Professor Pat Lawford

BSc, PhD

Department of Infection, Immunity and Cardiovascular Disease

Professor of Physiological Modelling

p.lawford@sheffield.ac.uk
+44 114 2159535

Full contact details

Professor Pat Lawford
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

The key driving force, throughout my career, has been my interest in the application of physics and engineering to medicine.

After graduating in biological sciences (BSc Human Anatomy and Cell Biology) my doctoral studies focused on the development of microinterferometric methods for the study of degeneration and healing of articular cartilage.

This was followed by a 4 year postdoctoral research post in Medical Physics, in Sheffield working on the development of a novel bioprosthetic heart valve.

In 1986, I was appointed as an NHS Senior Physicist, responsible for the UK Department of Health Centre for Heart Valve Evaluation, and subsequently spent 3 years as a Project Manager for a joint University/NHS Institute providing evaluation services to the medical devices industry.

In August 1991 I returned to academic medical physics to lead a new Masters programme in Medical Physics and Clinical Engineering.

I am currently Professor of Physiological Modelling in the Departmnet of Infection, Immunity & Cardiovascular Disease.

Research interests

My main activity is in the area of cardiovascular biomechanics and in cardiovascular implant devices. My key interest is the development and use of computational models for the study of cardiovascular disease and its treatment.

My primary aim is the translation of modelling tools to clinical workflows and the use of predictive modelling in treatment planning. This work falls within the remit of the European Union´s Virtual Physiological Human (VPH) initiative.


Current projects:

  1. euHeart: Integrated Cardiac Care using Patient-Specific Cardiovascular Modeling. Funded by the European Community’s 7th Framework Programme under the Information Society and Media’s Virtual Physiological Human initiative. Grant agreement 224495.
  2. Translating Biomedical Modelling to the Heart of the Clinic Funded by the EPSRC under its Digital Economy programme in the Grand Challenges in IT for Healthcare initiative.
  3. Virtual Physiological Human Network of Excellence: Funded by the European Community’s 7th Framework Programme under the Information Society and Media’s Virtual Physiological Human initiative.
  4. @neurIST: Integrated Biomedical Informatics for Management of Cerebral Aneurysms (2006-2010), Funded by the European Community’s 6th Framework Programme by DG-Infso.
  5. COAST: Complex Automata for modelling and simulation of complex systems. Funded by the European Community’s Future and Emerging Technologies Programme.
Publications

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Journal articles

Conference proceedings papers

All publications

Books

Journal articles

Chapters

Conference proceedings papers

  • Gosling R, Morris P, Lawford P, Hose R & Gunn J (2019) Virtual (computed) FFR and Virtual Coronary Intervention (VCI) vs angiography for guiding PCI: a virtual study.. Heart, Vol. 105(Suppl 6) (pp a45-a45). Manchester, UK, 3 June 2019 - 5 June 2019. View this article in WRRO RIS download Bibtex download
  • Sciola MI, Morris PD, Lawford PV, Hose DR & Gunn JP (2017) A novel mathematical signal processing application which automates and improves the accuracy of FFR assessment. EUROPEAN HEART JOURNAL, Vol. 38 (pp 183-184) View this article in WRRO RIS download Bibtex download
  • Warriner D, Webb P, Sheridan P & Lawford P (2016) 2 Cardiac Resynchronisation Therapy Leads to Reversal of Heart Failure Induced Sarcopenia. Heart, Vol. 102(Suppl 6) (pp A2.1-A2), 6 June 2016 - 8 June 2016. RIS download Bibtex download
  • Warriner D, Crapper R, Lawford P & Sheridan P (2016) 54 Measures of Endothelial Dysfunction Predict Response to Cardiac Resynchronisation Therapy. Heart, Vol. 102(Suppl 6) (pp A39.1-A39), 6 June 2016 - 8 June 2016. RIS download Bibtex download
  • Morris P, Zwierzak I, Lawford P, Sir D, Hose R & Gunn J (2015) 209 The Development and Validation of anin silicoModel of Coronary Arterial Physiology for Diagnostic Use. Heart, Vol. 101(Suppl 4) (pp A115.1-A115) RIS download Bibtex download
  • Morris PD, Ryan DR, Lycett R, Morton AC, Lawford PV, Hose DR & Gunn J (2012) COMPUTER MODELLED CORONARY PHYSIOLOGY AND "VIRTUAL" FRACTIONAL FLOW RESERVE FROM ROTATIONAL ANGIOGRAPHY. HEART, Vol. 98 (pp A14-A14) RIS download Bibtex download
  • Morris PD, Ryan DM, Lycett R, Morton AC, Lawford PV, Hose DR & Gunn JP (2011) Virtual Coronary Physiology and Anatomy Derived From Rotational Angiography: The First Step. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol. 58(20) (pp B189-B189) RIS download Bibtex download
  • Li Y, Nallamothu RK, Rafiroiu D, Iancu A, Díaz-Zuccarini V, Narracott AJ, Hose DR & Lawford PV (2011) CFD Analysis Study on the Impact of the Coronary Anatomy on the Efficiency of the Coronary Thrombectomy: The Effect of Bend Angles (pp 306-309) RIS download Bibtex download
  • Nallamothu RK, Li Y, Rafiroiu DR, Díaz-Zuccarini V, Narracott AJ, Lawford PV & Hose DR (2011) Multi-physics and Multi-scale Computational Evaluation of the Thrombogenic and Cavitational Potential of a Bileaflet Mechanical Heart Valve (pp 298-305) RIS download Bibtex download
  • Amatruda CM, Hose DR, Lawford PV & Narracott AJ (2011) Modelling the Development of In-Stent Restenosis: Preliminary Results of a Structural Model. INTERNATIONAL CONFERENCE ON ADVANCEMENTS OF MEDICINE AND HEALTH CARE THROUGH TECHNOLOGY, Vol. 36 (pp 276-279) RIS download Bibtex download
  • Hunter P, Coveney PV, de Bono B, Diaz V, Fenner J, Frangi AF, Harris P, Hose R, Kohl P, Lawford P , McCormack K et al (2010) A vision and strategy for the virtual physiological human in 2010 and beyond. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, Vol. 368(1920) (pp 2595-2614) RIS download Bibtex download
  • Rafiroiu D, Munteanu M, Ciupa R, Munteanu R, Diaz V, Narracott AJ, Lawford PV & Hose DR (2009) EXPERIMENTAL STUDIES AND NUMERICAL SIMULATIONS OF SOME MECHANICAL HEART VALVES' BIOMECHANICS. MANAGEMENT OF TECHNOLOGICAL CHANGES, VOL 1 (pp 445-448) RIS download Bibtex download
  • Turcu A, Lungu A, Vlad S, Rafiroiu D, Ciupa RV, Diaz VA, Narracott AJ, Lawford PV & Hose DR (2009) Closure Mechanics of Mechanical Heart Valve Prostheses - Experimental and Computational Analysis. INTERNATIONAL CONFERENCE ON ADVANCEMENTS OF MEDICINE AND HEALTH CARE THROUGH TECHNOLOGY, Vol. 26 (pp 363-368) RIS download Bibtex download
  • Evans DJW, Caiazzo A, Falcone JL, Hegewald J, Lorenz E, Stahl B, Wang D, Bernsdorf J, Chopard B, Gunn J , Walker D et al (2009) COAST: Modelling Restenosis and Stent Based Therapies. INTERNATIONAL CONFERENCE ON ADVANCEMENTS OF MEDICINE AND HEALTH CARE THROUGH TECHNOLOGY, Vol. 26 (pp 319-322) RIS download Bibtex download
  • Caiazzo A, Evans D, Falcone J-L, Hegewald J, Lorenz E, Stahl B, Wang D, Bernsdorf J, Chopard B, Gunn J , Hose DR et al (2009) Towards a Complex Automata Multiscale Model of In-Stent Restenosis.. ICCS (1), Vol. 5544 (pp 705-714) RIS download Bibtex download
  • Wright B, Fenner J, Gillott R, Spencer P, Lawford PV & Bardhan KD (2009) Patterns, Movement and Clinical Diagnosis of Abdominal Adhesions.. PRIB, Vol. 5780 (pp 415-426) RIS download Bibtex download
  • Bernsdorf J, Harrison SE, Smith SM, Lawford PV & Hose DR (2008) Applying the lattice Boltzmann technique to biofluids: A novel approach to simulate blood coagulation. COMPUTERS & MATHEMATICS WITH APPLICATIONS, Vol. 55(7) (pp 1408-1414) RIS download Bibtex download
  • Turcu AE, Rafiroiu DV, Diaz-Zuccarini V, Narracott AJ, Hose DR & Lawford PV (2008) Investigations of the thrombogenic and cavitational potentials of a bileaflet mechanical heart valve, using ANSYS-CFX. 2008 IEEE INTERNATIONAL CONFERENCE ON AUTOMATION, QUALITY AND TESTING, ROBOTICS (AQTR 2008), THETA 16TH EDITION, VOL III, PROCEEDINGS (pp 106-111) RIS download Bibtex download
  • Wright BP, Fenner JW, Gillott R, Lawford PV, Spencer P & Bardhan KD (2008) Novel image analysis methods for the non-invasive diagnosis of intra-abdominal adhesions. GUT, Vol. 57 (pp A132-A132) RIS download Bibtex download
  • Harrison SE, Bernsdorf J, Hose DR & Lawford PV (2007) Development of a lattice Boltzmann framework for numerical simulation of thrombosis. INTERNATIONAL JOURNAL OF MODERN PHYSICS C, Vol. 18(4) (pp 483-491) RIS download Bibtex download
  • Rafiroiu D, Díaz-Zuccarini V, Hose DR, Lawford PV, Narracott AJ & Ciupa RV (2007) The cavitational potential of a single-leaflet virtual MHV: A multi-physics and multiscale modelling approach. IFMBE Proceedings, Vol. 16(1) (pp 895-898) RIS download Bibtex download
  • Rafiroiu D, Diaz-Zuccarini V, Hose DR, Lawford PV, Narracott AJ & Ciupa RV (2007) The Cavitational Potential of a Single-leaflet Virtual MHV: A Multi-Physics and Multiscale Modelling Approach. 11TH MEDITERRANEAN CONFERENCE ON MEDICAL AND BIOLOGICAL ENGINEERING AND COMPUTING 2007, VOLS 1 AND 2, Vol. 16(1-2) (pp 895-898) RIS download Bibtex download
  • Clapworthy GJ, Kohl P, Gregerson H, Thomas SR, Viceconti M, Hose DR, Pinney D, Fenner J, McCormack K, Lawford P , Jan SVS et al (2007) Digital human modelling: A global vision and a European perspective. Digital Human Modeling, Vol. 4561 (pp 549-558) RIS download Bibtex download
  • Diaz-Zuccanni V, Rafirou D, Hose DR, Lawford PV & Narracott AJ (2007) Multi-physics and multi-scale modelling in cardiovascular physiology: Advanced user methods for simulation of biological systems with ANSYS/CFX. Computational Science - ICCS 2007, Pt 1, Proceedings, Vol. 4487 (pp 794-801) RIS download Bibtex download
  • Bernsdorf J, Harrison SE, Smith SM, Lawford PV & Hose DR (2006) Numerical simulation of clotting processes: A lattice Boltzmann application in medical physics. MATHEMATICS AND COMPUTERS IN SIMULATION, Vol. 72(2-6) (pp 89-92) RIS download Bibtex download
  • Jeays AD, Gillott R, Hose R, Lawford P, Jacob S, Spencer P & Bardham KD (2006) MRI studies of blood flow in the superior mesenteric artery (SMA). GASTROENTEROLOGY, Vol. 130(4) (pp A196-A196) RIS download Bibtex download
  • Gillott R, Jeays AD, Lawford PV, Jacob S, Bardhan KD, Hose DR & Spencer PA (2006) MRI studies of blood flow through the superior mesenteric artery. GUT, Vol. 55 (pp A114-A114) RIS download Bibtex download
  • Jeays A, Gillott R, Lawford P, Jacob S, Bardhan KD, Spencer PA & Hose R (2005) Gut blood flow: Modelling the dynamic anatomy of the superior mesenteric artery (SMA). GASTROENTEROLOGY, Vol. 128(4) (pp A656-A656) RIS download Bibtex download
  • Bernsdorf J, Harrison SE, Smith SM, Lawford PV & Hose DR (2005) Concurrent numerical simulation of flow and blood clotting using the lattice Boltzmann technique. 11th International Conference on Parallel and Distributed Systems Workshops, Vol II, Proceedings, (pp 336-340) RIS download Bibtex download
  • Cirovic S, Bhola RM, Hose DR, Howard IC, Lawford PW & Parsons MA (2005) A computational study of the optic nerve evulsion. IUTAM Symposium on Impact Biomechanics: From Fundamental Insights to Applications, Vol. 124 (pp 469-476) RIS download Bibtex download
  • Bhola RM, Cirovic S, Parson MA, Hose DR, Lawford PV & Howard IC (2005) Modeling of the eye and orbit to simulate Shaken Baby syndrome. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol. 46 RIS download Bibtex download
  • Chambers J, Oo L, Narracott A, Lawford P & Blauth C (2003) Continuity equation area in bileaflet prosthetic aortic valves: Valve size cannot be substituted for LV outflow tract diameter. HEART, Vol. 89 (pp 41-41) RIS download Bibtex download

Reports

  • Carusi A (2015) In silico Clinical Trials: How Computer Simulations Will Transform the Biomedical Industry. An International Roadmap for an Industry-Driven Initiative. RIS download Bibtex download

Website content

  • Lawford PV Home Page. RIS download Bibtex download
Teaching interests

I have had a sustained interest in Masters Level teaching for a number of years. I was course Director for the Masters Programme in Medical Physics and Clinical Engineering.

I have also been involved in the steering group for Masters programmes in the Medical School. I now lead this activity in the Medical School. I also helping to develop postgraduate training modules for VPH Training at a European level.

Professional activities
  • Associate Editor – Journal Medical Engineering and Technology.
  • Member of British Standards Committee, Cardiovascular Implants (CG/150/02).
  • Member of British Standards Committee, Biological evaluation of medical devices (CH/194).
  • Member of British Standards Committee, Cardiac valves (ISO/TC 150/SC 2WG 1).