Dr Vincenzo Leo

BSc, PhD

Department of Infection, Immunity and Cardiovascular Disease

Honorary Research Fellow

Profile

I joined the University of Sheffield in January 2013 as a Postdoctoral Research Associate in the Haemostasis Research Group, working on the genetic analysis of platelet-function disorders on a British Heart Foundation (BHF) - funded programme known as the Genotyping and Phenotyping of Platelets (GAPP) study.

Before coming to Sheffield, I completed a PhD at the University of Leeds working on the characterisation of a mitochondrial fission protein using a mouse model of dilated cardiomyopathy.

Research interests

My research is aimed at enhancing our understanding of platelet function disorders by using next generation sequencing technologies to facilitate identification of the underlying genetic defect in large cohorts of patients suffering from haemorrhagic disorders.

Increasing understanding of the dysfunction occurring within platelets will aid the development of novel therapies for the treatment of haemorrhagic disorders and identify potential targets for anti-platelet agents for the treatment of myocardial infarction and stroke.

Publications

Journal articles

Research group
  • Maryam Aldossary
  • Essa Sabi
Grants

Funder name: British Heart Foundation

  • (Ref: PG/15/61/31634)
  • Title: Identification and characterisation of FLI1 and RUNX1 regulated determinants of platelet granule biogenesis and secretion.
  • Start date: 4th January 2016, End Date: 3rd January 2019
Teaching interests
  • Tutor on the Doctoral Development Programme (DDP) module MED640: Critical review of research papers.
  • Facilitator on the Achieve More - Health Challenge Module.
Professional activities

Committee Member of the Faculty of Medicine, Dentistry and Health Research Staff Association.