Dr Aymen I Idris

MSc, PhD

Department of Oncology and Metabolism

Senior Lecturer

aymen.idris@sheffield.ac.uk
+44 114 215 9051

Full contact details

Dr Aymen I Idris
Department of Oncology and Metabolism
Room DU38
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

I am a Pharmacologist and Senior Lecturer in pharmacology at the Department of Oncology & Metabolism, University of Sheffield (England, UK). My interest in musculoskeletal pharmacology began in 2000 when I joined Professor Stuart H. Ralston's group at the University of Aberdeen (Scotland, UK), where I obtained a PhD in Medicine and underwent my early postdoctoral training.

One of my particular areas of interests during this period was the effect of cannabis-like substances on bone biology and pharmacology. In this area, I carried out significant research on the skeletal effects of endocannabinoids and their receptors on bone biology with publications in Nature Medicine, Cell Metabolism and Aging Cell.

I also conducted research into the role of the NFkB signalling pathway in bone disease resulting in a number of publications in Endocrinology, FASEB J and JBMR, and a series of patents of a novel family of NFkB inhibitors, which exhibit anti-resorptive, anti-inflammatory and anti-tumour properties. Between 2010 and 2013, I held a position of non-clinical lecturer in cancer associated bone disease at Edinburgh Cancer Research UK Centre at the University of Edinburgh (Scotland, UK).

During this period, my group developed a number of model systems to study tumour – immune - bone cell interactions in vitro, ex vivo and in vivo, a system we have successfully utilized in our research and publications in Cancer Letters, Oncotarget and J.Bio.Chem.

I graduated with a BSc (Hons) degree from University of Sunderland, UK, and I obtained an MSc in Pharmacology working in Professor G. H. Hawksworth’s laboratory at the university of Aberdeen.

    Research interests

    The primary interest of my group is pharmacology of inflammation. The specific aims of our research are to:

    1. uncover novel druggable pro-inflammatory transduction pathways essential for the regulation of cancer – immune - bone cell interactions, and guided by these studies
    2. design and test novel therapeutic agents - alone or in combination with drugs in clinical practice - for the treatment of chronic inflammation associated with bone diseases and cancer.

    Current Projects

    • Targeting of IKK-Epsilon alone or in combination with chemotherapeutic drugs for breast cancer treatment.
    • Regulation of adipocyte – cancer cell crosstalk by NFkB signalling.
    • Role of TRAFs/NFkB signalling in inflammation associated with metastatic cancer.
    • Role of RANK/NFkB signalling in cancer cell behaviour in bone.
    • Regulation of bone – immune – malignant cell interactions by the Endocannabinoid/NFkB axis.
    Publications

    Books

    • Idris AI (2019) Bone Research Protocols. Humana Press. RIS download Bibtex download
    • Idris AI (2019) Preface. RIS download Bibtex download

    Journal articles

    Chapters

    Conference proceedings papers

    Patents

    • Idris A (2009) Ketones and reduced ketones as therapeutic agents for the treatment of bone conditions. PCT/GB2004/001958 Appl. 11 Aug 2009. RIS download Bibtex download
    • Idris A (2006) Aryl Alkyl Sulfonamides as therapeutic agents for the treatment of bone conditions. PCT/GB2005/002043 Appl. 26 Jan 2006. RIS download Bibtex download
    • Idris A (2004) Cannabinoid receptor inverse agonists as therapeutic agents for the treatment of bone disorders. PCT/GB2004/000858 Appl. 16 Sep 2004. RIS download Bibtex download

    Other

    Teaching interests
    • Supervise undergraduates, MSc and PhD students in my laboratory
    • Teach a module on hypothesis testing and experimental design in medical research
    • Teach and run tutorials on research skills to PhD students
    • Act as lead tutor to postgraduate students
    • Act as personal academic tutor to medical, MSc and PhD students
    Professional activities
    • Founder of the cloud-based software PubFund.
    • Editor, Springer Bone Research Protocols, 3rd edition (2019)
    • Editor-in-Chief and Founder, HubLE - The IFMRS Learning Environment (2019)
    • Associated editor at BoneKEy Reports (2013 - 2017)
    • Member of editorial board of Calcified Tissue International
    • Editor, Cancer and Bone, Calcified Tissue International (February, 2018)
    • Member of British Pharmacological Society (BPS), European Calcified Tissue Society (ECTS), International Bone and Mineral Society (IBMS) and American Society for Bone and Mineral Research (ASBMR).
    • Ad hoc reviewer for a number of national and international science journals and research charities.
    • Board member of the Calcified Tissue International Society (ECTS, 2010 – 2013).
    • Founder of the ECTS Postdoc Gathering and co-founder of ECTS New Investigator Seminar.
    • Co-founder and chair of the ECTS New Investigator Committee (2010 – 2013).

    Startup Companies

    1. PF SYSTEM Ltd - Founder of PF System Ltd. (Registration No: 11983932), a company established to develop the cloud-based software, PubFund in collaboration with a team of independent software engineers.
    2. ArthElix Ltd - Founder and shareholder of ArthElix Ltd. (Registration No: 10597512), a company established in 2017 to develop and test novel TRAF/NFkB inhibitors as a novel class of anti-rheumatic and anti-metastatic drugs.
    3. OSTEORX LIMITED - Co-founder and shareholder of OSTEORX LIMITED (Registration No: SC288265), a company established in 2005 to develop biphenyl-carboxylic acid compounds and their non-hydrolysable derivatives as a novel class of anti-rheumatic drugs. OSTEORX LIMITED and Modern Biosciences plc. have recently entered into an R&D alliance and global option and licence agreement with Janssen Biotech, Inc.

    Awards

    • Young investigator award (ECTS, 2007)
    • AMGEN/ECTS Bone Biology Fellowship
    • Young investigator award (ECTS, 2006)
    • IBMS Young investigator award (ECTS, 2005)
    • Young investigator award (ECTS, 2004)
    • Frontiers of Skeletal Biology Young investigator award (2002)