Dr Mark S Thomas

BSc, PhD

Department of Infection, Immunity and Cardiovascular Disease

Senior Lecturer

m.s.thomas@sheffield.ac.uk
+44 114 215 9557

Full contact details

Dr Mark S Thomas
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

I obtained my PhD in the Department of Biochemistry at the University of Southampton followed by postdoctoral stints in Masayasu Nomura’s lab at the Institute for Enzyme Research, University of Wisconsin-Madison, and at the University of California-Irvine. I then spent some time working in Richard Flavell's group at IPSR in Cambridge and with Robert Glass at the University of Nottingham. I joined the University of Sheffield in 1994.

Research interests

Virulence mechanisms of pathogenic members of the Burkholderia, particularly B. cenocepacia and B. thailandensis. Areas of interest include:

  • Iron acquisition mechanisms.
  • Protein toxins and their mechanism of secretion.
  • Response to environmental stress, particularly the role of extracytoplasmic function (ECF) sigma factors.

Current projects

  • The mechanism of toxin secretion by the type VI secretion systems of B. cenocepacia and B. thailandensis
  • Identification and characterisation of secreted effector proteins of B. cenocepacia and B. thailandensis
  • Mechanisms of stress sensing and response in pathogenic Burkholderia
  • How does B. cenocepacia survive in a low iron environment?
  • Why does B. cenocepacia have so many TonB-dependent transporters?
Publications

Journal articles

Teaching interests

Currently, I teach bacterial molecular genetics, microbial pathogenicity, and microbiology to science undergraduates, medical students and Masters students.