Professor Eva E Qwarnstrom

Department of Infection, Immunity and Cardiovascular Disease

Professor of Cell Biology

e.qwarnstrom@sheffield.ac.uk
+44 114 215 9547

Full contact details

Professor Eva E Qwarnstrom
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

I graduated from the University of Lund Sweden in 1984 after spending three years as a Fogarty Fellow in Biological Structure, at the National Institute of Health, Bethesda, USA. This was followed by a postdoctoral fellowship in the Department of Pathology at the University of Washington in Seattle, where I was appointed Associate Professor in 1993.

In 1996 I was granted an Affiliated Associate Professorship in Pathology at the University of Washington, as I joined the University of Sheffield, where I took up a chair in Cell Biology in 2001.

Research interests

My research focuses on regulation of inflammatory responses, specifically on events related to receptor function and cell signalling. The programme includes analysis of activities induced by soluble mediators such as growth-factors and cytokines, and by biomechanical events, regulated through matrix structure and the cytoskeleton.

Current studies focus on TIR mediated responses, primarily the analysis of Toll-like and IL-1 receptor function and signal transduction. Recent findings include identification of a novel TIR regulating receptor (TILRR), which controls immune and inflammatory signal transduction through the IL-1 type I signalling receptor.

Work on signal transduction is centred on analysis of molecular mechanism controlling the NF-κβ pathway, with particular emphasis on signalling crosstalk, and the use of real time analysis of regulatory events. Collaborative projects include the use of single cell analysis and GFP-based methods as the basis for computational modelling of complex regulatory networks.

Current projects:

  • Vascular disease progression (collaboration with Sheila Francis and Rob Storey, Univ. Sheffield, and Siu-Pok Yee, Univ. Connecticut).
  • The impact of receptor polymorphisms on regulatory networks.
  • Extracellular protein interactions (collaboration with Mark Geoghegan, Univ. Sheffield).
  • Signalling crosstalk (collaboration with Chris Zhang, GIBH, Guangzhou).
  • Regulation of cancer metastasis (collaboration with Penelope Ottewell, Juha Rantala, Univ. Sheffield, Siu-Pok Yee, Univ. Connecticut).
Publications

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Research group

PhD students

  • Jiabao Zhou

Teaching interests

I teach on the MSc course in Molecular Medicine, the Cardiovascular Pathway, on interdisciplinary approaches, and using computational modelling to investigate inflammatory receptor function and signal transduction.

Professional activities

Editorial Member,
SM Journal of Cardiology and Cardiovascular Diseases.
Journal of Clinical and Interventional Cardiology (JCIC).
Journal of Cardiology and Cardiovascular Medicine.