Dr Roslyn Simms

BSc MBChB MRCP PhD

Department of Infection, Immunity and Cardiovascular Disease

Honorary Clinical Senior Lecturer

Honorary Senior Lecturer

r.simms@sheffield.ac.uk
+44 114 215 9555

Full contact details

Dr Roslyn Simms
Department of Infection, Immunity and Cardiovascular Disease
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

My research interest began during my intercalated BSc (2001) in University of Glasgow, where I also qualified in Medicine (2002).

After general medical and early nephrology training I moved to Newcastle (2007) to commence specialty nephrology training, where I developed my interest in renal genetics. I was awarded pump priming funding (Mason Medical Research Foundation, 2008) and a joint Kidney Research UK/MRC Clinical Training Fellowship (2009) to undertake my PhD on zebrafish models of inherited cystic kidney disease (2013) with Professor John Sayer.

I was appointed a NIHR Clinical Lecturer in Nephrology in Newcastle University (2013) and to further develop my clinical research interest in autosomal dominant polycystic kidney disease (ADPKD), I joined the University of Sheffield in 2014 as a NIHR Clinical Lecturer in Nephrology and Honorary Specialty Registrar.

In Sheffield, I have developed an interest in renal imaging and I was awarded an Academy of Medical Sciences starter grant (2015) to study multiparametric magnetic resonance imaging (MRI) in ADPKD and MRC Confidence in Concept funding (2016) to develop a semi-automated tool to measure total kidney volume in ADPKD.

In 2018 I completed a NIHR Clinical Trials Fellowship at the School of Health and Related Research (ScHARR) prior to commencing my current appointments.

Research interests

My research interests are in understanding progression in patients with ADPKD particularly at an early stage to optimise opportunities for intervention to facilitate timely access to treatment or enrolment in clinical trials. This will involve evaluating the feasibility and efficacy of using established and novel renal MRI techniques.

Additionally to assess novel treatments for ADPKD and health care delivery associated with patient benefit at both an individual (personalised) and population level. This will include evaluating quality of life and health economics with the intention of improving the overall patient experience and care.

Current projects

  • Developing translational methods of measuring total kidney volume (TKV) to inform progression.
  • Identifying a prognostic signature for patients with rapidly progressive ADPKD involving functional MRI techniques.
  • Evaluating treatment for ADPKD.
  • Extrarenal manifestations of ADPKD including polycystic liver disease.
Teaching interests

I give lectures to medical and dental students attending the University of Sheffield. I also teach junior doctors and specialty nephrology trainees on the wards and at training days.

Professional activities
  • ADPKD Clinical Study Group (Renal Association) – Chair (2019-2022).
  • James Lind Alliance: ADPKD Priority Setting Partnership for ADPKD – Steering Committee (2019-2020).
  • CYSTic Consortium: European ADPKD cohort – Principle Investigator (UK).
  • COST Association: PARENCHIMA, to evaluate MRI biomarkers for chronic kidney disease - Management Committee (UK rep) (2016-current).
  • Renal Association Working Group for Tolvaptan in ADPKD – Member.
  • UK Renal Imaging Network Clinical Study Group - Member.
  • UK Renal Association – Member.
  • European Renal Association-European Dialysis and Transplant Association – Member.
  • Faculty of 1000 Medicine, Nephrology - Associate Faculty Member.