Miss Diane Lefley
MPhil, BEng
Department of Oncology and Metabolism
Research Assistant
Full contact details
Department of Oncology and Metabolism
Department of Oral Maxillofacial Medicine
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
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I first started working at the University of Sheffield in 2003, directly after my undergraduate degree finished, in Professor Ingunn Holen’s group working on the role of bisphosphonates on breast cancer cells and the bone environment. It was here that I completed my MPhil in 2009.
In 2012, I moved into Professor Gill Tozer’s group to work on tumour microcirculation, and in particular the role of fibrosis in specific VEGF expressing cells working under Dr. Will English.I am currently working on the role of saracatinib on bone tumours with Dr. David Andrew (Neurology, Dental School), Professor. Ingunn Holen and Dr. Dan Lambert.
- Research interests
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My main research interests are tumour/ bone environment, western blotting and flow cytometry.
Current project: The role of Saracatinib (src inhibitor) on bone pain.
- Publications
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Featured publications
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Journal articles
- Differential Expression of VEGFA Isoforms Regulates Metastasis and Response to Anti-VEGFA Therapy in Sarcoma. Cancer Research, 77(10). View this article in WRRO
- Erratum to: Loss of plakoglobin promotes cell-cell contact, increased invasion and breast cancer cell dissemination in vivo.. Breast Cancer Research, 19.
- IL-1 drives breast cancer growth and bone metastasis in vivo.. Oncotarget, 7, 75571-75584. View this article in WRRO
- Differential Expression of VEGFA Isoforms Regulates Metastasis and Response to Anti-VEGFA Therapy in Sarcoma. Cancer Research, 77(10). View this article in WRRO