Dr Noémie Hamilton
PhD
Department of Infection, Immunity and Cardiovascular Disease
Research Fellow
+44 114 222 2769
Full contact details
Department of Infection, Immunity and Cardiovascular Disease
The Bateson Centre
Firth Court
Western Bank
Sheffield
S10 2TN
- Profile
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For enquiries, please contact – iicd-om-operational@sheffield.ac.uk
I joined the University of Sheffield in 2015 to work with zebrafish models of auto-inflammatory neurological disorders. My interest in disease modelling using zebrafish started early when I went to the University of Manchester with my ERASMUS bursary for a 6-month placement in Dr Hurlstone’s lab.
I continued my training using zebrafish as an animal model during my PhD and my post doctoral positions in Germany and in the UK, using zebrafish in cancer and neurological disease modelling.
I also worked for a short period of time with Astyanax Mexicanus, another fish model to study eye degeneration and heart regeneration.
2016-2010: PhD in genetics- University of Manchester (Supervisor: Dr Adam Hurlstone).
2010-2012: Post Doctoral Associate in Universitat Georg August Goettingen, Germany (Geartner/Henneke group).
2012-2015: Post Doctoral Associate at UCL (Prof Whitmore Group/ Dr Yamamoto/ Dr Mommersteeg).
2015-2016: Post Doctoral Associate at University of Sheffield (Prof Renshaw/Prof Sabroe).
2017-Present: ELA Research Fellow at University of Sheffield.Current PhD Opportunities
- Research interests
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My research interests are to dissect the mechanism of auto-inflammatory neurological disorders using zebrafish as an animal model.
My current fellowship is entitled: A zebrafish model to identify new therapeutic strategies for RNAseT2-deficient cystic leukoencephalopathy without megalencephaly.
Current Projects
- Elucidate the role of endogenous retrovirus in neurological disorders.
- Identifying therapeutic drugs to reverse brain inflammation in rnaset2 zebrafish mutants.
- Develop Gadolinium-based MRI to detect white matter lesions in live zebrafish brain.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- The failure of microglia to digest developmental apoptotic cells contributes to the pathology of RNASET2-deficient leukoencephalopathy. Glia. View this article in WRRO
- Animal models of leukodystrophy : a new perspective for the development of therapies. The FEBS Journal. View this article in WRRO
- A method for transplantation of human HSCs into zebrafish, to replace humanised murine transplantation models. F1000Research, 7, 594-594. View this article in WRRO
- rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA. Proceedings of the National Academy of Sciences, 108(3), 1099-1103.
- Failure to clear developmental apoptosis contributes to the pathology of RNASET2-deficient leukoencephalopathy. View this article in WRRO
All publications
Journal articles
- Longitudinal MRI brain studies in live adult zebrafish. NMR in Biomedicine.
- The effect of absent blood flow on the zebrafish cerebral and trunk vasculature. Vascular Biology, 3(1), 1-16.
- Pioneer neutrophils release chromatin within in vivo swarms. eLife, 10. View this article in WRRO
- Dirty fish versus squeaky clean mice: dissecting interspecies differences between animal models of interferonopathy. Frontiers in Immunology, 11. View this article in WRRO
- Zebrafish disease model of human RNASET2-deficient cystic leukoencephalopathy displays abnormalities in early microglia. Biology Open, 9(5). View this article in WRRO
- The failure of microglia to digest developmental apoptotic cells contributes to the pathology of RNASET2-deficient leukoencephalopathy. Glia. View this article in WRRO
- Animal models of leukodystrophy : a new perspective for the development of therapies. The FEBS Journal. View this article in WRRO
- Heart regeneration in the Mexican cavefish. Cell Reports, 25(8), 1997-2007, e1-e7. View this article in WRRO
- Cellular rearrangement of the prechordal plate contributes to eye degeneration in the cavefish. Developmental Biology, 441(2), 221-234. View this article in WRRO
- A method for transplantation of human HSCs into zebrafish, to replace humanised murine transplantation models. F1000Research, 7, 594-594. View this article in WRRO
- Circadian Clock Synchronization of the Cell Cycle in Zebrafish Occurs through a Gating Mechanism Rather Than a Period-phase Locking Process. Journal of Biological Rhythms, 33(2), 137-150. View this article in WRRO
- Impaired light detection of the circadian clock in a zebrafish melanoma model. Cell Cycle, 14(8), 1232-1241. View this article in WRRO
- rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA. Proceedings of the National Academy of Sciences, 108(3), 1099-1103.
- RNASET2-deficient cystic leukoencephalopathy: a new lysosomal disorder. Neuropediatrics, 41(02).
- Activated PI3K Delta Syndrome-1 mutations cause neutrophilia in zebrafish larvae. Disease Models & Mechanisms.
- A zebrafish reporter line reveals immune and neuronal expression of endogenous retrovirus. Disease Models & Mechanisms.
- Failure to clear developmental apoptosis contributes to the pathology of RNASET2-deficient leukoencephalopathy. View this article in WRRO
Preprints
- Longitudinal brain studies in adult zebrafish by MRI, Cold Spring Harbor Laboratory.
- A zebrafish reporter line reveals immune and neuronal expression of endogenous retrovirus, Cold Spring Harbor Laboratory.
- Endogenous pioneer neutrophils release NETs during the swarming response in zebrafish, Cold Spring Harbor Laboratory.
- The failure of microglia to digest developmental apoptotic cells contributes to the pathology of RNASET2-deficient leukoencephalopathy. Glia. View this article in WRRO
- Professional activities and memberships
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- Teaching on Masters courses Translational Neuroscience MSc and Molecular Medicine MSc.
- Supervisor of Students (bachelors, masters, PhD).
- Editor of FishForScience.org website.
- Reviewer for journal and funding agencies.
- Member of the Zebrafish Disease Model Society and British Society of Immunology.
- Departmental champion for the MDHRSA (2019-2021).
- Member of the Early Career Group (ECG) (2019-2021).
- Funding and awards
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- White Rose Collaboration Fund.
- Research Grant from Legacy of Angels Foundation.
- Jules Thorn Scholarship award.
- Fellowship from European Leukodystrophy Association (ELA).
- Pump Priming award from the Neuroscience Institute to develop live zebrafish MRI.
- 2020 Early Career Researcher award (Faculty of Medicine, Dentistry & Health).