Dr Noémie Hamilton

PhD

Department of Infection, Immunity and Cardiovascular Disease

ELA International Research Fellow

N.M.Hamilton@sheffield.ac.uk
+44 114 222 2769

Full contact details

Dr Noémie Hamilton
Department of Infection, Immunity and Cardiovascular Disease
The Bateson Centre
Firth Court
Western Bank
Sheffield
S10 2TN
Profile

I joined the University of Sheffield in 2015 to work with zebrafish models of auto-inflammatory neurological disorders. My interest in disease modelling using zebrafish started early when I went to the University of Manchester with my ERASMUS bursary for a 6-month placement in Dr Hurlstone’s lab.

I continued my training using zebrafish as an animal model during my PhD and my post doctoral positions in Germany and in the UK, using zebrafish in cancer and neurological disease modelling.

I also worked for a short period of time with Astyanax Mexicanus, another fish model to study eye degeneration and heart regeneration.

2016-2010: PhD in genetics- University of Manchester (Supervisor: Dr Adam Hurlstone)
2010-2012: Post Doctoral Associate in Universitat Georg August Goettingen, Germany (Geartner/Henneke group)
2012-2015: Post Doctoral Associate at UCL (Prof Whitmore Group/ Dr Yamamoto/ Dr Mommersteeg)
2015-2016: Post Doctoral Associate at University of Sheffield (Prof Renshaw/Prof Sabroe)
2017-Present: ELA Research Fellow at University of Sheffield

Research interests

My research interests are to dissect the mechanism of auto-inflammatory neurological disorders using zebrafish as an animal model.

My current fellowship is entitled: A zebrafish model to identify new therapeutic strategies for RNAseT2-deficient cystic leukoencephalopathy without megalencephaly.


Current Projects

  • Elucidate the role of endogenous retrovirus in neurological disorders.
  • Identifying therapeutic drugs to reverse brain inflammation in rnaset2 zebrafish mutants.
  • Develop Gadolinium-based MRI to detect white matter lesions in live zebrafish brain.
Publications

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Journal articles

All publications

Journal articles

Professional activities
  • Teaching on Masters courses Translational Neuroscience MSc and Molecular Medicine MSc.
  • Supervisor of Students (bachelors, masters, PhD).
  • Editor of FishForScience.org website.
  • Reviewer for journal and funding agencies.
  • Member of the Zebrafish Disease Model Society and British Society of Immunology.
Funding and awards
  • Fellowship from European Leukodystrophy Association (ELA).
  • Pump Priming award from the Neuroscience Institute to develop live zebrafish MRI.
  • 2020 Early Career Researcher award (Faculty of Medicine, Dentistry & Health).