Professor Martina Daly

BSc PhD

Department of Infection, Immunity and Cardiovascular Disease

Professor of Molecular Medicine

Faculty Lead for Postgraduate Research Programmes

m.daly@sheffield.ac.uk
+44 114 215 9521

Full contact details

Professor Martina Daly
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

I joined the University of Sheffield in 1991 when I took up a postdoctoral research post with the Section of Molecular Genetics working with Professor Ian Peake on the investigation of genotype-phenotype relationships in von Willebrand disease. Before this, I completed a PhD in the Children´s Research Centre, Dublin where I developed an interest in haemostasis, in particular antithrombin deficiency, and undertook postdoctoral research posts first in the Children´s Research Centre, Dublin and then in the Department of Haematology, Cambridge UK, where I worked with Professor Robin Carrell´s group on the investigation of the molecular basis of antithrombin deficiency. I was appointed Lecturer in 1992, Senior Lecturer in 2001 and Professor in 2017.

Research interests

My research is aimed at improving understanding of the pathogenesis of inherited haemostatic disorders. Current areas of interest include the identification and characterisation of novel genetic defects underlying inherited platelet bleeding disorders and inherited thrombocytopenia. I am also interested in the contribution of platelet gene variation to the bleeding tendency in patients with type 1 von Willebrand factor.

Current Projects:

  • Mapping and functional investigation of genetic mutations in patients with mild platelet bleeding disorders. Originally, funded through a British Heart Foundation Programme, this project seeks to identify and characterise the genetic defects underlying mild platelet bleeding abnormalities. Known as the Genotyping and Phenotyping of Platelets or GAPP project, the project is being carried out in collaboration with colleagues at the Universities of Birmingham (Steve Watson, Neil Morgan) and Bristol (Andrew Mumford, Stuart Mundell).
  • Identification and characterisation of FLI1 and RUNX1 regulated determinants of platelet granule biogenesis and secretion, funded by the British Heart Foundation and in collaboration with Dr Vincenzo Leo, Sheffield and Dr Neil Morgan, University of Birmingham.
  • The pathogenesis of inherited thrombocytopenia, in collaboration with Professor Mike Makris, Sheffield.
  • Investigation of the molecular basis of Glanzmann’s thrombasthenia.
Publications

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Journal articles

All publications

Journal articles

Conference proceedings papers

  • Watson S, Daly M, Dawood B, Gissen P, Makris M, Mundell S, Wilde J & Mumford A (2010) Phenotypic approaches to gene mapping in platelet function disorders. Hämostaseologie, Vol. 30(01) (pp 29-38) RIS download Bibtex download
  • Smith SMG, Buckland R, Daly ME & Storey RF (2007) Inhibition of platelet aggregation by clopiclogrel is unaffected by the CYP2C19 681G > A polyrnorphism in patients with coronary artery disease. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 49(9) (pp 375A-375A) RIS download Bibtex download
  • Smith SMG, Judge HM, Daly ME & Storey RF (2006) The G allele of the platelet P2Y1 1622 A > G polymorphism is not associated with platelet hyper-reactivity to ADP in either healthy volunteers or CAD patients. EUROPEAN HEART JOURNAL, Vol. 27 (pp 756-756) RIS download Bibtex download
  • Hop C, Guilliatt A, Daly M, de Leeuw HP, Brinkman H-JM, Peake IR, van Mourik JA & Pannekoek H (2000) Assembly of Multimeric von Willebrand Factor Directs Sorting of P-Selectin. Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 20(7) (pp 1763-1768) RIS download Bibtex download
  • Abuzenadah AM, Goodeve AC, Gursel T, Daly ME, Ingerslev J & Peake IR (1998) Mutations in the pro-peptide of VWF causing type 1 and type 3 VWD.. BRIT J HAEMATOL, Vol. 101 (pp 67-67) RIS download Bibtex download
  • Nesbitt IM, Goodeve AC, Daly ME, Hampton KK, Makris M, Preston FE & Peake IR (1997) Mutation at Arg611 in the von Willebrand factor gene results in unclassifiable type 2 von Willebrand disease. THROMB HAEMOSTASIS (pp P2665-P2665) RIS download Bibtex download
Teaching interests

I have a longstanding interest in postgraduate research programmes, and in devising ways to improve the postgraduate research experience. From 2008 to 2014, I was the Postgraduate Research Lead for the University of Sheffield Medical School. In 2014, I was appointed Lead for Postgraduate Research Programmes for the Faculty of Medicine, Dentistry and Health and Chair of the Faculty Graduate Research Committee which is responsible for postgraduate research degree programmes provision within the Faculty and training of Postgraduate research students, and oversees postgraduate research student progress, supervision and support.