Dr Bernard Corfe
BSc PhD
Department of Oncology and Metabolism
Senior Lecturer in Oncology
Principal Investigator in Molecular Gastroenterology
Fellow of Insigneo
b.m.corfe@sheffield.ac.uk
+44 114 215 9044
+44 114 215 9044
G Floor, The Medical School
Full contact details
Dr Bernard Corfe
Department of Oncology and Metabolism
G Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Department of Oncology and Metabolism
G Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
-
I joined the University of Sheffield as a lecturer in 2002 following training in molecular pharmacology. My research training was in microbial molecular biology and my first postdoc was in Sheffield with Professor Anne Moir in the Department of Molecular Biology and Biotechnology. I subsequently worked with Professor Caroline Dive in Manchester, studying the regulation of apoptosis in response to chemotherapeutic drugs. It was through this research that I became interested in the regulation of apoptosis by butyrate.
- Research interests
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Work in my group examines the relationship between diet, short-chain fatty acid production and metabolism and cell fate in the normal and neoplastic colon. A detailed summary is found on my Research Page .
Butyrate and cell fate determination: Butyrate is of particular interest as it is described as an inhibitor of histone deacetylases – (although we disagree with this: Corfe, 2012) is in clinical trials or clinical use, yet it is also a fermentation product of the gut microbiome present at pharmacologically active concentrations in the normal healthy colon lumen. It has been implicated as a mechanism for cancer prevention by fibre. A growing literature recognises protein acetylation as a regulatory mechanism comparable with phosphorylation. My group studies the transcription factor Sp1 (Chirakkal et al., 2006; Waby et al., 2010, Yu et al., 2010) and the cytoskeletal proteins keratin 8, 18 and 19 (Leech et al., 2008; Corfe et al., 2015; Evans et al., 2015) all of whose functions are controlled, inter alia, by acetylation.Computational and Mathematical Modelling of the Colon: We have noted changes in the composition of cell types in the colon crypt in response to butyrate and to neoplasia (Yu et al., 2011) and we have developed fully semantic mathematical models to examine crypt cell fate determination (Smallbone & Corfe, 2014). We have extended into computational modelling in collaboration with Dawn Walker, and have developed novel agent-based models of the crypt and gut (Ingham Dempster et al., 2017).
Diet, Nutrition and Irritable Bowel Syndrome: IBS is a prevalent, complex, multifactorial and under-funded / under-researched condition. My team are actively investigating the potential of nutrients in management of IBS, particularly vitamin D (Tazzyman et al., 2015; Sprake et al., 2012).
Appetite Biology: Regulation of intake is controlled at least in part by colon-released anorexigenic hormones, and we have a long-standing interest in reationships between diet, enteroendocrine cells and appetite and energy intake. A body of our work is involved in mythbusting the relationships (Holt et al., 2016), as well as developing new approaches to research in this area (Harden et al., 2012).
Current Projects
EPSRC PhD Studentship. Systems modelling of the effect of short-chain fatty acids on tubulin isoforms and cytoskeletal integrity. Steve Wilkinson [PI], Bernard Corfe.
Bardhan Research and Education Trust. Expression and acetylation of keratins 8 and 18 in colonic mucosa of patients with Ulcerative Colitis: role in pathogenesis of colitis-associated colorectal neoplasia and dysplasia. Alan Lobo [PI], Bernard Corfe, Debrata Majumdar - £22,000.
Obsidian Ltd/Welsh Assembly/Cardiff University: Metagenomic analysis of alteration in gut microflora in response to probiotics.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Volatile organic compounds emitted from faeces as a biomarker for colorectal cancer. Alimentary Pharmacology & Therapeutics, 49(8), 1005-1012.
- Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: what do we know and what do we need to know?. European Journal of Clinical Nutrition. View this article in WRRO
- A cellular based model of the colon crypt suggests novel effects for Apc phenotype in colorectal carcinogenesis. Journal of Computational Science, 24, 125-131. View this article in WRRO
- Inflammation decreases keratin level in ulcerative colitis; inadequate restoration associates with increased risk of colitis-associated cancer. BMJ Open Gastroenterology, 2. View this article in WRRO
- Investigating the nutritional advice and support given to colorectal cancer survivors in the UK: is it fit for purpose and does it address their needs?. Journal of Human Nutrition and Dietetics. View this article in WRRO
- Protein for Life: Review of Optimal Protein Intake, Sustainable Dietary Sources and the Effect on Appetite in Ageing Adults. Nutrients, 10(3), 360-360. View this article in WRRO
- Dysbiosis of the gut microbiota in disease. Microbial Ecology in Health & Disease, 26(0). View this article in WRRO
All publications
Journal articles
- Comparing supermarket loyalty card data with traditional diet survey data for understanding how protein is purchased and consumed in older adults for the UK, 2014–16. Nutrition Journal, 19(1).
- Inadequacy of protein intake in older UK adults. Geriatrics, 5(1). View this article in WRRO
- From cell to multi-crypt: Agent-based models of the human colon suggests novel processes of field cancerisation. Journal of Computational Science. View this article in WRRO
- Do people change their diet after colorectal adenoma diagnosis?. Proceedings of the Nutrition Society, 79(OCE2).
- Vitamin D, muscle strength and physical function in UK South Asian older women. Proceedings of the Nutrition Society, 79(OCE2).
- The effect of protein supplementation and its timing on energy intake and appetite in a middle-older aged adult population. Proceedings of the Nutrition Society, 79(OCE2).
- Effect of vitamin D supplementation on irritable bowel syndrome symptom severity and quality of life. Proceedings of the Nutrition Society, 79(OCE1).
- Does timing of a protein supplement affect energy and macronutrient intakes and measures of appetite in a middle-older aged adult population?. Proceedings of the Nutrition Society, 79(OCE3).
- Protein valuation in food choice is positively associated with lean mass in older adults. The Journal of Nutrition, 149(11), 2056-2064. View this article in WRRO
- Rate of change of circulating 25-hydroxyvitamin D following sublingual and capsular vitamin D preparations. European Journal of Clinical Nutrition. View this article in WRRO
- Letter: studies of salivary pepsin in patients with gastro-oesophageal reflux disease. Authors’ reply. Alimentary Pharmacology & Therapeutics, 49(9), 1249-1250.
- Studies of salivary pepsin in patients with gastro‐oesophageal reflux disease. Alimentary Pharmacology & Therapeutics, 49(9), 1173-1180. View this article in WRRO
- Volatile organic compounds emitted from faeces as a biomarker for colorectal cancer. Alimentary Pharmacology & Therapeutics, 49(8), 1005-1012.
- Prospective Study of Psychological Morbidity and Illness Perceptions in Young People with Inflammatory Bowel Disease.. Journal of Crohn's and Colitis. View this article in WRRO
- Application of Proteomics to inflammatory bowel disease research: Current status and future perspectives. Gastroenterology Research and Practice, 2019. View this article in WRRO
- Predicting the selection of protein-containing foods in older adults. Appetite, 130, 300-300.
- Correction to: Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease. Proteome Science, 16(1). View this article in WRRO
- Protein for Life: Towards a focussed dietary framework for healthy ageing. Nutrition Bulletin, 43(1), 97-102. View this article in WRRO
- Nutritional screening, assessment and provision of advice for people living with and beyond cancer – a UK survey of clinicians. Proceedings of the Nutrition Society, 77(OCE1).
- Vitamin D status in irritable bowel syndrome and the impact of supplementation on symptoms: what do we know and what do we need to know?. European Journal of Clinical Nutrition. View this article in WRRO
- Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease. Proteome Science, 16(1). View this article in WRRO
- A cellular based model of the colon crypt suggests novel effects for Apc phenotype in colorectal carcinogenesis. Journal of Computational Science, 24, 125-131. View this article in WRRO
- The role of diet and nutrition on mental health and wellbeing. Proceedings of the Nutrition Society, 76(4), 425-426. View this article in WRRO
- Systematic literature review shows that appetite rating does not predict energy intake. Critical Reviews in Food Science and Nutrition, 57(16), 3577-3582. View this article in WRRO
- An agent-based model of anoikis in the colon crypt displays novel emergent behaviour consistent with biological observations. Royal Society Open Science, 4. View this article in WRRO
- Letter: risk factors and impacts of psychological morbidity in young people with inflammatory bowel disease - authors’ reply. Alimentary Pharmacology & Therapeutics, 44(4), 426-426. View this article in WRRO
- Systematic review: psychological morbidity in young people with inflammatory bowel disease - risk factors and impacts. Alimentary Pharmacology & Therapeutics, 44(1), 3-15. View this article in WRRO
- Systematic review of the impact of psychological morbidity and associated risk factors in young people with inflammatory bowel disease. Journal of Crohn's and Colitis, 10(Suppl 1), S151-S151. View this article in WRRO
- A deterministic oscillatory model of microtubule growth and shrinkage for differential actions of short chain fatty acids. Molecular BioSystems, 12(1), 93-101. View this article in WRRO
- Inflammation decreases keratin level in ulcerative colitis; inadequate restoration associates with increased risk of colitis-associated cancer. BMJ Open Gastroenterology, 2. View this article in WRRO
- Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: outcomes from a pilot trial. BMJ Open Gastroenterology, 2(1). View this article in WRRO
- Reduced keratin expression in colorectal neoplasia and associated fields is reversible by diet and resection. BMJ Open Gastroenterology, 2(1). View this article in WRRO
- Sedation practice and comfort during colonoscopy. European Journal of Gastroenterology & Hepatology, 27(6), 741-746.
- Su1897 Keratin 8 Expression Is Reduced in Active Ulcerative Colitis Relative to Proximal Inactive Mucosa. Gastroenterology, 148(4), S-547.
- The multifactorial interplay of diet, the microbiome and appetite control: current knowledge and future challenges. Proceedings of the Nutrition Society, 74(3), 235-244. View this article in WRRO
- Appetite is not a reliable predictor of energy intake: interim reporting of a systematic literature review. Proceedings of the Nutrition Society, 74(OCE1).
- PTU-064 Increased Mucosal Expression Of Insoluble Keratins 8, 18 And 19 In Long-standing Ulcerative Colitis In Comparison To Recent-onset Ulcerative Colitis: Validation Of Mass Spectrometry Data.. Gut, 63 Suppl 1, A66-A67.
- Pulsatile exposure to simulated reflux leads to changes in gene expression in a 3D model of oesophageal mucosa.. Int J Exp Pathol, 95(3), 216-228. View this article in WRRO
- Are proteins a redundant ontology? Epistemological limitations in the analysis of multistate species.. Mol Biosyst, 10(6), 1228-1235.
- Riboflavin in development and cell fate. Subcellular Biochemistry, 56, 229-245.
- A double blind, placebo controlled, randomised pilot trial examining the effects of probiotic administration on mood and cognitive function. Proceedings of the Nutrition Society, 73(OCE1).
- Nutrition Research and the Impact of Computational Systems Biology. Journal of Computer Science & Systems Biology, 6, 271-285.
- Alteration in enteroendocrine cell population in early colonic neoplasia. International Journal of Surgery, 11(8), 624-624.
- Expression of neuropilin-1 in the normal colonic epithelium is enteroendocrine-like. International Journal of Surgery, 11(8), 600-600.
- Promotion of cancer metastasis: candidate validation using an iTRAQ-based approach.. Expert Rev Proteomics, 10(4), 321-323.
- OC-092 Alteration in Mucosal Keratin 8 Level, Phosphorylation and Relative Ratio to Vimentin Associate with development of Colitis-Associated Cancer. Gut, 62(Suppl 1), A40.1-A40.
- OC-091 Are There Changes in Keratin Expression Profile in Active Colitis and in Colitis Phenotypes Associated with Increased Cancer Risk?. Gut, 62(Suppl 1), A39.2-A40.
- Histone deacetylase inhibitors: recent outcomes from clinical trials and the implications for oncology treatment approaches. Clinical Investigation, 3, 571-594.
- Histone deacetylase inhibitors: recent outcomes from clinical trials and the implications for oncology treatment approaches. Clinical Investigations, 3(6), 571-594.
- Modelling of metabolic control by Short Chain Fatty Acids at the level of the functional proteome - II: systems biology model of SCFA metabolism. PROCEEDINGS OF THE NUTRITION SOCIETY, 72(OCE4), E236-E236.
- Preliminary meta-analysis of the effect of fish oil on body weight and body mass index in overweight and obese subjects does not support a link. PROCEEDINGS OF THE NUTRITION SOCIETY, 72(OCE4), E283-E283.
- Modelling of metabolic control by Short Chain Fatty Acids at the level of the functional proteomic analysis. PROCEEDINGS OF THE NUTRITION SOCIETY, 72(OCE4), E229-E229.
- Application of the CIRAD mass spectrometry approach for lysine acetylation site discovery. Methods in Molecular Biology, 981, 13-23.
- Application of high content biology to yield quantitative spatial proteomic information on protein acetylations. Methods in Molecular Biology, 981, 37-45.
- Application of the MIDAS approach for analysis of lysine acetylation sites. Methods in Molecular Biology, 981, 25-36.
- Long-chain polyunsaturated fatty acid supplementation had no effect on body weight but reduced energy intake in overweight and obese women. Nutrition Research.
- A mathematical model of the colon crypt capturing compositional dynamic interactions between cell types. International Journal of Experimental Pathology.
- Application of the MIDAS approach for analysis of lysine acetylation sites.. Methods Mol Biol, 981, 25-36.
- Application of the CIRAD mass spectrometry approach for lysine acetylation site discovery.. Methods Mol Biol, 981, 13-23.
- Application of high content biology to yield quantitative spatial proteomic information on protein acetylations.. Methods Mol Biol, 981, 37-45.
- Water intake and post-exercise cognitive performance: an observational study of long-distance walkers and runners.. Eur J Nutr, 52(2), 617-624.
- Keratins in colorectal epithelial function and disease.. Int J Exp Pathol, 93(5), 305-318.
- QUANTITATIVE PROTEOMIC ANALYSIS OF INTERMEDIATE FILAMENT PROFILE IN ULCERATIVE COLITIS REVEALS INCREASED LEVELS OF KERATINS 8, 18 AND 19 IN PATIENTS WITH LONGSTANDING PAN COLITIS WHICH ARE REDUCED WITH DEVELOPMENT OF DYSPLASIA. GUT, 61, A176-A176.
- An integrated workflow for extraction and solubilization of intermediate filaments from colorectal biopsies for proteomic analysis.. Electrophoresis, 33(13), 1967-1974.
- QUANTITATIVE PROTEOMICS IN ULCERATIVE COLITIS REVEALS MUCOSAL INFLAMMATION REDUCES LEVELS OF KERATINS IN THE INSOLUBLE FRACTION OF THE INTERMEDIATE FILAMENT PROTEOME. GUT, 61, A176-A177.
- Uptake and metabolism of the short-chain fatty acid butyrate, a critical review of the literature.. Curr Drug Metab, 13(6), 815-821.
- Tu1311 Quantitative Proteomics in Ulcerative Colitis Reveals Mucosal Inflammation Reduces Levels of Keratins in the Insoluble Fraction of the Intermediate Filament Proteome. Gastroenterology, 142(5).
- Mo1592 Quantitative Proteomic Analysis of Intermediate Filament Profile in Ulcerative Colitis Reveals Increased Levels of Keratins 8, 18 and 19 in Patients With Longstanding Pan Colitis Which are Reduced With Development of Dysplasia. Gastroenterology, 142(5), S-636.
- Neuropilins: expression and roles in the epithelium.. Int J Exp Pathol, 93(2), 81-103.
- Hypothesis: butyrate is not an HDAC inhibitor, but a product inhibitor of deacetylation.. Mol Biosyst, 8(6), 1609-1612.
- Effect of different long-chain fatty acids on cholecystokinin release in vitro and energy intake in free-living healthy males.. Br J Nutr, 108(4), 755-758.
- The effect of different lipid emulsions on appetite and energy intake. Proceedings of the Nutrition Society, 71(OCE2).
- Saliva as a source of novel biomarkers of appetite. Proceedings of the Nutrition Society, 71(OCE2).
- Typology of Irritable bowel syndrome (IBS), dietary triggers and food and nutrient intake: a cross-sectional study. Proceedings of the Nutrition Society, 71(OCE2).
- Vitamin D3 as a novel treatment for irritable bowel syndrome: single case leads to critical analysis of patient-centred data.. BMJ case reports, 2012.
- Alteration in composition of keratin intermediate filaments in a model of breast cancer progression and the potential to reverse hallmarks of metastasis.. Cancer Biomark, 12(2), 49-64.
- Riboflavin depletion of intestinal cells in vitro leads to impaired energy generation and enhanced oxidative stress. European Journal of Nutrition, 1-9.
- Vitamin D3 as a novel treatment for irritable bowel syndrome: single case leads to critical analysis of patient-centred data.. BMJ Case Rep, 2012.
- Evaluation of the salivary proteome as a surrogate tissue for systems biology approaches to understanding appetite. Journal of Proteomics, 75(10), 2916-2923.
- Riboflavin in development and cell fate.. Subcell Biochem, 56, 229-245.
- Evaluation of the salivary proteome as a surrogate tissue for systems biology approaches to understanding appetite.. J Proteomics, 75(10), 2916-2923.
- A proteomic analysis of differential cellular responses to the short-chain fatty acids butyrate, valerate and propionate in colon epithelial cancer cells.. Mol Biosyst, 8(4), 1146-1156.
- Classification and functions of enteroendocrine cells of the lower gastrointestinal tract.. Int J Exp Pathol, 92(4), 219-231.
- Short-chain fatty acid level and field cancerization show opposing associations with enteroendocrine cell number and neuropilin expression in patients with colorectal adenoma.. Mol Cancer, 10, 27. View this article in WRRO
- Dietary intakes in people with irritable bowel syndrome.. BMC Gastroenterol, 11, 9. View this article in WRRO
- Modelling the microtubule: towards a better understanding of short-chain fatty acid molecular pharmacology.. Mol Biosyst, 7(4), 975-983.
- Keratin 8 expression in colon cancer associates with low faecal butyrate levels.. BMC Gastroenterol, 11, 2. View this article in WRRO
- Long chain fatty acids: in vitro cholecystokinin production and in vivo energy intake and body composition alteration. Proceedings of the Nutrition Society, 70(OCE3).
- The effect of supplementation with different oil emulsions on energy intake and body weight – the results of two different studies. Proceedings of the Nutrition Society, 70(OCE6).
- Development of a high throughput, quantitative assay of the effects of fungal-derived griseofulvin and cordycepin, and butyrate on the cytoskeleton. Proceedings of the Nutrition Society, 70(OCE3).
- Preliminary evaluation of the salivary proteome as a source of novel biomarkers of appetite. Proceedings of the Nutrition Society, 70(OCE6).
- Application of high content biology demonstrates differential responses of keratin acetylation sites to short chain fatty acids and to mitosis. Journal of Integrated OMICS, 1(2), 253-259.
- NF-κB is activated in oesophageal fibroblasts in response to a paracrine signal generated by acid-exposed primary oesophageal squamous cells. International Journal of Experimental Pathology, 92(5), 345-356. View this article in WRRO
- An ionic-gelling alginate drink attenuates postprandial glycaemia in males. Journal of Functional Foods.
- Riboflavin depletion impairs cell proliferation in adult human duodenum: Identification of potential effectors. Digestive Diseases and Sciences, 56(4), 1007-1019.
- Butyrate suppresses expression of neuropilin I in colorectal cell lines through inhibition of Sp1 transactivation.. Mol Cancer, 9, 276. View this article in WRRO
- Sp1 acetylation is associated with loss of DNA binding at promoters associated with cell cycle arrest and cell death in a colon cell line.. Mol Cancer, 9, 275. View this article in WRRO
- The development and characterization of an organotypic tissue-engineered human esophageal mucosal model.. Tissue Eng Part A, 16(3), 1053-1064. View this article in WRRO
- Assessing the Loss of Information through Application of the ‘Two-hit Rule’ in iTRAQ Datasets. Journal of Integrated Omics, 1(1), 124-134. View this article in WRRO
- Body mass index and age affect Three-Factor Eating Questionnaire scores in male subjects.. Nutr Res, 29(6), 379-382.
- Development and characterisation of a tissue engineered oesophagus. European Cells and Materials, 18(SUPPL. 2), 64.
- Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study. ALIMENT PHARM THER, 29(1), 97-103.
- A study protocol to investigate the relationship between dietary fibre intake and fermentation, colon cell turnover, global protein acetylation and early carcinogenesis: the FACT study.. BMC Cancer, 9, 332. View this article in WRRO
- Application of high-content analysis to the study of post-translational modifications of the cytoskeleton.. J Proteome Res, 8(1), 28-34.
- Daily ingestion of alginate reduces energy intake in free-living subjects.. Appetite, 51(3), 713-719.
- Alginate reduces the increased uptake of cholesterol and glucose in overweight male subjects: a pilot study.. Nutr Res, 28(8), 501-505.
- Critical role for fibre gelation in regulation of glucose uptake: implications for diabetes management. Proceedings of the Nutrition Society, 67(OCE8).
- Post-translational control of sp-family transcription factors.. Curr Genomics, 9(5), 301-311. View this article in WRRO
- Commonly used bowel preparations have significant and different effects upon cell proliferation in the colon: a pilot study.. BMC Gastroenterol, 8, 54. View this article in WRRO
- Proteomic analyses of intermediate filaments reveals cytokeratin8 is highly acetylated--implications for colorectal epithelial homeostasis.. Proteomics, 8(2), 279-288.
- The application of a hypothesis-driven strategy to the sensitive detection and location of acetylated lysine residues.. J Am Soc Mass Spectrom, 18(8), 1423-1428.
- Upregulation of BAK by butyrate in the colon is associated with increased Sp3 binding.. Oncogene, 25(54), 7192-7200.
- Nutritional strategies of mountain marathon competitors--an observational study.. International Journal of Sport Nutrition and Exercise Metabolism, 15(2), 160-172.
- Nutritional strategies of mountain marathon competitors--an observational study.. Int J Sport Nutr Exerc Metab, 15(2), 160-172.
- Mesalazine is safe for the treatment of IBD.. Gut, 53(1), 155.
- Diet and colorectal cancer: fibre back on the menu?. Gut, 53(1), 155-156.
- Suicide: a way of life: Programmed cell death. The Biochemist, 24(3), 9-11.
- Spore germination.. Cell Mol Life Sci, 59(3), 403-409.
- Damage-induced Bax N-terminal change, translocation to mitochondria and formation of Bax dimers/complexes occur regardless of cell fate.. EMBO J, 20(22), 6306-6315.
- Cellular damage signals promote sequential changes at the N-terminus and BH-1 domain of the pro-apoptotic protein Bak.. Oncogene, 20(52), 7668-7676.
- Damage-induced Bax N-terminal change and translocation to mitochondria occur regardless of cell fate. BRIT J CANCER, 85, 32-32.
- Localization of GerAA and GerAC germination proteins in the Bacillus subtilis spore.. J Bacteriol, 183(14), 4317-4322.
- The role of the Bcl-2 family proteins in integrating signals generated by drug-induced cellular damage. BRIT J PHARMACOL, 133, U132-U132.
- Damage-induced Bax N-terminal change and translocation to mitochondria occur regardless of cell fate. European Journal of Cancer, 37, S125-S125.
- Activation of the pro-apoptotic protein Bak is a two-step process. BRIT J CANCER, 83, 20-20.
- Changes in intercellular junctions during apoptosis precede nuclear condensation or phosphatidylserine exposure on the cell surface.. Cell Death Differ, 7(2), 234-235.
- Identification of a novel domain, distinct from BH1-3, critical for the activation by cellular damage of the pro-apoptotic protein Bak.. BRIT J CANCER, 80, 71-71.
- A conformational change in the pro-apoptotic protein Bak integrates diverse cellular damage signals. BRIT J CANCER, 80, 10-10.
- Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis.. J Cell Biol, 144(5), 903-914. View this article in WRRO
- Alanine germination receptors of Bacillus subtilis.. Lett Appl Microbiol, 23(5), 290-294.
- Analysis of the expression and regulation of the gerB spore germination operon of Bacillus subtilis 168.. Microbiology, 140 ( Pt 11), 3079-3083.
- Molecular genetical and phenotypical analysis of the gerM spore germination gene of Bacillus subtilis 168.. FEMS Microbiol Lett, 121(3), 315-320.
- The gerB region of the Bacillus subtilis 168 chromosome encodes a homologue of the gerA spore germination operon.. Microbiology, 140 ( Pt 3), 471-478.
- Investigating the nutritional advice and support given to colorectal cancer survivors in the UK: is it fit for purpose and does it address their needs?. Journal of Human Nutrition and Dietetics. View this article in WRRO
- Nutrition and cancer: evidence gaps and opportunities for improving knowledge. Proceedings of the Nutrition Society, 1-6.
- Protein for Life: Review of Optimal Protein Intake, Sustainable Dietary Sources and the Effect on Appetite in Ageing Adults. Nutrients, 10(3), 360-360. View this article in WRRO
- Correlation between Faecal Tumour M2 Pyruvate Kinase and Colonoscopy for the Detection of Adenomatous Neoplasia in a Secondary Care Cohort. Journal of Gastrointestinal and Liver Diseases, 25(1), 71-77.
- Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model. Journal of Visualized Experiments(99). View this article in WRRO
- Dysbiosis of the gut microbiota in disease. Microbial Ecology in Health & Disease, 26(0). View this article in WRRO
- A Novel High Throughput High Content Analysis Assay for Intermediate Filament Perturbing Drugs. Journal of Integrated OMICS, 4(1).
Conference proceedings papers
- Diet advice in colorectal cancer survivors - are we doing enough?. Proceedings of the Nutrition Society, Vol. 77(OCE1)
- Efficacy and comparative uptake rates of sublingual and capsular vitamin D preparations. Proceedings of the Nutrition Society, Vol. 77(OCE4)
- PWE-055 Health-related behaviours in young people with inflammatory bowel disease. Inflammatory Bowel Disease
- The effects of probiotic supplementation on emotional memory and pain response. Proceedings of the Nutrition Society, Vol. 76(OCE1)
- OC-048 The Use of Volatile Organic Compounds Emitted from Stool as a Biomarker for Colonic Neoplasia. Gut, Vol. 65(Suppl 1) (pp A28.1-A28)
- OC-087 Frequency of Health Risk Behaviours in Young People With Inflammatory Bowel Disease. Gut, Vol. 65(Suppl 1) (pp A51.1-A51)
- Systematic Literature Review Shows That Appetite Rating does Not Predict Energy Intake. Proceedings of the Nutrition Society, Vol. 75(OCE3)
- Analysis of Metachronous Adenoma Sites Suggest Proximal Occurrence is More Probable. BRITISH JOURNAL OF SURGERY, Vol. 102 (pp 73-73)
- Identification of Altered Keratin in Cancerized Colonic Fields using Isobaric Tags for Relative and Absolute Quantification (iTRAQ) for protein profiling. BRITISH JOURNAL OF SURGERY, Vol. 102 (pp 60-60)
- PTU-070 The fate of epithelial keratins in recent-onset and long-standing colitis in remission. Gut, Vol. 64(Suppl 1) (pp A91.1-A91)
- PTU-069 The fate of epithelial keratins in active ulcerative colitis. Gut, Vol. 64(Suppl 1) (pp A90.2-A90)
- PTU-059 “i can cope right now, because i know where i have come from”; a qualitative exploration of the lived experience of young adults with inflammatory bowel disease. Gut, Vol. 64(Suppl 1) (pp A85.2-A86)
- Keratin 8 Expression Is Reduced in Active Ulcerative Colitis Relative to Proximal Inactive Mucosa. GASTROENTEROLOGY, Vol. 148(4) (pp S547-S547)
- Hepatic Glyoxalase 1 is Downregulated and Hyperacetylated in Pediatric Non-alcoholic Fatty Liver Disease. HEPATOLOGY, Vol. 58 (pp 813A-814A)
- Neuropilin-1 expression in the normal colon is enteroendocrine-like. BRITISH JOURNAL OF SURGERY, Vol. 100 (pp 123-123)
- Comparison and Optimisation of a strategy to isolate a single cell population of epithelial cells from the crypt compartment of the murine colon. BRITISH JOURNAL OF SURGERY, Vol. 100 (pp 99-99)
- IDENTIFICATION OF ALTERED KERATIN LEVEL IN CANCERIZED COLONIC FIELDS USING ISOBARIC TAGS FOR RELATIVE AND ABSOLUTE QUANTIFICATION (ITRAQ) FOR PROTEIN PROFILING. GUT, Vol. 62 (pp A198-A198)
- ANALYSIS OF METACHRONOUS COLORECTAL ADENOMA SITES SUGGESTS PROXIMAL OCCURRENCE IS MORE PROBABLE. GUT, Vol. 62 (pp A229-A229)
- Cross-sectional analyses show no association between fibre intake and faecal butyrate level. PROCEEDINGS OF THE NUTRITION SOCIETY, Vol. 72(OCE4) (pp E235-E235)
- Barrett's Metaplasia: Exploiting a Tissue-engineered Model to Understand the Response of the Oesophageal Squamous Mucosa to Bile and Acid Exposure. JOURNAL OF PATHOLOGY, Vol. 228 (pp S3-S3)
- Why do Patients get Metachronous Colorectal Adenomas?. JOURNAL OF PATHOLOGY, Vol. 228 (pp S3-S3)
- Quantitative Proteomic Analysis of Intermediate Filament Profile in Ulcerative Colitis Reveals Increased Levels of Keratins 8, 18 and 19 in Patients With Longstanding Pan Colitis Which are Reduced With Development of Dysplasia. GASTROENTEROLOGY, Vol. 142(5) (pp S636-S636)
- Quantitative Proteomics in Ulcerative Colitis Reveals Mucosal Inflammation Reduces Levels of Keratins in the Insoluble Fraction of the Intermediate Filament Proteome. GASTROENTEROLOGY, Vol. 142(5) (pp S799-S800)
- Faecal butyrate levels have different effect on cancer and adenoma tissues: Suggestion of early beneficial role of butyrate during carcinogenesis. BRITISH JOURNAL OF SURGERY, Vol. 99 (pp 29-29)
- Neuropilin-1: A predictor of early carcinogenesis in the colonic epithelium. BRITISH JOURNAL OF SURGERY, Vol. 99 (pp 24-24)
- Short chain fatty acids regulate the structure and function of K8, A major cytoskeleton protein in colonocytes. BRITISH JOURNAL OF SURGERY, Vol. 99 (pp 30-30)
- The relationship between dietary micro and macronutrients intake and cell proliferation in the colon. Proceedings of the Nutrition Society, Vol. 70(OCE3)
- Invasive behaviour of the OE33 oesophageal adenocarcinoma cell line is dependent on co-operation with fibroblasts.. JOURNAL OF PATHOLOGY, Vol. 222 (pp S43-S43)
- Keratin 8, a determinant of colonocyte function, is regulated at the expression and function level by short chain fatty acids. BRITISH JOURNAL OF SURGERY, Vol. 97 (pp 12-12)
- Markers of epithelial mesenchymal transition precede morphological formation of colorectal adenoma. BRITISH JOURNAL OF SURGERY, Vol. 97 (pp 44-44)
- Butyrate-mediated apoptosis: Towards a mechanism of action. GUMS AND STABILIZERS FOR THE FOOD INDUSTRY 12(294) (pp 539-545)
- Butyrate-mediated cell cycle arrest of HCT116 colon carcinoma cells is accompanied by hyperploidy. GUMS AND STABILIZERS FOR THE FOOD INDUSTRY 12(294) (pp 535-538)
- The genetic analysis of bacterial spore germination.. J Appl Bacteriol, Vol. 77(3) (pp 9S-16S). England
- The genetic analysis of bacterial spore germination.. Journal of Applied Microbiology, Vol. 76 (pp 9S-16S). ENGLAND
- The genetic analysis of bacterial spore germination.. Soc Appl Bacteriol Symp Ser, Vol. 23 (pp 9S-16S). England
- Volatile organic compounds emitted from faeces as a biomarker for colorectal cancer. Alimentary Pharmacology & Therapeutics, 49(8), 1005-1012.
- Research group
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PhD Students
- Vicky Grant
- Dr Alenka Brooks
- Tim Ingham Dempster
- Claire Williams
- Dr Gloria Tun
- Dr Arash Assadsangabi
- Jon Wild
MD Students
- Sophie Matsell
- Marina Sanchez
- Sara Dedeche
- James Cater
Research Team
- Ms Joanna Chowdry
Clinical Trainees
- Jayan George
- Dr Suneil Raju
- Teaching interests
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I developed and lead Literature Review module for MSc Translational Oncology. I lead an In silico Oncology submodule for the MSc in Translational Oncology and I deliver the bioinformatics components of the cross-Faculty DDP in Proteomics-Informatics.
I previously developed and led the Literature Review Module in the MMedSci in Human Nutrition (2011), I developed and led the Research Skills Module (in 2011), which si used on Translational Oncology and Human nutrition, I developed and led the Molecular Nutrition Module (in 2008). Previously I led the Clinical Nutrition Module (in 2002) in the MMedSci in Human Nutrition.I run a course for The Nutrition Society on Scientific Writing.
- Professional activities
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Editorial Board Member for Molecular Physiology and Cell Signalling, European Journal of Nutrition.
Scientific Theme Leader, Cellular and Molecular Nutrition, Nutrition Society.
Organiser of CPD accredited conferences on Diet and Microbiome2013 ; Diet and Mental Health, 2016; Diet and Cancer Survivorship, 2017
Member of the Training and Education Committee, Nutrition Society.
Training courses in Bioinformatics for Proteomics, Scientific WritingMember of Steering Committee and Workstream Lead, NIHR Cancer and Nutrition Infrastructure Collaboration.
Associate Editor, International Journal of Experimental Pathology.
Associate Editor, Nutrition & Cancer.
Associate Editor, Journal of Integrated OMICS.Consulted for: INSERM, Norgine Ltd.
Manuscript reviewer for: Gut, Oncogene, Journal of Proteome Research, American Journal of Physiology, FEMS Microbiology Ecology, British Journal of Pharmacology, Nutrition and Cancer, Diversity, Clinical Biochemistry, Clinical and Experimental Immunology, Cell Death and Differentiation, Nutrition Journal, British Journal of Cancer, International Journal of Cancer.
Grant reviewer for: BBSRC, MRC, AICR, Tenovus, WCRF.