Professor Jonathan Wadsley
MA MRCP FRCR
Department of Oncology and Metabolism
Honorary Professor
+44 114 226 5744
Full contact details
Department of Oncology and Metabolism
1st Floor Broomcross Building
Weston Park Hospital
Whitham Road
Sheffield
S10 2SJ
- Profile
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For enquiries, please contact - iicd-om-operational@sheffield.ac.uk
I was appointed a Consultant Clinical Oncologist at Weston Park Hospital in 2004. My clinical interests are in thyroid cancer, neuroendocrine tumours and pancreatic/biliary tract cancers. I am a member of the Sheffield European Neuorendocrine Tumour Society Centre of Excellence team and provide clinical leadership for the Sheffield molecular radiotherapy service.
I am academic director for the directorate of Specialised Cancer Services and Clinical Director of the Sheffield Cancer Clinical Trials Centre.
If have numerous national roles, including NIHR National Specialty Lead for Radiotherapy and Imaging, NIHR Cluster co-lead, chair of the NCRI Thyroid Cancer Group, and I am a member of ARSAC.
- Qualifications
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- MBBChir University of Cambridge
- MA University of Cambridge
- MRCP
- FRCR
- Research interests
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My research interests reflect my clinical interests, in thyroid cancer, neuroendocrine tumours and pancreatic cancer. I have a particular interest in molecular radiotherapy dosimetry research and I am Chief Investigator of the multicentre SELIMETRY trial.
- Publications
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Show: Featured publications All publications
Featured publications
Journal articles
- Recommendations for multicentre clinical trials involving dosimetry for molecular radiotherapy. Clinical Oncology, 33(2), 131-136.
- Molecular Radiotherapy Comes of Age. Clinical Oncology, 33(2), 65-67.
- Radiotherapy Trial Set-up in the UK: Identifying Inefficiencies and Potential Solutions. Clinical Oncology, 32(4), 266-275.
- Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study. The Lancet Oncology, 20(5), 663-673.
- Recurrence after low-dose radioiodine ablation and recombinant human thyroid-stimulating hormone for differentiated thyroid cancer (HiLo): long-term results of an open-label, non-inferiority randomised controlled trial. The Lancet Diabetes and Endocrinology, 7(1), 44-51. View this article in WRRO
- Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial. The Lancet, 389(10073), 1011-1024. View this article in WRRO
- Vandetanib plus gemcitabine versus placebo plus gemcitabine in locally advanced or metastatic pancreatic carcinoma (ViP): a prospective, randomised, double-blind, multicentre phase 2 trial. The Lancet Oncology.
- Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial. The Lancet Oncology, 15(8), 829-840.
- Docetaxel versus active symptom control for refractory oesophagogastric adenocarcinoma (COUGAR-02): an open-label, phase 3 randomised controlled trial. The Lancet Oncology, 15(1), 78-86.
- Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): A prospectively stratified randomised trial. The Lancet Oncology, 14(8), 749-759.
- Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial. LANCET ONCOLOGY, 14(6), 481-489.
- Feasibility of preoperative chemotherapy for locally advanced, operable colon cancer: The pilot phase of a randomised controlled trial. The Lancet Oncology, 13(11), 1152-1160.
- Ablation with low-dose radioiodine and thyrotropin alfa in thyroid cancer.. N Engl J Med, 366(18), 1674-1685.
- Investigation of relationship between change in locoregional control and change in overall survival in randomized controlled trials of modified radiotherapy in head-and-neck cancer. International Journal of Radiation Oncology Biology Physics, 60(5), 1405-1409.
- Standardised quantitative radioiodine SPECT/CT Imaging for multicentre dosimetry trials in molecular radiotherapy. Physics in Medicine & Biology, 64(24), 245013-245013.
All publications
Journal articles
- Mental health burden for NHS healthcare staff during the COVID-19 pandemic: First results of a longitudinal survey. Heliyon, e13765-e13765.
- Significance of alterations in DNA damage repair (DDR) genes in advanced biliary cancers (ABCs) treated with second-line active-symptom-control (ASC) alone or ASC with oxaliplatin/5-FU chemotherapy (ASC+FOLFOX) in the randomised phase III, multicentre, open-label ABC-06 trial.. Journal of Clinical Oncology, 41(4_suppl), 593-593.
- NET-02 final results: A randomised, phase II trial of liposomal irinotecan (nal-IRI)/5-fluorouracil (5-FU)/folinic acid or docetaxel as second-line (2L) therapy in patients (pts) with progressive poorly differentiated extrapulmonary neuroendocrine carcinoma (PD-EP-NEC).. Journal of Clinical Oncology, 41(4_suppl), 646-646.
- Safeguarding Clinical Research in the National Health Service. Clinical Oncology.
- Immediate surgery compared with short-course neoadjuvant gemcitabine plus capecitabine, FOLFIRINOX, or chemoradiotherapy in patients with borderline resectable pancreatic cancer (ESPAC5): a four-arm, multicentre, randomised, phase 2 trial. The Lancet Gastroenterology & Hepatology.
- Dabrafenib and Trametinib Therapy for Advanced Anaplastic Thyroid Cancer – Real-World Outcomes From UK Centres. Clinical Oncology.
- Guidelines on the Use of Systemic Therapy in Patients with Advanced Thyroid Cancer. Clinical Oncology.
- Quality of life in post-surgical hypoparathyroidism (PoSH) in thyroid and parathyroid surgery. World Journal of Surgery, 46(12), 3025-3033.
- Health-related quality of life (HRQoL) in patients (pts) with progressive, poorly differentiated, extra-pulmonary neuroendocrine carcinoma (PD-EP-NEC) enrolled in NET-02: A phase II trial of liposomal irinotecan (nal-IRI)/5-fluorouracil (5-FU)/folinic acid or docetaxel as second-line therapy.. Journal of Clinical Oncology, 40(28_suppl), 293-293.
- 54MO Quality of life (QoL) and value of health (V-He) in advanced biliary cancers (ABC) treated with second-line active-symptom-control (ASC) alone or ASC with oxaliplatin/5-FU chemotherapy (ASC+FOLFOX) in the randomised phase III, multi-centre, open-label ABC-06 trial. Annals of Oncology, 33, S564-S565.
- Patient Preparation and Radiation Protection Guidance for Adult Patients Undergoing Radioiodine Treatment for Thyroid Cancer in the UK. Clinical Oncology.
- Body composition parameters as survival predictors in patients with pancreatic cancer – A retrospective multicenter analysis. Zeitschrift für Gastroenterologie, 60(08), e530-e530.
- Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis. The Lancet, 400(10349), 359-368.
- Importance of clinical research for the UK's 10-year cancer plan. The Lancet Oncology. View this article in WRRO
- NET-02: A multicenter, randomized, phase II trial of liposomal irinotecan (nal-IRI) and 5-fluorouracil (5-FU)/folinic acid or docetaxel as second-line therapy in patients (pts) with progressive poorly differentiated extra-pulmonary neuroendocrine carcinoma (PD-EP-NEC).. Journal of Clinical Oncology, 40(16_suppl), 4005-4005.
- P-88 Clinical role of tumour markers in advanced biliary cancers (ABC) treated with second-line active-symptom-control (ASC) alone or ASC with oxaliplatin/5-FU chemotherapy (ASC+mFOLFOX) in the randomised phase III, multi-centre, open-label ABC-06 trial. Annals of Oncology, 33, S280-S280.
- Identifying ways to improve diabetes management during cancer treatments (INDICATE): protocol for a qualitative interview study with patients and clinicians. BMJ Open, 12(2).
- Hypofractionated radiotherapy to the pancreas: U.K. experience.. Journal of Clinical Oncology, 40(4_suppl), 525-525.
- A rare case of NUT carcinoma arising in the thyroid. Diagnostic Histopathology.
- 1476P Is it worth adding concurrent chemo-radiotherapy or radiotherapy on the top of neoadjuvant chemotherapy in the management of borderline resectable and locally advanced pancreatic adenocarcinoma? A systematic review. Annals of Oncology, 32, s1090.
- Second-line FOLFOX chemotherapy for advanced biliary tract cancer – Authors' reply. The Lancet Oncology, 22(7), e288-e289.
- Maintenance durvalumab after first-line platinum-based chemotherapy in advanced oesophago-gastric (OG) adenocarcinoma: Results from the PLATFORM trial.. Journal of Clinical Oncology, 39(15_suppl), 4015-4015.
- Digital histological markers based on routine H&E slides to predict benefit from maintenance immunotherapy in esophagogastric adenocarcinoma.. Journal of Clinical Oncology, 39(15_suppl), e16074-e16074.
- Efficacy of Reduced-Intensity Chemotherapy With Oxaliplatin and Capecitabine on Quality of Life and Cancer Control Among Older and Frail Patients With Advanced Gastroesophageal Cancer: The GO2 Phase 3 Randomized Clinical Trial.. JAMA Oncol.
- Second-line FOLFOX chemotherapy versus active symptom control for advanced biliary tract cancer (ABC-06): a phase 3, open-label, randomised, controlled trial.. Lancet Oncol.
- Recommendations for multicentre clinical trials involving dosimetry for molecular radiotherapy. Clinical Oncology, 33(2), 131-136.
- Molecular Radiotherapy Comes of Age. Clinical Oncology, 33(2), 65-67.
- ESPAC-4: A randomized controlled phase III trial of adjuvant gemcitabine (GEM) and capecitabine (CAP) versus gemcitabine in resected pancreatic ductal adenocarcinoma: five year follow up.. Pancreatology, 20, S17-S18.
- Scheduling nab-paclitaxel combined with gemcitabine as first-line treatment for metastatic pancreatic adenocarcinoma. British Journal of Cancer, 122(12), 1760-1768.
- ESPAC-5F: Four-arm, prospective, multicenter, international randomized phase II trial of immediate surgery compared with neoadjuvant gemcitabine plus capecitabine (GEMCAP) or FOLFIRINOX or chemoradiotherapy (CRT) in patients with borderline resectable pancreatic cancer.. Journal of Clinical Oncology, 38(15_suppl), 4505-4505.
- ESPAC-4: A multicenter, international, open-label randomized controlled phase III trial of adjuvant combination chemotherapy of gemcitabine (GEM) and capecitabine (CAP) versus monotherapy gemcitabine in patients with resected pancreatic ductal adenocarcinoma: Five year follow-up.. Journal of Clinical Oncology, 38(15_suppl), 4516-4516.
- A pragmatic assessment of the British Thyroid Association “U classification” of thyroid nodules with a focus on their follow-up. Clinical Radiology, 75(6), 466-473.
- NET-02 trial protocol: a multicentre, randomised, parallel group, open-label, phase II, single-stage selection trial of liposomal irinotecan (nal-IRI) and 5-fluorouracil (5-FU)/folinic acid or docetaxel as second-line therapy in patients with progressive poorly differentiated extrapulmonary neuroendocrine carcinoma (NEC). BMJ Open, 10(2). View this article in WRRO
- Evaluating maintenance therapies in advanced oesophago-gastric adenocarcinoma (OGA): Interim analysis and biomarker results from the PLATFORM study.. Journal of Clinical Oncology, 38(4_suppl), 282-282.
- Expert Consensus on the Management of Adverse Events During Treatment with Lenvatinib for Thyroid Cancer. Clinical Oncology, 32(5), e145-e153.
- Radiotherapy Trial Set-up in the UK: Identifying Inefficiencies and Potential Solutions. Clinical Oncology, 32(4), 266-275.
- CTRad 10 Years On: From 10-point Plan to Top 10 Achievements. Clinical Oncology, 32(1), 9-12.
- OPTIMIZING CHEMOTHERAPY FOR FRAIL AND/OR ELDERLY PATIENTS WITH ADVANCED GASTROESOPHAGEAL CANCER (AGOAC): THE GO2 PHASE III TRIAL. Journal of Geriatric Oncology, 10(6), S8-S8.
- Peri-operative FLOT versus ECX chemotherapy in operable lower oesophageal adenocarcinoma – a South Yorkshire experience. Clinical Oncology, 31, e8-e8.
- Patterns of Recurrence After Resection of Pancreatic Ductal Adenocarcinoma. JAMA Surgery, 154(11), 1038-1038.
- Investigating the potential clinical benefit of Selumetinib in resensitising advanced iodine refractory differentiated thyroid cancer to radioiodine therapy (SEL-I-METRY): protocol for a multicentre UK single arm phase II trial. BMC Cancer, 19(1). View this article in WRRO
- Can digital skeletal muscle index predict palliative chemotherapy uptake before patients undergo endoscopic pancreatic biopsy?. Pancreatology, 19, S106-S107.
- OWE-29 Can digital skeletal muscle index predict palliative chemotherapy uptake before patients undergo endoscopic pancreatic biopsy?. Pancreas.
- Optimizing chemotherapy for frail and elderly patients (pts) with advanced gastroesophageal cancer (aGOAC): The GO2 phase III trial.. Journal of Clinical Oncology, 37(15_suppl), 4006-4006.
- ABC-06 | A randomised phase III, multi-centre, open-label study of active symptom control (ASC) alone or ASC with oxaliplatin / 5-FU chemotherapy (ASC+mFOLFOX) for patients (pts) with locally advanced / metastatic biliary tract cancers (ABC) previously-treated with cisplatin/gemcitabine (CisGem) chemotherapy.. Journal of Clinical Oncology, 37(15_suppl), 4003-4003.
- NET-02: A multi-center, randomised, phase II trial of liposomal irinotecan (nal-IRI) and 5-fluorouracil (5-FU)/folinic acid or docetaxel as second-line therapy in patients (pts) with progressive poorly differentiated extra-pulmonary neuroendocrine carcinoma (PD-EP-NEC).. Journal of Clinical Oncology, 37(15_suppl), TPS4158-TPS4158.
- Differentiated Thyroid Cancer in Children: A UK Multicentre Review and Review of the Literature. Clinical Oncology, 31(6), 385-390.
- Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study. The Lancet Oncology, 20(5), 663-673.
- Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model. Health Technology Assessment, 23(8), 1-144. View this article in WRRO
- Ramucirumab with cisplatin and fluoropyrimidine as first-line therapy in patients with metastatic gastric or junctional adenocarcinoma (RAINFALL): a double-blind, randomised, placebo-controlled, phase 3 trial. The Lancet Oncology, 20(3), 420-435.
- Recurrence after low-dose radioiodine ablation and recombinant human thyroid-stimulating hormone for differentiated thyroid cancer (HiLo): long-term results of an open-label, non-inferiority randomised controlled trial. The Lancet Diabetes and Endocrinology, 7(1), 44-51. View this article in WRRO
- The National Institute for Health Research: making an impact in imaging research. Clinical Radiology, 74(3), 242-246.
- Genomic loss of heterozygosity and survival in the REAL3 trial. Oncotarget, 9(94), 36654-36665. View this article in WRRO
- Gefitinib and EGFR Gene Copy Number Aberrations in Esophageal Cancer. Journal of Clinical Oncology, 35(20), 2279-2287.
- SELIMETRY- a multicentre I-131 dosimetry trial: a clinical perspective. The British Journal of Radiology, 90(1073). View this article in WRRO
- Radioiodine for High Risk and Radioiodine Refractory Thyroid Cancer: Current Concepts in Management. Clinical Oncology, 29(5), 307-309.
- Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial. The Lancet, 389(10073), 1011-1024. View this article in WRRO
- Vandetanib plus gemcitabine versus placebo plus gemcitabine in locally advanced or metastatic pancreatic carcinoma (ViP): a prospective, randomised, double-blind, multicentre phase 2 trial. The Lancet Oncology.
- Day-case Treatment with Radioactive I-131 for Thyroid Cancer. Clinical Oncology.
- Adult Thyroglossal Duct Carcinoma of Thyroid Epithelial Origin: A Retrospective Observational Study. Indian Journal of Otolaryngology and Head and Neck Surgery, 1-6. View this article in WRRO
- The HABP2 G534E Variant Is an Unlikely Cause of Familial Nonmedullary Thyroid Cancer. The Journal of Clinical Endocrinology & Metabolism, 101(3), 1098-1103.
- The relationship between smoking and quality of life in advanced lung cancer patients: a prospective longitudinal study. Supportive Care in Cancer, 24(4), 1507-1516. View this article in WRRO
- Quality of life, support and smoking in advanced lung cancer patients: a qualitative study. BMJ Supportive & Palliative Care, 6(1), 35-42.
- Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial. The Lancet Oncology, 15(8), 829-840.
- Treatment related morbidity in differentiated thyroid cancer–a survey of clinicians. Thyroid Research, 7(1), 3-3. View this article in WRRO
- The effects of gemcitabine and capecitabine combination chemotherapy and of low-dose adjuvant GM-CSF on the levels of myeloid-derived suppressor cells in patients with advanced pancreatic cancer. Cancer Immunology, Immunotherapy, 63(2), 175-183.
- Sentinel node biopsy in papillary thyroid cancer—what is the potential?. Langenbeck's Archives of Surgery, 399(2), 245-251.
- Docetaxel versus active symptom control for refractory oesophagogastric adenocarcinoma (COUGAR-02): an open-label, phase 3 randomised controlled trial. The Lancet Oncology, 15(1), 78-86.
- Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): A prospectively stratified randomised trial. The Lancet Oncology, 14(8), 749-759.
- A phase III randomized trial of chemoimmunotherapy comprising gemcitabine and capecitabine with or without telomerase vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer.. Journal of Clinical Oncology, 31(15_suppl), LBA4004-LBA4004.
- Cougar-02: A randomized phase III study of docetaxel versus active symptom control in patients with relapsed esophago-gastric adenocarcinoma.. Journal of Clinical Oncology, 31(15_suppl), 4023-4023.
- Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial. LANCET ONCOLOGY, 14(6), 481-489.
- A randomised phase III trial of the pharmacokinetic biomodulation of irinotecan using oral ciclosporin in advanced colorectal cancer: Results of the Panitumumab, Irinotecan & Ciclosporin in COLOrectal cancer therapy trial (PICCOLO). European Journal of Cancer, 49(16), 3507-3516.
- Biomarker analysis in oesophagogastric cancer: Results from the REAL3 and TransMAGIC trials. European Journal of Cancer.
- Feasibility of preoperative chemotherapy for locally advanced, operable colon cancer: The pilot phase of a randomised controlled trial. The Lancet Oncology, 13(11), 1152-1160.
- Palliative radiotherapy in patients with esophageal carcinoma: A retrospective review. Practical Radiation Oncology, 2(4), 257-264.
- A randomized, multicenter trial of epirubicin, oxaliplatin, and capecitabine (EOC) plus panitumumab in advanced esophagogastric cancer (REAL3).. Journal of Clinical Oncology, 30(15_suppl), LBA4000-LBA4000.
- Ablation with low-dose radioiodine and thyrotropin alfa in thyroid cancer.. N Engl J Med, 366(18), 1674-1685.
- Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24.. J Med Genet, 49(3), 158-163. View this article in WRRO
- Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk. Nature Genetics, 44(7), 770-776.
- Risk factors in thyroid-type carcinoma arising in ovarian struma: a report of 15 cases with comparison to ordinary struma ovarii. HISTOPATHOLOGY, 57(1), 148-152.
- Metastatic Struma Ovarii: Late Presentation, Unusual Features and Multiple Radioactive Iodine Treatments. Clinical Oncology, 18(10), 768-772.
- Investigation of relationship between change in locoregional control and change in overall survival in randomized controlled trials of modified radiotherapy in head-and-neck cancer. International Journal of Radiation Oncology Biology Physics, 60(5), 1405-1409.
- Iridium-192 implantation for T1 and T2a carcinoma of the tongue and floor of mouth: Retrospective study of the results of treatment at the Royal Berkshire Hospital. British Journal of Radiology, 76(906), 414-417.
- Consensus statement on the management of incidentally discovered FDG avid thyroid nodules in patients being investigated for other cancers. Clinical Endocrinology.
- Redifferentiation therapy for iodine refractory differentiated thyroid cancers- current status. Thyroid.
- Parathyroid related peptide (PTHrP) secreting pancreatic neuroendocrine tumour (PNET): a case of PTHrP, hypercalcaemia and osteoarthrosis (OA) controlled by somatostatin analogue therapy (SSA). Endocrine Abstracts.
- Novel target therapies for advanced thyroid cancers. Endocrine Abstracts.
- A rare Presentation of Carcinoid Crisis Following Radioactive Iodine Treatment for Thyroid Cancer in a Patient with Metastatic Midgut Neuroendocrine Tumour. Endocrine Abstracts.
- Long-Term Outcomes and Exploratory Analyses of the Randomized Phase III BILCAP Study. Journal of Clinical Oncology.
- Computed Tomographic Sarcopenia in Pancreatic Cancer: Further Utilization to Plan Patient Management. Journal of Gastrointestinal Cancer.
- Systematic review of health-related quality of life following thyroid cancer. Tumori Journal, 030089162110250-030089162110250.
- EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers. Gut.
- Medullary Thyroid Cancer Patient’s Assessment of Quality of Life Tools: Results from the QaLM Study. European Thyroid Journal, 1-7.
- PancREatic Cancer and Individualised Supervised Exercise (PRECISE): a feasibility trial protocol for patients with resectable pancreatic ductal adenocarcinoma. AMRC Open Research, 2, 22-22.
- PancREatic Cancer and Individualised Supervised Exercise (PRECISE): a feasibility trial protocol for patients with resectable pancreatic ductal adenocarcinoma. AMRC Open Research, 2, 22-22.
- Standardised quantitative radioiodine SPECT/CT Imaging for multicentre dosimetry trials in molecular radiotherapy. Physics in Medicine & Biology, 64(24), 245013-245013.
- Sheffield experience of administering Lutathera as a day case treatment. Endocrine Abstracts.
- Efficacy of somatostatin analogues in managing hypercalcaemia due to PTHrP in a well differentiated metastatic pancreatic neuroendocrine tumour and discussion of modern treatment options: A clinical case. Endocrine Abstracts.
- Chronic diarrhoea - a rare endocrine cause. Endocrine Abstracts.
Conference proceedings papers
- Quality of life in post-surgical hypoparathyroidism (PoSH). BRITISH JOURNAL OF SURGERY, Vol. 109
- ESPAC-5F: Four arm, international randomised phase II trial of immediate surgery compared with neoadjuvant gemcitabine plus capecitabine (GEMCAP) or FOLFIRINOX or chemoradiotherapy (CRT) in patients with borderline resectable pancreatic cancer. Pancreatology, Vol. 20 (pp S4-S5)
- EGFR amplification (amp) and survival in the REAL-3 trial. Annals of Oncology, Vol. 29 (pp viii217-viii217)
- ACELARATE: A randomised phase III, open label, clinical study comparing NUC-1031 with gemcitabine in patients with metastatic pancreatic carcinoma. Annals of Oncology, Vol. 29 (pp viii269-viii270)
- Biomarker predication of efficacy to gemcitabine plus vandetanib in phase II, double blind multicentre randomised controlled trial of gemcitabine placebo in locally advanced or metastatic pancreatic carcinoma. Pancreatology, Vol. 18(4) (pp S127-S128)
- PTU-023 Endoscopic ultrasound biopsy prior to palliative treatment for pancreatic cancer: can we prevent unnecessary procedures?. Pancreas
- Audit of outcomes from Chemoradiotherapy for locally advanced pancreatic cancer at Weston Park Hospital and comparison with SCALOP trial. European Journal of Surgical Oncology, Vol. 44 (pp S9-S9)
- ACELARATE: A phase III, open label, multicentre randomised clinical study comparing Acelarin (NUC-1031) with gemcitabine in patients with metastatic pancreatic carcinoma.. Journal of Clinical Oncology, Vol. 36(4_suppl) (pp TPS537-TPS537)
- Strong tumour cytidine deaminase (CDA) staining predicts for improved survival associated with sequential nab-Paclitaxel (nabP) and gemcitabine (GEM) chemotherapy as first line treatment of patients (pts) with metastatic pancreatic adenocarcinoma (mPDAC). Annals of Oncology, Vol. 28 (pp v251-v252)
- Biomarker prediction of efficacy to vandetanib plus gemcitabine in a phase II double blind multicenter randomized placebo-controlled trial in locally advanced or metastatic pancreatic carcinoma.. Journal of Clinical Oncology, Vol. 35(15_suppl) (pp 4104-4104)
- A randomized phase II trial comparing different schedules of nab-paclitaxel (nabP) combined with gemcitabine (GEM) as first line treatment for metastatic pancreatic adenocarcinoma (mPDAC).. Journal of Clinical Oncology, Vol. 35(15_suppl) (pp 4100-4100)
- Adjuvant capecitabine for biliary tract cancer: The BILCAP randomized study.. Journal of Clinical Oncology, Vol. 35(15_suppl) (pp 4006-4006)
- UK phase IV, observational study to assess quality of life in patients (pts) with pancreatic neuroendocrine tumours (pNETS) receiving treatment with everolimus: The “real-world” OBLIQUE study. Annals of Oncology, Vol. 27 (pp vi143-vi143)
- ESPAC-4: A multicenter, international, open-label randomized controlled phase III trial of adjuvant combination chemotherapy of gemcitabine (GEM) and capecitabine (CAP) versus monotherapy gemcitabine in patients with resected pancreatic ductal adenocarcinoma.. Journal of Clinical Oncology, Vol. 34(18_suppl) (pp LBA4006-LBA4006)
- ESPAC-4: A multicenter, international, open label randomized controlled phase III trial of adjuvant combination chemotherapy of gemcitabine (GEM) and capecitabine (CAP), versus monotherapy gemcitabine in patients with resected pancreatic ductal adenocarcinoma. Pancreatology, Vol. 16(3) (pp S63-S63)
- 18. Thyroid cancer – Incidence trends and distribution patterns in South Yorkshire, United Kingdom. European Journal of Surgical Oncology (EJSO), Vol. 41(10) (pp S84-S85)
- Quality of life (QoL) analysis from the randomized phase III REAL3 trial of epirubicin, oxaliplatin, and capecitabine (EOC) with or without panitumumab (P) in advanced esophagogastric adenocarcinoma.. Journal of Clinical Oncology, Vol. 32(15_suppl) (pp 4067-4067)
- Predictive cytokine biomarkers for survival in patients with advanced pancreatic cancer randomized to sequential chemoimmunotherapy comprising gemcitabine and capecitabine (GemCap) followed by the telomerase vaccine GV1001 compared to concurrent chemoimmunotherapy in the TeloVac phase III trial.. Journal of Clinical Oncology, Vol. 32(15_suppl) (pp 4121-4121)
- Prognostication in esophagogastric adenocarcinoma (OGA): Factors influencing overall survival (OS) in REAL3.. Journal of Clinical Oncology, Vol. 32(3_suppl) (pp 91-91)
- A phase III randomized trial of chemoimmunotherapy comprising gemcitabine and capecitabine with or without telomerase vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer.. Journal of Clinical Oncology, Vol. 31(18_suppl) (pp LBA4004-LBA4004)
- COUGAR-02: A randomized phase III study of docetaxel versus active symptom control in advanced esophagogastric adenocarcinoma.. Journal of Clinical Oncology, Vol. 31(4_suppl) (pp LBA4-LBA4)
- TH-302 + Gemcitabine (G + T) vs Gemcitabine (G) in Patients with Previously Untreated advanced Pancreatic Cancer (PAC). Annals of Oncology, Vol. 23 (pp ix224-ix224)
- A randomized multicenter trial of epirubicin, oxaliplatin, and capecitabine (EOC) plus panitumumab in advanced esophagogastric cancer (REAL3).. Journal of Clinical Oncology, Vol. 30(18_suppl) (pp LBA4000-LBA4000)
- Addition of panitumumab to irinotecan: Results of PICCOLO, a randomized controlled trial in advanced colorectal cancer (aCRC).. Journal of Clinical Oncology, Vol. 29(15_suppl) (pp 3523-3523)
- REAL3: A multicenter randomized phase II/III trial of epirubicin, oxaliplatin, and capecitabine (EOC) versus modified (m) EOC plus panitumumab (P) in advanced oesophagogastric (OG) cancer—Response rate (RR), toxicity, and molecular analysis from phase II.. Journal of Clinical Oncology, Vol. 29(15_suppl) (pp 4131-4131)
- Functional or non-function pancreatic NET; Novel use of a flash glucose monitoring system. Endocrine Abstracts
Preprints
- Investigating the Clinical Benefit of Selumetinib in Resensitising Advanced Iodine Refractory Differentiated Thyroid Cancer to Radioiodine Therapy: Results of the SEL-I-METRY Phase II Trial.
- Digital Detection of Sarcopenia in Pancreatic Cancer: Additional Utilization to Plan Patient Management, Research Square Platform LLC.
- Long Term Outcomes and Exploratory Analyses of the Randomised Phase 3 BILCAP Study.
- Optimising Chemotherapy for Frail and Older Patients With Advanced Gastroesophageal Cancer: The GO2 Phase III Trial.
- FOLFOX as Second-Line Chemotherapy for Advanced Biliary Tract Cancer.
- Recommendations for multicentre clinical trials involving dosimetry for molecular radiotherapy. Clinical Oncology, 33(2), 131-136.
- Professional activities and memberships
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- Clinical Director of Sheffield Cancer Clinical Trials Centre
- Cancer Specialty Lead Yorkshire and Humber LCRN
- NIHR National Specialty Lead for Radiotherapy and Imaging.
- NIHR Cluster F Co-Lead.
- Member of CTRad Executive Group
- Chair of NCRI Thyroid Cancer Group
- Member of NCRI Neuroendocrine Tumour Group
- Member of ARSAC
- Member of RCR Clinical Oncology Academic Committee