Dr Matteo De Marco
Department of Neuroscience
Non-Clinical Lecturer in Neuroscience of Dementia
+44 114 215 9106
Full contact details
Department of Neuroscience
N floor, Room N152
Royal Hallamshire Hospital
I completed my BSc studies in Psychology at the University of Trieste (Italy) in September 2006, and obtained a MSc in Neuropsychology at the same university in March 2009. I then joined the Department of Psychology at the University of Hull for my post-graduate studies.
I was awarded a Post-Graduate Certificate in Research Training in 2011 and completed a PhD in Cognitive Neuroscience at the University of Sheffield in December 2012. In the two-year period between 2013 and 2014 I worked as post-doctoral researcher at the IRCCS Fondazione San Camillo research hospital in Venice (Italy).
I moved back to Sheffield in December 2014 for a three-year post-doc within the Department of Neuroscience. In January 2018, finally, I was appointed to a lectureship.
- Research interests
- Circuital representation of cognitive function in healthy adults and in Alzheimer-related pathological ageing;
- Stimulation-induced changes in cerebral connectivity;
- Effect of genetic polymorphism on neural structure and function;
- Classificatory accuracy of machine-learning algorithms for the diagnosis of mild cognitive impairment;
- Biological correlates of volumetric MRI indices.
- Home-based cognitive training in early stage Alzheimer’s disease with the use of a tablet: A feasibility study", as P.I. in collaboration with Annalena Venneri and Riccardo Manca (Department of Neuroscience, University of Sheffield) and Khymeia Group
- Defining risk for conversion to dementia for patients with amnestic mild cognitive impairment using an index of semantic memory and ApoE genotype", as P.I. in collaboration with Annalena Venneri (Department of Neuroscience, University of Sheffield) and Ptolemaios Sarrigiannis (Department of Clinical Neurophysiology, Sheffield Teaching Hospitals).
- A quantitative EEG project to detect dysfunction of cerebellar modulation on specific neocortical areas. Can we identify the immune ataxias?", as Co.I. in collaboration with Ptolemaios Sarrigiannis (Department of Clinical Neurophysiology, Sheffield Teaching Hospitals), Marios Hadjivassiliou (Sheffield Ataxia Centre, Sheffield teaching Hospitals), Annalena Venneri (Department of Neuroscience, University of Sheffield) and Nigel Hoggard (Academic Unit of Radiology, University of Sheffield).
- A Randomized Pivotal Study of RenewTM NCP-5 for the Treatment of Mild Cognitive Impairment due to Alzheimer's Disease or Mild Dementia of the Alzheimer's Type" as Co.I. at the Sheffield centre in collaboration with Annalena Venneri (Department of Neuroscience, University of Sheffield)
- European Prevention of Alzheimer's Dementia Consortium (EPAD)" as Co.I. at the Sheffield centre in collaboration with Annalena Venneri (Department of Neuroscience, University of Sheffield)
- Using interictal seizure-free EEG data to recognise patients with epilepsy based on machine learning of brain functional connectivity. Biomedical Signal Processing and Control, 67.
- Targeting mechanisms in cognitive training for neurodegenerative diseases. Neural Regeneration Research, 16(3), 500-500.
- Obesity and brain vulnerability in normal and abnormal aging: a multimodal MRI study. Journal of Alzheimer's Disease Reports, 5(1), 65-77. View this article in WRRO
- Modulatory effects of cognitive exertion on regional functional connectivity of the salience network in women with ME/CFS: A pilot study. Journal of the Neurological Sciences, 117326-117326.
- Using graph theory to detect ageing and Alzheimer’s disease‐ related changes in the structure of cognitive networks. Alzheimer's & Dementia, 16(S6).
- Functional brain network correlates of theory of mind and social cognition in early Alzheimer’s disease. Alzheimer's & Dementia, 16(S5).
- Reduced monoaminergic nuclei MRI signal detectable in pre-symptomatic older adults with future memory decline. Scientific Reports, 10(1).
- The association between polygenic hazard scores and clinical markers of Alzheimer’s disease following stratification for APOE genotype. Alzheimer's & Dementia, 16(S4).
- Do deficits in mitochondrial spare respiratory capacity contribute to neuropsychological changes seen in Alzheimer’s disease?. Alzheimer's & Dementia, 16(S6).
- Exploring the effect of type 2 diabetes on brain structure and cerebral perfusion in patients with early Alzheimer’s disease. Alzheimer's & Dementia, 16(S4).
- The association between polygenic hazard and markers of Alzheimer’s disease following stratification for APOE genotype. Current Alzheimer Research, 17(7), 667-679.
- Neuroanatomical and cognitive correlates of domain-specific anosognosia in early Alzheimer’s disease. Cortex. View this article in WRRO
- Deficits in mitochondrial spare respiratory capacity contribute to the neuropsychological changes of alzheimer’s disease. Journal of Personalized Medicine, 10(2). View this article in WRRO
- Right fronto-parietal white matter disruption contributes to speech impairments in amyotrophic lateral sclerosis. Brain Research Bulletin, 158, 77-83.
- Imaging of nonlinear and dynamic functional brain connectivity based on EEG recordings with the application on the diagnosis of Alzheimer’s disease. IEEE Transactions on Medical Imaging. View this article in WRRO
- Age and hippocampal volume predict distinct parts of default mode network activity. Scientific Reports, 9(1). View this article in WRRO
- The association between distinct frontal brain volumes and behavioral symptoms in mild cognitive impairment, alzheimer's disease, and frontotemporal dementia. Frontiers in Neurology, 10. View this article in WRRO
- Altered frontal and insular functional connectivity as pivotal mechanisms for apathy in Alzheimer’s disease. Cortex, 119, 100-110. View this article in WRRO
- Understanding the effect of cognitive/brain reserve and depression on regional atrophy in early Alzheimer’s disease. Postgraduate Medicine. View this article in WRRO
- The modulatory effect of cerebrovascular burden in response to cognitive stimulation in healthy ageing and mild cognitive impairment. Neural Plasticity, 2019, 1-12. View this article in WRRO
- Left amygdala and putamen activation modulate emotion driven decisions in the iterated Prisoner’s Dilemma game. Frontiers in Neuroscience, 13. View this article in WRRO
- A study of within-subject reliability of the brain’s default-mode network. Magnetic Resonance Materials in Physics, Biology and Medicine, 32(3), 391-405. View this article in WRRO
- A Dementia Classification Framework using Frequency and Time-frequency Features based on EEG signals.. IEEE Transactions on Neural Systems and Rehabilitation Engineering. View this article in WRRO
- Brain activation in Highly Superior Autobiographical Memory: The role of the precuneus in the autobiographical memory retrieval network. Cortex. View this article in WRRO
- Beyond episodic memory: Semantic processing as independent predictor of hippocampal/perirhinal volume in aging and mild cognitive impairment due to Alzheimer’s disease.. Neuropsychology. View this article in WRRO
- A Pilot Study Investigating a Novel Non-Linear Measure of Eyes Open versus Eyes Closed EEG Synchronization in People with Alzheimer’s Disease and Healthy Controls. Brain Sciences, 8(7), 134-134. View this article in WRRO
- Motion artifacts in standard clinical setting obscure disease-specific differences in quantitative susceptibility mapping.. Physics in Medicine and Biology, 63(14), 14nt01-14nt01. View this article in WRRO
- O3-12-06: THE EFFECT OF BRAIN AND COGNITIVE RESERVE ON DECLARATIVE MEMORY: ARE WE NOT FORGETTING THEIR INTERACTIVE EFFECT?. Alzheimer's & Dementia, 14(7S_Part_19), P1053-P1054.
- Diagnostic and prognostic role of semantic processing in preclinical Alzheimer's disease.. Biomarkers in Medicine. View this article in WRRO
- Volume and Connectivity of the Ventral Tegmental Area are Linked to Neurocognitive Signatures of Alzheimer’s Disease in Humans. Journal of Alzheimer's Disease, 63(1), 167-180. View this article in WRRO
- Up-regulation of DMN Connectivity in Mild Cognitive Impairment Via Network-based Cognitive Training.. Current Alzheimer Research, 15(6), 578-589. View this article in WRRO
- Machine-learning Support to Individual Diagnosis of Mild Cognitive Impairment Using Multimodal MRI and Cognitive Assessments. Alzheimer Disease & Associated Disorders, 31(4), 278-286. View this article in WRRO
- White Matter Hyperintensity Load Modulates Brain Morphometry and Brain Connectivity in Healthy Adults: A Neuroplastic Mechanism?. Neural Plasticity, 2017. View this article in WRRO
- [P3-353]: AGEING, NOT ALZHEIMER's DISEASE, INFLUENCES TASK-POSITIVE BRAIN NETWORKS. Alzheimer's & Dementia, 13(7S_Part_22), P1091-P1091.
- THE VOLUME OF THE HUMAN VENTRAL TEGMENTAL AREA AS A POTENTIAL PRECLINICAL BIOMARKER OF ALZHEIMER’S DISEASE. Alzheimer's & Dementia, 13(7), P1541-P1541.
- Cognitive Efficiency in Alzheimer's Disease is Associated with Increased Occipital Connectivity.. Journal of Alzheimer's Disease, 57(2), 541-556.
- Cognitive Efficiency in Alzheimer's Disease is Associated with Increased Occipital Connectivity.. Journal of Alzheimer's Disease, 57(2), 541-556. View this article in WRRO
- ApoE ε4 allele relateted alterations in hippocampal connectivity in early Alzheimer's disease support memory performance.. Current Alzheimer Research, 14. View this article in WRRO
- The network substrate of confabulatory tendencies in Alzheimer's disease. Cortex, 87, 69-79. View this article in WRRO
- P3-231: Separating the Concurrent Effects of Ageing and Alzheimer's Disease in the Dysregulation of Default-Mode Network Connectivity. Alzheimer's & Dementia, 12, P914-P914.
- P1-365: Refined Semantic Memory Assessment Can Potentially Improve Clinical Diagnosis of Preclinical Alzheimer’s Disease. Alzheimer's & Dementia, 12, P571-P571.
- Cognitive stimulation of the default-mode network modulates functional connectivity in healthy aging. Brain Research Bulletin, 121, 26-41. View this article in WRRO
- Paradigm shift: semantic memory decline as a biomarker of preclinical Alzheimer's disease. Biomarkers in Medicine, 10(1), 5-8. View this article in WRRO
- Two Day-Date Processing Methods in an Autistic Savant Calendar Calculator. Journal of Autism and Developmental Disorders, 46(3), 1096-1102. View this article in WRRO
- Anatomical substrates and neurocognitive predictors of daily numerical abilities in mild cognitive impairment. Cortex, 71, 58-67. View this article in WRRO
- ‘O’ blood type is associated with larger grey-matter volumes in the cerebellum. Brain Research Bulletin, 116, 1-6. View this article in WRRO
- Morphometric correlates of dysarthric deficit in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 16(7-8), 464-472. View this article in WRRO
- Apolipoprotein E ε4 Allele Modulates the Immediate Impact of Acute Exercise on Prefrontal Function. Behavior Genetics, 45(1), 106-116.
- Integration of Cognitive Tests and Resting State fMRI for the Individual Identification of Mild Cognitive Impairment. Current Alzheimer Research, 12(6), 592-603.
- P2-211: PATTERNS OF HIPPOCAMPUS FUNCTIONAL CONNECTIVITY IN APOE ɛ4 CARRIERS WITH MILD COGNITIVE IMPAIRMENT. Alzheimer's & Dementia, 10, P550-P550.
- IC-P-219: INTEGRATION OF COGNITIVE TESTS AND RESTING STATE FMRI INDICES FOR THE IDENTIFICATION OF AMNESTIC MILD COGNITIVE IMPAIRMENT. Alzheimer's & Dementia, 10, P118-P118.
- Cognitive Stimulation: The Evidence Base for its Application in Neurodegenerative Disease. Current Alzheimer Research, 11(5), 469-483.
- P4-308: Morphometric evidence of neuroplastic effects induced by intensive cognitive stimulation in healthy ageing and in mild cognitive impairment. Alzheimer's & Dementia, 9, P817-P817.
- P3-346: Intensive cognitive stimulation increases function in the temporal cortex and precuneus in mild cognitive impairment. Alzheimer's & Dementia, 8(4S_Part_16), P578-P578.
- Functional Neural Architecture Supporting Highly Superior Autobiographical Memory. Brain Connectivity.
- Regional strength of large-scale functional brain networks is associated with regional volumes in older adults and in Alzheimer’s disease. Brain Connectivity.
- The Impact of COVID-19 Infection and Enforced Prolonged Social Isolation on Neuropsychiatric Symptoms in Older Adults With and Without Dementia: A Review. Frontiers in Psychiatry, 11.
- Mitochondrial Dysfunction in Alzheimer’s Disease: A Biomarker of the Future?. Biomedicines, 9(1), 63-63.
- Brain Morphometry: Alzheimer’s Disease, Neuromethods (pp. 217-240). Springer New York View this article in WRRO
- Ethical issues in the use of information and communication technologies in the health care of patients with neurological disorders, Neuro-Rehabilitation with Brain Interface (pp. 121-141).
Conference proceedings papers
- Volume and Functional Connectivity of the Ventral Tegmental Area as Early Markers of Alzheimer's Disease. NEUROLOGY, Vol. 90
- A novel quantitative EEG approach to distiguish Alzheimer’s disease from fronto tempura dementia and healthy controls. Journal of the Neurological Sciences, Vol. 381 (pp 319-319)
- QEEG CAN DISTINGUISH PATIENTS WITH AD AND VOLUNTEERS. Journal of Neurology, Neurosurgery & Psychiatry, Vol. 87(12) (pp e1.192-e1)
- O4-09-02: Quantitative Eeg Can Identify Difference Between Patients with Alzheimer's Disease and Healthy Volunteers on an Individual Level. Alzheimer's & Dementia, Vol. 12 (pp P353-P354)
- Network Correlates of Neurocognitive Efficiency at the Early Stages of Alzheimer's Neurodegeneration. NEUROLOGY, Vol. 86
- Teaching interests
- I regularly contribute to the University teaching programme for MSc students with lectures on research methodology and basic principles of neuroimaging and data analysis.
- I supervise post-graduate students as part of their MSc thesis projects, and, at the moment, I am co-supervisor of four PhD students.
- Professional activities
I contribute as Reviewer to the editorial process of peer-reviewed manuscripts submitted to neuroscience journals.