during the Autumn term and a further 3 core modules in the Spring term. The course will conclude with a 20-week laboratory project. All taught modules are worth 15 credits, whilst the research project is worth 75 credits.
All taught modules are worth 15 credits.
You will learn basic and functional neuroanatomy through dissection of the human brain and spinal cord and microscopic examination of histology specimens.
- Pathology and Modelling of Neurodegenerative Diseases
You will explore the cellular and molecular causes of neurodegeneration in the major neurological diseases. You will discover how hypotheses can be tested in model systems and utilised to develop new therapeutic strategies.
- Molecular Neuroscience
You will develop skills in advanced molecular techniques and state-of-the-art informatics for studying gene and protein expression, and will discover how these techniques are applied to investigate the underlying pathology of neurological diseases.
- Ethics and Public Awareness of Science
You will be introduced to the legislative limitations and ethical influences on biomedical science, how these are influenced by public attitudes and the scientific community. You will explore your personal views and how they influence your perception of research.
- Basic Principles of Pathology and Histopathology
You will be trained in histological methods from section cutting through to molecular staining techniques, and discover how histological examination of human tissue provides insight into the underlying pathology of the major neurological diseases.Introduces core aspects of contemporary neuroscience including neural signalling, sensation and sensory processing, movement and its central control, development and plasticity and complex brain functions.
- Neuroinflammation, Neuro-Oncology and Neurovascular Pathology
You will explore the underlying pathology and clinical manifestation of the major neuroinflammatory, neuro-oncology and neurovascular diseases, and discover how laboratory breakthroughs have been translated into clinical benefits.
- Literature Review and Critical Analysis of Science
You will be required to undertake an in-depth survey of the current literature in order to prepare a written essay on a research topic. A series of tutorials and seminars will run alongside to develop your ability to read and understand scientific literature.
The significant practical component of the course will enable you to develop your laboratory skills to characterise brain tissue and understand how pathology relates to disease processes. The research project will give you a further opportunity to work with renowned researchers who are experts in their field, and provide training on highly specialised, state of the art equipment.
Examples of Neuropathology-related MSc research projects
- Do Astrocytes die of Apoptosis in Motor Neuron Disease?
- Glial pathology in motor neurone disease
- The effects of cell stress on the insulin/IGF-1 signalling pathways in astrocytes
- Neurofilament expression in the ageing brain: relationship to Alzheimer-type pathology and the neuronal DNA damage response
- Investigating the association between neuronal telomere length and dementia in the ageing population
- Micro RNAs dysregulation in amyotrophic lateral sclerosis.
- Nuclear retention of FOXO-3 increases glutamine synthetase expression by astrocytes in the ageing brain
See full course information on our Prospectus
The content of our courses is reviewed annually to make sure it is up-to-date and relevant. Individual modules are occasionally updated or withdrawn. This is in response to discoveries through our world-leading research, funding changes, professional accreditation requirements, student or employer feedback, outcomes of reviews, and variations in staff or student numbers. In the event of any change we'll consult and inform students in good time and take reasonable steps to minimise disruption.
Information last updated: 28 June 2021
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