Professor Peter Monk

BSc, PhD

Department of Infection, Immunity and Cardiovascular Disease

Professor of Immunology

p.monk@sheffield.ac.uk
+44 114 215 9538

Full contact details

Professor Peter Monk
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

I began my career in the Biochemistry Department in Sheffield in 1988 as a post-doctoral researcher, working for Professor Banks on chemoattractant signalling in monocytes, before working with Dr Birgit Helm on mast cell degranulation.

In 1992, I became an independent researcher, funded by Arthritis Research UK to study the important pro-inflammatory mediator, complement fragment 5A (C5a).

In 1995, Arthritis Research UK awarded me a post-doctoral fellowship to establish my own laboratory, working on the interactions between C5a and its receptor.

We were the first group to characterise the second C5a receptor, C5L2, now recognised to have important roles in inflammation and neurodegeneration.

During this time, I also began work on the tetraspanin family of membrane proteins, identifying the hepatitis C virus E2 glycoprotein binding site on CD81.

I became a lecturer in the Department of Neurosciences in 2001 and was promoted to Senior Lecturer in 2007, before moving to the Department of Infection and Immunity in 2009.

I became Reader in Immunology in 2013 and Professor in 2017.

Research interests

Models of infection in human tissue

Controlling bacterial infection by the repeated use of antibiotics invites the development of bacterial resistance (e.g. MRSA) and so new approaches for control are urgently required. One such strategy is the prevention of bacterial adhesion.

Bacteria are rapidly removed by normal immune mechanisms unless the bacteria can adhere strongly to host tissues; if this initial step in colonisation can be prevented, infection becomes much less likely.

Testing new drugs that can prevent bacterial binding requires more sophisticated models of infection than are currently available and so I am working with colleagues in the Faculties of Engineering and Science to develop models of human skin, cornea and bladder infections.

Using our new facilities in the Sheffield Collabatorium on Biofilms and Antibiotic Resistance (SCARAB), we have are developing new long-term infection models that can be exploited to develop new therapies and improve our understanding of infections.

Tetraspanins

Tetraspanins have been implicated in many of the fundamental processes involved in the development and functioning of multicellular organisms, from sponges to man. These include cell fusion, migration, secretion, adhesion and signalling.

Recently, several tetraspanins have been shown to have roles in microbial infections, including hepatitis C, HIV-1 and Chlamydia. Cell ingress and egress mechanisms involving tetraspanins are exploited by these intracellular pathogens.

These mechanisms can be blocked by tetraspanin-specific reagents, suggesting that tetraspanins may be valuable drug targets. However, the molecular details of tetraspanin functions have yet to be fully elucidated.

We are using mammalian and zebrafish models to further our understanding of this fascinating protein family.


Current projects

  • Analysis of the C5a receptor ligand binding site.
  • Control of C5a function by the second C5a receptor, C5aR2.
  • Development of C3aR and C5aR2 antagonists.
  • Tetraspanin function in monocyte giant cell formation.
  • Tetraspanins and intracellular pathogens.
Publications

Show: Featured publications All publications

Journal articles

All publications

Journal articles

Chapters

Conference proceedings papers

  • Moamin MR, Monk P, Cox A, Ottewell P, Saint-Pol J, Rubinstein E & Muthana M (2019) Abstract LB-036: Tetraspanin 5 expressing macrophages promote mammary tumor growth. Tumor Biology RIS download Bibtex download
  • Moamin MR, Monk P, Cox A, Ottewell P, Saint-Pol J, Rubinstein E & Muthana M (2019) Abstract LB-036: Tetraspanin 5 expressing macrophages promote mammary tumor growth. Tumor Biology RIS download Bibtex download
  • Wannigama DL, Kicic A, Hurst C, Monk PN, Storer RJ, Chatsuwan T, Stick SM & Cf A (2019) FIGHTING PSEUDOMONAS AERUGINOSA AND NONTYPEABLE HAEMOPHILUS INFLUENZAE BIOFILMS WITH HOST DEFENCE PEPTIDE AS A NOVEL STEP FORWARD IN THE TREATMENT OF CHRONIC LUNG INFECTIONS. Chest, Vol. 155(4) (pp 73A-73A) RIS download Bibtex download
  • Wannigama D, Kicic A, Hurst C, Monk P, Chatsuwan T, Stick S & Arest CF (2019) HOST DEFENCE PEPTIDE AS AN INNOVATIVE NOVEL THERAPY FOR PSEUDOMONAS AERUGINOSA BIOFILM INFECTIONS IN THE CYSTIC FIBROSIS LUNG. RESPIROLOGY, Vol. 24 (pp 45-45) RIS download Bibtex download
  • Wannigama DL, Hurst C, Monk P, Kicic A, Stick S & Chatsuwan T (2018) OVERCOMING BIOFILM MEDIATED RESPIRATORY INFECTIONS THROUGH EXPLOITATION OF PATHOGEN AND HOST-DIRECTED NOVEL PEPTIDES. RESPIROLOGY, Vol. 23 (pp 67-68) RIS download Bibtex download
  • West EE, Freeley S, Kolev M, Niyonzima N, Espevik T, Mollnes TE, Lappegard K, Woodruff TM, Monk PN & Kemper C (2018) Auto-regulation of Th1 responses requires intracellular carboxypeptidase M-mediated complement regulation. Molecular Immunology, Vol. 102 (pp 228-228) RIS download Bibtex download
  • Stott M, van den Berg C, Forton J, Monk P, Morgan BP & McGreal E (2017) Post-translational modification of complement anaphylatoxins during chronic neutrophilic inflammation. Molecular Immunology, Vol. 89 (pp 167-167) RIS download Bibtex download
  • West EE, Freeley S, Le Friec G, Kolev M, Niyonzima N, Espevik T, Mollnes TE, Lappegard K, Woodruff TM, Monk P & Kemper C (2017) Auto-regulation of Th1 responses through carboxypeptidase M-generated C5a-desArg. Molecular Immunology, Vol. 89 (pp 135-135) RIS download Bibtex download
  • Freeley S, Le Friec G, Kolev M, Niyonzima N, Espevik T, Mollnes TE, Lappegard K, Woodruff TM, Monk P & Kemper C (2016) Auto-regulation of Th1 responses through carboxypeptidase M-generated C5a-desArg. Immunobiology, Vol. 221(10) (pp 1178-1178) RIS download Bibtex download
  • Arbore G, West E, Robertson A, Klos A, Rheinheimer C, Dutow P, Woodruff T, O'Neill L, Coll R, Sher A , Leonard W et al (2016) Autocrine NLRP3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-gamma in CD4+T cells. EUROPEAN JOURNAL OF IMMUNOLOGY, Vol. 46 (pp 534-535) RIS download Bibtex download
  • West EE, Arbore G, Robertson AAB, Klos A, Woodruff TM, O'Neill LA, Coll RC, Sher A, Leonard WJ, Koehl J , Monk P et al (2016) Autocrine NLPR3 inflammasome activity is critical to normal adaptive immunity via regulation of IFN-gamma in CD4(+) T cells. JOURNAL OF IMMUNOLOGY, Vol. 196 RIS download Bibtex download
  • Croker DE, Halai R, Kaeslin G, Morikis D, Woodruff T, Floudas CA, Monk PN & Cooper MA (2014) 32. Cytokine, Vol. 70(1) (pp 35-35) RIS download Bibtex download
  • Hassuna N, Monk P, Read R & Partridge L (2010) The role of tetraspanin proteins in macrophage uptake of Salmonella bacteria. IMMUNOLOGY, Vol. 131 (pp 80-80) RIS download Bibtex download
  • Holt JR, Monk PN, Fairlie DP & Madala PK (2010) Modelling of the C5a receptor by iterative mutation. MOLECULAR IMMUNOLOGY, Vol. 47(13) (pp 2215-2216) RIS download Bibtex download
  • Partridge LJ, Varadharajan P, Hulme R & Monk P (2008) Roles for tetraspanin proteins in the fusion of human monocytes to form multinucleated giant cells. IMMUNOLOGY, Vol. 125 (pp 6-7) RIS download Bibtex download
  • Moore T, Woodruff T, Manthey H, Monk P, Taylor S & Shiels I (2008) Novel haemodynamic effects of recombinant C5a and C5a des Arg in rats and mice. MOLECULAR IMMUNOLOGY, Vol. 45(16) (pp 4150-4150) RIS download Bibtex download
  • Madala PK, Stoermer M, Tyndall JDA, Monk PN, Higginbottom A & Fairlie DP (2008) COMP 264-Unraveling the mechanism of antagonism for human C5a receptor: Comparison of three structurally different antagonists. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 236 RIS download Bibtex download
  • Scola AM & Monk P (2007) Constitutive recycling of the C5a-receptor like protein, C5L2. MOLECULAR IMMUNOLOGY, Vol. 44(16) (pp 3932-3932) RIS download Bibtex download
  • Dhungana S, Woodroofe NM, Sharrack B, Monk P, Howell SJ & Price S (2007) Cerebrospinal and serum cytokine and chemokine profiles in idiopathic intracranial hypertension. ANNALS OF NEUROLOGY, Vol. 62 (pp S31-S31) RIS download Bibtex download
  • Scola AM & Monk P (2007) Evidence that the C5a-receptor like protein (C5L2) acts a decoy receptor for anaphylatoxins, C5a and C5adesR(74). MOLECULAR IMMUNOLOGY, Vol. 44(1-3) (pp 237-238) RIS download Bibtex download
  • Blackburn D, Sargsyan S, Monk P, Shaw P, Heath P & Holden H (2007) The role of microglial cells in MND. NEURON GLIA BIOL, Vol. 2 (pp S56-S56) RIS download Bibtex download
  • Scola AM, Higginbottom A, Partridge LJ & Monk PN (2007) Different ligand-binding mechanisms used by the two C5a receptors, C5L2 and C5aR. MOLECULAR IMMUNOLOGY, Vol. 44(1-3) (pp 237-237) RIS download Bibtex download
  • Monk PN, Higginbottom A, Madala PK, Tyndall JDA, Stoermer M & Fairlie DP (2006) Defining the ligand binding site on the human C5a receptor. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 231 RIS download Bibtex download
  • Johswich K, Schaefer M, Thalmann J, Rheinheimer C, Monk P & Klos A (2006) Regulation of the C5L2-receptor in myeloid and epithelial cell-lines. MOLECULAR IMMUNOLOGY, Vol. 43(1-2) (pp 149-150) RIS download Bibtex download
  • Sarma JV, Huber-Lang M, Rittirsch D, Gao H, Guo RF, Zetoune F, Monk P & Ward PA (2005) Changes in the C5a receptors C5aR and C5L2 on neutrophils during sepsis. JOURNAL OF LEUKOCYTE BIOLOGY (pp 64-65) RIS download Bibtex download
  • Proctor LM, Woodruff TM, Pazckowski NP, Monk PN & Taylor SM (2004) Dual C3a/C5a receptor agonism by a C5a C-terminal analogue decapeptide. MOLECULAR IMMUNOLOGY, Vol. 41(2-3) (pp 297-297) RIS download Bibtex download
  • Rittirsch D, Huber-Lang M, Sarma JV, Younkin EM, Weiss M, Neff T, Monk P & Ward PA (2004) Expression of C5a-like receptor 2 (C5L2) on neutrophils during sepsis in humans. FASEB JOURNAL, Vol. 18(4) (pp A559-A559) RIS download Bibtex download
  • Huber-Lang M, Sarma V, Rittirsch D, Schreiber H, Schneider M, Weiss M, Younkin E, Zetoune F, Gebhard F, Monk P & Ward PA (2004) Role of novel orphan receptor C5L2 during sepsis in humans. SHOCK, Vol. 21 (pp 26-26) RIS download Bibtex download
  • Rennen HJ, Boerman OC, Oyen WJ, Cain SA, Monk PN, Kohl J & Corstens FH (2001) Infection imaging with Tc-99m-labeled C5a and C5a-antagonists. EUR J NUCL MED, Vol. 28(8) (pp 1043-1043) RIS download Bibtex download
  • Rennen HJ, Boerman OC, Oyen WJ, Monk PN, Cain SA & Corstens FH (2001) Tc-99m-labeled C5a and C5a-des-Arg(74) for infection imaging.. J NUCL MED, Vol. 42(5) (pp 259P-259P) RIS download Bibtex download
  • Wong CH, Higginbottom A, Monk P, Partridge LJ & Moore HD (2001) Inhibition of sperm-oolemma interactions by the extracellular domains of CD9 and CD81. ANDROLOGY IN THE 21ST CENTURY, SHORT COMMUNICATIONS (pp 565-572) RIS download Bibtex download
  • Murdoch C, Monk PN & Finn A (1998) CXC chemokine receptor expression on human endothelial cells. J VASC RES, Vol. 35(5) (pp 388-388) RIS download Bibtex download
  • Barker MD, Monk PN, Pease JE, Klos A, Crass T & Bautsch W (1997) Structure-function relationships of leucocyte chemoattractant receptors. Biochemical Society Transactions, Vol. 25(3) RIS download Bibtex download
  • Higginbottom A, Partridge LJ & Monk PN (1996) Identification of potential ligands for CD63 from random peptide libraries. IMMUNOLOGY, Vol. 89 (pp OM117-OM117) RIS download Bibtex download
  • Murdoch C, Barker MD, Pease JE, Finn A & Monk PN (1996) Leukocyte chemoattractant receptor expression on endothelial and epithelial cells. IMMUNOLOGY, Vol. 89 (pp OM115-OM115) RIS download Bibtex download
  • Monk PN, Barker MD, Pease JE, Crass T & Bautsch W (1996) Studies on the interaction between human C5A and its receptor. IMMUNOLOGY, Vol. 89 (pp OM116-OM116) RIS download Bibtex download
  • McCullough B, Peppa D, Monk PN, Skubitz KM & Partridge LJ (1996) A role for CD63 in signal transduction. IMMUNOLOGY, Vol. 89 (pp OM114-OM114) RIS download Bibtex download
  • Murdoch C, Monk PN & Finn A (1996) Analysis of the endothelial panel reactivity against the type II alveolar epithelial cell line, A549.. TISSUE ANTIGENS, Vol. 48(4-II) (pp EC216-EC216) RIS download Bibtex download
  • BINGHAM B, AHMAD T, MONK P & HELM BA (1993) IMPAIRED MEDIATOR SECRETION AND HIGH-AFFINITY RECEPTOR (FC-EPSILON-R1) PHOSPHORYLATION IN A VARIANT OF THE RAT BASOPHILIC LEUKEMIA CELL-LINE (RBL-2H3) FOLLOWING AN IMMUNOLOGICAL STIMULUS. J IMMUNOL, Vol. 150(8) (pp A222-A222) RIS download Bibtex download

Patents

  • Monk P (2019) Discovery of the first selective c5a2 receptor (c5l2/c5ar2) ligands. US10280197B2 Appl. 29 May 2019. RIS download Bibtex download

Website content

Posters

  • JEYAKUMAR M, MONK P, MAKRIS M & FINN A (1995) PRIMING EFFECTS OF INTERMEDIATE PURITY FVIII CONCENTRATE ON NEUTROPHIL RESPIRATORY BURST FUNCTION. RIS download Bibtex download

Dictionary/encyclopaedia entries

Research group
  • Muslim Algabri
  • Hyfa Alzahrani
  • Nathan Wong
Teaching activities
  • MSc Molecular Medicine MED6006 Complement; Allergy and Imunotherapy.
  • Preclinical Medicine Innate Immunity and Allergy; Laboratory-based SSC; Student PATS tutor.
  • MSc Genomic Medicine MEDT32/33 Complement Genetics.
  • MBB311 Molecular Immunology (innate immunity).
  • MBB360 Third Year Undergraduate projects.
  • MBB460 Fourth Year Undergraduate Projects.
Professional activities
  • Member of British Society for Immunology; Biochemical Society, British Inflammation Research Association.
  • INSERM scientific evaluation Infection and Immunity panel member.
  • Co-organiser for international research conferences on tetraspanins.
  • Associate editor for BMC Immunology, Frontiers of Immunology.
  • Industry Consultancies.