Professor Michael Makris

MA, MB BS, MD, FRCP, FRCPath

Department of Infection, Immunity and Cardiovascular Disease

Professor of Haemostasis & Thrombosis

m.makris@sheffield.ac.uk
+44 114 271 2760
+44 114 226 1408 (Secretary: Claire Warsop)

Full contact details

Professor Michael Makris
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

I joined the University of Sheffield in 1989 as a Lecturer in Haematology. Following completion of my haematology training I was appointed initially Senior Lecturer in 1994 followed by Reader in Haemostasis and Thrombosis in 2002.

I became Professor of Haemostasis & Thrombosis in 2013. I hold an Honorary contract with the Sheffield Teaching Hospitals NHS Foundation Trust as a Consultant Haematologist and I am the president of the European Association for Haemophilia and Allied Disorders (EAHAD).

Research interests

My research activities are in the area of haemostasis and thrombosis centring around a number of areas:

  1. The use of global coagulation assays (thrombin generation estimation and thromboelastography) for the diagnosis and management of inherited and acquired haemostatic and thrombotic disorders.
  2. The role of different coagulation and chromogenic assays in the accurate assessment of FVIII:C.
  3. The molecular pathogenesis and diagnosis of inherited platelet defects with special emphasis on Glanzmann´s thrombasthenia and MYH-9 related thrombocytopenias.
  4. The natural history and management of chronic hepatitis C in haemophilia.
  5. Adverse event reporting in patients with inherited bleeding disorders. I am the project leader of the EUHASS system.
Publications

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Journal articles

All publications

Journal articles

Chapters

Conference proceedings papers

  • Tahhan M, Makris M & Watson H (2019) Glanzmann Thrombocythaemia with very mild bleeding phenotype. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 185 (pp 143-143) RIS download Bibtex download
  • Miners A, Phillips M, Beech D, Collins P, Curry N, Grimley C, Hay C, Hanley J, Makris M, Mangles S , Mathias M et al (2019) UK EHL outcomes registry: First report on baseline pain and quality of life. HAEMOPHILIA, Vol. 25 (pp 38-38) RIS download Bibtex download
  • Roberts T, Curry N, Mathias M, Hanley J, Tait C, Evans G, Mangles S, Makris M, Collins P & Chowdary P (2018) Establishment of a UK registry for haemophilia patients switched to extended half-life clotting factor concentrates: 1 year update. HAEMOPHILIA, Vol. 24 (pp 39-39) RIS download Bibtex download
  • van der Valk P, Makris M, Tait C, Collins P, Chowdary P, Meijer K, Mauser-Bunschoten E & Schutgens R (2018) Reduced cardiovascular events in haemophilia - Results from a 5 year prospective study. HAEMOPHILIA, Vol. 24 (pp 33-34) RIS download Bibtex download
  • Bowyer A, Sampson B, Shepherd F, Jones R, Kitchen S & Makris M (2018) The FIX C assessment of extended half-life recombinant factor IX products in clinical practice. HAEMOPHILIA, Vol. 24 (pp 56-56) RIS download Bibtex download
  • Akinwale OJ, Wilkinson I, Hough C, Lillicrap D, Makris M & Ross R (2017) A Factor VIII Fusion with an Inactivated FIX Generates a Biologically Active Molecule with Delayed Clearance in a FVIII/VWF Knockout Mouse Model. BLOOD, Vol. 130 RIS download Bibtex download
  • Makris M (2017) EUHANET, European Reference Networks and EuroBloodNet. HAEMOPHILIA, Vol. 23 (pp 11-12) RIS download Bibtex download
  • Palla R, Menegatti M, Boscarino M, Blatny J, Zapletal O, Schved J-F, Giansily-Blaizot M, Halimeh S, Lachmann B, Platokouki H , Pergantou H et al (2016) Prospective Evaluation of Bleeding Incidence in Fibrinogen Deficiency (PRO-RBDD Study). Blood, Vol. 128(22) (pp 207-207) RIS download Bibtex download
  • Bucko AM, Saccullo G, van Veen JJ & Makris M (2016) Prothrombin complex concentrate (PCC) related thrombosis: A systematic review. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 173 (pp 52-52) RIS download Bibtex download
  • Cooper P, Hickey K, Maclean R, Kitchen S & Makris M (2014) C0327: Pregnancy May Falsely Reduce Antithrombin Antigen Levels in Latex-Based Assays. Thrombosis Research, Vol. 133 (pp S109-S109) RIS download Bibtex download
  • Jennings I, Kitchen S, Kitchen DP, Munroe-Peart ST, Woods TAL, Makris M & Walker ID (2014) Factor IX assays in patients receiving factor IX concentrate therapy; data from a UK NEQAS (Blood Coagulation) exercise. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 165 (pp 9-9) RIS download Bibtex download
  • Cooper P, Hickey K, Coath F & Makris M (2012) An automated antithrombin antigen assay on instrumentation laboratory ACL top analyser. THROMBOSIS RESEARCH, Vol. 130 (pp S182-S182) RIS download Bibtex download
  • Cooper P, Hickey K, Coath F & Makris M (2012) An automated progressive assay of antithrombin. THROMBOSIS RESEARCH, Vol. 130 (pp S182-S183) RIS download Bibtex download
  • Martinowitz U, Shapiro A, Quon DV, Escobar M, Kempton C, Collins PW, Chowdary P, Makris M, Mannucci PM, Morfini M , Valentino LA et al (2012) Pharmacokinetic properties of IB1001, an investigational recombinant factor IX, in patients with haemophilia B: Repeat pharmacokinetic evaluation and sialylation analysis. Haemophilia, Vol. 18(6) (pp 881-887) RIS download Bibtex download
  • Martinowitz U, Shapiro AD, Quon DV, Escobar MA, Kempton CL, Collins P, Chowdary P, Makris M, Mannucci PM, Morfini M , Valentino LA et al (2011) Pharmacokinetic Behavior of IB1001, An Investigational Recombinant Factor IX, in Patients with Hemophilia B: Repeat Pharmacokinetic Study and Subgroup Analysis. BLOOD, Vol. 118(21) (pp 984-985) RIS download Bibtex download
  • Rendo P, Berntorp E, Keeling DM, Makris M, Hermans CR, Mauser-Bunschosten EP, Musso R, Tagliaferri A, Kollmer C, Baumann J & Charnigo R (2010) Safety of Recombinant Human Factor IX, Nonacog Alfa, for Usual Use In Pediatric Patients: Results From a Prospective Registry of European Hemophilia B Patients. BLOOD, Vol. 116(21) (pp 1504-1504) RIS download Bibtex download
  • Rendo P, Berntorp E, Keeling DM, Makris M, Hermans CR, Bunschosten EPM, Musso R, Tagliaferri A, Kollmer C, Baumann J & Charnigo R (2010) Safety of Recombinant Human Factor IX, Nonacog Alfa, for Usual Use In Pediatric Patients Results From a Prospective Registry of European Hemophilia B Patients. BLOOD, Vol. 116(21) (pp 1504-1504) RIS download Bibtex download
  • Coath FL, Cooper PC, Hickey KP & Makris M (2010) Heparin resistance and antithrombin deficiency. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 149 (pp 14-14) RIS download Bibtex download
  • Watson S, Daly M, Dawood B, Gissen P, Makris M, Mundell S, Wilde J & Mumford A (2010) Phenotypic approaches to gene mapping in platelet function disorders. HAMOSTASEOLOGIE, Vol. 30(1) (pp 29-38) RIS download Bibtex download
  • Gatt A, Riddell A, Calvaruso V, Makris M, Tuddenham E & Burroughs A (2009) Thrombin generation is normal in most patients with cirrhosis despite a prolonged INR. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 145 (pp 4-5) RIS download Bibtex download
  • van Veen JJ & Makris M (2009) Factor XIII deficiency: effective haemostasis despite treatment for the wrong diagnosis. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 145 (pp 37-37) RIS download Bibtex download
  • Farquharson NR, Maclean RM, Hampton KK, McAlindon M, van Veen JJ & Makris M (2009) Gastrointestinal bleeding due to angiodysplasia in patients with inherited platelet function disorders. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 145 (pp 34-35) RIS download Bibtex download
  • Gatt A, Riddell A, van Veen JJ, Kitchen S, Tuddenham E & Makris M (2008) Prothrombin Complex Concentrate for Warfarin Reversal: A Single Dose Is Effective for All INRs > 4.5. BLOOD, Vol. 112(11) (pp 693-693) RIS download Bibtex download
  • Gatt A, Riddell A, Calvaruso V, Makris M, Tuddenham E & Burroughs A (2008) Thrombin Generation Is Normal in Most Patients with Cirrhosis despite a Prolonged INR. BLOOD, Vol. 112(11) (pp 643-644) RIS download Bibtex download
  • Warkentin TE, Jay RM, Makris M & Kelton JG (2006) Platelet-activating anti-platelet factor 4/polyanion antibodies without preceding heparin therapy: A transient autoimmune disorder resembling heparin-induced thrombocytopenia ("spontaneous HIT").. BLOOD, Vol. 108(11) (pp 311A-312A) RIS download Bibtex download
  • Gatt A, van Veen J, Cooper P, Kitchen S & Makris M (2006) A novel Protac (R)-modified thrombin generation assay to identify individuals at higher thrombotic risk.. BLOOD, Vol. 108(11) (pp 425A-426A) RIS download Bibtex download
  • Gatt A, van Veen J, Cooper P, Kitchen S & Makris M (2006) Reversal of anticoagulation as assessed by thrombin generation measurement.. BLOOD, Vol. 108(11) (pp 263A-263A) RIS download Bibtex download
  • Gatt A, Van Veen JJ, Cooper P, Kitchen S & Makris M (2006) Poor correlation in thrombin generation estimation between ROTEM thromboelastometry and the fluorogenic thrombogram in normal subjects. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 133 (pp 42-42) RIS download Bibtex download
  • Posthouwer D, Yee TT, Makris M, Fischer K, Griffioen A, Van Veen J & Mauser-Bunschoten EP (2006) Response to antiviral therapy in patients with congenital bleeding disorders infected with hepatitis C. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 133 (pp 85-86) RIS download Bibtex download
  • Posthouwer D, Makris M, Yee TT, Fischer K, Van Veen J, Griffioen A & Mauser-Bunschoten EP (2006) The natural history of hepatitis C in patients with bleeding disorders. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 133 (pp 20-20) RIS download Bibtex download
  • Van Veen JJ, Gatt A, Bowyer AE, Cooper PC, Kitchen S & Makris M (2006) Factor VIII concentration and thrombin generation determination. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 133 (pp 40-41) RIS download Bibtex download
  • Collins P, Baglin T, Brown S, Dolan G, Hanley J, Keeling D, Liesner R, Makris M, Hay C & UKHCDO (2005) UKHCDO acquired haemophilia study: A complete national cohort.. BLOOD, Vol. 106(11) (pp 98A-98A) RIS download Bibtex download
  • Van Veen JJ, Laidlaw S, Maclean RM, Hampton KK & Makris M (2005) Clinical use of protamine for the emergency reversal of anticoagulation with low molecular weight heparin (LMWH). BRITISH JOURNAL OF HAEMATOLOGY, Vol. 129 (pp 17-17) RIS download Bibtex download
  • Payne JH, Maclean RM, Hampton KK & Makris M (2005) Haemoperitoneum associated with ovulation in women with autosomal recessive bleeding disorders. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 129 (pp 57-57) RIS download Bibtex download
  • van Veen J, Elliot CA, Martin L, Armstrong I, Kiely DG, Bowyer AE & Makris M (2004) Elevated factor VIII : C levels in patients with pulmonary hypertension. A marker of endothelial dysfunction?. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 125 (pp 46-46) RIS download Bibtex download
  • van Veen J, Pereira MRD, Goodeve AC, Bowyer A, Kitchen S & Makris M (2004) Gene defects in patients with factor XI deficiency. BRITISH JOURNAL OF HAEMATOLOGY, Vol. 125 (pp 35-35) RIS download Bibtex download
  • Elliot CA, Martin L, Armstrong I, Kiely DG, Bowyer AE & Makris M (2003) Elevated factor FVIII: C levels as a marker of endothelial dysfunction in patients with pulmonary hypertension. THORAX, Vol. 58 (pp 9-9) RIS download Bibtex download
  • Winter M, Allder S, Sharrack B & Makris M (2003) Lack of classical thrombophilic risk factors in cerebral venous thrombosis.. BLOOD, Vol. 102(11) (pp 115B-115B) RIS download Bibtex download
  • de Matos Pereira MR, van Veen J, Goodeve AC, Bowyer AE & Makris M (2003) Conformation sensitive gel electrophoresis detects mutations in most patients with factor XI deficiency.. BLOOD, Vol. 102(11) (pp 309A-309A) RIS download Bibtex download
  • Hampton KK & Makris M (2003) The use of two plasma derived factor VIII concentrates in type 2 a von Willebrand's disease (VWD).. BLOOD, Vol. 102(11) (pp 99B-99B) RIS download Bibtex download
  • Vossen C, Conard J, Fontcuberta J, De Jonge I, Makris M, van der Meer F, Pabinger I, Palareti G, Preston F, Scharrer I , Souto J et al (2002) Thromboprophylaxis reduces the risk of fetal loss in women with hereditary thrombophilia.. BLOOD, Vol. 100(11) (pp 273A-273A) RIS download Bibtex download
  • Tait RC, Morfini M, Waker ID, Makris M, Dolan G, Menon R, Noonan PK, Frieling J, Boafiglio J & Streisand J (2002) A pharmacokinetic model for dosing of rh AT by continuous infusion in patients with hereditary AT deficiency.. BLOOD, Vol. 100(11) (pp 122B-122B) RIS download Bibtex download
  • Makris M, Marsden L, Timms JM, Cox A & Daly M (2002) Polymorphisms in the interleukin-1 (IL-1) gene cluster do not contibute to thrombotic risk in patients with heritable thrombophilia.. BLOOD, Vol. 100(11) (pp 271A-271A) RIS download Bibtex download
  • Morley NJ, Makris M & Hampton KK (2002) A comparison of two coagulation factor concentrates in type 2A and acquired von Willebrand's disease (VWD).. BLOOD, Vol. 100(11) (pp 494A-494A) RIS download Bibtex download
  • Makris M (2000) Successful use of desmopressin (DDAVP) in pregnant women with inherited storage pool disease. HAEMOPHILIA, Vol. 6 (pp 28-28) RIS download Bibtex download
  • Coughlan TC, Goodeve AC, Hampton KK, Makris M & Peake IR (1998) Null alleles are not a common cause of type 1 vonWillebrand's disease. BRIT J HAEMATOL, Vol. 102(1) (pp 15-15) RIS download Bibtex download
  • Nesbitt IM, Goodeve AC, Daly ME, Hampton KK, Makris M, Preston FE & Peake IR (1997) Mutation at Arg611 in the von Willebrand factor gene results in unclassifiable type 2 von Willebrand disease. THROMB HAEMOSTASIS (pp P2665-P2665) RIS download Bibtex download
  • PRESTON FE, MAKRIS M, TRIGER DR, ADELMAN MI & UNDERWOOD JCE (1990) A PROSPECTIVE RANDOMIZED CONTROLLED LIVER-BIOPSY STUDY OF RECOMBINANT ALPHA-INTERFERON IN CHRONIC NON-A-NON-B HEPATITIS IN HEMOPHILIA. RECENT ADVANCES IN HEMOPHILIA CARE, Vol. 324 (pp 135-136) RIS download Bibtex download

Posters

  • JEYAKUMAR M, MONK P, MAKRIS M & FINN A (1995) PRIMING EFFECTS OF INTERMEDIATE PURITY FVIII CONCENTRATE ON NEUTROPHIL RESPIRATORY BURST FUNCTION. RIS download Bibtex download
Professional activities

Editorial board member for British Journal of Haematology, Blood Transfusion and Journal of Thrombosis and Haemostasis.