Dr Chryso Kanthou

BSc, MPhil, PhD

Department of Oncology and Metabolism

Reader

c.kanthou@sheffield.ac.uk
+44 114 215 9052

Full contact details

Dr Chryso Kanthou
Department of Oncology and Metabolism
Room FU31
The Medical School
Beech Hill Road
Sheffield
S10 2RX
Profile

I joined the University of Sheffield in 2005 as Senior Lecturer in the Department of Oncology. Before joining Sheffield, I worked at the Gray Cancer Institute in Northwood, Middlesex, as senior scientist (1999-2005) and as post-doctoral scientist at the Thrombosis Research Institute in London (1994-1999).

In 1994, I and was awarded my PhD in Cell and Molecular Biology by the University of London. Before embarking on my PhD studies I worked as a research assistant at the Ludwig Institute for Cancer Research London and King´s College Hospital Medical School.

In addition to my PhD, I also hold a BSc degree in Cell Biology and an MPhil degree also in Cell Biology, both from King´s College, London.

Research interests

My interests are in the field of endothelial vascular biology and angiogenesis. A main aim of my research is to understand the role played by factors within the tumour microenvironment in vessel network development and to decipher how this impacts on tumour response to vascular-targeted therapies.

I am particularly interested in studying molecular signalling pathways associated with the remodelling of the endothelial cytoskeleton, a target of vascular disrupting agents (VDAs) and ionizing radiation.

My research is part of a multidisciplinary approach aimed at investigating mechanisms at the molecular and cellular level that can then be tested at the level of the whole organism.


Current Projects

I am co-investigator on Professor Gillian Tozer´s `Tumour Microcirculation´ programme grant funded by Cancer Research UK. This programme focuses on the maturation phase of angiogenesis and interactions with vascular disrupting therapies.

The main aim is to investigate molecular mechanisms through which alternatively spliced variants of VEGF influence pericyte recruitment, differentiation and vessel stabilization and their relationship with endothelial responsiveness to VDAs.

Part of this work involves modeling the tumour microenvironment using co-culture systems of endothelial cells, pericytes and tumour cells under conditions of hypoxia and analysing signalling interactions.

I am principal investigator and work package leader on a collaborative European FP7-funded study investigating mechanisms of microvascular damage by ionizing radiation in the context of normal tissue damage, which is a crucial dose-limiting factor in radiotherapy.

Our main aim is to establish cellular and molecular mechanisms that mediate damaging effects of radiation on repair and angiogenesis within the microvasculature of the heart myocardium.

Publications

Journal articles

Chapters

  • Tozer G & Kanthou C (2009) Tumor vascular disrupting agents, Recent Advances in Angiogenesis and Antiangiogenesis (pp. 101-111). RIS download Bibtex download
  • Kanthou C, Tozer GM & Chaplin DJ (2007) Vascular disrupting agents in cancer therapy. In Marmé D & Fusenig N (Ed.), Tumor angiogenesis: Basic Mechanisms and Cancer Therapy (pp. 809-829). Springer Verlag RIS download Bibtex download
  • Kanthou C, Khelifi AL, Prise VE, Foresti R, Clarke JE, Motterlini R & Tozer GM (2002) Heme-oxygenase and the novel tumour-specific anti-vascular compound combetastatin A-4-phosphate In Abraham NG (Ed.), Hemeoxygenase in Biology and Medicine (pp. 303-312). Springer RIS download Bibtex download
  • Kanthou C, Benzakour O & Kakkar VV (1998) Cellular and molecular effects of thrombin in the vascular system In Maragoudakis ME (Ed.), Angiogenesis (pp. 263-282). Springer RIS download Bibtex download

Conference proceedings papers

  • Reyes-Aldasoro CC, Bjorndahl M, Kanthou C & Tozer GM (2017) Topological Analysis of the Vasculature of Angiopoietin-Expressing Tumours Through Scale-Space Tracing (pp 285-296) RIS download Bibtex download
  • English WR, Lunt SJ, Fisher M, Hurrell JE, Lefley DV, Mukherjee D, Daniel R, Lyons SK, Kanthou C & Tozer GM (2015) Abstract A57: Differential tumor cell expression of VEGF isoforms impacts on the tumor microenvironment, metastasis and radiation response in a mouse fibrosarcoma model. Translational and Therapeutic Potential of the Tumor Microenvironment RIS download Bibtex download
  • Drake TM, Kanthou C, Ritchie JE & Wyld L (2015) Activation of the Endoplasmic Reticulum Stress Pathwaymay Enhance the Radiosensitivity of Human Colorectal Cancer Cells in Vitro. BRITISH JOURNAL OF SURGERY, Vol. 102 (pp 6-6) RIS download Bibtex download
  • Bowyer S, Kanthou C & Reyes-Aldasoro CC (2014) Analysis of Capillary-like Structures Formed by Endothelial Cells in a Novel Organotypic Assay Developed from Heart Tissue.. MIUA (pp 235-240) RIS download Bibtex download
  • Williams L, Fisher M, Reyes-Aldasoro CC, Kanthou C & Tozer GM (2011) Abstract 1578: A critical role for RhoA-GTPase signaling in the tumor vascular disrupting action of combretastatin-A4-phosphatein vivo. Tumor Biology RIS download Bibtex download
  • Kalia N (2009) ABSTRACTS OF THE 59thMEETING OF THE BRITISH MICROCIRCULATION SOCIETY 30th– 31stMarch, 2009, The Medical School, University of Birmingham, UK. Microcirculation, Vol. 16(5) (pp 444-486) RIS download Bibtex download
  • Al-Jamal KT, Podesta JE, Al-Jamal WT, Akerman S, Turton JA, Kanthou C, Vargesson N, Tozer GM & Kostarelos K (2008) COLL 236-Dendrimeric nanocontainers as anti-angiogenic therapeutics. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 236 RIS download Bibtex download
  • Gabrys D, Tozer G & Kanthou C (2004) The effects of radiation and the anti-vascular agent Combretastatin A-4-Phosphate on the cytoskeleton of human endothelial cells and on enclothelial monolayer permeability. RADIOTHERAPY AND ONCOLOGY, Vol. 73 (pp S326-S326) RIS download Bibtex download
  • Ireson CR, Hill SA, Lewis G, Steele A, Coralli C, Dachs GU, Barber P, Honess D, Kanthou C, Shima D & Tozer G (2004) The role of tumour vascular maturation in determining response to tubulin-binding vascular targeting agents. BRITISH JOURNAL OF CANCER, Vol. 91 (pp S60-S60) RIS download Bibtex download
  • Brooks AC, Parkins CS, Kanthou C & Tozer GM (2003) Combretastatin A-4-phosphate (CA-4-P) activates NFB in human endothelial cells.. BRITISH JOURNAL OF CANCER, Vol. 88 (pp S28-S28) RIS download Bibtex download
  • Dachs GU, Kanthou C, Greco O, Coralli C & Tozer GM (2002) Effect of cell cycle on cellular HIF-1 alpha localisation. BRIT J CANCER, Vol. 86 (pp S99-S99) RIS download Bibtex download
  • Dachs GU, Kanthou C & Tozer GM (2002) Effect of radiation and combretastatin A-4-P on cellular localisation of hypoxia inducible factor 1. 22ND MEETING OF THE EUROPEAN SOCIETY FOR MICROCIRCULATION: MICROCIRCULATION AND VASCULAR BIOLOGY (pp 19-23) RIS download Bibtex download
  • Parkins CS, Cook IH, Kanthou C, Mapp P & Tozer GM (2002) Nitrotyrosination of endothelial alpha-tubulin: Potential effects on binding of the tumour vascular-targeting agent, combretastatin A-4-P. 22ND MEETING OF THE EUROPEAN SOCIETY FOR MICROCIRCULATION: MICROCIRCULATION AND VASCULAR BIOLOGY (pp 33-37) RIS download Bibtex download
  • Khelifi AF, Prise VE, Kanthou C, Clark JE, Foresti R, Motterlini R & Tozer GM (2001) Haem oxygenase and Combretastatin A4-Phosphate vascular damage. BRIT J CANCER, Vol. 85 (pp 35-35) RIS download Bibtex download
  • Holder AL, Tozer GM, Kanthou C, Davis PD, Douglas S & Blakey D (2000) In vitro characterization of the novel tumour vascular targeting agent ZD6126. BRIT J CANCER, Vol. 83 (pp 31-31) RIS download Bibtex download
  • Kanthou C, Tozer GM & Tumour Microcirculation Grp (2000) Studies on the mechanism of action of the vascular targeting agent combretastatin A-4 phosphate. BRIT J CANCER, Vol. 83 (pp 12-12) RIS download Bibtex download
  • Edmead C, Kanthou C & Benzakour O (1999) Thrombin activates transcription factors Sp1, NF-kappa B and CREB. Importance of the nuclear protein extraction procedure in the assessment of transcription factor DNA binding activities. THROMB HAEMOSTASIS (pp 299-299) RIS download Bibtex download
  • Kanthou C & Benzakour O (1999) Protein S is expressed by cultured human vascular smooth muscle cells (HVSMC). THROMB HAEMOSTASIS (pp 564-564) RIS download Bibtex download
  • Benzakour O, Kanthou C, Kanse S & Preissner K (1999) Identification of annexin-II as a receptor for the anti-coagulant factor, protein S, in human vascular smooth muscle cells. THROMB HAEMOSTASIS (pp 215-215) RIS download Bibtex download
  • Kanthou C & Benzakour O (1999) The anticoagulant factor protein S acts as a survival factor for cultured human vascular smooth muscle cells (HVSMC). THROMB HAEMOSTASIS (pp 241-242) RIS download Bibtex download
  • Yeh HI, Kanthou C, Dupont E, Lupu F & Severs NJ (1998) Differential effects of growth factors on gap junction expression in cultured human aortic smooth muscle cells. ATHEROSCLEROSIS, Vol. 136 (pp S51-S51) RIS download Bibtex download
  • Kanthou C, Kakkar VV & Benzakour O (1998) Cellular and molecular effects of thrombin in the vascular system.. ANGIOGENESIS, Vol. 298 (pp 263-282) RIS download Bibtex download
  • Lupu C, Kanthou C, Lupu F & Kakkar VV (1997) Heparin induces release of intracellular tissue factor pathway inhibitor from human endothelial cells in culture. THROMB HAEMOSTASIS (pp P2312-P2312) RIS download Bibtex download
  • Kanse SM, Kost C, Benzakour O, Kanthou C, Lijnen R & Preissner KT (1997) Urokinase-type plasminogen activator in vasoproliferative disorders: Induction of vascular smooth muscle cell proliferation indicates a novel mechanism of action. THROMB HAEMOSTASIS (pp O2377-O2377) RIS download Bibtex download
  • Kanthou C, Benzakour O, Kakkar VV & Lupu F (1997) Interactions of tissue type plasminogen activator (t-PA) with human vascular smooth muscle cells. THROMB HAEMOSTASIS (pp O1635-O1635) RIS download Bibtex download
  • Benzakour O, Kanthou C, Kanse SM, Gleig F, Dahlback B, Preissner KT & Kakkar VV (1997) Induction of human vascular smooth muscle cell proliferation by protein S: Binding studies and mechanism of action. THROMB HAEMOSTASIS (pp P2278-P2278) RIS download Bibtex download
  • Preissner KT, Kost C, Benzakour O, Kanthou C & Kanse SM (1997) Induction of vascular smooth muscle cell proliferation by urokinase indicates a novel mechanism of action in vasoproliferative disorders.. FASEB J, Vol. 11(3) (pp 898-898) RIS download Bibtex download
  • Briggs IM, Kanthou C, Moradoghli-Haftvani A, Esmail A, Kakkar VV & Lupu F (1996) Decreased expression of low density lipoprotein related protein (lrp) by the neointimal smooth muscle cells in rabbit balloon-injured abdominal aorta. Fibrinolysis, Vol. 10(SUPPL. 3) (pp 11) RIS download Bibtex download
  • Kanthou C, Das S, Kakkar VV & Lupu F (1996) Expression of some components of plasminogen activation (pa) pathway by arterial segments in organ culture after in vitro injury. Fibrinolysis, Vol. 10(SUPPL. 3) (pp 4) RIS download Bibtex download
  • KANTHOU C, DENNEHY U, BENZAKOU O & KAKKAR V (1995) CONVERSION OF PROTHROMBIN TO AN ENZYMATICALLY AND MITOGENICALLY ACTIVE FORM AT THE SURFACE OF HUMAN VASCULAR SMOOTH-MUSCLE CELLS. THROMB HAEMOSTASIS, Vol. 73(6) (pp 911-911) RIS download Bibtex download
  • BENZAKOUR O, FORMSTONE C, RAHMAN S, KANTHOU C, DENNEHY U, SCULLY MF, COOPER DN & KAKKAR VV (1995) EVIDENCE FOR PROTEIN-S RECEPTOR(S) ON HUMAN VASCULAR SMOOTH-MUSCLE CELLS - ANALYSIS OF THE BINDING CHARACTERISTICS AND MITOGENIC PROPERTIES OF PROTEIN-S ON HUMAN VASCULAR SMOOTH-MUSCLE CELLS. THROMB HAEMOSTASIS, Vol. 73(6) (pp 939-939) RIS download Bibtex download
  • KANSE SM, WIJELATH E, KANTHOU C, KOTHARI SS, KAKKAR VV & DEMOLIOUMASON C (1993) ENDOTHELIN (ET) IS A MITOGEN FOR HUMAN VASCULAR SMOOTH-MUSCLE CELLS (HVSMC). THROMB HAEMOSTASIS, Vol. 69(6) (pp 971-971) RIS download Bibtex download
  • WIJELATH E, HESS S, NEWMAN P, KANTHOU C, KAKKAR VV, PREISSNER KT & DEMOLIOUMASON C (1993) SUPPRESSION OF HUMAN VASCULAR SMOOTH-MUSCLE CELL (HVSMC) PROLIFERATION BY VITRONECTIN. THROMB HAEMOSTASIS, Vol. 69(6) (pp 971-971) RIS download Bibtex download
  • KANTHOU C, KANSE SM, KAKKAR VV & DEMOLIOUMASON C (1993) SIGNAL-TRANSDUCTION MECHANISMS INVOLVED IN THE MITOGENIC ACTIVITY OF THROMBIN IN HUMAN VASCULAR SMOOTH-MUSCLE CELLS (HVSMC). THROMB HAEMOSTASIS, Vol. 69(6) (pp 802-802) RIS download Bibtex download
  • KANTHOU C, KAKKAR VV & DEMOLIOUMASON C (1993) INHIBITION OF THROMBIN-INDUCED HUMAN VASCULAR SMOOTH CELL (HVSMC) PROLIFERATION BY INHIBITORS OF THROMBIN. THROMB HAEMOSTASIS, Vol. 69(6) (pp 804-804) RIS download Bibtex download
  • WIJELATH E, KANTHOU C, KAKKAR V & DEMOLIOUMASON C (1991) INHIBITION OF CELL-PROLIFERATION BY HEPARIN. THROMB HAEMOSTASIS, Vol. 65(6) (pp 993-993) RIS download Bibtex download
  • KANTHOU C, WIJELATH E, KAKKAR V & DEMOLIOUMASON C (1991) THE ROLE OF THROMBIN ON HUMAN VASCULAR SMOOTH-MUSCLE CELL-PROLIFERATION. THROMB HAEMOSTASIS, Vol. 65(6) (pp 732-732) RIS download Bibtex download
  • MELISSARI E, DAS S, KANTHOU C, PEMBERTON KD & KAKKAR VV (1991) THE USE OF LMW HEPARIN IN TREATING THROMBOEMBOLISM DURING PREGNANCY AND PREVENTION OF OSTEOPOROSIS. THROMB HAEMOSTASIS, Vol. 65(6) (pp 926-926) RIS download Bibtex download
  • KANTHOU C, PARKER C, HUBER DE, STROOBANT P, KAKKAR VV, PRINGLE N & RICHARDSON W (1987) PLATELET-DERIVED GROWTH-FACTOR A-CHAIN GENE ACTIVATION AND GROWTH-FACTOR PRODUCTION BY HUMAN AORTIC SMOOTH-MUSCLE CELLS. THROMB HAEMOSTASIS, Vol. 58(1) (pp 261-261) RIS download Bibtex download
  • PARKER CJ, KANTHOU C, STROOBANT P, HUBER DE, RICHARDSON W, PRINGLE N & KAKKAR VV (1987) ATHEROMA - A NEW HYPOTHESIS. BRIT J SURG, Vol. 74(6) (pp 526-526) RIS download Bibtex download
  • KAKKAR VV, FOK PJ, KANTHOU C & FREEMAN GE (1985) MODIFICATION OF PLATELET-DERIVED GROWTH-FACTOR BY ANTIPLATELET THERAPY AND ITS RELATIONSHIP TO VASCULAR GRAFT PATENCY. THROMB HAEMOSTASIS, Vol. 54(1) (pp 280-280) RIS download Bibtex download
  • KANTHOU C, FREEMAN GE & SCULLY M (1985) COMPARISON OF 3 MOLECULAR-WEIGHT FRACTIONS OF HEPARIN FOR THEIR ABILITY TO MODIFY PIG AORTIC SMOOTH-MUSCLE CELL (PASM) PROLIFERATION IN CULTURE. THROMB HAEMOSTASIS, Vol. 54(1) (pp 97-97) RIS download Bibtex download

Reports

  • Kanthou C (2012) Lexibulin, a vascular targeting agent and tubulin inhibitor for the potential treatment of solid tumors. View this article in WRRO RIS download Bibtex download
  • McMillan TJ, Bennett MR, Hendry J, Jones B, Kanthou C, Little MP, Taylor A, Tzoulaki I, Bouffler SD & Zhang W (2010) “Circulatory Disease Risk”, report of the independent Advisory Group on Ionising Radiation Published by the Health Protection Agency. View this article in WRRO RIS download Bibtex download
Research group

PhD Students

  • Zahra Gharaei
  • Venkata Satish Kolli
Teaching interests

I supervise and co-supervise several PhD, MSc and BMed Sciences students and Clinical Research Fellows.

I lecture on the MSc Molecular Medicine course at the School of Medicine in Sheffield, an MSc Radiation Biology course at University College London, and MSc Oncology course at the University of Nottingham. I also tutor MSc students and mentor PhD and Medical students.

Professional activities

I am a member of a sub-group of the Advisory Group on Ionising Radiation set up by the Health Protection Agency to consider circulatory disease risks of radiation and perform critical appraisal (since April 2008). I am also currently a member of the executive committee of the British Association for Cancer Research.