Professor Bernard Corfe

BSc PhD

Department of Oncology and Metabolism

Honorary Fellow

Professor of Human Nutrition and Health, Newcastle University.

Dr Bernard Corfe staff profile
b.m.corfe@sheffield.ac.uk

Full contact details

Professor Bernard Corfe
Department of Oncology and Metabolism
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

I was an academic at University of Sheffield from 2002-2021 following training in molecular pharmacology. I am currently Professor of Human Nutrition and Health at Newcastle University. I continue to collaborate closely with colleagues in Sheffield, including jointly supervising multiple PhD students.  

Research interests

Work in my group examines the relationship between diet, short-chain fatty acid production and metabolism and cell fate in the normal and neoplastic colon.  

Butyrate, cell fate determination and the role of keratins: Butyrate is described as an inhibitor of histone deacetylases – (although we disagree with this: Corfe, 2012), yet it is also a fermentation product of the gut microbiome present at pharmacologically active concentrations in the normal healthy colon lumen. It has been implicated as a mechanism for cancer prevention by fibre. A growing literature recognises protein acetylation as a regulatory mechanism comparable with phosphorylation. My group studies the cytoskeletal proteins keratin 8, 18 and 19 (Leech et al., 2008; Corfe et al., 2015; Evans et al., 2015) whose functions are controlled, inter alia, by acetylation and which are critical for normal metabolism in the colon, 

Diet, Nutrition and Irritable Bowel Syndrome: IBS is a prevalent, complex, multifactorial and under-funded / under-researched condition. My team are actively investigating the potential of nutrients in management of IBS, particularly vitamin D (Tazzyman et al., 2015). 

Publications

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Journal articles

All publications

Journal articles

Conference proceedings papers

  • Matsell SL, Sanchez Garcia MA, Williams EA & Corfe BM (2018) Diet advice in colorectal cancer survivors - are we doing enough?. Proceedings of the Nutrition Society, Vol. 77(OCE1) RIS download Bibtex download
  • Williams CE, Williams EA & Corfe BM (2018) Efficacy and comparative uptake rates of sublingual and capsular vitamin D preparations. Proceedings of the Nutrition Society, Vol. 77(OCE4) RIS download Bibtex download
  • Brooks AJ, Rowse G, Peach EJ, Ryder AH, Lees R, Narula P, Corfe BM, Norman P & Lobo AJ (2017) PWE-055 Health-related behaviours in young people with inflammatory bowel disease. Inflammatory Bowel Disease RIS download Bibtex download
  • Noorwali EA, Beaumont JD, Corfe BM & Owen L (2017) The effects of probiotic supplementation on emotional memory and pain response. Proceedings of the Nutrition Society, Vol. 76(OCE1) RIS download Bibtex download
  • Bond A, Greenwood R, Lewis S, Corfe B, Sarkar S, Rooney P & Probert C (2016) OC-048 The Use of Volatile Organic Compounds Emitted from Stool as a Biomarker for Colonic Neoplasia. Gut, Vol. 65(Suppl 1) (pp A28.1-A28) RIS download Bibtex download
  • Brooks AJ, Rowse G, Peach EJ, Ryder A, Narula P, Corfe BM, Norman P & Lobo AJ (2016) OC-087 Frequency of Health Risk Behaviours in Young People With Inflammatory Bowel Disease. Gut, Vol. 65(Suppl 1) (pp A51.1-A51) RIS download Bibtex download
  • Holt GM, Owen LJ, Till S, Cheng Y, Grant VA, Harden CJ & Corfe BM (2016) Systematic Literature Review Shows That Appetite Rating does Not Predict Energy Intake. Proceedings of the Nutrition Society, Vol. 75(OCE3) RIS download Bibtex download
  • Rosser R, Corfe BM & Chapple KS (2015) Analysis of Metachronous Adenoma Sites Suggest Proximal Occurrence is More Probable. BRITISH JOURNAL OF SURGERY, Vol. 102 (pp 73-73) RIS download Bibtex download
  • Rosser R, Evans CE, Chapple KS & Corfe BM (2015) Identification of Altered Keratin in Cancerized Colonic Fields using Isobaric Tags for Relative and Absolute Quantification (iTRAQ) for protein profiling. BRITISH JOURNAL OF SURGERY, Vol. 102 (pp 60-60) RIS download Bibtex download
  • Assad-Sangabi A, Evans C, Majumdar D, Cross SS, Corfe BM & Lobo AJ (2015) PTU-070 The fate of epithelial keratins in recent-onset and long-standing colitis in remission. Gut, Vol. 64(Suppl 1) (pp A91.1-A91) RIS download Bibtex download
  • Assad-Sangabi A, Evans C, Majumdar D, Cross SS, Corfe BM & Lobo AJ (2015) PTU-069 The fate of epithelial keratins in active ulcerative colitis. Gut, Vol. 64(Suppl 1) (pp A90.2-A90) RIS download Bibtex download
  • Brooks AJ, Rowse G, Ryder A, Narula P, Corfe BM, Norman P & Lobo AJ (2015) PTU-059 “i can cope right now, because i know where i have come from”; a qualitative exploration of the lived experience of young adults with inflammatory bowel disease. Gut, Vol. 64(Suppl 1) (pp A85.2-A86) RIS download Bibtex download
  • Assadsangabi A, Evans C, Majumdar D, Cross SS, Corfe BM & Lobo AJ (2015) Keratin 8 Expression Is Reduced in Active Ulcerative Colitis Relative to Proximal Inactive Mucosa. GASTROENTEROLOGY, Vol. 148(4) (pp S547-S547) RIS download Bibtex download
  • Moore JB, Spanos C, Fisher CP, Evans C, Corfe BM, Quaglia A, Fitzpatrick E & Dhawan A (2013) Hepatic Glyoxalase 1 is Downregulated and Hyperacetylated in Pediatric Non-alcoholic Fatty Liver Disease. HEPATOLOGY, Vol. 58 (pp 813A-814A) RIS download Bibtex download
  • Wild JRL, Gunawardene AR, Staton CA, Chapple KS & Corfe BM (2013) Neuropilin-1 expression in the normal colon is enteroendocrine-like. BRITISH JOURNAL OF SURGERY, Vol. 100 (pp 123-123) RIS download Bibtex download
  • Wild JRL, Staton CA, Chapple KS & Corfe BM (2013) Comparison and Optimisation of a strategy to isolate a single cell population of epithelial cells from the crypt compartment of the murine colon. BRITISH JOURNAL OF SURGERY, Vol. 100 (pp 99-99) RIS download Bibtex download
  • Rosser R, Evans CE, Chapple KS & Corfe BM (2013) IDENTIFICATION OF ALTERED KERATIN LEVEL IN CANCERIZED COLONIC FIELDS USING ISOBARIC TAGS FOR RELATIVE AND ABSOLUTE QUANTIFICATION (ITRAQ) FOR PROTEIN PROFILING. GUT, Vol. 62 (pp A198-A198) RIS download Bibtex download
  • Rosser R, Corfe BM & Chapple KS (2013) ANALYSIS OF METACHRONOUS COLORECTAL ADENOMA SITES SUGGESTS PROXIMAL OCCURRENCE IS MORE PROBABLE. GUT, Vol. 62 (pp A229-A229) RIS download Bibtex download
  • Williams EA, Lai DYL, Bury JP, Riley SA, Plummer S, Marchesi JR & Corfe BM (2013) Cross-sectional analyses show no association between fibre intake and faecal butyrate level. PROCEEDINGS OF THE NUTRITION SOCIETY, Vol. 72(OCE4) (pp E235-E235) RIS download Bibtex download
  • Green NH, Nicholls Z, Heath PR, Highley JR, Cooper-Knock J, Corfe BM, Wilson JH, Rattray M, Liu X, MacNeil S & Bury JP (2012) Barrett's Metaplasia: Exploiting a Tissue-engineered Model to Understand the Response of the Oesophageal Squamous Mucosa to Bile and Acid Exposure. JOURNAL OF PATHOLOGY, Vol. 228 (pp S3-S3) RIS download Bibtex download
  • Bury JP, Riley S, Evans CA, Williams EA, Staton CA, Murabito E, Smallbone K & Corfe BM (2012) Why do Patients get Metachronous Colorectal Adenomas?. JOURNAL OF PATHOLOGY, Vol. 228 (pp S3-S3) RIS download Bibtex download
  • Majumdar D, Evans C, Corfe BM & Lobo AJ (2012) Quantitative Proteomic Analysis of Intermediate Filament Profile in Ulcerative Colitis Reveals Increased Levels of Keratins 8, 18 and 19 in Patients With Longstanding Pan Colitis Which are Reduced With Development of Dysplasia. GASTROENTEROLOGY, Vol. 142(5) (pp S636-S636) RIS download Bibtex download
  • Majumdar D, Evans C, Corfe BM & Lobo AJ (2012) Quantitative Proteomics in Ulcerative Colitis Reveals Mucosal Inflammation Reduces Levels of Keratins in the Insoluble Fraction of the Intermediate Filament Proteome. GASTROENTEROLOGY, Vol. 142(5) (pp S799-S800) RIS download Bibtex download
  • Khan AQ, Wild J, Nai X, Brown S, Staton C, Brown S & Corfe B (2012) Faecal butyrate levels have different effect on cancer and adenoma tissues: Suggestion of early beneficial role of butyrate during carcinogenesis. BRITISH JOURNAL OF SURGERY, Vol. 99 (pp 29-29) RIS download Bibtex download
  • Wild JRL, Khan AQ, Li NX, Staton C, Chapple K & Corfe BM (2012) Neuropilin-1: A predictor of early carcinogenesis in the colonic epithelium. BRITISH JOURNAL OF SURGERY, Vol. 99 (pp 24-24) RIS download Bibtex download
  • Khan AQ, Waby JS, Brown S & Corfe B (2012) Short chain fatty acids regulate the structure and function of K8, A major cytoskeleton protein in colonocytes. BRITISH JOURNAL OF SURGERY, Vol. 99 (pp 30-30) RIS download Bibtex download
  • McGuinness C, O'Shea D, Gunawardene AR, Williams EA & Corfe BM (2011) The relationship between dietary micro and macronutrients intake and cell proliferation in the colon. Proceedings of the Nutrition Society, Vol. 70(OCE3) RIS download Bibtex download
  • Green N, Haque A, Corfe B, MacNeil S & Bury J (2010) Invasive behaviour of the OE33 oesophageal adenocarcinoma cell line is dependent on co-operation with fibroblasts.. JOURNAL OF PATHOLOGY, Vol. 222 (pp S43-S43) RIS download Bibtex download
  • Khan AQ, Waby J, Brown SR & Corfe BM (2010) Keratin 8, a determinant of colonocyte function, is regulated at the expression and function level by short chain fatty acids. BRITISH JOURNAL OF SURGERY, Vol. 97 (pp 12-12) RIS download Bibtex download
  • Khan AQ, Waby J, Brown SR & Corfe BM (2010) Markers of epithelial mesenchymal transition precede morphological formation of colorectal adenoma. BRITISH JOURNAL OF SURGERY, Vol. 97 (pp 44-44) RIS download Bibtex download
  • Chirakkal HC, Brookes KE, Prais AL & Corfe BM (2004) Butyrate-mediated apoptosis: Towards a mechanism of action. GUMS AND STABILIZERS FOR THE FOOD INDUSTRY 12(294) (pp 539-545) RIS download Bibtex download
  • Prais AL, Dive C & Corfe BM (2004) Butyrate-mediated cell cycle arrest of HCT116 colon carcinoma cells is accompanied by hyperploidy. GUMS AND STABILIZERS FOR THE FOOD INDUSTRY 12(294) (pp 535-538) RIS download Bibtex download
  • Moir A, Kemp EH, Robinson C & Corfe BM (1994) The genetic analysis of bacterial spore germination.. J Appl Bacteriol, Vol. 77(3) (pp 9S-16S). England RIS download Bibtex download
  • Moir A, Kemp EH, Robinson C & Corfe BM (1994) The genetic analysis of bacterial spore germination.. Journal of Applied Microbiology, Vol. 76 (pp 9S-16S). ENGLAND RIS download Bibtex download
  • Moir A, Kemp EH, Robinson C & Corfe BM (1994) The genetic analysis of bacterial spore germination.. Soc Appl Bacteriol Symp Ser, Vol. 23 (pp 9S-16S). England RIS download Bibtex download
Research group

PhD Students

  • Dr Alenka Brooks
  • Claire Williams 
  • Sabeen Zahra 
  • Abeir Elmogassabi 
  • Brenda Ojeda Lopez 
  • Azeer Zafar 

MD Students

  • Dr Thomas Archer
  • Dr Gloria Tun 
Professional activities
  • Editorial Board Member: European Journal of Nutrition.
  • Editorial Board Member: International Journal of Experimental Pathology. 
  • Trustee, Honorary Programmes Officer, Nutrition Society.
  • Associate Editor, Nutrition & Cancer.
  • Associate Editor, Journal of Integrated OMICS.